| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenzhen Wei, Gang Wang, Yunyun Cheng, Rui Yang, Jie Song, Shan Huang, Haoyang Li, Hongwei Geng, Hao Yu, Songcai Liu, Linlin Ha. A miR-511-binding site SNP in the 3'UTR of IGF-1 gene is associated with proliferation and apoptosis of PK-15 cells. In vitro cellular & developmental biology. Animal. vol 55. issue 5. 2019-09-04. PMID:30945114. |
mir-511 significantly inhibited cell proliferation and promoted cell apoptosis by downregulating the phosphorylation level of akt and erk1/2. |
2019-09-04 |
2023-08-13 |
Not clear |
| Xin-Jie Hao, Cheng-Zhen Xu, Jin-Tai Wang, Xiao-Jie Li, Ming-Min Wang, Yi-Hai Gu, Zhi-Gang Lian. miR-21 promotes proliferation and inhibits apoptosis of hepatic stellate cells through targeting PTEN/PI3K/AKT pathway. Journal of receptor and signal transduction research. vol 38. issue 5-6. 2019-09-04. PMID:31038023. |
proliferation, apoptosis, and phosphatase and tensin homolog (pten)/phosphoinositide 3-kinase (pi3k)/protein kinase b (akt) signaling pathway related genes and proteins were detected by quantitative real-time polymerase chain reaction (qrt-pcr) and western blot, respectively. |
2019-09-04 |
2023-08-13 |
Not clear |
| Arabo Avanes, Gal Lenz, Jamil Moman. Darpp-32 and t-Darpp protein products of PPP1R1B: Old dogs with new tricks. Biochemical pharmacology. vol 160. 2019-09-03. PMID:30552871. |
more than one research team has demonstrated that these proteins, through mechanisms that to date remain cloudy, activate akt, a protein whose phosphorylation leads to cell survival and blocks apoptosis. |
2019-09-03 |
2023-08-13 |
mouse |
| Kirti S Prabhu, Kodappully S Siveen, Shilpa Kuttikrishnan, Anh Jochebeth, Tayyiba A Ali, Noor R Elareer, Ahmad Iskandarani, Abdul Quaiyoom Khan, Maysaloun Merhi, Said Dermime, Tamam El-Elimat, Nicholas H Oberlies, Feras Q Alali, Martin Steinhoff, Shahab Uddi. Greensporone A, a Fungal Secondary Metabolite Suppressed Constitutively Activated AKT via ROS Generation and Induced Apoptosis in Leukemic Cell Lines. Biomolecules. vol 9. issue 4. 2019-09-03. PMID:30934922. |
greensporone a, a fungal secondary metabolite suppressed constitutively activated akt via ros generation and induced apoptosis in leukemic cell lines. |
2019-09-03 |
2023-08-13 |
Not clear |
| Kirti S Prabhu, Kodappully S Siveen, Shilpa Kuttikrishnan, Anh Jochebeth, Tayyiba A Ali, Noor R Elareer, Ahmad Iskandarani, Abdul Quaiyoom Khan, Maysaloun Merhi, Said Dermime, Tamam El-Elimat, Nicholas H Oberlies, Feras Q Alali, Martin Steinhoff, Shahab Uddi. Greensporone A, a Fungal Secondary Metabolite Suppressed Constitutively Activated AKT via ROS Generation and Induced Apoptosis in Leukemic Cell Lines. Biomolecules. vol 9. issue 4. 2019-09-03. PMID:30934922. |
greensporone a treatment of leukemic cells causes inactivation of constitutively activated akt and its downstream targets, including members gsk3 and foxo1, and causes downregulation of antiapoptotic genes such as inhibitor of apoptosis (iaps) and bcl-2. |
2019-09-03 |
2023-08-13 |
Not clear |
| Krishnamachari Srira. Bifurcation analysis of insulin regulated mTOR signalling pathway in cancer cells. IET systems biology. vol 12. issue 5. 2019-08-30. PMID:30259865. |
metformin is shown to negatively regulate pi3k through ampk induced irs1 phosphorylation and this brings about a reversal of akt bistablity in codimension-1 bifurcation diagram from s-shaped, related to cell proliferation in the absence of drug metformin, to z-shaped, related to apoptosis in the presence of drug metformin. |
2019-08-30 |
2023-08-13 |
Not clear |
| Shaoyan Jiang, Hong Chang, Shaojie Deng, Danyi Fa. Icariin enhances the chemosensitivity of cisplatin‑resistant ovarian cancer cells by suppressing autophagy via activation of the AKT/mTOR/ATG5 pathway. International journal of oncology. vol 54. issue 6. 2019-08-30. PMID:31081049. |
we investigated the sensitivity of skvcr cells to cisplatin, as well as the effects of an autophagy agonist (rapamycin) on autophagy, apoptosis, and the protein kinase b (akt) signaling pathway. |
2019-08-30 |
2023-08-13 |
Not clear |
| Shaoyan Jiang, Hong Chang, Shaojie Deng, Danyi Fa. Icariin enhances the chemosensitivity of cisplatin‑resistant ovarian cancer cells by suppressing autophagy via activation of the AKT/mTOR/ATG5 pathway. International journal of oncology. vol 54. issue 6. 2019-08-30. PMID:31081049. |
finally, the mechanism underlying the effects of autophagy‑related (atg) protein atg5 overexpression on autophagy, apoptosis and akt signaling in skvcr cells were determined. |
2019-08-30 |
2023-08-13 |
Not clear |
| Ming-Horng Tsai, Ju-Fang Liu, Yao-Chang Chiang, Stephen Chu-Sung Hu, Lee-Fen Hsu, Yu-Ching Lin, Zih-Chan Lin, Hui-Chun Lee, Mei-Chuan Chen, Chieh-Liang Huang, Chiang-Wen Le. Correction: Artocarpin, an isoprenyl flavonoid, induces p53-dependent or independent apoptosis via ROS-mediated MAPKs and Akt activation in non-small cell lung cancer cells. Oncotarget. vol 10. issue 36. 2019-08-30. PMID:31448047. |
correction: artocarpin, an isoprenyl flavonoid, induces p53-dependent or independent apoptosis via ros-mediated mapks and akt activation in non-small cell lung cancer cells. |
2019-08-30 |
2023-08-13 |
Not clear |
| Liangyu Zhao, Zijue Zhu, Chencheng Yao, Yuhua Huang, Erlei Zhi, Huixing Chen, Ruhui Tian, Peng Li, Qingqing Yuan, Yunjing Xue, Zhong Wan, Chao Yang, Yuehua Gong, Zuping He, Zheng L. VEGFC/VEGFR3 Signaling Regulates Mouse Spermatogonial Cell Proliferation via the Activation of AKT/MAPK and Cyclin D1 Pathway and Mediates the Apoptosis by affecting Caspase 3/9 and Bcl-2. Cell cycle (Georgetown, Tex.). vol 17. issue 2. 2019-08-29. PMID:29169284. |
collectively, these data suggested that vegfc/vegfr3 signaling promotes the proliferation of gc-1 cells via the akt /mapk and cyclin d1 pathway and it inhibits the cell apoptosis through caspase-3/9, parp and bcl-2. |
2019-08-29 |
2023-08-13 |
mouse |
| Hongji Liu, Wei Wang, Xiang Li, Chao Huang, Zongduan Zhang, Mingyue Yuan, Xiangyu L. High hydrostatic pressure induces apoptosis of retinal ganglion cells via regulation of the NGF signalling pathway. Molecular medicine reports. vol 19. issue 6. 2019-08-29. PMID:31059045. |
western blotting, reverse transcription‑quantitative polymerase chain reaction and immunofluorescence were used to detect the expression and mrna levels of nerve growth factor (ngf), protein kinase b (akt), apoptosis signal‑regulating kinase 1 (ask1), forkhead box o1 (foxo1) and camp response element binding protein (creb). |
2019-08-29 |
2023-08-13 |
rat |
| Xubin Yang, Xiaoshan Li, Qiongyan Lin, Quanfu X. Up-regulation of microRNA-203 inhibits myocardial fibrosis and oxidative stress in mice with diabetic cardiomyopathy through the inhibition of PI3K/Akt signaling pathway via PIK3CA. Gene. vol 715. 2019-08-27. PMID:31336140. |
the obtained results indicated that up-regulation of mir-203 reduced myocardial hypertrophy, myocardial fibrosis, myocardial apoptosis, and levels of pik3ca, pi3k, akt, coi i, coi iii, anp, mda and ros in the myocardial tissues, by which dm-induced cardiac dysfunction and pathological changes could be ameliorated. |
2019-08-27 |
2023-08-13 |
mouse |
| Yiming Bi, Han Li, Dazhuang Yi, Yuxue Sun, Yang Bai, Sheng Zhong, Yang Song, Gang Zhao, Yong Che. Cordycepin Augments the Chemosensitivity of Human Glioma Cells to Temozolomide by Activating AMPK and Inhibiting the AKT Signaling Pathway. Molecular pharmaceutics. vol 15. issue 11. 2019-08-26. PMID:30336060. |
accumulating evidence has shown that both ampk and akt are activated by tmz, while only ampk contributes to apoptosis via mammalian target of rapamycin (mtor) inhibition. |
2019-08-26 |
2023-08-13 |
human |
| Nina Xue, Fangfang Lai, Tingting Du, Ming Ji, Di Liu, Chunhong Yan, Sen Zhang, Xiaoming Yu, Jing Jin, Xiaoguang Che. Chaperone-mediated autophagy degradation of IGF-1Rβ induced by NVP-AUY922 in pancreatic cancer. Cellular and molecular life sciences : CMLS. vol 76. issue 17. 2019-08-26. PMID:30980109. |
we found that the hsp90α inhibitor nvp-auy922 (922) effectively downregulated and destabilized the igf-1rβ protein, substantially reduced the levels of downstream signaling molecules (p-akt, akt and p-erk1/2), and resulted in growth inhibition and apoptosis in igf-1rβ-overexpressing pc cells. |
2019-08-26 |
2023-08-13 |
Not clear |
| Fu-Chi Kang, Shu-Chun Wang, Edmund Cheung So, Ming-Min Chang, Kar-Lok Wong, Ka Shun Cheng, Yung-Chia Chen, Bu-Miin Huan. Propofol may increase caspase and MAPK pathways, and suppress the Akt pathway to induce apoptosis in MA‑10 mouse Leydig tumor cells. Oncology reports. vol 41. issue 6. 2019-08-20. PMID:31002349. |
propofol may increase caspase and mapk pathways, and suppress the akt pathway to induce apoptosis in ma‑10 mouse leydig tumor cells. |
2019-08-20 |
2023-08-13 |
mouse |
| Fu-Chi Kang, Shu-Chun Wang, Edmund Cheung So, Ming-Min Chang, Kar-Lok Wong, Ka Shun Cheng, Yung-Chia Chen, Bu-Miin Huan. Propofol may increase caspase and MAPK pathways, and suppress the Akt pathway to induce apoptosis in MA‑10 mouse Leydig tumor cells. Oncology reports. vol 41. issue 6. 2019-08-20. PMID:31002349. |
additionally, propofol diminished the phosphorylation of akt to activate apoptosis in ma‑10 cells. |
2019-08-20 |
2023-08-13 |
mouse |
| Fu-Chi Kang, Shu-Chun Wang, Edmund Cheung So, Ming-Min Chang, Kar-Lok Wong, Ka Shun Cheng, Yung-Chia Chen, Bu-Miin Huan. Propofol may increase caspase and MAPK pathways, and suppress the Akt pathway to induce apoptosis in MA‑10 mouse Leydig tumor cells. Oncology reports. vol 41. issue 6. 2019-08-20. PMID:31002349. |
in conclusion, propofol may induce ma‑10 cell apoptosis by activating caspase and mapk pathways, and inhibiting the akt pathway in ma‑10 cells, demonstrating that propofol may be a potential anticancer agent against leydig cell cancer. |
2019-08-20 |
2023-08-13 |
mouse |
| Run-Ze Li, Xing-Xing Fan, Dan-Feng Shi, Guo-Yuan Zhu, Yu-Wei Wang, Lian-Xiang Luo, Hu-Dan Pan, Xiao-Jun Yao, Elaine Lai-Han Leung, Liang Li. Identification of a new pyruvate kinase M2 isoform (PKM2) activator for the treatment of non-small-cell lung cancer (NSCLC). Chemical biology & drug design. vol 92. issue 5. 2019-08-19. PMID:29931766. |
an in vitro enzyme activity assay showed that 0089-0022 is a direct pkm2 activator and that it effectively induces apoptosis in a549 and h1975 cells through inhibition of akt phosphorylation. |
2019-08-19 |
2023-08-13 |
Not clear |
| Sitai Liang, Edward A Medina, Boajie Li, Samy L Habi. Preclinical evidence of the enhanced effectiveness of combined rapamycin and AICAR in reducing kidney cancer. Molecular oncology. vol 12. issue 11. 2019-08-12. PMID:30107094. |
treatment with drug combinations significantly decreased cell proliferation, increased cell apoptosis, and abolished akt phosphorylation and hif-2α expression in renal cell carcinoma cells, including primary cells isolated from kidney cancer patients. |
2019-08-12 |
2023-08-13 |
mouse |
| Yafei Zheng, Yuyun Wu, Ying Liu, Zhirui Guo, Tingting Bai, Ping Zhou, Jin Wu, Qin Yang, Zhengxia Liu, Xiang L. Intrinsic Effects of Gold Nanoparticles on Oxygen-Glucose Deprivation/Reperfusion Injury in Rat Cortical Neurons. Neurochemical research. vol 44. issue 7. 2019-08-12. PMID:31093902. |
taken together, these results show that 20-nm au-nps can protect primary cortical neurons against ogd/r injury, possibly by decreasing apoptosis and oxidative stress, while activating akt signaling and mitochondrial pathways. |
2019-08-12 |
2023-08-13 |
rat |