| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Haiyan Zhu, Yinshen Jiang, Yibin Pan, Libing Shi, Songying Zhan. Human menstrual blood-derived stem cells promote the repair of impaired endometrial stromal cells by activating the p38 MAPK and AKT signaling pathways. Reproductive biology. vol 18. issue 3. 2018-12-11. PMID:29941287. |
the proliferation, apoptosis, and migration of escs were assessed, together with the expression of related signaling proteins including total p38 mitogen-activated protein kinase, p-p38, total protein kinase b (akt), p-akt, β-catenin, and vascular endothelial growth factor (vegf). |
2018-12-11 |
2023-08-13 |
human |
| Jiangli Zheng, Xue Dai, Hailin Chen, Chunli Fang, Jian Chen, Lizhou Su. Down-regulation of LHPP in cervical cancer influences cell proliferation, metastasis and apoptosis by modulating AKT. Biochemical and biophysical research communications. vol 503. issue 2. 2018-12-11. PMID:29944886. |
down-regulation of lhpp in cervical cancer influences cell proliferation, metastasis and apoptosis by modulating akt. |
2018-12-11 |
2023-08-13 |
human |
| Ming Li, Shuo Wang, Xianjie Li, Lulu Jiang, Xujing Wang, Ruirui Kou, Qiong Wang, Lin Xu, Ning Zhao, Keqin Xi. Diallyl sulfide protects against lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting oxidative stress, inflammation and apoptosis in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 120. 2018-12-11. PMID:30075314. |
das also up-regulated the expression of p-pi3k p85 and p-akt in a dose-dependent manner, and akt inhibitor mk-2206 weakened the inhibitory effect of das on hepatocyte apoptosis induced by lps/d-galn. |
2018-12-11 |
2023-08-13 |
mouse |
| Yi Mu, Deyu Su. Lapatinib, a Dual Inhibitor of Epidermal Growth Factor Receptor (EGFR) and HER-2, Enhances Radiosensitivity in Mouse Bladder Tumor Line-2 (MBT-2) Cells In Vitro and In Vivo. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-12-11. PMID:30125265. |
western blot measured phosphorylated epidermal growth factor receptor (p-egfr), phosphorylated akt (p-akt), and phosphorylated her-2 (p-her2) and the apoptosis marker, parp. |
2018-12-11 |
2023-08-13 |
mouse |
| Chen Liu, Wu QiNan, Lei XiaoTian, Yang MengLiu, Gan XiaGuang, Leng WeiLing, Liang ZiWen, Zhang Ling, Yang GangYi, Chen Bin. TERT and Akt Are Involved in the Par-4-Dependent Apoptosis of Islet Journal of diabetes research. vol 2018. 2018-12-11. PMID:30186877. |
tert and akt are involved in the par-4-dependent apoptosis of islet islet |
2018-12-11 |
2023-08-13 |
Not clear |
| Jian Zhang, Wen-Li Liu, Lu Zhang, Rui Ge, Fang He, Tian-Yuan Gao, Qiong Tian, Xin Mu, Li-Hong Chen, Wei Chen, Xu L. MiR-637 suppresses melanoma progression through directly targeting P-REX2a and inhibiting PTEN/AKT signaling pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 64. issue 11. 2018-12-11. PMID:30213289. |
taken together, our study demonstrates that mir-637 inhibites melanoma cell proliferation by activation of akt signaling pathway and induces apoptosis through regulation of bcl-2/bax expression via targeting p-rex2a. |
2018-12-11 |
2023-08-13 |
human |
| Yuexia Liao, Yang Xu, Mengyao Cao, Yuanyuan Huan, Lei Zhu, Ye Jiang, Weigan Shen, Guoqiang Zh. Luteolin Induces Apoptosis and Autophagy in Mouse Macrophage ANA-1 Cells via the Bcl-2 Pathway. Journal of immunology research. vol 2018. 2018-12-11. PMID:30246034. |
luteolin treatment resulted in obvious activation of the p38, jnk, and akt signaling pathways, which is important in modulating apoptosis and autophagy. |
2018-12-11 |
2023-08-13 |
mouse |
| Yuexia Liao, Yang Xu, Mengyao Cao, Yuanyuan Huan, Lei Zhu, Ye Jiang, Weigan Shen, Guoqiang Zh. Luteolin Induces Apoptosis and Autophagy in Mouse Macrophage ANA-1 Cells via the Bcl-2 Pathway. Journal of immunology research. vol 2018. 2018-12-11. PMID:30246034. |
thus, we concluded that luteolin induced the apoptosis and autophagy of ana-1 cells most likely by regulating the p38, jnk, and akt pathways, inhibiting the activity of bcl-2 and beclin-1 and upregulating caspase 3 and caspase 8 expression. |
2018-12-11 |
2023-08-13 |
mouse |
| Yilin Chen, Ying Huang, Xingrong Lu, Gaoxiong Wang, Pan Ch. Antitumor effects of the silencing of programmed cell death ligand 1 in colorectal cancer via immunoregulation. Oncology reports. vol 40. issue 6. 2018-12-11. PMID:30272332. |
compared with the control, the shpd‑l1 group demonstrated reduced tumor growth, a high level of apoptosis in tumor cells, a low level of pi3k and akt expression, and an increased number of cells and greater activity of cd4+ t and cd8+ t cells. |
2018-12-11 |
2023-08-13 |
mouse |
| Jun Wang, Weiwei Feng, Yuanqiang Dong, Xiang Mao, Fenghua Guo, Fen Lu. MicroRNA‑495 regulates human gastric cancer cell apoptosis and migration through Akt and mTOR signaling. Oncology reports. vol 40. issue 6. 2018-12-11. PMID:30272336. |
microrna‑495 regulates human gastric cancer cell apoptosis and migration through akt and mtor signaling. |
2018-12-11 |
2023-08-13 |
human |
| Zhi Yang, Xiaodi Jiang, Deming Li, Qianze Dong, Haiying Zhao, Xiaofeng Jian. TCF21 inhibits proliferation and chemoresistance through the AKT pathway in human gastric cancer. Gene. vol 682. 2018-12-11. PMID:30296564. |
ly294002, an akt inhibitor, blocked the effect of tcf21 on bcl-xl, caspase 3 and cddp-induced apoptosis. |
2018-12-11 |
2023-08-13 |
mouse |
| Wei Pan, Shaohua Gong, Yanhua Li, Huiwen Zhang, Na Li, Bo Tan. A DR4 capturer with AKT siRNA for the synergetic enhancement of death receptor-mediated apoptosis. Chemical communications (Cambridge, England). vol 54. issue 95. 2018-12-11. PMID:30430148. |
a dr4 capturer with akt sirna for the synergetic enhancement of death receptor-mediated apoptosis. |
2018-12-11 |
2023-08-13 |
Not clear |
| Wei Pan, Shaohua Gong, Yanhua Li, Huiwen Zhang, Na Li, Bo Tan. A DR4 capturer with AKT siRNA for the synergetic enhancement of death receptor-mediated apoptosis. Chemical communications (Cambridge, England). vol 54. issue 95. 2018-12-11. PMID:30430148. |
a graphene-based nanocarrier modified with death receptor 4 (dr4) antibody and akt sirna has been developed, which can synergistically strengthen death receptor-mediated apoptosis and enhance the cancer therapeutic effect in vivo. |
2018-12-11 |
2023-08-13 |
Not clear |
| Liang Xu, Yu Jia, Xiang-Hong Yang, Fang Han, Yang Zheng, Yin Ni, Xu Chen, Jun Hong, Jing-Quan Liu, Qian Li, Ren-Hua Sun, Shi-Jing M. MicroRNA-130b transcriptionally regulated by histone H3 deacetylation renders Akt ubiquitination and apoptosis resistance to 6-OHDA. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 6. 2018-11-26. PMID:28412322. |
microrna-130b transcriptionally regulated by histone h3 deacetylation renders akt ubiquitination and apoptosis resistance to 6-ohda. |
2018-11-26 |
2023-08-13 |
Not clear |
| Liang Xu, Yu Jia, Xiang-Hong Yang, Fang Han, Yang Zheng, Yin Ni, Xu Chen, Jun Hong, Jing-Quan Liu, Qian Li, Ren-Hua Sun, Shi-Jing M. MicroRNA-130b transcriptionally regulated by histone H3 deacetylation renders Akt ubiquitination and apoptosis resistance to 6-OHDA. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 6. 2018-11-26. PMID:28412322. |
akt may become a potential therapeutic target for pd since akt has been deactivated during da neuron apoptosis. |
2018-11-26 |
2023-08-13 |
Not clear |
| Liang Xu, Yu Jia, Xiang-Hong Yang, Fang Han, Yang Zheng, Yin Ni, Xu Chen, Jun Hong, Jing-Quan Liu, Qian Li, Ren-Hua Sun, Shi-Jing M. MicroRNA-130b transcriptionally regulated by histone H3 deacetylation renders Akt ubiquitination and apoptosis resistance to 6-OHDA. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 6. 2018-11-26. PMID:28412322. |
we previously demonstrated that akt confers apoptosis resistance against 6-ohda in da neuron-like pc12 cells, yet the underlying mechanisms accounted for this are not fully understood. |
2018-11-26 |
2023-08-13 |
Not clear |
| Liang Xu, Yu Jia, Xiang-Hong Yang, Fang Han, Yang Zheng, Yin Ni, Xu Chen, Jun Hong, Jing-Quan Liu, Qian Li, Ren-Hua Sun, Shi-Jing M. MicroRNA-130b transcriptionally regulated by histone H3 deacetylation renders Akt ubiquitination and apoptosis resistance to 6-OHDA. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 6. 2018-11-26. PMID:28412322. |
here we report that microrna-130b (mir-130b)-dependent and cylindromatosis (cyld) repression-mediated akt ubiquitination renders apoptosis resistance of pc12 cells to 6-ohda, which elicits histone h3 deacetylation-induced transcriptional downregulation of mir-130b vice versa. |
2018-11-26 |
2023-08-13 |
Not clear |
| Liang Xu, Yu Jia, Xiang-Hong Yang, Fang Han, Yang Zheng, Yin Ni, Xu Chen, Jun Hong, Jing-Quan Liu, Qian Li, Ren-Hua Sun, Shi-Jing M. MicroRNA-130b transcriptionally regulated by histone H3 deacetylation renders Akt ubiquitination and apoptosis resistance to 6-OHDA. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 6. 2018-11-26. PMID:28412322. |
cyld deficiency ubiquitinates akt at lys63, thereby phosphorylating akt and antagonizing 6-ohda-initiated apoptosis. |
2018-11-26 |
2023-08-13 |
Not clear |
| Liang Xu, Yu Jia, Xiang-Hong Yang, Fang Han, Yang Zheng, Yin Ni, Xu Chen, Jun Hong, Jing-Quan Liu, Qian Li, Ren-Hua Sun, Shi-Jing M. MicroRNA-130b transcriptionally regulated by histone H3 deacetylation renders Akt ubiquitination and apoptosis resistance to 6-OHDA. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 6. 2018-11-26. PMID:28412322. |
furthermore, epo potentiates the ability of mir-130b to activate akt and augment apoptosis resistance. |
2018-11-26 |
2023-08-13 |
Not clear |
| Daiying Zuo, Yumiao Liu, Zi Liu, Jiahui Cui, Xuejiao Zhou, Yang Liu, Zengqiang Li, Yingliang W. Alcohol aggravates ketamine-induced behavioral, morphological and neurochemical alterations in adolescent rats: The involvement of CREB-related pathways. Behavioural brain research. vol 349. 2018-11-26. PMID:29738804. |
further mechanistic study demonstrated that alcohol potentiated ketamine-induced neurotoxicity through down-regulation of akt (a serine/threonine kinase or protein kinase, pkb), protein kinase a (pka), calmodulin-dependent kinase iv (camk-iv)-mediated cyclic amp-responsive element binding protein (creb) pathways and induction of neuronal apoptosis in the cortex and hippocampus of the adolescent rats. |
2018-11-26 |
2023-08-13 |
rat |