| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Min Kyung Shin, Ki-Heon Jeong, Hyeongwon Choi, Hye-Jin Ahn, Mu-Hyoung Le. Heat shock protein 90 inhibitor enhances apoptosis by inhibiting the AKT pathway in thermal-stimulated SK-MEL-2 human melanoma cell line. Journal of dermatological science. vol 90. issue 3. 2018-10-01. PMID:29433909. |
heat shock protein 90 inhibitor enhances apoptosis by inhibiting the akt pathway in thermal-stimulated sk-mel-2 human melanoma cell line. |
2018-10-01 |
2023-08-13 |
human |
| Ruobing Cao, Weihua Jin, Yeqi Shan, Ju Wang, Ge Liu, Shan Kuang, Chaomin Su. Marine Bacterial Polysaccharide EPS11 Inhibits Cancer Cell Growth via Blocking Cell Adhesion and Stimulating Anoikis. Marine drugs. vol 16. issue 3. 2018-10-01. PMID:29518055. |
moreover, we showed that eps11 induces apoptosis of a549 cells through stimulating βiii-tubulin associated anoikis: (i) eps11 inhibits the expression of βiii-tubulin in both transcription and translation levels; and (ii) eps11 treatment dramatically decreases the phosphorylation of protein kinase b (pkb or akt), a critical downstream effector of βiii-tubulin. |
2018-10-01 |
2023-08-13 |
human |
| Wei Zhang, Meng-Wei Liu, Ming Li, Wei Xiao, Xue-Wen Zhang, Hao-Juan He, Ya-Bin Chen, Lei Ding, Kai-Jun Lu. Unexpected link between insect innexins and apoptosis of HeLa cells. Archives of insect biochemistry and physiology. vol 99. issue 1. 2018-09-28. PMID:29862562. |
the two cte-inx mrnas were associated with a significant decrease in akt phosphorylation in hela cells undergoing apoptosis. |
2018-09-28 |
2023-08-13 |
Not clear |
| Saliha Boumaza, Aicha Belkebir, Samia Neggazi, Hamid Sahraoui, Sihem Berdja, Leila Smail, Yasmina Benazzoug, Ghoti Kacimi, Souhila Aouichat Bouguerr. Therapeutic Role of Resveratrol and Quercetin on Aortic Fibroblasts of Psammomys obesus After Oxidative Stress by Hydrogen Peroxide. American journal of therapeutics. vol 25. issue 3. 2018-09-27. PMID:26766292. |
stressed fibroblasts showed a decrease of cell proliferation and viability, hypertrophy and oncosis, chromatin hypercondensation and increase of cytochrome c release characteristic of apoptosis, activation of erk1/2 and akt pathway, and decreases in p38 mapk pathways marking the cellular resistance. |
2018-09-27 |
2023-08-13 |
Not clear |
| Zhaomeng Wu, Qingyi Zhu, Yu Zhang, Yingying Yin, Dan Kang, Runyi Cao, Qian Tian, Shan Lu, Ping Li. EGFR‑associated pathways involved in traditional Chinese medicine (TCM)‑1‑induced cell growth inhibition, autophagy and apoptosis in prostate cancer. Molecular medicine reports. vol 17. issue 6. 2018-09-26. PMID:29620175. |
inhibition of egfr further suppressed the downstream phosphatidylinositol 3‑kinase (pi3k)/rac‑α serine/threonine‑protein kinase (akt) and raf proto‑oncogene serine/threonine‑protein kinase/extracellular signal regulated kinase signaling pathways and resulted in a decrease in the phosphorylated‑forkhead box protein o1 (at ser256, thr24 and ser319) expression level, and induced cell growth inhibition and apoptosis by regulating the expression of apoptosis‑and cell cycle‑associated genes. |
2018-09-26 |
2023-08-13 |
mouse |
| Li-Juan Li, Ye Chai, Xiao-Jia Guo, Song-Lin Chu, Lian-Sheng Zhan. Effects of endoplasmic reticulum stress on autophagy and apoptosis of human leukemia cells via inhibition of the PI3K/AKT/mTOR signaling pathway. Molecular medicine reports. vol 17. issue 6. 2018-09-26. PMID:29620275. |
the present study aimed to explore the regulatory effects of endoplasmic reticulum stress (ers) on the phosphoinositide 3‑kinase (pi3k)/akt serine/threonine kinase 1 (akt)/mammalian target of rapamycin (mtor) signaling pathway, and its subsequent effects on autophagy and apoptosis of human leukemia cells. |
2018-09-26 |
2023-08-13 |
human |
| X Zhang, M Zhang, Y Su, Z Wang, Q Zhao, H Zhu, Z Qian, J Xu, S Tang, D Wu, Y Lin, N Kemper, J Hartung, E Ba. Inhibition of heat stress-related apoptosis of chicken myocardial cells through inducing Hsp90 expression by aspirin administration in vivo. British poultry science. vol 59. issue 3. 2018-09-21. PMID:29557194. |
hsf-1, 2 and 3 regulation of hsp90 expression in turn inhibited the synthesis and activation of protein kinase β (akt), which resulted in a significant increase in caspase-3 at 2 and 10 h, caspase-9 from 1 to 7 h (except at 5 h), and the heat-stressed apoptosis of the myocardial cells. |
2018-09-21 |
2023-08-13 |
chicken |
| X Zhang, M Zhang, Y Su, Z Wang, Q Zhao, H Zhu, Z Qian, J Xu, S Tang, D Wu, Y Lin, N Kemper, J Hartung, E Ba. Inhibition of heat stress-related apoptosis of chicken myocardial cells through inducing Hsp90 expression by aspirin administration in vivo. British poultry science. vol 59. issue 3. 2018-09-21. PMID:29557194. |
the resultant increase in akt expression and activation, compared with the hs group, inhibited caspase-3 and caspase-9 activities and reduced the myocardial cells apoptosis rate (by 2.14-2.56 times). |
2018-09-21 |
2023-08-13 |
chicken |
| Yan Zhen Zhang, Chun Feng Wang, Lian Feng Zhan. Cucurbitacin D impedes gastric cancer cell survival via activation of the iNOS/NO and inhibition of the Akt signalling pathway. Oncology reports. vol 39. issue 6. 2018-09-20. PMID:29658590. |
in conclusion, cud inhibited akt and activated the inos pathway, leading to higher ros and nitric oxide production, which accelerated gastric cancer cell apoptosis. |
2018-09-20 |
2023-08-13 |
human |
| Moureq R Alotaibi, Zeinab K Hassan, Salim S Al-Rejaie, Musaad A Alshammari, Mashal M Almutairi, Ali R Alhoshani, Wael A Alanazi, Mohamed M Hafez, Othman A Al-Shabana. Characterization of Apoptosis in a Breast Cancer Cell Line after IL-10 Silencing Asian Pacific journal of cancer prevention : APJCP. vol 19. issue 3. 2018-09-19. PMID:29582634. |
results: inhibition of il-10 by the sirna accelerated apoptosis and was accompanied by significantincrease in caspase-3 and caspase-9 and a significant decrease in pi3k, akt and bcl2 expression levels compared tothe non-transfected case. |
2018-09-19 |
2023-08-13 |
Not clear |
| Qun Li, Yucong Peng, Linfeng Fan, Hangzhe Xu, Pingyou He, Shenglong Cao, Jianru Li, Ting Chen, Wu Ruan, Gao Che. Phosphodiesterase-4 inhibition confers a neuroprotective efficacy against early brain injury following experimental subarachnoid hemorrhage in rats by attenuating neuronal apoptosis through the SIRT1/Akt pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 99. 2018-09-17. PMID:29710495. |
moreover, rolipram increased the expression of sirtuin1 (sirt1) and up-regulated the phosphorylation of akt, which was accompanied by the reduction of neuronal apoptosis. |
2018-09-17 |
2023-08-13 |
rat |
| Rui Liu, Hui-Li Wang, Man-Jing Deng, Xiu-Jie Wen, Yuan-Yuan Mo, Fa-Ming Chen, Chun-Li Zou, Wei-Feng Duan, Lei Li, Xin Ni. Melatonin Inhibits Reactive Oxygen Species-Driven Proliferation, Epithelial-Mesenchymal Transition, and Vasculogenic Mimicry in Oral Cancer. Oxidative medicine and cellular longevity. vol 2018. 2018-09-17. PMID:29725496. |
in this study, we found that melatonin impaired the proliferation and apoptosis resistance of oral cancer cells by inactivating ros-dependent akt signaling, involving in downregulation of cyclin d1, pcna, and bcl-2 and upregulation of bax. |
2018-09-17 |
2023-08-13 |
Not clear |
| Yu-Xiang Liao, Zhi-Ping Zhang, Jie Zhao, Jing-Ping Li. Effects of Fibronectin 1 on Cell Proliferation, Senescence and Apoptosis of Human Glioma Cells Through the PI3K/AKT Signaling Pathway. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 48. issue 3. 2018-09-14. PMID:30048971. |
the current study aimed to investigate the role by which fibronectin 1 (fn1) influences the cell cycle, senescence and apoptosis in human glioma cells through the pi3k/ akt signaling pathway. |
2018-09-14 |
2023-08-13 |
human |
| Laila Ahmed Eissa, Hany Ibrahim Kenawy, Amro El-Karef, Nehal Mohsen Elsherbiny, Kholoud Alaa El-Mih. Antioxidant and anti-inflammatory activities of berberine attenuate hepatic fibrosis induced by thioacetamide injection in rats. Chemico-biological interactions. vol 294. 2018-09-14. PMID:30138605. |
inhibition of akt pathway has been linked to the intrinsic pathway of apoptosis. |
2018-09-14 |
2023-08-13 |
rat |
| Gong Deuk Bae, Eun-Young Park, Dong Jae Baek, Hee-Sook Jun, Yoon Sin O. Liquiritigenin prevents palmitate-induced beta-cell apoptosis via estrogen receptor-mediated AKT activation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 101. 2018-09-12. PMID:29499409. |
liquiritigenin prevents palmitate-induced beta-cell apoptosis via estrogen receptor-mediated akt activation. |
2018-09-12 |
2023-08-13 |
mouse |
| Baodong Wang, Yankun Luo, Xiaoshuang Zhou, Rongshan L. Trifluoperazine induces apoptosis through the upregulation of Bax/Bcl‑2 and downregulated phosphorylation of AKT in mesangial cells and improves renal function in lupus nephritis mice. International journal of molecular medicine. vol 41. issue 6. 2018-09-10. PMID:29568865. |
trifluoperazine induces apoptosis through the upregulation of bax/bcl‑2 and downregulated phosphorylation of akt in mesangial cells and improves renal function in lupus nephritis mice. |
2018-09-10 |
2023-08-13 |
mouse |
| Chang Liu, Guangyang Xing, Cailiang Wu, Jun Zhu, Min Wei, Dajiang Liu, Yan Ge, Yao Chen, Ting Lei, Yongxiu Yan. Inhibition of Expression of the S100A8 Gene Encoding the S100 Calcium-Binding Protein A8 Promotes Apoptosis by Suppressing the Phosphorylation of Protein Kinase B (Akt) in Endometrial Carcinoma and HEC-1A Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-09-06. PMID:29595187. |
inhibition of expression of the s100a8 gene encoding the s100 calcium-binding protein a8 promotes apoptosis by suppressing the phosphorylation of protein kinase b (akt) in endometrial carcinoma and hec-1a cells. |
2018-09-06 |
2023-08-13 |
Not clear |
| Chang Liu, Guangyang Xing, Cailiang Wu, Jun Zhu, Min Wei, Dajiang Liu, Yan Ge, Yao Chen, Ting Lei, Yongxiu Yan. Inhibition of Expression of the S100A8 Gene Encoding the S100 Calcium-Binding Protein A8 Promotes Apoptosis by Suppressing the Phosphorylation of Protein Kinase B (Akt) in Endometrial Carcinoma and HEC-1A Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-09-06. PMID:29595187. |
background the aim of this study was to investigate the expression and silencing of the s100a8 gene, which encodes the s100 calcium-binding protein a8 (s100a8), and apoptosis and phosphorylation of protein kinase b (akt) in tissue samples of endometrial carcinoma and hec-1a endometrial adenocarcinoma cells in vitro. |
2018-09-06 |
2023-08-13 |
Not clear |
| Chang Liu, Guangyang Xing, Cailiang Wu, Jun Zhu, Min Wei, Dajiang Liu, Yan Ge, Yao Chen, Ting Lei, Yongxiu Yan. Inhibition of Expression of the S100A8 Gene Encoding the S100 Calcium-Binding Protein A8 Promotes Apoptosis by Suppressing the Phosphorylation of Protein Kinase B (Akt) in Endometrial Carcinoma and HEC-1A Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-09-06. PMID:29595187. |
s100a8 gene knockdown reduced cell proliferation in the hec-1a cells compared with control cells, induced cell apoptosis, inhibited the phosphorylation of protein kinase b (akt), and induced the expression of pro-apoptotic genes, including the cytochrome c gene, cycs, bad, bax, foxo1, foxo3, casp9, and casp3. |
2018-09-06 |
2023-08-13 |
Not clear |
| Chang Liu, Guangyang Xing, Cailiang Wu, Jun Zhu, Min Wei, Dajiang Liu, Yan Ge, Yao Chen, Ting Lei, Yongxiu Yan. Inhibition of Expression of the S100A8 Gene Encoding the S100 Calcium-Binding Protein A8 Promotes Apoptosis by Suppressing the Phosphorylation of Protein Kinase B (Akt) in Endometrial Carcinoma and HEC-1A Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-09-06. PMID:29595187. |
conclusions in endometrial carcinoma cells, down-regulation of the s100a8 gene induced cell apoptosis via inhibition of the phosphorylated or active form of protein kinase b (akt). |
2018-09-06 |
2023-08-13 |
Not clear |