| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tie-Jun Liu, Bin Wang, Qun-Xi Li, Xiao-Liu Dong, Xiao-Liang Han, Shu-Bo Zhan. Effects of microRNA-206 and its target gene IGF-1 on sevoflurane-induced activation of hippocampal astrocytes in aged rats through the PI3K/AKT/CREB signaling pathway. Journal of cellular physiology. vol 233. issue 5. 2019-02-21. PMID:29052839. |
compared with the normal/blank group, the sevo, and mir-206 nc+sevo groups showed decreased mir-206 and gfap expressions, cell viability and mtp but increased expressions of igf-1, pi3k, akt, creb, ppi3k, pakt, pcreb, cyt-c and caspase-3, as well as cell apoptosis. |
2019-02-21 |
2023-08-13 |
rat |
| Xue Wang, Bennian Huo, Jie Liu, Xin Huang, Siyao Zhang, Tao Fen. Hepatitis B virus X reduces hepatocyte apoptosis and promotes cell cycle progression through the Akt/mTOR pathway in vivo. Gene. vol 691. 2019-02-21. PMID:30630095. |
however, inactivation of apoptosis by overexpression of hbx was abolished by the treatment with an akt inhibitor. |
2019-02-21 |
2023-08-13 |
mouse |
| Bruno Tota, Daniela Amelio, Maria Carmela Cerra, Filippo Garofal. The morphological and functional significance of the NOS/NO system in the respiratory, osmoregulatory, and contractile organs of the African lungfish. Acta histochemica. vol 120. issue 7. 2019-02-08. PMID:30195500. |
the modifications of nos and its partners akt and hsp-90, and hif-1α, detected by immunohistochemical and molecular biology methods, are discussed together with the apoptosis rate, evaluated by tunel. |
2019-02-08 |
2023-08-13 |
Not clear |
| Jia-Ru Wang, Gui-Nan Shen, Ying-Hua Luo, Xian-Ji Piao, Meng Shen, Chang Liu, Yue Wang, Ling-Qi Meng, Yi Zhang, Hao Wang, Jin-Qian Li, Wan-Ting Xu, Yang Liu, Hu-Nan Sun, Ying-Hao Han, Mei-Hua Jin, Long-Kui Cao, Cheng-Hao Ji. The compound 2-(naphthalene-2-thio)-5,8-dimethoxy-1,4-naphthoquinone induces apoptosis via reactive oxygen species-regulated mitogen-activated protein kinase, protein kinase B, and signal transducer and activator of transcription 3 signaling in human gastric cancer cells. Drug development research. vol 79. issue 6. 2019-02-05. PMID:30222185. |
taken together, the present findings indicate that ntdmnq-induced gastric cancer cell apoptosis via ros-mediated regulation of the mapk, akt, and stat3 signaling pathways. |
2019-02-05 |
2023-08-13 |
human |
| Raj Pranap Arun, Divya Sivanesan, Prasanna Vidyasekar, Rama Shanker Verm. PTEN/FOXO3/AKT pathway regulates cell death and mediates morphogenetic differentiation of Colorectal Cancer Cells under Simulated Microgravity. Scientific reports. vol 7. issue 1. 2019-02-04. PMID:28729699. |
gene expression analysis on dld1 cells showed upregulation of tumor suppressors pten and foxo3; leading to akt downregulation and further induction of apoptosis, through upregulation of cdk inhibitors cdkn2b, cdkn2d. |
2019-02-04 |
2023-08-13 |
Not clear |
| Cun-Dong Fan, Xiao-Yan Fu, Zong-Yong Zhang, Ming-Zhi Cao, Jing-Yi Sun, Ming-Feng Yang, Xiao-Ting Fu, Shi-Jun Zhao, Lu-Rong Shao, Hui-Fang Zhang, Xiao-Yi Yang, Bao-Liang Su. Selenocysteine induces apoptosis in human glioma cells: evidence for TrxR1-targeted inhibition and signaling crosstalk. Scientific reports. vol 7. issue 1. 2019-02-04. PMID:28743999. |
however, inhibition of ros overproduction effectively attenuated sec-induced oxidative damage and apoptosis, and normalized the expression of mapks and akt pathways, indicating the significance of ros in sec-induced apoptosis. |
2019-02-04 |
2023-08-13 |
mouse |
| Feng He, Ning Ma, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Zhe Zhang, Guangwu Huang, Kazuhiko Takeuchi, Mariko Murat. Taurine exhibits an apoptosis-inducing effect on human nasopharyngeal carcinoma cells through PTEN/Akt pathways in vitro. Amino acids. vol 50. issue 12. 2019-02-04. PMID:30225664. |
in conclusion, taurine may inhibit cell proliferation and induce apoptosis in npc through pten activation with concomitant akt inactivation. |
2019-02-04 |
2023-08-13 |
human |
| Zefei Wang, Chunzhi Yu, Hong Wan. HOXA5 inhibits the proliferation and induces the apoptosis of cervical cancer cells via regulation of protein kinase B and p27. Oncology reports. vol 41. issue 2. 2019-02-04. PMID:30483748. |
additionally, significant elevation of akt activation measured by western blot analysis abrogated the effect of hoxa5 on caspase‑3 activity, cell apoptosis, proliferation, invasion and cell viability. |
2019-02-04 |
2023-08-13 |
Not clear |
| Donglin He, Zhihai Yu, Sheng Liu, Hong Dai, Qing Xu, Feng L. Methylenetetrahydrofolate Dehydrogenase 1 (MTHFD1) is Underexpressed in Clear Cell Renal Cell Carcinoma Tissue and Transfection and Overexpression in Caki-1 Cells Inhibits Cell Proliferation and Increases Apoptosis. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2019-01-30. PMID:30459299. |
mthfd1 transfection of human ccrcc caki-1 cells in vitro inhibited cell proliferation and promoted apoptosis, associated with reduced expression of cyclin d1, reduced akt phosphorylation, and increased expression of bax/bcl-2 and p53. |
2019-01-30 |
2023-08-13 |
human |
| Kuang-Jen Chien, Ming-Ling Yang, Ping-Kun Tsai, Chun-Hung Su, Chia-Hui Chen, Chi-Ting Horng, Chung-Hsin Yeh, Wen-Ying Chen, Meng-Liang Lin, Chun-Jung Chen, Chen-Yu Chian, Yu-Hsiang Kua. Safrole induced cytotoxicity, DNA damage, and apoptosis in macrophages via reactive oxygen species generation and Akt phosphorylation. Environmental toxicology and pharmacology. vol 64. 2019-01-28. PMID:30312850. |
safrole induced cytotoxicity, dna damage, and apoptosis in macrophages via reactive oxygen species generation and akt phosphorylation. |
2019-01-28 |
2023-08-13 |
Not clear |
| Kuang-Jen Chien, Ming-Ling Yang, Ping-Kun Tsai, Chun-Hung Su, Chia-Hui Chen, Chi-Ting Horng, Chung-Hsin Yeh, Wen-Ying Chen, Meng-Liang Lin, Chun-Jung Chen, Chen-Yu Chian, Yu-Hsiang Kua. Safrole induced cytotoxicity, DNA damage, and apoptosis in macrophages via reactive oxygen species generation and Akt phosphorylation. Environmental toxicology and pharmacology. vol 64. 2019-01-28. PMID:30312850. |
these results indicated that the induction of cytotoxicity, dna damage, and apoptosis in macrophages by safrole was through generation of ros and inhibition of antioxidative enzymes possibly via akt phosphorylation. |
2019-01-28 |
2023-08-13 |
Not clear |
| Ting Yu, Yunren Fan, Yunfeng Xu, Liangdie Xu, Guangda Xu, Fangchuan Cao, Hailong Jian. Standardized Ginkgo biloba extract EGb 761® attenuates early brain injury following subarachnoid hemorrhage via suppressing neuronal apoptosis through the activation of Akt signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 107. 2019-01-22. PMID:30098550. |
standardized ginkgo biloba extract egb 761® attenuates early brain injury following subarachnoid hemorrhage via suppressing neuronal apoptosis through the activation of akt signaling. |
2019-01-22 |
2023-08-13 |
Not clear |
| Nouf T Al-Damry, Hala A Attia, Nawal M Al-Rasheed, Nouf M Al-Rasheed, Raeesa A Mohamad, Maha A Al-Amin, Nduna Dizmiri, Muhammad Attey. Sitagliptin attenuates myocardial apoptosis via activating LKB-1/AMPK/Akt pathway and suppressing the activity of GSK-3β and p38α/MAPK in a rat model of diabetic cardiomyopathy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 107. 2019-01-22. PMID:30099338. |
the present study aimed to investigate the protective effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on diabetic cardiomyopathy (dcm)-associated apoptosis and if this effect is mediated via modulating the activity of the survival kinases; amp-activated protein kinase (ampk) and akt & the apoptotic kinases; glycogen synthase kinase-3 β (gsk-3β) and p38 mitogen-activated protein kinase (p38mapk). |
2019-01-22 |
2023-08-13 |
rat |
| Nouf T Al-Damry, Hala A Attia, Nawal M Al-Rasheed, Nouf M Al-Rasheed, Raeesa A Mohamad, Maha A Al-Amin, Nduna Dizmiri, Muhammad Attey. Sitagliptin attenuates myocardial apoptosis via activating LKB-1/AMPK/Akt pathway and suppressing the activity of GSK-3β and p38α/MAPK in a rat model of diabetic cardiomyopathy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 107. 2019-01-22. PMID:30099338. |
cardiac protein levels of cleaved casapse-3, bax were elevated, whereas, the levels of bcl-2 and p-bad were reduced indicating cardiac apoptosis which could be attributed to the diabetes-induced reduced phosphorylation of akt and ampk with concomitant augmented activation of gsk-3β and p38mapk. |
2019-01-22 |
2023-08-13 |
rat |
| Nouf T Al-Damry, Hala A Attia, Nawal M Al-Rasheed, Nouf M Al-Rasheed, Raeesa A Mohamad, Maha A Al-Amin, Nduna Dizmiri, Muhammad Attey. Sitagliptin attenuates myocardial apoptosis via activating LKB-1/AMPK/Akt pathway and suppressing the activity of GSK-3β and p38α/MAPK in a rat model of diabetic cardiomyopathy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 107. 2019-01-22. PMID:30099338. |
sitagliptin administration alleviated the decreased phosphorylation of ampk and akt, inactivated the gsk-3β and p38 ampk, therefore, attenuating the apoptosis and hypertrophy induced by hyperglycemia in the diabetic heart. |
2019-01-22 |
2023-08-13 |
rat |
| Xiaohua Xu, Jianyang Jiang, Lijuan Yao, Bing J. Silencing the FOLR2 Gene Inhibits Cell Proliferation and Increases Apoptosis in the NCI-H1650 Non-Small Cell Lung Cancer Cell Line via Inhibition of AKT/Mammalian Target of Rapamycin (mTOR)/Ribosomal Protein S6 Kinase 1 (S6K1) Signaling. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2019-01-22. PMID:30415267. |
silencing of the expression of the folr2 gene in nci-h1650 cells reduced cell viability, increased cell apoptosis, and arrested cells in the g1 phase of the cell cycle, decreased the expression of cyclin d1, upregulated expression of cell cycle inhibitors, p21 and p27, upregulated the expression of bax/bcl-2, and inhibited phosphorylation of akt, mtor, and s6k1. |
2019-01-22 |
2023-08-13 |
human |
| Xiaohua Xu, Jianyang Jiang, Lijuan Yao, Bing J. Silencing the FOLR2 Gene Inhibits Cell Proliferation and Increases Apoptosis in the NCI-H1650 Non-Small Cell Lung Cancer Cell Line via Inhibition of AKT/Mammalian Target of Rapamycin (mTOR)/Ribosomal Protein S6 Kinase 1 (S6K1) Signaling. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2019-01-22. PMID:30415267. |
conclusions silencing of the folr2 gene inhibited phosphorylation of akt, mtor, and s6k1, inhibited cell proliferation and increased apoptosis in the nci-h1650 human nsclc cell line. |
2019-01-22 |
2023-08-13 |
human |
| Chao He, Tingting Wu, Yongqiang Ha. Anlotinib induces hepatocellular carcinoma apoptosis and inhibits proliferation via Erk and Akt pathway. Biochemical and biophysical research communications. vol 503. issue 4. 2019-01-15. PMID:30146257. |
anlotinib induces hepatocellular carcinoma apoptosis and inhibits proliferation via erk and akt pathway. |
2019-01-15 |
2023-08-13 |
Not clear |
| Jing An, Qian Zhou, Meiying Wu, Lu Wang, Yufang Zhong, Jialiang Feng, Yu Shang, Yingjun Che. Interactions between oxidative stress, autophagy and apoptosis in A549 cells treated with aged black carbon. Toxicology in vitro : an international journal published in association with BIBRA. vol 54. 2019-01-14. PMID:30240709. |
the akt inhibitor (mk-2206) significantly reduced both autophagy and apoptosis. |
2019-01-14 |
2023-08-13 |
Not clear |
| Sandrine L Verstraeten, Marie Albert, Adrien Paquot, Giulio G Muccioli, Donatienne Tyteca, Marie-Paule Mingeot-Leclerc. Membrane cholesterol delays cellular apoptosis induced by ginsenoside Rh2, a steroid saponin. Toxicology and applied pharmacology. vol 352. 2019-01-08. PMID:29782965. |
the treatment with rh2 conducts to the dephosphorylation of akt and the activation of the intrinsic pathway of apoptosis (loss of mitochondrial membrane potential, caspase-9 and -3 activation). |
2019-01-08 |
2023-08-13 |
Not clear |