| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Justin Kale, Ozgur Kutuk, Glauber Costa Brito, Tallulah S Andrews, Brian Leber, Anthony Letai, David W Andrew. Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance. EMBO reports. vol 19. issue 9. 2019-06-04. PMID:29987135. |
here, we connect akt pathway activation to reduced sensitivity to chemotherapy via akt phosphorylation of bax at residue s184, one of the pro-apoptotic bcl-2 family proteins required for cells to undergo apoptosis. |
2019-06-04 |
2023-08-13 |
human |
| Zhi Lan Guo, Jing Zhe Li, Yan Yan Ma, Dan Qian, Ju Ying Zhong, Meng Meng Jin, Peng Huang, Lu Yang Che, Bing Pan, Yi Wang, Zhen Xiao Sun, Chang Zhen Li. Shikonin sensitizes A549 cells to TRAIL-induced apoptosis through the JNK, STAT3 and AKT pathways. BMC cell biology. vol 19. issue 1. 2019-05-31. PMID:30594131. |
shikonin sensitizes a549 cells to trail-induced apoptosis through the jnk, stat3 and akt pathways. |
2019-05-31 |
2023-08-13 |
human |
| Guang Yang, Ning Wang, Sai Wang Seto, Dennis Chang, Huangzheng Lian. Hydroxysafflor yellow a protects brain microvascular endothelial cells against oxygen glucose deprivation/reoxygenation injury: Involvement of inhibiting autophagy via class I PI3K/Akt/mTOR signaling pathway. Brain research bulletin. vol 140. 2019-05-30. PMID:29775658. |
the protective effect of hsya was evaluated by assessing (1) cellular morphologic and ultrastructural changes; (2) cell viability and cytotoxicity; (3) transendothelial electrical resistance (teer) of monolayer bmecs; (4) cell apoptosis; (5) fluorescence intensity of lc3b; (6) lc3 mrna expression; (7) protein expressions of lc3, beclin-1, zonula occludens-1 (zo-1), phospho-akt (p-akt), akt, phospho-mtor (p-mtor) and mtor. |
2019-05-30 |
2023-08-13 |
rat |
| Souvik Roy, Sritama Banerjee, Tania Chakrabort. Vanadium quercetin complex attenuates mammary cancer by regulating the P53, Akt/mTOR pathway and downregulates cellular proliferation correlated with increased apoptotic events. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 31. issue 4. 2019-05-28. PMID:29855745. |
in vitro studies established that the complex upregulated the expressions of p53, caspase 3 and 9, whereas down regulating akt, mtor and vegf expressions and also induced apoptosis and dna fragmentation in a dose dependent manner. |
2019-05-28 |
2023-08-13 |
human |
| Xiaoge Gao, Lanqi Cen, Fangyuan Li, Ren Wen, Hongru Yan, Hong Yao, Songlei Zh. Oral administration of indole substituted dipyrido[2,3-d]pyrimidine derivative exhibits anti-tumor activity via inhibiting AKT and ERK1/2 on hepatocellular carcinoma. Biochemical and biophysical research communications. vol 505. issue 3. 2019-05-28. PMID:30293685. |
interestingly, 4p significantly induced the cell cycle arrest and apoptosis of hepg2 via targeting akt and erk1/2 signaling pathways in vitro. |
2019-05-28 |
2023-08-13 |
mouse |
| Youbang Xie, Xuefeng Shi, Kuo Sheng, Guoxiong Han, Wenqian Li, Qiangqiang Zhao, Baili Jiang, Jianming Feng, Jianping Li, Yuhai G. PI3K/Akt signaling transduction pathway, erythropoiesis and glycolysis in hypoxia (Review). Molecular medicine reports. vol 19. issue 2. 2019-05-28. PMID:30535469. |
threonine and serine phosphorylation contribute to akt translocation from the cytoplasm to the nucleus and further mediates enzymatic biological effects, including those involved in cell proliferation, apoptosis inhibition, cell migration, vesicle transport and cell cancerous transformation. |
2019-05-28 |
2023-08-13 |
Not clear |
| Jun Li, Jianping Zhen. Theaflavins prevent cartilage degeneration via AKT/FOXO3 signaling in vitro. Molecular medicine reports. vol 19. issue 2. 2019-05-28. PMID:30569095. |
furthermore, tfs enhanced the activity of glutathione peroxidase 1 and catalase, but reduced the expression levels of phosphorylated (p)‑akt serine/threonine kinase (akt) and p‑forkhead box o3 (foxo3)a. conversely, the effects of tfs on apoptosis and dna damage were reversed by persistent activation of akt. |
2019-05-28 |
2023-08-13 |
Not clear |
| Fan He, Nannan Zhang, Yan Lv, Wenhao Sun, Huisheng Che. Low‑dose lipopolysaccharide inhibits neuronal apoptosis induced by cerebral ischemia/reperfusion injury via the PI3K/Akt/FoxO1 signaling pathway in rats. Molecular medicine reports. vol 19. issue 3. 2019-05-24. PMID:30628689. |
following the addition of pi3k signaling pathway inhibitor ly294002 to microglia, lps reduced the levels of activated akt, increased the downstream regulatory gene phosphorylation of foxo1 and reduced microglia apoptosis. |
2019-05-24 |
2023-08-13 |
rat |
| Xiaofang Cao, Chunling Han, Jinsuo Wen, Xiaokun Guo, Kejian Zhan. Nicotine increases apoptosis in HUVECs cultured in high glucose/high fat via Akt ubiquitination and degradation. Clinical and experimental pharmacology & physiology. vol 45. issue 2. 2019-05-23. PMID:28963785. |
nicotine increases apoptosis in huvecs cultured in high glucose/high fat via akt ubiquitination and degradation. |
2019-05-23 |
2023-08-13 |
human |
| Xiaofang Cao, Chunling Han, Jinsuo Wen, Xiaokun Guo, Kejian Zhan. Nicotine increases apoptosis in HUVECs cultured in high glucose/high fat via Akt ubiquitination and degradation. Clinical and experimental pharmacology & physiology. vol 45. issue 2. 2019-05-23. PMID:28963785. |
moreover, nicotine induced akt degradation via ups, and akt overexpression blocked nicotine-induced apoptosis in huvecs cultured in hg/hf media. |
2019-05-23 |
2023-08-13 |
human |
| Xiaofang Cao, Chunling Han, Jinsuo Wen, Xiaokun Guo, Kejian Zhan. Nicotine increases apoptosis in HUVECs cultured in high glucose/high fat via Akt ubiquitination and degradation. Clinical and experimental pharmacology & physiology. vol 45. issue 2. 2019-05-23. PMID:28963785. |
furthermore, the ttc3 and mul1 shrna adenovirus dramatically decreased the akt ubiquitination and apoptosis induced by nicotine. |
2019-05-23 |
2023-08-13 |
human |
| Xiaofang Cao, Chunling Han, Jinsuo Wen, Xiaokun Guo, Kejian Zhan. Nicotine increases apoptosis in HUVECs cultured in high glucose/high fat via Akt ubiquitination and degradation. Clinical and experimental pharmacology & physiology. vol 45. issue 2. 2019-05-23. PMID:28963785. |
these results indicate that nicotine-induced akt ubiquitination and degradation occurs through ttc3 and mul1 and results in a dramatic increase in apoptosis in huvecs cultured in hg/hf media. |
2019-05-23 |
2023-08-13 |
human |
| Mengxing Chen, Rong Yan, Kangxi Zhou, Xiaodong Li, Yang Zhang, Chunliang Liu, Mengxiao Jiang, Honglei Ye, Xingjun Meng, Ningbo Pang, Lili Zhao, Jun Liu, Weiling Xiao, Renping Hu, Qingya Cui, Wei Zhong, Yunxiao Zhao, Mingqing Zhu, Anning Lin, Changgeng Ruan, Kesheng Da. Akt-mediated platelet apoptosis and its therapeutic implications in immune thrombocytopenia. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 45. 2019-05-22. PMID:30337485. |
we demonstrate that anti-gpibα antibody binding activates akt, which elicits platelet apoptosis through activation of phosphodiesterase (pde3a) and pde3a-mediated pka inhibition. |
2019-05-22 |
2023-08-13 |
Not clear |
| Mengxing Chen, Rong Yan, Kangxi Zhou, Xiaodong Li, Yang Zhang, Chunliang Liu, Mengxiao Jiang, Honglei Ye, Xingjun Meng, Ningbo Pang, Lili Zhao, Jun Liu, Weiling Xiao, Renping Hu, Qingya Cui, Wei Zhong, Yunxiao Zhao, Mingqing Zhu, Anning Lin, Changgeng Ruan, Kesheng Da. Akt-mediated platelet apoptosis and its therapeutic implications in immune thrombocytopenia. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 45. 2019-05-22. PMID:30337485. |
genetic ablation or chemical inhibition of akt or blocking of akt signaling abolishes anti-gpibα antibody-induced platelet apoptosis. |
2019-05-22 |
2023-08-13 |
Not clear |
| Hu-Nan Sun, Ying-Hua Luo, Ling-Qi Meng, Xian-Ji Piao, Yue Wang, Jia-Ru Wang, Hao Wang, Yi Zhang, Jin-Qian Li, Wan-Ting Xu, Yang Liu, Yu Zhang, Tong Zhang, Ying-Hao Han, Mei-Hua Jin, Gui-Nan Shen, Yan-Qing Zang, Long-Kui Cao, Dong-Jie Zhang, Cheng-Hao Ji. Cryptotanshinone induces reactive oxygen species‑mediated apoptosis in human rheumatoid arthritis fibroblast‑like synoviocytes. International journal of molecular medicine. vol 43. issue 2. 2019-05-20. PMID:30535477. |
western blotting was used to assess the expression levels of proteins associated with apoptosis and with the mitogen‑activated protein kinase (mapk), protein kinase b (akt), and signal transducer and activator of transcription‑3 (stat3) signaling pathways. |
2019-05-20 |
2023-08-13 |
human |
| Hu-Nan Sun, Ying-Hua Luo, Ling-Qi Meng, Xian-Ji Piao, Yue Wang, Jia-Ru Wang, Hao Wang, Yi Zhang, Jin-Qian Li, Wan-Ting Xu, Yang Liu, Yu Zhang, Tong Zhang, Ying-Hao Han, Mei-Hua Jin, Gui-Nan Shen, Yan-Qing Zang, Long-Kui Cao, Dong-Jie Zhang, Cheng-Hao Ji. Cryptotanshinone induces reactive oxygen species‑mediated apoptosis in human rheumatoid arthritis fibroblast‑like synoviocytes. International journal of molecular medicine. vol 43. issue 2. 2019-05-20. PMID:30535477. |
these results suggest that ros‑mediated akt, mapk and stat3 signaling pathways serve important roles in the ct‑induced apoptosis of ra‑flss. |
2019-05-20 |
2023-08-13 |
human |
| Katrin Brockhaus, Michael R R Böhm, Harutyun Melkonyan, Solon Thano. Age-related Beta-synuclein Alters the p53/Mdm2 Pathway and Induces the Apoptosis of Brain Microvascular Endothelial Cells In Vitro. Cell transplantation. vol 27. issue 5. 2019-05-17. PMID:29808713. |
viability, apoptosis, expression levels of snca, and the members of phospholipase d2 (pld2)/ p53/ mouse double minute 2 homolog (mdm2)/p19(arf) pathway, response in rac-alpha serine/threonine-protein kinase (akt), and stress-mediating factors such as heme oxygenase (decycling) 1 (hmox) and nicotinamide adenine dinucleotide phosphate oxygenase 4 (nox4) were examined. |
2019-05-17 |
2023-08-13 |
mouse |
| Zhen Yu, Ronglei Zha. Inhibition of anaplastic lymphoma kinase promotes apoptosis and suppresses proliferation in human hepatocellular carcinoma. Anti-cancer drugs. vol 29. issue 6. 2019-05-16. PMID:29570100. |
alk inhibitor exhibited antitumor effects by inhibiting alk activation, repressing akt and erk pathways, and suppressing antiapoptotic gene expressions, which subsequently promoted apoptosis and suppressed hcc cell proliferations. |
2019-05-16 |
2023-08-13 |
human |
| Jian Wang, Hong-Man Xue, Yan-Ru Chen, Hong-Gui Xu, Shao-Fen Lin, Xi-Kang Tang, Chun Che. Evaluation of Insulin-mediated Regulation of AKT Signaling in Childhood Acute Lymphoblastic Leukemia. Journal of pediatric hematology/oncology. vol 41. issue 2. 2019-05-14. PMID:30688831. |
in response to increased glucose levels, insulin is secreted, and several studies have shown that insulin-induced akt signaling can regulate tumor cell proliferation and apoptosis. |
2019-05-14 |
2023-08-13 |
Not clear |
| Xue-Li Li, Ji-Ping Fan, Jian-Xun Liu, Li-Na Lian. Salvianolic Acid A Protects Neonatal Cardiomyocytes Against Hypoxia/Reoxygenation-Induced Injury by Preserving Mitochondrial Function and Activating Akt/GSK-3β Signals. Chinese journal of integrative medicine. vol 25. issue 1. 2019-05-13. PMID:28197936. |
to investigate the effects of salvianolic acid a (saa) on cardiomyocyte apoptosis and mitochondrial dysfunction in response to hypoxia/reoxygenation (h/r) injury and to determine whether the akt signaling pathway might play a role. |
2019-05-13 |
2023-08-13 |
Not clear |