| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao-Feng Yin, Qiong Zhang, Zhuo-Yu Chen, Hai-Fang Wang, Xin Li, Hong-Xia Wang, Hai-Xia Li, Chun-Min Kang, Shuai Chu, Kai-Fei Li, Yao Li, Yu-Rong Qi. NLRP3 in human glioma is correlated with increased WHO grade, and regulates cellular proliferation, apoptosis and metastasis via epithelial-mesenchymal transition and the PTEN/AKT signaling pathway. International journal of oncology. vol 53. issue 3. 2018-11-26. PMID:30015880. |
consistently, the upregulation of nlrp3 significantly increased the expression of asc, caspase‑1, il‑1β and phosphorylated-pten, promoted proliferation, migration, invasion and emt, inhibited apoptosis, and activated the akt signaling pathway. |
2018-11-26 |
2023-08-13 |
human |
| Yanyan Ma, Lifang Yang, Jipeng Ma, Linhe Lu, Xiaowu Wang, Jun Ren, Jian Yan. Rutin attenuates doxorubicin-induced cardiotoxicity via regulating autophagy and apoptosis. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 8. 2018-11-20. PMID:28069395. |
western blot analysis indicated that the underlying mechanisms included inhibition excessive autophagy and apoptosis mediated by akt activation. |
2018-11-20 |
2023-08-13 |
mouse |
| Samir Attoub, Kholoud Arafat, Tamam Khalaf, Shahrazad Sulaiman, Rabah Iratn. Frondoside A Enhances the Anti-Cancer Effects of Oxaliplatin and 5-Fluorouracil on Colon Cancer Cells. Nutrients. vol 10. issue 5. 2018-11-15. PMID:29724012. |
we further demonstrate that apoptosis induction upon the treatment of colon cancer cells was at least in part a result of the inhibition of phosphorylation of the survival kinase akt, leading to caspase-3 activation, poly (adp-ribose) polymerase (parp) inactivation, and consequently dna damage, as suggested by the increase in the level of γh2ax. |
2018-11-15 |
2023-08-13 |
human |
| Meng-Xian Guo, Yong Zou, Lu-Hui Lin, Xu-Dong Ma, Yi-Qun Huan. [Effects of Silencing NSD2 Gene by shRNA on Proliferation, Apoptosis and Akt /mTOR Signal Pathway in OCI-Ly3 Cells]. Zhongguo shi yan xue ye xue za zhi. vol 26. issue 3. 2018-11-15. PMID:29950218. |
[effects of silencing nsd2 gene by shrna on proliferation, apoptosis and akt /mtor signal pathway in oci-ly3 cells]. |
2018-11-15 |
2023-08-13 |
Not clear |
| Meng-Xian Guo, Yong Zou, Lu-Hui Lin, Xu-Dong Ma, Yi-Qun Huan. [Effects of Silencing NSD2 Gene by shRNA on Proliferation, Apoptosis and Akt /mTOR Signal Pathway in OCI-Ly3 Cells]. Zhongguo shi yan xue ye xue za zhi. vol 26. issue 3. 2018-11-15. PMID:29950218. |
to investigate the effect of silencing nsd2 gene by rna interference on the proliferation, apoptosis and the alteration of akt /mtor signaling pathway in diffuse large b cell lymphoma oci-ly3 cells. |
2018-11-15 |
2023-08-13 |
Not clear |
| Gang Chen, Gangcai Zhu, Xin Zhan. [Research progress in PRAS40]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 43. issue 6. 2018-11-13. PMID:30110013. |
pras40 may be involved in various of signaling pathways, such as mammalian target of rapamycin complex 1 (mtorc1), protein kinase b (akt), nf-κb and ribosomal protein l11 (rpl11) etc, which can regulate cell proliferation, senescence, autophagy, apoptosis and exosome secretion. |
2018-11-13 |
2023-08-13 |
Not clear |
| Syed Mukhtar Ahmed, Ian G Macar. The Par3 polarity protein is an exocyst receptor essential for mammary cell survival. Nature communications. vol 8. 2018-11-09. PMID:28358000. |
par3 silencing causes apoptosis, triggered by phosphoinositide trisphosphate depletion and decreased akt phosphorylation, resulting from failure of the exocyst to deliver basolateral proteins to the cortex. |
2018-11-09 |
2023-08-13 |
Not clear |
| Bing Peng, Chao Li, Peng Cai, Liuyang Yu, Bolin Zhao, Guiming Che. Knockdown of miR‑935 increases paclitaxel sensitivity via regulation of SOX7 in non‑small‑cell lung cancer. Molecular medicine reports. vol 18. issue 3. 2018-11-08. PMID:30066948. |
it was further observed that the inhibition of mir‑935 decreased the b cell lymphoma (bcl)‑2 and phosphorylated‑rac‑α serine/threonine‑protein kinase (akt) protein levels and increased the bcl‑2 associated x, apoptosis regulator protein levels, without affecting the akt levels in the presence of paclitaxel within a549 cells. |
2018-11-08 |
2023-08-13 |
Not clear |
| Ruixin Gu, Minqin Zhang, Hu Meng, Dandan Xu, Yonghua Xi. Gallic acid targets acute myeloid leukemia via Akt/mTOR-dependent mitochondrial respiration inhibition. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 105. 2018-11-06. PMID:29883944. |
overexpression of constitutively active akt restores gallic acid-mediated inhibition of mtor signaling, mitochondrial dysfunction, energy crisis and apoptosis. |
2018-11-06 |
2023-08-13 |
Not clear |
| Kimita Suyama, Jiahong Yao, Huizhi Liang, Outhiriaradjou Benard, Olivier D Loudig, Dulguun Amgalan, Wendy M McKimpson, Greg R Phillips, Jeffrey Segall, Yihong Wang, Susan Fineberg, Larry Norton, Richard N Kitsis, Rachel B Haza. An Akt3 Splice Variant Lacking the Serine 472 Phosphorylation Site Promotes Apoptosis and Suppresses Mammary Tumorigenesis. Cancer research. vol 78. issue 1. 2018-11-05. PMID:29038347. |
these findings demonstrate an unexpected function of an endogenously expressed akt isoform in promoting, as opposed to suppressing, apoptosis, underscoring that akt isoforms may exert dissonant functions in malignancy. |
2018-11-05 |
2023-08-13 |
Not clear |
| Xin-Bin Guo, Xin Deng, Ying We. Hematopoietic Substrate-1-Associated Protein X-1 Regulates the Proliferation and Apoptosis of Endothelial Progenitor Cells Through Akt Pathway Modulation. Stem cells (Dayton, Ohio). vol 36. issue 3. 2018-11-05. PMID:29139175. |
hematopoietic substrate-1-associated protein x-1 regulates the proliferation and apoptosis of endothelial progenitor cells through akt pathway modulation. |
2018-11-05 |
2023-08-13 |
Not clear |
| Klaudia Szymonowicz, Sebastian Oeck, Adam Krysztofiak, Jansje van der Linden, George Iliakis, Verena Jendrosse. Restraining Akt1 Phosphorylation Attenuates the Repair of Radiation-Induced DNA Double-Strand Breaks and Reduces the Survival of Irradiated Cancer Cells. International journal of molecular sciences. vol 19. issue 8. 2018-11-05. PMID:30065170. |
the survival kinase protein kinase b (akt) participates in the regulation of essential subcellular processes, e.g., proliferation, growth, survival, and apoptosis, and has a documented role in promoting resistance against genotoxic stress including radiotherapy, presumably by influencing the dna damage response and dna double-strand break (dsb) repair. |
2018-11-05 |
2023-08-13 |
Not clear |
| Qi Luan, Lixiao Pan, Dongyong He, Xingji Gong, Hui Zho. SC79, the AKT Activator Protects Cerebral Ischemia in a Rat Model of Ischemia/Reperfusion Injury. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-11-05. PMID:30074018. |
background activation of akt pathway attenuates brain damage and neuronal apoptosis during cerebral ischemia/reperfusion (i/r) injury. |
2018-11-05 |
2023-08-13 |
mouse |
| Annu Makker, Madhu Mati Goel, Dipti Nigam, Abbas Ali Mahdi, Vinita Das, Anjoo Agarwal, Amita Pandey, Abnish Gauta. Aberrant Akt Activation During Implantation Window in Infertile Women With Intramural Uterine Fibroids. Reproductive sciences (Thousand Oaks, Calif.). vol 25. issue 8. 2018-11-02. PMID:29113583. |
aberrant akt activation and the associated imbalance in endometrial proliferation and apoptosis observed in infertile women with intramural fibroids during the midsecretory phase might contribute to impaired endometrial receptivity leading to infertility in these patients. |
2018-11-02 |
2023-08-13 |
Not clear |
| Kosuke Kaji, Norihisa Nishimura, Kenichiro Seki, Shinya Sato, Soichiro Saikawa, Keisuke Nakanishi, Masanori Furukawa, Hideto Kawaratani, Mitsuteru Kitade, Kei Moriya, Tadashi Namisaki, Hitoshi Yoshij. Sodium glucose cotransporter 2 inhibitor canagliflozin attenuates liver cancer cell growth and angiogenic activity by inhibiting glucose uptake. International journal of cancer. vol 142. issue 8. 2018-11-02. PMID:29205334. |
this agent also induced g2/m arrest and apoptosis with inhibited phosphorylation of erk, p38 and akt and cleavage of caspase3. |
2018-11-02 |
2023-08-13 |
mouse |
| Guy Nadel, Zhong Yao, Ido Ben-Ami, Zvi Naor, Rony Sege. Gq-Induced Apoptosis is Mediated by AKT Inhibition That Leads to PKC-Induced JNK Activation. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 50. issue 1. 2018-11-02. PMID:30278445. |
gq-induced apoptosis is mediated by akt inhibition that leads to pkc-induced jnk activation. |
2018-11-02 |
2023-08-13 |
Not clear |
| Guy Nadel, Zhong Yao, Ido Ben-Ami, Zvi Naor, Rony Sege. Gq-Induced Apoptosis is Mediated by AKT Inhibition That Leads to PKC-Induced JNK Activation. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 50. issue 1. 2018-11-02. PMID:30278445. |
in a previous study, we found that in prostate cancer cells, the gqpcr of gnrh induces apoptosis by reducing the pkc-dependent akt activity and elevating jnk phosphorylation. |
2018-11-02 |
2023-08-13 |
Not clear |
| Wei Duan, Yan Chen, Xiao-Rong Wan. MicroRNA‑155 contributes to the occurrence of epilepsy through the PI3K/Akt/mTOR signaling pathway. International journal of molecular medicine. vol 42. issue 3. 2018-10-29. PMID:29901097. |
overexpression of mirna‑155 resulted in decreased brain‑derived neurotrophic factor (bdnf) and tropomyosin receptor kinase b (trkb) protein expression, increased caspase‑3 activity, tumor protein p53 (p53) and apoptosis regulator bax (bax) protein expression, and inhibited phosphoinositide 3‑kinase (pi3k), phosphorylated (p‑)protein kinase b (akt) and p‑mechanistic target of rapamycin (mtor) protein expression in epilepsy cells. |
2018-10-29 |
2023-08-13 |
human |
| H T Nie, Y X Guo, X L Yao, T W Ma, K P Deng, Z Wang, G M Zhang, L W Sun, Z Y Wang, H C Wang, F Wan. Acute nutrient treatment causes alterations in intra-follicular antioxidation and AKT signaling. Reproduction (Cambridge, England). vol 155. issue 1. 2018-10-26. PMID:29066528. |
this study aimed to determine if short-term nutrient alteration affects (1) ovarian morphology, (2) plasma and ovarian antioxidant capability and (3) cell apoptosis and akt signaling within the ovary. |
2018-10-26 |
2023-08-13 |
Not clear |
| Guang Li, Yanping Song, Gangcan Li, Jingjing Ren, Jia Xie, Yunjie Zhang, Fei Gao, Jiao Mu, Jinqian Da. Downregulation of microRNA‑21 expression inhibits proliferation, and induces G1 arrest and apoptosis via the PTEN/AKT pathway in SKM‑1 cells. Molecular medicine reports. vol 18. issue 3. 2018-10-26. PMID:30015844. |
in addition, the expression levels of apoptosis regulator bcl‑2 (bcl2), cyclind1 and phosphorylated‑protein kinase b (akt) were significantly decreased in skm‑1 cells transfected with the mir‑21 inhibitor, whilst the expression levels of phosphatase and tensin homolog (pten), bcl‑associated protein x (bax) and cleaved caspase 3 were significantly elevated. |
2018-10-26 |
2023-08-13 |
Not clear |