| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luciene Cristina Gastalho Campos, João Carlos Ribeiro-Silva, Alessandra Santos Menegon, Valerio Garrone Barauna, Ayumi Aurea Miyakawa, Jose Eduardo Kriege. Cyclic stretch-induced Crp3 sensitizes vascular smooth muscle cells to apoptosis during vein arterialization remodeling. Clinical science (London, England : 1979). 2019-11-20. PMID:29437853. |
immunoblotting analysis indicated that ceramide stretch-induced apoptosis in smc is accompanied by a decrease in the phosphorylation status of both fak and akt, leading to an increase in bax expression and caspase-3 cleavage. |
2019-11-20 |
2023-08-13 |
human |
| Keigo Okada, Ayako Nogami, Shinya Ishida, Hiroki Akiyama, Cheng Chen, Yoshihiro Umezawa, Osamu Miur. FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway. Oncotarget. vol 9. issue 10. 2019-11-20. PMID:29507660. |
the specific pan-pim kinase inhibitor azd1208 as well as pim447 in combination with the pi3k inhibitor gdc-0941 or the akt inhibitor mk-2206 cooperatively downregulated the mtorc1/4ebp1 pathway, formation of the eif4e/eif4g complex, and mcl-1 expression leading to activation of bak and bax to induce caspase-dependent apoptosis synergistically in these cells. |
2019-11-20 |
2023-08-13 |
Not clear |
| Mahiro Iizuka-Ohashi, Motoki Watanabe, Mamiko Sukeno, Mie Morita, Ngoc Thi Hong Hoang, Takahiro Kuchimaru, Shinae Kizaka-Kondoh, Yoshihiro Sowa, Koichi Sakaguchi, Tetsuya Taguchi, Toshiyuki Saka. Blockage of the mevalonate pathway overcomes the apoptotic resistance to MEK inhibitors with suppressing the activation of Akt in cancer cells. Oncotarget. vol 9. issue 28. 2019-11-20. PMID:29731968. |
we here demonstrate that the blockade of the mevalonate pathway using the antilipidemic drug statins represses akt activation following mek inhibition and induces significant apoptosis when co-treated with ch5126766 or trametinib. |
2019-11-20 |
2023-08-13 |
human |
| Francesca Punzo, Iolanda Manzo, Chiara Tortora, Elvira Pota, Velia D' Angelo, Giulia Bellini, Alessandra Di Paola, Federica Verace, Fiorina Casale, Francesca Ross. Effects of CB2 and TRPV1 receptors' stimulation in pediatric acute T-lymphoblastic leukemia. Oncotarget. vol 9. issue 30. 2019-11-20. PMID:29765535. |
we analyzed the effect on apoptosis and cell cycle progression by a cytofluorimetric assays and evaluated the expression level of several target genes (caspase 3, bax, bcl-2, akt, erk, pten, notch-1, cdk2, p53) involved in cell survival and apoptosis, by real-time pcr and western blotting. |
2019-11-20 |
2023-08-13 |
Not clear |
| Kari Högstrand, Stephanie Darmanin, TachaZi Plym Forshell, Alf Grandie. Transformation of mouse T cells requires MYC and AKT activity in conjunction with inhibition of intrinsic apoptosis. Oncotarget. vol 9. issue 30. 2019-11-20. PMID:29765548. |
transformation of mouse t cells requires myc and akt activity in conjunction with inhibition of intrinsic apoptosis. |
2019-11-20 |
2023-08-13 |
mouse |
| Seyung S Chung, Pranabananda Dutta, David Austin, Piwen Wang, Adam Awad, Jaydutt V Vadgam. Combination of resveratrol and 5-flurouracil enhanced anti-telomerase activity and apoptosis by inhibiting STAT3 and Akt signaling pathways in human colorectal cancer cells. Oncotarget. vol 9. issue 68. 2019-11-20. PMID:30250641. |
combination of resveratrol and 5-flurouracil enhanced anti-telomerase activity and apoptosis by inhibiting stat3 and akt signaling pathways in human colorectal cancer cells. |
2019-11-20 |
2023-08-13 |
human |
| JongYeob Choi, MinWha Jo, EunYoung Lee, Seongsoo Hwang, DooSeok Cho. Aberrant PTEN expression in response to progesterone reduces endometriotic stromal cell apoptosis Reproduction (Cambridge, England). vol 153. issue 1. 2019-11-20. PMID:30390418. |
subsequently, autophagy and apoptosis induction increased through the inhibition of akt and mtor activity. |
2019-11-20 |
2023-08-13 |
human |
| JongYeob Choi, MinWha Jo, EunYoung Lee, Seongsoo Hwang, DooSeok Cho. Aberrant PTEN expression in response to progesterone reduces endometriotic stromal cell apoptosis Reproduction (Cambridge, England). vol 153. issue 1. 2019-11-20. PMID:30390418. |
in contrast, progesterone had no significant effects on pten expression, akt, mtor activity, autophagy or apoptosis in ecscs. |
2019-11-20 |
2023-08-13 |
human |
| Xiang Li, Lei Ning, Xiangde Zhao, Shuanglin Wa. MicroRNA-543 promotes ovariectomy-induced osteoporosis through inhibition of AKT/p38 MAPK signaling pathway by targeting YAF2. Journal of cellular biochemistry. 2019-11-20. PMID:30506950. |
akt inhibitor mk2206 and p38 mapk inhibitor sb203580 also enhanced the effects of mirna-543 on apoptosis in osteoblasts. |
2019-11-20 |
2023-08-13 |
rat |
| Tao Sun, Han Liu, Yutong Cheng, Lixiao Yan, Chayakrit Krittanawong, Shihong Li, Wang Qian, Wang Su, Xuanzu Chen, Xuejian Hou, Hongju Zhan. 2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-glucoside eliminates ischemia/reperfusion injury-induced H9c2 cardiomyocytes apoptosis involving in Bcl-2, Bax, caspase-3, and Akt activation. Journal of cellular biochemistry. 2019-11-20. PMID:30891810. |
2,3,5,4'-tetrahydroxystilbene-2-o-β-d-glucoside eliminates ischemia/reperfusion injury-induced h9c2 cardiomyocytes apoptosis involving in bcl-2, bax, caspase-3, and akt activation. |
2019-11-20 |
2023-08-13 |
Not clear |
| MacRae F Linton, Javid J Moslehi, Vladimir R Babae. Akt Signaling in Macrophage Polarization, Survival, and Atherosclerosis. International journal of molecular sciences. vol 20. issue 11. 2019-11-20. PMID:31159424. |
therefore, elimination of pro-apoptotic factors as well as factors that antagonize or suppress akt signaling in macrophages increases cell viability, protecting them from apoptosis, and this markedly accelerates atherosclerosis in mice. |
2019-11-20 |
2023-08-13 |
mouse |
| Miriam S Hohmann, David M Habiel, Ana L Coelho, Waldiceu A Verri, Cory M Hogaboa. Quercetin Enhances Ligand-induced Apoptosis in Senescent Idiopathic Pulmonary Fibrosis Fibroblasts and Reduces Lung Fibrosis In Vivo. American journal of respiratory cell and molecular biology. vol 60. issue 1. 2019-11-18. PMID:30109946. |
collectively, these data indicate that quercetin reverses the resistance to death ligand-induced apoptosis by promoting fasl receptor and caveolin-1 expression and inhibiting akt activation, thus mitigating the progression of established pulmonary fibrosis in aged mice. |
2019-11-18 |
2023-08-13 |
mouse |
| Li Sun, Yuan Huang, Yeying Liu, Yujie Zhao, Xiaoxiao He, Lingling Zhang, Feng Wang, Yingjie Zhan. Ipatasertib, a novel Akt inhibitor, induces transcription factor FoxO3a and NF-κB directly regulates PUMA-dependent apoptosis. Cell death & disease. vol 9. issue 9. 2019-11-15. PMID:30185800. |
ipatasertib, a novel akt inhibitor, induces transcription factor foxo3a and nf-κb directly regulates puma-dependent apoptosis. |
2019-11-15 |
2023-08-13 |
Not clear |
| Li Sun, Yuan Huang, Yeying Liu, Yujie Zhao, Xiaoxiao He, Lingling Zhang, Feng Wang, Yingjie Zhan. Ipatasertib, a novel Akt inhibitor, induces transcription factor FoxO3a and NF-κB directly regulates PUMA-dependent apoptosis. Cell death & disease. vol 9. issue 9. 2019-11-15. PMID:30185800. |
ipatasertib led to p53-independent puma activation by inhibiting akt, thereby activating both foxo3a and nf-κb synchronously that will directly bind to puma promoter, up-regulating puma transcription and bax-mediated intrinsic mitochondrial apoptosis. |
2019-11-15 |
2023-08-13 |
Not clear |
| Qi Liu, Jie Yang, Yafan Gong, Jingzeng Cai, Ziwei Zhan. Role of miR-731 and miR-2188-3p in mediating chlorpyrifos induced head kidney injury in common carp via targeting TLR and apoptosis pathways. Aquatic toxicology (Amsterdam, Netherlands). vol 215. 2019-11-14. PMID:31479757. |
during cpf exposure, mrna expression of tlr pathway genes and its downstream genes involved in autophagy and apoptosis pathway including tlr1, tlr2, tlr7, tlr9, myd88, irak1, irak4, irf7, pi3k, akt, mtor, caspase3, caspase8 and bax were differentially increased under cpf exposure, along with atg13 and bcl2 decreased at the same time. |
2019-11-14 |
2023-08-13 |
Not clear |
| Rumeng Tan, Hongzhe Tian, Bo Yang, Bo Zhang, Chen Dai, Zhenyi Han, Meixi Wang, Yakun Li, Lai Wei, Dong Chen, Guangyao Wang, Huifang Yang, Fan He, Zhishui Che. Autophagy and Akt in the protective effect of erythropoietin helix B surface peptide against hepatic ischaemia/reperfusion injury in mice. Scientific reports. vol 8. issue 1. 2019-11-13. PMID:30279567. |
we assessed alanine aminotransferase (alt), aspartate aminotransferase (ast) and lactate dehydrogenase (ldh) levels in mouse sera, and performed haematoxylin/eosin (he) staining, immunohistochemistry, electron microscopy, immunofluorescence microscopy, and western blotting on liver tissue to detect the degree of liver injury, liver apoptosis, autophagy, and the expression of microtubule associated protein 1 light chain 3 alpha (map1lc3, or lc3), beclin 1, phospho-mtor, mtor, phospho-akt (p-akt), and akt. |
2019-11-13 |
2023-08-13 |
mouse |
| Cuijuan Shi, Chun Rao, Cuiyun Sun, Lin Yu, Xuexia Zhou, Dan Hua, Run Wang, Wenjun Luo, Zhendong Jiang, Junhu Zhou, Qian Wang, Shizhu Y. miR-29s function as tumor suppressors in gliomas by targeting TRAF4 and predict patient prognosis. Cell death & disease. vol 9. issue 11. 2019-11-13. PMID:30348972. |
an investigation of the mechanism revealed that mir-29a/b/c promoted apoptosis through the traf4/akt/mdm2 pathway in a p53-dependent manner, while mir-29a/b/c induced g1 arrest and inhibited tumor cell proliferation by blocking the phosphorylation of akt and gsk-3β, and the expression of cyclin d1 and c-myc. |
2019-11-13 |
2023-08-13 |
human |
| Fei Ye, Long Tian, Qingzhong Zhou, Daxiong Fen. LncRNA FER1L4 induces apoptosis and suppresses EMT and the activation of PI3K/AKT pathway in osteosarcoma cells via inhibiting miR-18a-5p to promote SOCS5. Gene. vol 721. 2019-11-07. PMID:31473323. |
furthermore, the suppressor of cytokine signaling 5 (socs5) was confirmed a target gene of mir-18a-5p by luciferase gene reporter assay and socs5 suppression by mir-18a-5p attenuated the effects of fer1l4 overexpression on the os cells apoptosis and the expressed levels of pi3k, akt, twist1, n-cadherin and vimentin. |
2019-11-07 |
2023-08-13 |
Not clear |
| Ying Fu, Gang Ma, Guolong Liu, Bin Li, Hui Li, Xishan Hao, Liren Li. USP14 as a novel prognostic marker promotes cisplatin resistance via Akt/ERK signaling pathways in gastric cancer. Cancer medicine. vol 7. issue 11. 2019-11-06. PMID:30296012. |
thus, knockdown of usp14 sensitized gc cells to cisplatin by triggering cisplatin-induced apoptosis via impeding akt and erk signaling pathways. |
2019-11-06 |
2023-08-13 |
Not clear |
| Xinmei Zhao, Chaolan Lv, Shengbo Chen, Fachao Zh. A role for the non-receptor tyrosine kinase ACK1 in TNF-alpha-mediated apoptosis and proliferation in human intestinal epithelial caco-2 cells. Cell biology international. vol 42. issue 9. 2019-11-04. PMID:28921811. |
moreover, ack1 activated akt and src enhanced nuclear factor-кb (nf-кb) activity, suggesting a correlation between nf-кb signaling and tnf-alpha-mediated apoptosis in caco-2 cells. |
2019-11-04 |
2023-08-13 |
human |