| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jung Sun Park, Hoon In Choi, Eun Hui Bae, Seong Kwon Ma, Soo Wan Ki. Paricalcitol attenuates indoxyl sulfate-induced apoptosis through the inhibition of MAPK, Akt, and NF-kB activation in HK-2 cells. The Korean journal of internal medicine. vol 34. issue 1. 2020-01-29. PMID:28992684. |
paricalcitol attenuates indoxyl sulfate-induced apoptosis through the inhibition of mapk, akt, and nf-kb activation in hk-2 cells. |
2020-01-29 |
2023-08-13 |
Not clear |
| Peng Li, Dong Fu, Qingfeng Sheng, Shenghua Yu, Xingqi Bao, Zhibao L. TUDCA attenuates intestinal injury and inhibits endoplasmic reticulum stress-mediated intestinal cell apoptosis in necrotizing enterocolitis. International immunopharmacology. vol 74. 2020-01-28. PMID:31254957. |
furthermore, we confirmed that tudca inhibited the apoptosis of intestinal cells by modulating the perk-eif2α ers pathway and the akt pathway in vitro studies. |
2020-01-28 |
2023-08-13 |
mouse |
| Peng Li, Dong Fu, Qingfeng Sheng, Shenghua Yu, Xingqi Bao, Zhibao L. TUDCA attenuates intestinal injury and inhibits endoplasmic reticulum stress-mediated intestinal cell apoptosis in necrotizing enterocolitis. International immunopharmacology. vol 74. 2020-01-28. PMID:31254957. |
therefore, these results indicated that tudca alleviated intestinal injury in a mouse model of nec and inhibited ers-mediated intestinal cell apoptosis by activating the akt pathway. |
2020-01-28 |
2023-08-13 |
mouse |
| Sanjuan Yang, Junyao Li, Lan Han, Guoqi Zh. Early maternal separation promotes apoptosis in dentate gyrus and alters neurological behaviors in adolescent rats. International journal of clinical and experimental pathology. vol 10. issue 11. 2020-01-26. PMID:31966424. |
mechanically, ms promoted apoptosis, and reduced protein kinase b (akt) phosphorylation in the dg region in the early phase (p21). |
2020-01-26 |
2023-08-13 |
rat |
| Sanjuan Yang, Junyao Li, Lan Han, Guoqi Zh. Early maternal separation promotes apoptosis in dentate gyrus and alters neurological behaviors in adolescent rats. International journal of clinical and experimental pathology. vol 10. issue 11. 2020-01-26. PMID:31966424. |
our data implicate that the inactivation of akt pathway and apoptosis of dg cells might contribute to ms-induced behavioral changes. |
2020-01-26 |
2023-08-13 |
rat |
| Huanhuan Liu, Jiaqi Zhao, Rongzhan Fu, Chenhui Zhu, Daidi Fa. The ginsenoside Rk3 exerts anti-esophageal cancer activity in vitro and in vivo by mediating apoptosis and autophagy through regulation of the PI3K/Akt/mTOR pathway. PloS one. vol 14. issue 5. 2020-01-24. PMID:31091245. |
further studies indicated that pretreatment with the akt inhibitor gsk690693 or the mtor inhibitor rapamycin promoted rk3-induced apoptosis and autophagy, demonstrating that the pi3k/akt/mtor pathway is related to rk3-induced apoptosis and autophagy. |
2020-01-24 |
2023-08-13 |
human |
| Hsin-Ling Yang, Ruei-Wan Lin, Peramaiyan Rajendran, Dony Chacko Mathew, Varadharajan Thigarajan, Chuan-Chen Lee, Chih-Jung Hsu, You-Cheng Hse. Antrodia salmonea-induced oxidative stress abrogates HER-2 signaling cascade and enhanced apoptosis in ovarian carcinoma cells. Journal of cellular physiology. vol 234. issue 3. 2020-01-20. PMID:30146791. |
salmonea-induced apoptosis is associated with the suppression of human epidermal growth factor receptor-2 (her-2/neu) and phosphoinositide 3-kinase (pi3k)-protein kinase b (akt) expression in her-2/neu overexpressing skov-3 cells. |
2020-01-20 |
2023-08-13 |
human |
| Zhi-Juan Cao, Xiao-Hang Xu, Tian Gao, Yi Zhang, Hong Xia, Yu-Qing Zhao, Jian-Jun Wan. siRNA directed against Annexin II receptor inhibits HeLa cell proliferation, migration and invasion and induces apoptosis via suppressing ERK1/2 and Akt signaling pathways. International journal of clinical and experimental pathology. vol 11. issue 1. 2020-01-19. PMID:31938090. |
sirna directed against annexin ii receptor inhibits hela cell proliferation, migration and invasion and induces apoptosis via suppressing erk1/2 and akt signaling pathways. |
2020-01-19 |
2023-08-13 |
Not clear |
| Jing Zhang, Ying Han, Yang Zhao, Qin-Rui Li, Hong-Fang Jin, Jun-Bao Du, Jiong Qi. Role of endoplasmic reticulum stress-associated gene TRIB3 in rats following kainic acid-induced seizures. International journal of clinical and experimental pathology. vol 12. issue 2. 2020-01-17. PMID:31933865. |
these results indicate that er stress, trib3 and akt signaling are involved in the acute and prolonged hippocampal injury following ka induced seizure, suggesting that the er stress-associated gene trib3 plays an important role in neuronal apoptosis after seizure. |
2020-01-17 |
2023-08-13 |
rat |
| Wenfeng Cai, Shuping Zhong, Fuchun Zheng, Yanmei Zhang, Fenfei Gao, Hongquan Xu, Xiangna Cai, Junhong Lan, Danmei Huang, Ganggang Sh. Angiotensin II confers resistance to apoptosis in cardiac myofibroblasts through the AT1/ERK1/2/RSK1 pathway. IUBMB life. vol 71. issue 2. 2020-01-13. PMID:30452117. |
here, we show that ang ii rapidly activates mapks but not akt in cmfs and confers apoptosis resistance, as evidenced by the inhibition of caspase-3 cleavage, early apoptotic cells and late apoptotic cells. |
2020-01-13 |
2023-08-13 |
human |
| Joo Eon Lee, Dong Gwang Lee, Soon Yong Park, Ara Jo, Hyoung Kyu Kim, Jin Han, Jeong-Ki Min, Jin Woong Chun. Gekkonidae, Lizard tail extracts elicit apoptotic response against non-small cell lung cancer via inhibiting Akt signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 116. 2020-01-13. PMID:31170662. |
we also found that lte induced apoptosis in a caspase-3/7 cascade-dependent manner and inhibited the phosphorylation of akt by participating in the pi3k/akt pathway. |
2020-01-13 |
2023-08-13 |
mouse |
| Jian-Bo Fan, Wei Liu, Xin-Hui Zhu, Sheng-Yu Cui, Zhi-Ming Cui, Jian-Ning Zha. microRNA-7 inhibition protects human osteoblasts from dexamethasone via activation of epidermal growth factor receptor signaling. Molecular and cellular biochemistry. vol 460. issue 1-2. 2020-01-13. PMID:31313024. |
in ob-6, hfob1.19, and primary human osteoblasts, mir-7 depletion by a lentiviral antagomir-7 construct (lv-antagomir-7) increased egfr expression and downstream akt activation, protecting cells from dex-induced viability reduction, cell death, and apoptosis. |
2020-01-13 |
2023-08-13 |
human |
| Hao Wang, Ying-Hua Luo, Gui-Nan Shen, Xian-Ji Piao, Wan-Ting Xu, Yi Zhang, Jia-Ru Wang, Yu-Chao Feng, Jin-Qian Li, Yu Zhang, Tong Zhang, Shi-Nong Wang, Hui Xue, Hong-Xing Wang, Chang-Yuan Wang, Cheng-Hao Ji. Two novel 1,4‑naphthoquinone derivatives induce human gastric cancer cell apoptosis and cell cycle arrest by regulating reactive oxygen species‑mediated MAPK/Akt/STAT3 signaling pathways. Molecular medicine reports. vol 20. issue 3. 2020-01-13. PMID:31322207. |
the apoptotic effect was determined by flow cytometry, and the results showed that bq and oq induced cell apoptosis by regulating the mitochondrial pathway and cell cycle arrest at the g2/m phase via inhibition of the akt signaling pathway in ags cells. |
2020-01-13 |
2023-08-13 |
human |
| Hao Wang, Ying-Hua Luo, Gui-Nan Shen, Xian-Ji Piao, Wan-Ting Xu, Yi Zhang, Jia-Ru Wang, Yu-Chao Feng, Jin-Qian Li, Yu Zhang, Tong Zhang, Shi-Nong Wang, Hui Xue, Hong-Xing Wang, Chang-Yuan Wang, Cheng-Hao Ji. Two novel 1,4‑naphthoquinone derivatives induce human gastric cancer cell apoptosis and cell cycle arrest by regulating reactive oxygen species‑mediated MAPK/Akt/STAT3 signaling pathways. Molecular medicine reports. vol 20. issue 3. 2020-01-13. PMID:31322207. |
these results demonstrated that bq and oq induced apoptosis and cell cycle arrest at the g2/m phase in ags cells by stimulating ros generation, which caused subsequent activation of mapk, akt and stat3 signaling pathways. |
2020-01-13 |
2023-08-13 |
human |
| Na Li, Tian Yang, Wenqian Yu, Hao Liu, Chong Qiao, Caixia Li. The role of Zeb1 in the pathogenesis of morbidly adherent placenta. Molecular medicine reports. vol 20. issue 3. 2020-01-13. PMID:31322233. |
in addition, zeb1 regulated the viability, apoptosis and migration of htr‑8/sv neo cells and human umbilical vein endothelial cells by regulating the akt pathway. |
2020-01-13 |
2023-08-13 |
human |
| Lingling Liang, Xiaomei Wang, Yajuan Zheng, Yang Li. All‑trans‑retinoic acid modulates TGF‑β‑induced apoptosis, proliferation, migration and extracellular matrix synthesis of conjunctival fibroblasts by inhibiting PI3K/AKT signaling. Molecular medicine reports. vol 20. issue 3. 2020-01-13. PMID:31322252. |
atra treatment resulted in an increased level of hconf apoptosis, reduced proliferation and migration, decreased collagen i and fibronectin expression, and decreased phosphorylation of pi3k and akt. |
2020-01-13 |
2023-08-13 |
human |
| Lili Zhuang, Hongmei Qu, Jianxiang Cong, Huangguan Dai, Xiaoyan Li. MiR-181c affects estrogen-dependent endometrial carcinoma cell growth by targeting PTEN. Endocrine journal. vol 66. issue 6. 2020-01-09. PMID:30971627. |
besides, overexpression of pten markedly promoted the apoptosis of e2-induced rl95-2 cells through regulating the bax and bcl-2 expression, and modulated the expression of akt pathway, p53 and cyclin d. in conclusion, our findings revealed that mir-181c affected the estrogen-dependent endometrial carcinoma cell growth by targeting pten. |
2020-01-09 |
2023-08-13 |
human |
| Ryo Terao, Megumi Honjo, Takashi Ueta, Hideru Obinata, Takashi Izumi, Makoto Kurano, Yutaka Yatomi, Hideto Koso, Sumiko Watanabe, Makoto Aihar. Light Stress-Induced Increase of Sphingosine 1-Phosphate in Photoreceptors and Its Relevance to Retinal Degeneration. International journal of molecular sciences. vol 20. issue 15. 2020-01-09. PMID:31357484. |
s1p treatment reduced protein kinase b (akt) phosphorylation and increased the protein expression of cleaved caspase-3, and induced photoreceptor cell apoptosis. |
2020-01-09 |
2023-08-13 |
Not clear |
| Ruixin Wang, Yuehong Yan, Cuicui L. LINC00462 is involved in high glucose-induced apoptosis of renal tubular epithelial cells via AKT pathway. Cell biology international. 2020-01-08. PMID:31489995. |
linc00462 is involved in high glucose-induced apoptosis of renal tubular epithelial cells via akt pathway. |
2020-01-08 |
2023-08-13 |
human |
| Ruixin Wang, Yuehong Yan, Cuicui L. LINC00462 is involved in high glucose-induced apoptosis of renal tubular epithelial cells via AKT pathway. Cell biology international. 2020-01-08. PMID:31489995. |
in conclusion, our study demonstrated that knockdown of linc00462 can ameliorate oxidative stress and apoptosis in hg-induced rtec by activating the akt pathway, suggesting that knockdown of linc00462 may provide a potential therapeutic approach for dn. |
2020-01-08 |
2023-08-13 |
human |