| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Meng-Yao Sun, Dan-Dan Wang, Jian Sun, Xiao-Hua Zhao, Si Cai, Qiu-Xue Wu, Tao Jie, Zhen-Hua Ni, Jian-Yue Sun, Qing-Feng Tan. The Zuo Jin Wan Formula increases chemosensitivity of human primary gastric cancer cells by AKT mediated mitochondrial translocation of cofilin-1. Chinese journal of natural medicines. vol 17. issue 3. 2019-07-17. PMID:30910056. |
these data revealed that zjw can increase the chemosensitivity in ddp-resistant primary gc cells by inducing mitochondrial apoptosis and akt inactivation. |
2019-07-17 |
2023-08-13 |
human |
| Zhiwei Gu, Changjie Lin, Jian Hu, Jing Xia, Shaohua Wei, Dekang Ga. USP34 Regulated Human Pancreatic Cancer Cell Survival via AKT and PKC Pathways. Biological & pharmaceutical bulletin. vol 42. issue 4. 2019-07-16. PMID:30686807. |
moreover, usp34 overexpression reversed akt inhibitor and pkc inhibitor induced pacn-1 cell apoptosis. |
2019-07-16 |
2023-08-13 |
human |
| Caixia Li, Bing Zhao, Caizhao Lin, Zhiping Gong, Xiaoxia A. TREM2 inhibits inflammatory responses in mouse microglia by suppressing the PI3K/NF-κB signaling. Cell biology international. vol 43. issue 4. 2019-07-15. PMID:29663649. |
then, the cell viability, apoptosis, phagocytosis, nitric oxide (no), lactate dehydrogenase (ldh), and cytokine production, as well as the activation of akt and nf-kb were determined, respectively. |
2019-07-15 |
2023-08-13 |
mouse |
| Yonghao Qi, Xuan Zhao, Jiaying Chen, Ambara R Pradipta, Jing Wei, Haihua Ruan, Lijun Zhou, Richard P Hsung, Katsunori Tanak. In vitro and in vivo cancer cell apoptosis triggered by competitive binding of Cinchona alkaloids to the RING domain of TRAF6. Bioscience, biotechnology, and biochemistry. vol 83. issue 6. 2019-07-15. PMID:31074699. |
results reported herein would demonstrate that cinchona alkaloids could induce apoptosis in hela cells, inhibit the ubiquitination and phosphorylation of both akt and tak1, and up-regulate the ratio of bax/bcl-2. |
2019-07-15 |
2023-08-13 |
Not clear |
| Xin-Gang Nie, Dong-Sheng Fan, Yan-Xia Huang, Ying-Ying He, Bo-Li Dong, Feng Ga. Downregulation of microRNA-149 in retinal ganglion cells suppresses apoptosis through activation of the PI3K/Akt signaling pathway in mice with glaucoma. American journal of physiology. Cell physiology. vol 315. issue 6. 2019-07-08. PMID:30183321. |
additionally, downregulated mir-149 was noted to increase the levels of btc, pi3k, and akt in both the retinal tissues and rgcs, whereas the silencing of mir-149 was observed to promote the viability of rgc and inhibit rgc apoptosis. |
2019-07-08 |
2023-08-13 |
mouse |
| Tânia R Mielcke, Thaís C Muradás, Eduardo C Filippi-Chiela, Maria Eduarda A Amaral, Luiza W Kist, Maurício R Bogo, Alessandra Mascarello, Patrícia D Neuenfeldt, Ricardo J Nunes, Maria M Campo. Mechanisms underlying the antiproliferative effects of a series of quinoxaline-derived chalcones. Scientific reports. vol 7. issue 1. 2019-07-02. PMID:29158524. |
the selected chalcones, mainly n9 and n17, displayed marked antiproliferative effects, via apoptosis and autophagy induction, with an increase of sub-g1 population and akt inhibition. |
2019-07-02 |
2023-08-13 |
human |
| L Tian, Z Z Tao, H P Ye, G Y Li, Z F Zhan, H W Tu. Over-expression of MEOX2 promotes apoptosis through inhibiting the PI3K/Akt pathway in laryngeal cancer cells. Neoplasma. vol 65. issue 5. 2019-07-01. PMID:29940775. |
real-time quantitative pcr (rt-qpcr) and western blot were used to detect mrna and protein levels of meox2 in laryngeal cancer tissues and cells (hep-2, tu212, amc-nh-8 and tu686 cells), and also apoptosis and phosphoinositide 3-kinase (pi3k)/protein kinase (akt) related factors in tu212 cells transfected with meox2. |
2019-07-01 |
2023-08-13 |
Not clear |
| Min Yu, Yujie Li, Mingyan Li, Dayun L. Eudesmin exerts antitumor effects by down-regulating EZH2 expression in nasopharyngeal carcinoma cells. Chemico-biological interactions. vol 307. 2019-06-26. PMID:31026422. |
moreover, knockdown of ezh2 attenuated the effects of akt overexpression on cell viability and apoptosis in npc cells. |
2019-06-26 |
2023-08-13 |
Not clear |
| Suyang Yu, Hong Guo, Xin Gao, Meng Li, Honglei Bia. Daphnoretin: An invasion inhibitor and apoptosis accelerator for colon cancer cells by regulating the Akt signal pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 111. 2019-06-21. PMID:30841414. |
daphnoretin: an invasion inhibitor and apoptosis accelerator for colon cancer cells by regulating the akt signal pathway. |
2019-06-21 |
2023-08-13 |
human |
| Suyang Yu, Hong Guo, Xin Gao, Meng Li, Honglei Bia. Daphnoretin: An invasion inhibitor and apoptosis accelerator for colon cancer cells by regulating the Akt signal pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 111. 2019-06-21. PMID:30841414. |
daphnoretin-treated hct116 had declined invasion and migration, increased apoptosis rate, and variations in gene expressions related to the akt signal pathway. |
2019-06-21 |
2023-08-13 |
human |
| Suyang Yu, Hong Guo, Xin Gao, Meng Li, Honglei Bia. Daphnoretin: An invasion inhibitor and apoptosis accelerator for colon cancer cells by regulating the Akt signal pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 111. 2019-06-21. PMID:30841414. |
those results indicated that daphnoretin can inhibit the proliferation, invasion, and migration of hct116 and promote its apoptosis by regulating the activity of akt signal pathway. |
2019-06-21 |
2023-08-13 |
human |
| Ana Filipa Silva, Gabriel Faria-Costa, Fábio Sousa-Nunes, Manuel Filipe Santos, Manuel João Ferreira-Pinto, Delfim Duarte, Ilda Rodrigues, João Tiago Guimarães, Adelino Leite-Moreira, Daniel Moreira-Gonçalves, Tiago Henriques-Coelho, Rita Negrã. Anti-Remodeling Effects of Xanthohumol-Fortified Beer in Pulmonary Arterial Hypertension Mediated by ERK and AKT Inhibition. Nutrients. vol 11. issue 3. 2019-06-18. PMID:30857304. |
this improvement was paralleled with the downregulation in expression of proteins responsible for proliferation (erk1/2), cell viability (akt), and apoptosis (bcl-xl). |
2019-06-18 |
2023-08-13 |
rat |
| Ying-Ya Cao, Jing Yu, Ting-Ting Liu, Kai-Xia Yang, Li-Yan Yang, Qun Chen, Feng Shi, Jia-Jie Hao, Yan Cai, Ming-Rong Wang, Wei-Hua Lu, Yu Zhan. Plumbagin inhibits the proliferation and survival of esophageal cancer cells by blocking STAT3-PLK1-AKT signaling. Cell death & disease. vol 9. issue 2. 2019-06-17. PMID:29339720. |
enforced plk1 expression in escc cells not only markedly rescued cells from plumbagin-induced apoptosis and proliferation inhibition but also restored the impaired akt activity. |
2019-06-17 |
2023-08-13 |
human |
| Hui Qi, Dan-Ping Liu, Da-Wei Xiao, Da-Chuan Tian, Yong-Wei Su, Shao-Feng Ji. Exosomes derived from mesenchymal stem cells inhibit mitochondrial dysfunction-induced apoptosis of chondrocytes via p38, ERK, and Akt pathways. In vitro cellular & developmental biology. Animal. vol 55. issue 3. 2019-06-14. PMID:30783864. |
exosomes derived from mesenchymal stem cells inhibit mitochondrial dysfunction-induced apoptosis of chondrocytes via p38, erk, and akt pathways. |
2019-06-14 |
2023-08-13 |
Not clear |
| Hui Qi, Dan-Ping Liu, Da-Wei Xiao, Da-Chuan Tian, Yong-Wei Su, Shao-Feng Ji. Exosomes derived from mesenchymal stem cells inhibit mitochondrial dysfunction-induced apoptosis of chondrocytes via p38, ERK, and Akt pathways. In vitro cellular & developmental biology. Animal. vol 55. issue 3. 2019-06-14. PMID:30783864. |
the present study demonstrated that bmsc-exos inhibited mitochondrial-induced apoptosis in response to il-1β, and p38, erk, and akt pathways were involved. |
2019-06-14 |
2023-08-13 |
Not clear |
| Natalia Pawłowska, Agnieszka Gornowicz, Anna Bielawska, Arkadiusz Surażyński, Anna Szymanowska, Robert Czarnomysy, Krzysztof Bielawsk. The molecular mechanism of anticancer action of novel octahydropyrazino[2,1-a:5,4-a']diisoquinoline derivatives in human gastric cancer cells. Investigational new drugs. vol 36. issue 6. 2019-06-10. PMID:29549610. |
confocal microscopy bioimaging was used to demonstrate the expression of pivotal proteins engaged in apoptosis (caspase-8, caspase-3, p53) and cell signaling (akt, erk1/2). |
2019-06-10 |
2023-08-13 |
human |
| Xi Ou, Guang-Tao Zhang, Zhe Xu, Jing-Sen Chen, Yong Xie, Ji-Kui Liu, Xiao-Ping Li. Desumoylating Isopeptidase 2 (DESI2) Inhibits Proliferation and Promotes Apoptosis of Pancreatic Cancer Cells through Regulating PI3K/AKT/mTOR Signaling Pathway. Pathology oncology research : POR. vol 25. issue 2. 2019-06-10. PMID:30411297. |
cell cycling, apoptosis, invasion, and the expression of phosphatidylinositol-3-kinase (pi3k)-protein kinase b (akt)-mammalian target of rapamycin (mtor) pathway and caspase 3 were measured. |
2019-06-10 |
2023-08-13 |
Not clear |
| Xi Ou, Guang-Tao Zhang, Zhe Xu, Jing-Sen Chen, Yong Xie, Ji-Kui Liu, Xiao-Ping Li. Desumoylating Isopeptidase 2 (DESI2) Inhibits Proliferation and Promotes Apoptosis of Pancreatic Cancer Cells through Regulating PI3K/AKT/mTOR Signaling Pathway. Pathology oncology research : POR. vol 25. issue 2. 2019-06-10. PMID:30411297. |
in aspc-1 and pance-1 cells, sh-desi2 group showed decreased apoptosis, increased cell invasion and increased expression of akt, p-akt, pi3k, p-pi3k, p-mtor and mtor and decreased caspase 3 expression compared with the control group, while overexpression of desi2 leaded to increased apoptosis, decreased cell invasion and reduced expression of akt, p-akt, pi3k, p-pi3k, p-mtor and mtor and increased expression of caspase 3. |
2019-06-10 |
2023-08-13 |
Not clear |
| Li Wang, Yanyang Liu, Yueling Zhou, Jiantao Wang, Li Tu, Zhen Sun, Xiujie Wang, Feng Lu. Zoledronic acid inhibits the growth of cancer stem cell derived from cervical cancer cell by attenuating their stemness phenotype and inducing apoptosis and cell cycle arrest through the Erk1/2 and Akt pathways. Journal of experimental & clinical cancer research : CR. vol 38. issue 1. 2019-06-10. PMID:30791957. |
zoledronic acid inhibits the growth of cancer stem cell derived from cervical cancer cell by attenuating their stemness phenotype and inducing apoptosis and cell cycle arrest through the erk1/2 and akt pathways. |
2019-06-10 |
2023-08-13 |
Not clear |
| Si-Zhou Huang, Wang-Yu Liu, Yue Huang, A-Ling Shen, Li-Ya Liu, Jun Pen. Patrinia scabiosaefolia Inhibits Growth of 5-FU-Resistant Colorectal Carcinoma Cells via Induction of Apoptosis and Suppression of AKT Pathway. Chinese journal of integrative medicine. vol 25. issue 2. 2019-06-06. PMID:29948597. |
patrinia scabiosaefolia inhibits growth of 5-fu-resistant colorectal carcinoma cells via induction of apoptosis and suppression of akt pathway. |
2019-06-06 |
2023-08-13 |
Not clear |