| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Junjie Wang, Dongdong Fu, Soulixay Senouthai, Yanwu Yo. Critical roles of PI3K/Akt/NF‑κB survival axis in angiotensin II‑induced podocyte injury. Molecular medicine reports. vol 20. issue 6. 2020-03-30. PMID:31638199. |
ly294002 further enhanced ang ii‑induced downregulation of akt and p65 nf‑κb activation, as well as upregulation of caspase‑9 mrna and protein, and promoted the apoptosis of podocytes. |
2020-03-30 |
2023-08-13 |
mouse |
| Junjie Wang, Dongdong Fu, Soulixay Senouthai, Yanwu Yo. Critical roles of PI3K/Akt/NF‑κB survival axis in angiotensin II‑induced podocyte injury. Molecular medicine reports. vol 20. issue 6. 2020-03-30. PMID:31638199. |
of note, 740y‑p restored ang ii‑induced downregulation of akt and p65 nf‑κb activation, and upregulation of caspase‑9, and decreased podocyte apoptosis. |
2020-03-30 |
2023-08-13 |
mouse |
| Fang Wei, Mofei Wang, Zhen Li, Yong Wang, Yong Zho. miR‑593 inhibits proliferation and invasion and promotes apoptosis in non‑small cell lung cancer cells by targeting SLUG‑associated signaling pathways. Molecular medicine reports. vol 20. issue 6. 2020-03-30. PMID:31661137. |
introduction of a mir‑593 mimic suppressed cell proliferation by inactivating the slug/protein kinase b (akt)/cyclin d1/cdk4 or cdk6 signaling pathway, while it induced apoptosis by activating the slug/akt/bcl‑2/bax signaling pathway. |
2020-03-30 |
2023-08-13 |
Not clear |
| Dongjoon Kim, Dayeun Lee, Philip C Trackman, Sayon Ro. Effects of High Glucose-Induced Lysyl Oxidase Propeptide on Retinal Endothelial Cell Survival: Implications for Diabetic Retinopathy. The American journal of pathology. vol 189. issue 10. 2020-03-27. PMID:31537300. |
in addition, cells exposed to rlox-pp alone exhibited increased apoptosis concomitant with decreased akt phosphorylation. |
2020-03-27 |
2023-08-13 |
rat |
| W U Chengzhu, Meijia Gao, Lin Shen, L I Bohan, Xiangjian Bai, Jiahui Gui, L I Hongmei, Qiang Huo, M A Ta. Miconazole triggers various forms of cell death in human breast cancer MDA-MB-231 cells. Die Pharmazie. vol 74. issue 5. 2020-03-26. PMID:31109399. |
the initial mechanism of mcz-mediated cell death in human breast cancer mda-mb-231 cells involves an increase in the bax/bcl-2 ratio, downregulation of apoptosis induced by akt and p-akt-473, a simultaneous upregulation of the receptor-interacting protein 3 (rip3) and mixed lineage kinase domain-like (mlkl) protein expression, and ros production to induce necroptosis. |
2020-03-26 |
2023-08-13 |
human |
| An-Quan Shang, Wei-Wei Wang, Yi-Bao Yang, Chen-Zheng Gu, Ping Ji, Chen Chen, Bing-Jie Zeng, Jun-Lu Wu, Wen-Ying Lu, Zu-Jun Sun, Dong L. Knockdown of long noncoding RNA PVT1 suppresses cell proliferation and invasion of colorectal cancer via upregulation of microRNA-214-3p. American journal of physiology. Gastrointestinal and liver physiology. vol 317. issue 2. 2020-03-24. PMID:31125260. |
with increased levels of mir-214-3p and decreased levels of lncrna pvt1 in crc cells, the expression of phosphatidylinositol 3-kinase, putative (pi3k) and akt was reduced, and consequently, the cell apoptosis was stimulated and cell proliferation and invasion were suppressed. |
2020-03-24 |
2023-08-13 |
Not clear |
| Maria Liliana Piredda, Girish Gaur, Gianfranco Catalano, Mariadomenica Divona, Cristina Banella, Serena Travaglini, Maria Carmen Puzzangara, Maria Teresa Voso, Francesco Lo-Coco, Nelida Ines Noguer. PML/RARA inhibits expression of HSP90 and its target AKT. British journal of haematology. vol 184. issue 6. 2020-03-20. PMID:30536958. |
akt plays a crucial regulatory role in differentiation, cell cycle, transcription, translation, metabolism and apoptosis. |
2020-03-20 |
2023-08-13 |
Not clear |
| Haizhen Wang, Zhenghua Tang, Ting Li, Menglu Liu, Yong Li, Baoling Xin. CRISPR/Cas9-Mediated Gene Knockout of ARID1A Promotes Primary Progesterone Resistance by Downregulating Progesterone Receptor B in Endometrial Cancer Cells. Oncology research. vol 27. issue 9. 2020-03-20. PMID:31072420. |
pretreatment with ly294002 significantly enhanced the ability of mpa to suppress proliferation and to induce apoptosis in the parental and ishikawa-pr cells via the inhibition of akt activation and upregulation of prb transcriptional activity. |
2020-03-20 |
2023-08-13 |
Not clear |
| Shaoqing Lei, Wating Su, Zhong-Yuan Xia, Yafeng Wang, Lu Zhou, Shigang Qiao, Bo Zhao, Zhengyuan Xia, Michael G Irwi. Hyperglycemia-Induced Oxidative Stress Abrogates Remifentanil Preconditioning-Mediated Cardioprotection in Diabetic Rats by Impairing Caveolin-3-Modulated PI3K/Akt and JAK2/STAT3 Signaling. Oxidative medicine and cellular longevity. vol 2019. 2020-03-20. PMID:31583053. |
rpc significantly attenuated postischemic infarction, cardiac dysfunction, myocardial apoptosis, and 15-f2t-isoprostane production (a specific marker of oxidative stress), accompanied with increased cav-3 expression and enhanced akt and stat3 activation in control but not in diabetic rats. |
2020-03-20 |
2023-08-13 |
rat |
| Fanling Hong, Yujun Zhang, Wenjin Cheng, Xiuli Sun, Jianliu Wan. β-arrestin-2 up-regulates toll-like receptor 2 signaling and inhibits apoptosis in human endometrial cancer heterotransplants in nude mice. BMC cancer. vol 19. issue 1. 2020-03-20. PMID:31675995. |
this study aimed to investigate the effects of the stable overexpression of arr2 on the proliferation and apoptosis of human ec heterotransplants and the expression of associated molecules, including toll-like receptor 2(tlr2), serine-threonine kinase akt (akt), glycogen synthase kinase-3β(gsk3β) and some typical inflammatory cytokines such as nf-κb p56, tnf-α and il-6 & il-8. |
2020-03-20 |
2023-08-13 |
mouse |
| Xiaoqing Dong, Rui Zhao, Yue Li, Qianyun Yu, Xin Chen, Xiaoyu Hu, Jing Ma, Xiaoling Chen, Shile Huang, Long Che. Maduramicin inactivation of Akt impairs autophagic flux leading to accumulated autophagosomes-dependent apoptosis in skeletal myoblast cells. The international journal of biochemistry & cell biology. vol 114. 2020-03-19. PMID:31325628. |
maduramicin inactivation of akt impairs autophagic flux leading to accumulated autophagosomes-dependent apoptosis in skeletal myoblast cells. |
2020-03-19 |
2023-08-13 |
Not clear |
| Xiaoqing Dong, Rui Zhao, Yue Li, Qianyun Yu, Xin Chen, Xiaoyu Hu, Jing Ma, Xiaoling Chen, Shile Huang, Long Che. Maduramicin inactivation of Akt impairs autophagic flux leading to accumulated autophagosomes-dependent apoptosis in skeletal myoblast cells. The international journal of biochemistry & cell biology. vol 114. 2020-03-19. PMID:31325628. |
inhibition of akt with inhibitor x potentiated mad-induced decrease in phosphorylated akt, and increases in lc3-ii and p62 levels, autophagosome formation and cell apoptosis, whereas ectopic expression of constitutively active akt rendered resistance to these events. |
2020-03-19 |
2023-08-13 |
Not clear |
| Xiaoqing Dong, Rui Zhao, Yue Li, Qianyun Yu, Xin Chen, Xiaoyu Hu, Jing Ma, Xiaoling Chen, Shile Huang, Long Che. Maduramicin inactivation of Akt impairs autophagic flux leading to accumulated autophagosomes-dependent apoptosis in skeletal myoblast cells. The international journal of biochemistry & cell biology. vol 114. 2020-03-19. PMID:31325628. |
collectively, these results indicate that mad inactivation of akt impairs autophagic flux leading to accumulated autophagosomes-dependent apoptosis in skeletal myoblast cells. |
2020-03-19 |
2023-08-13 |
Not clear |
| Lingfang Zhuang, Chenni Li, Qiujing Chen, Qi Jin, Liqun Wu, Lin Lu, Xiaoxiang Yan, Kang Che. Fatty acid-binding protein 3 contributes to ischemic heart injury by regulating cardiac myocyte apoptosis and MAPK pathways. American journal of physiology. Heart and circulatory physiology. vol 316. issue 5. 2020-03-16. PMID:30735072. |
we found that overexpression of fabp3 upregulated the phosphorylation of mapk signaling pathway and decreased phosphorylated akt levels, which may account for the augmentation of apoptosis and remodeling after mi. |
2020-03-16 |
2023-08-13 |
rat |
| Yi Zhang, Ying-Hua Luo, Xian-Ji Piao, Gui-Nan Shen, Jia-Ru Wang, Yu-Chao Feng, Jin-Qian Li, Wan-Ting Xu, Yu Zhang, Tong Zhang, Chang-Yuan Wang, Cheng-Hao Ji. The design of 1,4-naphthoquinone derivatives and mechanisms underlying apoptosis induction through ROS-dependent MAPK/Akt/STAT3 pathways in human lung cancer cells. Bioorganic & medicinal chemistry. vol 27. issue 8. 2020-03-12. PMID:30846406. |
in addition, they induced the apoptosis of a549 lung cancer cells by increasing the phosphorylation of p38 and c-jun n-terminal kinase (p-jnk), and decreasing the phosphorylation of extracellular signal-related kinase (p-erk), protein kinase b (akt), and signal transducer and activator of transcription 3 (stat3). |
2020-03-12 |
2023-08-13 |
human |
| Yi Zhang, Ying-Hua Luo, Xian-Ji Piao, Gui-Nan Shen, Jia-Ru Wang, Yu-Chao Feng, Jin-Qian Li, Wan-Ting Xu, Yu Zhang, Tong Zhang, Chang-Yuan Wang, Cheng-Hao Ji. The design of 1,4-naphthoquinone derivatives and mechanisms underlying apoptosis induction through ROS-dependent MAPK/Akt/STAT3 pathways in human lung cancer cells. Bioorganic & medicinal chemistry. vol 27. issue 8. 2020-03-12. PMID:30846406. |
in conclusion, epdmnq and endmnq induced g1 phase cell cycle arrest and apoptosis in a549 cells via the ros-mediated activation of mitogen activated protein kinase (mapk), akt and stat3 signaling pathways. |
2020-03-12 |
2023-08-13 |
human |
| Lu Ji, Bing Zhong, Xi Jiang, Fei Mao, Gang Liu, Bin Song, Cheng-Yuan Wang, Yong Jiao, Jiang-Ping Wang, Zhi-Bin Xu, Xing Li, Bo Zha. Actein induces autophagy and apoptosis in human bladder cancer by potentiating ROS/JNK and inhibiting AKT pathways. Oncotarget. vol 8. issue 68. 2020-03-06. PMID:29348843. |
actein induces autophagy and apoptosis in human bladder cancer by potentiating ros/jnk and inhibiting akt pathways. |
2020-03-06 |
2023-08-13 |
human |
| Lu Ji, Bing Zhong, Xi Jiang, Fei Mao, Gang Liu, Bin Song, Cheng-Yuan Wang, Yong Jiao, Jiang-Ping Wang, Zhi-Bin Xu, Xing Li, Bo Zha. Actein induces autophagy and apoptosis in human bladder cancer by potentiating ROS/JNK and inhibiting AKT pathways. Oncotarget. vol 8. issue 68. 2020-03-06. PMID:29348843. |
in contrast, akt and mammalian target of rapamycin (mtor) were greatly de-phosphorylated by act, while suppressing akt and mtor activity could enhance the effects of act on apoptosis and autophagy induction. |
2020-03-06 |
2023-08-13 |
human |
| Lei Song, Yi Luo, Xinyue Wang, Mohammed M Almutairi, Huafeng Pan, Weirong Li, Yongqiang Liu, Qi Wang, Ming Hon. Exploring the active mechanism of berberine against HCC by systematic pharmacology and experimental validation. Molecular medicine reports. vol 20. issue 5. 2020-02-28. PMID:31545468. |
in addition, inhibition of the akt pathway by bbr also contributed to cell apoptosis in mhcc97‑h and hepg2 cells. |
2020-02-28 |
2023-08-13 |
Not clear |
| Bin Sun, Changxian Dong, Hongzhao Lei, Yubin Gong, Miaomiao Li, Yuanfang Zhang, Hongyu Zhang, Longlong Su. Propranolol inhibits proliferation and induces apoptosis of hemangioma-derived endothelial cells via Akt pathway by down-regulating Ang-2 expression. Chemico-biological interactions. vol 316. 2020-02-27. PMID:31838054. |
propranolol inhibits proliferation and induces apoptosis of hemangioma-derived endothelial cells via akt pathway by down-regulating ang-2 expression. |
2020-02-27 |
2023-08-13 |
human |