| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ali A Shat. Resveratrol improves sperm parameter and testicular apoptosis in cisplatin-treated rats: Effects on ERK1/2, JNK, and Akt pathways. Systems biology in reproductive medicine. vol 65. issue 3. 2020-01-06. PMID:30507263. |
resveratrol improves sperm parameter and testicular apoptosis in cisplatin-treated rats: effects on erk1/2, jnk, and akt pathways. |
2020-01-06 |
2023-08-13 |
rat |
| Ali A Shat. Resveratrol improves sperm parameter and testicular apoptosis in cisplatin-treated rats: Effects on ERK1/2, JNK, and Akt pathways. Systems biology in reproductive medicine. vol 65. issue 3. 2020-01-06. PMID:30507263. |
in addition, activation of er stress, p53, erk1/2, jnk, and akt and markers of apoptosis were evaluated in rats' testis. |
2020-01-06 |
2023-08-13 |
rat |
| Ali A Shat. Resveratrol improves sperm parameter and testicular apoptosis in cisplatin-treated rats: Effects on ERK1/2, JNK, and Akt pathways. Systems biology in reproductive medicine. vol 65. issue 3. 2020-01-06. PMID:30507263. |
in conclusion, res protects against cis-induced testicular damage and reproductive dysfunction via improving testosterone levels, increasing sperm count, reducing testicular apoptosis via an antioxidant potential, inhibition of er stress, p53, erk1/2, jnk, and activation of akt. |
2020-01-06 |
2023-08-13 |
rat |
| Huannan Li, Xiaoren Cao, Xiongbing Chen, Xiaohong Yi, Jun Xia, Jilan Chen, Lan Yan. Bufadienolides induce apoptosis and autophagy by inhibiting the AKT signaling pathway in melanoma A‑375 cells. Molecular medicine reports. vol 20. issue 3. 2020-01-06. PMID:31322190. |
bufadienolides induce apoptosis and autophagy by inhibiting the akt signaling pathway in melanoma a‑375 cells. |
2020-01-06 |
2023-08-13 |
Not clear |
| Huannan Li, Xiaoren Cao, Xiongbing Chen, Xiaohong Yi, Jun Xia, Jilan Chen, Lan Yan. Bufadienolides induce apoptosis and autophagy by inhibiting the AKT signaling pathway in melanoma A‑375 cells. Molecular medicine reports. vol 20. issue 3. 2020-01-06. PMID:31322190. |
western blot analysis was used to evaluate the expression levels of proteins involved in the akt pathway that are associated with apoptosis and autophagy. |
2020-01-06 |
2023-08-13 |
Not clear |
| Huannan Li, Xiaoren Cao, Xiongbing Chen, Xiaohong Yi, Jun Xia, Jilan Chen, Lan Yan. Bufadienolides induce apoptosis and autophagy by inhibiting the AKT signaling pathway in melanoma A‑375 cells. Molecular medicine reports. vol 20. issue 3. 2020-01-06. PMID:31322190. |
in conclusion, these results revealed that bufadienolides effectively induced apoptosis and autophagy in a‑375 cells via the akt pathway, and therefore may be one of the candidate targets for the future development of targeted drugs to treat melanoma. |
2020-01-06 |
2023-08-13 |
Not clear |
| Cinzia Antognelli, Roberta Frosini, Maria F Santolla, Matthew J Peirce, Vincenzo N Tales. Oleuropein-Induced Apoptosis Is Mediated by Mitochondrial Glyoxalase 2 in NSCLC A549 Cells: A Mechanistic Inside and a Possible Novel Nonenzymatic Role for an Ancient Enzyme. Oxidative medicine and cellular longevity. vol 2019. 2020-01-03. PMID:31428230. |
our results indicate that op is able to induce apoptosis in a549 cells through the upregulation of mitochondrial glo2 (mglo2), mediated by the superoxide anion and akt signaling pathway. |
2020-01-03 |
2023-08-13 |
human |
| Liming Wang, Jae-Hyung Chang, Anne F Buckley, Robert F Spurne. Knockout of TRPC6 promotes insulin resistance and exacerbates glomerular injury in Akita mice. Kidney international. vol 95. issue 2. 2020-01-02. PMID:30665571. |
in cultured podocytes, hyperglycemia stimulated p38 signaling and induced apoptosis, which was reduced by insulin and ask1 inhibition and enhanced by akt or erk inhibition. |
2020-01-02 |
2023-08-13 |
mouse |
| Qiuchen Qi, Yanhong Hou, Ang Li, Yueyue Sun, Siying Li, Zhongxi Zha. Yifei Tongluo, a Chinese Herbal Formula, Suppresses Tumor Growth and Metastasis and Exerts Immunomodulatory Effect in Lewis Lung Carcinoma Mice. Molecules (Basel, Switzerland). vol 24. issue 4. 2020-01-02. PMID:30781674. |
the results suggest that akt and mitogen-activated protein kinase (mapks) pathways may be involved in yftl-induced apoptosis. |
2020-01-02 |
2023-08-13 |
mouse |
| Kangmu Ma, Jiapei Qiu, Mi Zhou, Yang Yang, Xiaofeng Y. Cox-2 Negatively Affects the Protective Role of Propofol against Hypoxia/Reoxygenation Induced Cardiomyocytes Apoptosis through Suppressing Akt Signaling. BioMed research international. vol 2019. 2020-01-02. PMID:31380437. |
cox-2 negatively affects the protective role of propofol against hypoxia/reoxygenation induced cardiomyocytes apoptosis through suppressing akt signaling. |
2020-01-02 |
2023-08-13 |
human |
| Kangmu Ma, Jiapei Qiu, Mi Zhou, Yang Yang, Xiaofeng Y. Cox-2 Negatively Affects the Protective Role of Propofol against Hypoxia/Reoxygenation Induced Cardiomyocytes Apoptosis through Suppressing Akt Signaling. BioMed research international. vol 2019. 2020-01-02. PMID:31380437. |
conversely, the over-expression of cox-2 inhibited akt phosphorylation while enhancing cardiomyocytes apoptosis. |
2020-01-02 |
2023-08-13 |
human |
| Kangmu Ma, Jiapei Qiu, Mi Zhou, Yang Yang, Xiaofeng Y. Cox-2 Negatively Affects the Protective Role of Propofol against Hypoxia/Reoxygenation Induced Cardiomyocytes Apoptosis through Suppressing Akt Signaling. BioMed research international. vol 2019. 2020-01-02. PMID:31380437. |
thus, it could be concluded that cox-2 negatively affects the protective effect of propofol against hypoxia/reoxygenation induced cardiomyocyte apoptosis by suppressing akt phosphorylation. |
2020-01-02 |
2023-08-13 |
human |
| S H Moon, C M Lee, M J Na. Cytoprotective effects of taxifolin against cadmium-induced apoptosis in human keratinocytes. Human & experimental toxicology. vol 38. issue 8. 2019-12-31. PMID:31079487. |
the cytoprotective effects of tax against cd-induced apoptosis were also characterized by the changes in the activity of caspase 3, -7, poly adp-ribose polymerase, the cellular proliferation-related erk1/2, and akt. |
2019-12-31 |
2023-08-13 |
human |
| Nataly de Dios, Santiago Orrillo, Martín Irizarri, María Susana Theas, Florence Boutillon, Marianela Candolfi, Adriana Seilicovich, Vincent Goffin, Daniel Pisera, Jimena Ferrari. JAK2/STAT5 Pathway Mediates Prolactin-Induced Apoptosis of Lactotropes. Neuroendocrinology. vol 108. issue 2. 2019-12-26. PMID:30376668. |
our results suggest that (i) the prlr/jak2/stat5 pathway is constitutively active in gh3 cells and contributes to prl-induced apoptosis by increasing the bax/bcl-2 ratio, (ii) prl inhibits erk1/2 and akt phosphorylation, thereby contributing to its proapoptotic effect, and (iii) the pi3k/akt pathway participates in the prl-mediated control of lactotrope proliferation. |
2019-12-26 |
2023-08-13 |
Not clear |
| Zhen-Tang Jing, Wei Liu, Chao-Rong Xue, Shu-Xiang Wu, Wan-Nan Chen, Xin-Jian Lin, Xu Li. AKT activator SC79 protects hepatocytes from TNF-α-mediated apoptosis and alleviates d-Gal/LPS-induced liver injury. American journal of physiology. Gastrointestinal and liver physiology. vol 316. issue 3. 2019-12-26. PMID:30629471. |
akt activator sc79 protects hepatocytes from tnf-α-mediated apoptosis and alleviates d-gal/lps-induced liver injury. |
2019-12-26 |
2023-08-13 |
mouse |
| Zhen-Tang Jing, Wei Liu, Chao-Rong Xue, Shu-Xiang Wu, Wan-Nan Chen, Xin-Jian Lin, Xu Li. AKT activator SC79 protects hepatocytes from TNF-α-mediated apoptosis and alleviates d-Gal/LPS-induced liver injury. American journal of physiology. Gastrointestinal and liver physiology. vol 316. issue 3. 2019-12-26. PMID:30629471. |
since the phosphoinositide-3-kinase/protein kinase b (pi3k/akt) pathway is known to have a protective role in death factor-mediated apoptosis, it is our hypothesis that activation of akt may represent a therapeutic strategy to alleviate tnf-α-induced hepatocyte apoptosis and liver injury. |
2019-12-26 |
2023-08-13 |
mouse |
| Zhen-Tang Jing, Wei Liu, Chao-Rong Xue, Shu-Xiang Wu, Wan-Nan Chen, Xin-Jian Lin, Xu Li. AKT activator SC79 protects hepatocytes from TNF-α-mediated apoptosis and alleviates d-Gal/LPS-induced liver injury. American journal of physiology. Gastrointestinal and liver physiology. vol 316. issue 3. 2019-12-26. PMID:30629471. |
we report here that the akt activator sc79 protects hepatocytes from tnf-α-induced apoptosis and protects mice from d-galactosamine (d-gal)/lipopolysaccharide (lps)-induced tnf-α-mediated liver injury and damage. |
2019-12-26 |
2023-08-13 |
mouse |
| Xin-Xin Xu, Si-Si Zhang, Hui-Long Lin, Qi Lin, Lai-En Shen, Emmanuel Ansong, Xue-Qing W. Metformin Promotes Regeneration of the Injured Endometrium Via Inhibition of Endoplasmic Reticulum Stress-Induced Apoptosis. Reproductive sciences (Thousand Oaks, Calif.). vol 26. issue 4. 2019-12-23. PMID:30466344. |
moreover, we determined that the effect of metformin was related to the inhibition of endoplasmic reticulum stress-induced apoptosis via the phosphatidylinositol 3 kinase (pi3k)/protein kinase b (akt) and extracellular regulated protein kinases1/2 pathways. |
2019-12-23 |
2023-08-13 |
rat |
| Yingli Kang, Ying Li, Tao Zhang, Yanqing Chi, Maodong Li. Effects of transcription factor EB on oxidative stress and apoptosis induced by high glucose in podocytes. International journal of molecular medicine. vol 44. issue 2. 2019-12-23. PMID:31173156. |
furthermore, when the akt phosphorylation inhibitor ly294002 was added, the improvement by tfeb to high glucose‑induced apoptosis was significantly reduced. |
2019-12-23 |
2023-08-13 |
Not clear |
| Ke Li, Fangzheng Zhou, Yu Zhou, Sheng Zhang, Qianwen Li, Zhenyu Li, Li Liu, Gang Wu, Rui Men. Quinalizarin, a specific CK2 inhibitor, can reduce icotinib resistance in human lung adenocarcinoma cell lines. International journal of molecular medicine. vol 44. issue 2. 2019-12-23. PMID:31173177. |
in conclusion, quinalizarin may partially sensitize cells to icotinib by inhibiting proliferation and promoting apoptosis mediated by akt and erk in egfr‑tki resistant nsclc cell lines. |
2019-12-23 |
2023-08-13 |
human |