| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bin Sun, Changxian Dong, Hongzhao Lei, Yubin Gong, Miaomiao Li, Yuanfang Zhang, Hongyu Zhang, Longlong Su. Propranolol inhibits proliferation and induces apoptosis of hemangioma-derived endothelial cells via Akt pathway by down-regulating Ang-2 expression. Chemico-biological interactions. vol 316. 2020-02-27. PMID:31838054. |
futhermore, inhibition of the akt pathway attenuated the effects of ang-2 on proliferation and apoptosis in hemecs. |
2020-02-27 |
2023-08-13 |
human |
| Bin Sun, Changxian Dong, Hongzhao Lei, Yubin Gong, Miaomiao Li, Yuanfang Zhang, Hongyu Zhang, Longlong Su. Propranolol inhibits proliferation and induces apoptosis of hemangioma-derived endothelial cells via Akt pathway by down-regulating Ang-2 expression. Chemico-biological interactions. vol 316. 2020-02-27. PMID:31838054. |
in conclusion, propranolol inhibited proliferation and induced apoptosis of hemecs via akt pathway by down-regulating ang-2 expression, which contributes to our understanding on the pathogenesis of hemangioma and promotes the development of therapeutic approaches for hemangioma. |
2020-02-27 |
2023-08-13 |
human |
| Lu Liang, Aftab Amin, Wing-Yan Cheung, Rui Xu, Rujian Yu, Jinshan Tang, Xinsheng Yao, Chun Lian. Parameritannin A-2 from Urceola huaitingii enhances doxorubicin-induced mitochondria-dependent apoptosis by inhibiting the PI3K/Akt, ERK1/2 and p38 pathways in gastric cancer cells. Chemico-biological interactions. vol 316. 2020-02-27. PMID:31843629. |
moreover, pa-2 attenuates the dox-induced activation of akt, erk1/2 and p38 signaling pathways, providing a molecular mechanism for the synergistic effects of dox and pa-2 in the induction of apoptosis. |
2020-02-27 |
2023-08-13 |
Not clear |
| Junbo Xia, Lujun Dai, Liusheng Wang, Jing Zh. Ganoderic acid DM induces autophagic apoptosis in non-small cell lung cancer cells by inhibiting the PI3K/Akt/mTOR activity. Chemico-biological interactions. vol 316. 2020-02-27. PMID:31874162. |
when overexpression of akt reactivated akt/mtor pathway in a549 or nci-h460 cells, the increase of autophagy related marker lc3b-ii and apoptosis related protein cleaved parp and cleaved caspase 3 and the ration of apoptotic cells by ga-dm was reversed, suggesting that ga-dm promoted autophagy and apoptosis by inhibiting akt/mtor pathway-mediated autophagy induction. |
2020-02-27 |
2023-08-13 |
Not clear |
| Chen Liu, Wu QiNan, Lei XiaoTian, Yang MengLiu, Gan XiaGuang, Leng WeiLing, Liang ZiWen, Zhang Ling, Yang GangYi, Chen Bin. Corrigendum to "TERT and Akt Are Involved in the Par-4-Dependent Apoptosis of Islet Journal of diabetes research. vol 2020. 2020-02-25. PMID:32064274. |
corrigendum to "tert and akt are involved in the par-4-dependent apoptosis of islet [this corrects the article doi: 10.1155/2018/7653904. |
2020-02-25 |
2023-08-13 |
Not clear |
| Nenghong Sun, Lichao Chu, Lei Yuan, Zongcai Q. Inactivation of P2YR12 contributes to isoflurane-induced neuronal injury by altering TLR-4/BDNF/TNF-α. Folia neuropathologica. vol 57. issue 2. 2020-02-20. PMID:31556575. |
in addition, apoptosis of neuronal cells decreased in the prasugrel-treated group, as it ameliorated expression of the pi3k, bcl-2, bad, and akt proteins in the isoflurane-induced neuronal injury rats. |
2020-02-20 |
2023-08-13 |
rat |
| Feng Qiu, Yubo Zhou, Yeke Deng, Junzhi Yi, Mengting Gong, Ning Liu, Chenxi Wei, Shuanglin Xian. Knockdown of TNFAIP1 prevents di-(2-ethylhexyl) phthalate-induced neurotoxicity by activating CREB pathway. Chemosphere. vol 241. 2020-02-20. PMID:31683445. |
we found that exposure to dehp induced apoptosis and downregulated the expression of brain-derived neurotrophic factor (bdnf), synaptic proteins psd 95 and synapsin-1 while upregulated the expression of tnfaip1 and decreased the levels of phosphorylated akt, camk Ⅳ, catalytic subunits of pka and creb in creb signaling pathway. |
2020-02-20 |
2023-08-13 |
mouse |
| Xinghuo Wu, Suyun Li, Kun Wang, Wenbin Hua, Shuai Li, Yu Song, Yukun Zhang, Shuhua Yang, Cao Yan. TNF-α Regulates ITGβ1 and SYND4 Expression in Nucleus Pulposus Cells: Activation of FAK/PI3K Signaling. Inflammation. vol 42. issue 5. 2020-02-19. PMID:31111299. |
tnf-α induction could weaken fak activity and downstream levels of phospho-pi3k and akt, resulting in decreased adherence capacity and increased apoptosis. |
2020-02-19 |
2023-08-13 |
Not clear |
| Hao Chen, Jingquan Yuan, Ji Hao, Yanzhang Wen, Yibing Lv, Lu Chen, Xinzhou Yan. α-Humulene inhibits hepatocellular carcinoma cell proliferation and induces apoptosis through the inhibition of Akt signaling. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 134. 2020-02-17. PMID:31562948. |
α-humulene inhibits hepatocellular carcinoma cell proliferation and induces apoptosis through the inhibition of akt signaling. |
2020-02-17 |
2023-08-13 |
mouse |
| Hao Chen, Jingquan Yuan, Ji Hao, Yanzhang Wen, Yibing Lv, Lu Chen, Xinzhou Yan. α-Humulene inhibits hepatocellular carcinoma cell proliferation and induces apoptosis through the inhibition of Akt signaling. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 134. 2020-02-17. PMID:31562948. |
hcc cells show abnormal akt signaling to resist apoptosis. |
2020-02-17 |
2023-08-13 |
mouse |
| Jae Kwang Kim, Nu Ri Han, Sang Mi Park, Kyung Hwan Jegal, Ji Yun Jung, Eun Hye Jung, Eun Ok Kim, Doyeon Kim, Dae Hwa Jung, Jong Rok Lee, Chung A Park, Sae Kwang Ku, Il Je Cho, Sang Chan Ki. Hemistepsin A alleviates liver fibrosis by inducing apoptosis of activated hepatic stellate cells via inhibition of nuclear factor-κB and Akt. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 135. 2020-02-17. PMID:31830547. |
hemistepsin a alleviates liver fibrosis by inducing apoptosis of activated hepatic stellate cells via inhibition of nuclear factor-κb and akt. |
2020-02-17 |
2023-08-13 |
mouse |
| Jae Kwang Kim, Nu Ri Han, Sang Mi Park, Kyung Hwan Jegal, Ji Yun Jung, Eun Hye Jung, Eun Ok Kim, Doyeon Kim, Dae Hwa Jung, Jong Rok Lee, Chung A Park, Sae Kwang Ku, Il Je Cho, Sang Chan Ki. Hemistepsin A alleviates liver fibrosis by inducing apoptosis of activated hepatic stellate cells via inhibition of nuclear factor-κB and Akt. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 135. 2020-02-17. PMID:31830547. |
transfection experiments suggested that inhibition of nf-κb or akt is essential for hsa-induced apoptosis of hscs. |
2020-02-17 |
2023-08-13 |
mouse |
| Ye Hong, Jia Zhang, Qunyi Guo, Min Zhu, Baoguo Chen, Wenda Lu. Diacetyl Hexamethylene Diamine (CAHB) Exerts Pro-Apoptotic and Anti-Proliferative Function in Leukemic T Lymphocytes via Downregulating PI3K/Akt Signaling. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-02-13. PMID:31301225. |
results cahb inhibited the proliferation and promoted the apoptosis of jurkat cells in a time- and dose-dependent manner by decreasing activation of akt, reducing the mitochondrial membrane potential, and downregulating the bcl-2/bax ratio. |
2020-02-13 |
2023-08-13 |
Not clear |
| Kuo Jiang, Jia Li, Jitao Zhang, Lei Wang, Qianfeng Zhang, Junli Ge, Yunshan Guo, Biao Wang, Yi Huang, Tuanmin Yang, Dingjun Hao, Lequn Sha. SDF-1/CXCR4 axis facilitates myeloid-derived suppressor cells accumulation in osteosarcoma microenvironment and blunts the response to anti-PD-1 therapy. International immunopharmacology. vol 75. 2020-02-13. PMID:31437795. |
the binding of sdf-1 to its receptor cxcr4 results in the activation of downstream akt pathway that mediates reduced apoptosis of mdscs. |
2020-02-13 |
2023-08-13 |
Not clear |
| Xiaoli Wu, Wencui Kong, Xiaoyan Qi, Shuiliang Wang, Ying Chen, Zhongquan Zhao, Wenwu Wang, Xiandong Lin, Jinhuo Lai, Zongyang Yu, Guoxiang La. Icariin induces apoptosis of human lung adenocarcinoma cells by activating the mitochondrial apoptotic pathway. Life sciences. vol 239. 2020-02-13. PMID:31682849. |
mechanistically, icariin activated the mitochondrial pathway by inhibiting the activation of the pi3k-akt pathway-associated kinase, akt, resulting in the activation of members of the caspase family of proteins, and thus inducing apoptosis of a549 cells. |
2020-02-13 |
2023-08-13 |
mouse |
| Guo-Xing Wan, Lan Cheng, Hai-Lun Qin, Yun-Zhang Zhang, Ling-Yu Wang, Yong-Gang Zhan. MiR-15b-5p is Involved in Doxorubicin-Induced Cardiotoxicity via Inhibiting Bmpr1a Signal in H9c2 Cardiomyocyte. Cardiovascular toxicology. vol 19. issue 3. 2020-02-11. PMID:30535663. |
moreover, we also confirmed that overexpression of mir-15b-5p may exacerbate the dox-induced apoptosis of h9c2 cardiomyocytes by affecting the protein expression ratio of bcl-2/bax and akt activation, while this pro-apoptotic effect was able to be suppressed by bmpr1a agonist. |
2020-02-11 |
2023-08-13 |
rat |
| Dan Tao, Ninghua Ni, Tiesong Zhang, Chao Li, Qing Sun, Ling Wang, Yan Me. Accumulation of advanced glycation end products potentiate human retinal capillary endothelial cells mediated diabetic retinopathy. Molecular medicine reports. vol 20. issue 4. 2020-02-07. PMID:31432194. |
akt inhibition increased cell apoptosis and death in hrcecs. |
2020-02-07 |
2023-08-13 |
human |
| Li Zhou, Ming Li, Xinyou Yu, Feng Gao, Wei L. Repression of Hexokinases II-Mediated Glycolysis Contributes to Piperlongumine-Induced Tumor Suppression in Non-Small Cell Lung Cancer Cells. International journal of biological sciences. vol 15. issue 4. 2020-02-03. PMID:30906213. |
moreover, our results revealed that piperlongumine down-regulated the akt signaling, exogenous overexpression of constitutively activated akt1 in hcc827 and h1975 cells significantly rescued piperlongumine-induced glycolysis suppression and apoptosis. |
2020-02-03 |
2023-08-13 |
mouse |
| Naiyan Wen, Baofeng Guo, Hongwu Zheng, Libo Xu, Hang Liang, Qian Wang, Ding Wang, Xuyang Chen, Shengnan Zhang, Yang Li, Ling Zhan. Bromodomain inhibitor jq1 induces cell cycle arrest and apoptosis of glioma stem cells through the VEGF/PI3K/AKT signaling pathway. International journal of oncology. vol 55. issue 4. 2020-02-03. PMID:31485609. |
in addition, treatment with sibrd4 or jq1 induced apoptosis by activating akt downstream target genes involved in apoptosis. |
2020-02-03 |
2023-08-13 |
Not clear |
| Shuangshuang Yin, Yuling Qiu, Chengyun Jin, Rui Wang, Song Wu, Hongwei Liu, Sangho Koo, Lifeng Han, Yi Zhang, Xiumei Gao, Xu Pang, Tao Wang, Haiyang Y. 7-Deoxynarciclasine shows promising antitumor efficacy by targeting Akt against hepatocellular carcinoma. International journal of cancer. vol 145. issue 12. 2020-01-30. PMID:31081930. |
finally, higher p-akt expression is associated with poor prognosis, and higher level of akt was positively correlated with the enrichment of both apoptosis and autophagy downregulation, and emt upregulation in hcc patients. |
2020-01-30 |
2023-08-13 |
Not clear |