| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Meini Kang, Shuai Shao, Yue Zhang, Xue Liang, Kai Zhang, Guangping L. Beneficial Effects of Ticagrelor on Oxidized Low-Density Lipoprotein (ox-LDL)-Induced Apoptosis in Human Umbilical Vein Endothelial Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-06-26. PMID:31863577. |
results after treatment with 50 ug/ml ox-ldl or 100 ug/ml ox-ldl, we found that the late apoptosis and necrosis rate and the expression levels of bax and caspase-3 were significantly increased in huvecs, whereas the expression levels of akt, p-akt, bcl-2, enos, and no were significantly decreased. |
2020-06-26 |
2023-08-13 |
human |
| Sanqiang Li, Ruifang Li, Yu Ma, Cong Zhang, Tao Huang, Sha Zh. Transcriptome analysis of differentially expressed genes and pathways associated with mitoxantrone treatment prostate cancer. Journal of cellular and molecular medicine. vol 23. issue 3. 2020-06-25. PMID:30592148. |
functional and pathway enrichment analyses revealed that these degs were closely related to cellular activity, androgen synthesis, dna damage and repair, also involved in the erk/mapk, pi3k/serine-threonine protein kinase, also known as protein kinase b, pkb (akt) and apoptosis signalling pathways. |
2020-06-25 |
2023-08-13 |
mouse |
| Xiaomin Wang, Wei Du, Meng Li, Yong Zhang, Hongyu Li, Kai Sun, Jianping Liu, Pengxia Dong, Xianda Meng, Wensi Yi, Liu Yang, Ruiping Zhao, Jiang H. The β subunit of soluble guanylyl cyclase GUCY1B3 exerts cardioprotective effects against ischemic injury via the PKCε/Akt pathway. Journal of cellular biochemistry. vol 120. issue 3. 2020-06-22. PMID:30485489. |
in a mouse model of coronary artery ligation-induced mi, gucy1b3 silencing aggravated mi-induced cardiac dysfunction and increased infarct size and exacerbated cardiomyocyte apoptosis in association with the inactivation of pkcε and akt. |
2020-06-22 |
2023-08-13 |
mouse |
| Su-Ya Wang, Jiang-Wei Sang, Wei Ding, Ting-Wu Qin, Lin Bai, Jie Zhang, Jing-Cong Lu. The cytoptrotection of small intestinal submucosa-derived gel in HL-1 cells during hypoxia/reoxygenation-induced injury. Journal of tissue engineering and regenerative medicine. vol 13. issue 8. 2020-06-19. PMID:31062928. |
furthermore, sis gel protected cardiomyocytes from apoptosis by activating protein kinase b (akt) and extracellular-signal-regulated kinase (erk) pathways, and markedly up-regulated antiapoptotic bcl-2 expression but inhibited that of proapoptotic bax and c-caspase 3. |
2020-06-19 |
2023-08-13 |
Not clear |
| Shiori Umemura, Yoshihiro Sowa, Yosuke Iizumi, Jo Kitawaki, Toshiyuki Saka. Synergistic effect of the inhibitors of RAF/MEK and AXL on KRAS-mutated ovarian cancer cells with high AXL expression. Cancer science. vol 111. issue 6. 2020-06-19. PMID:32291856. |
we found that ch5126766 and r428 suppressed the phosphorylation of erk and akt, respectively, and their combination synergistically inhibited the growth of both cell lines with enhancement of apoptosis accompanied by the bim upregulation. |
2020-06-19 |
2023-08-13 |
Not clear |
| Guang-Cai Li, Xu-Ling Qin, Huai-Hua Song, Ying-Ni Li, Yu-Yan Qiu, Shi-Chang Cui, Yong-Sheng Wang, Hui Wang, Jun-Ling Gon. Upregulated microRNA-15b alleviates ovarian cancer through inhitbition of the PI3K/Akt pathway by targeting LPAR3. Journal of cellular physiology. vol 234. issue 12. 2020-06-15. PMID:31140597. |
restored mir-15b promoted bax expression, apoptosis, and senescence, inhibited expression of lpar3 and bcl-2, the extent of pi3k and akt phosphorylation, as well as ovarian cancer cell proliferation, migration, and invasion. |
2020-06-15 |
2023-08-13 |
mouse |
| Annett Kühnel, Daniela Schilling, Stephanie E Combs, Bernhard Haller, Melissa Schwab, Gabriele Multhof. Radiosensitization of HSF-1 Knockdown Lung Cancer Cells by Low Concentrations of Hsp90 Inhibitor NVP-AUY922. Cells. vol 8. issue 10. 2020-06-15. PMID:31569342. |
protein expression (i.e., hsp27/hsp70, hsf-1, phsf-1, akt, ß-actin) and transcriptional activity was assessed by western blot analysis and luciferase assays and radiosensitivity was measured by proliferation, apoptosis (annexin v, active caspase 3), clonogenic cell survival, alkaline comet, γh2ax, 53bp1, and rad51 foci assays. |
2020-06-15 |
2023-08-13 |
Not clear |
| Chang Liu, Ying-Hua Luo, Xian-Ji Piao, Yue Wang, Ling-Qi Meng, Hao Wang, Jia-Ru Wang, Yi Zhang, Jin-Qian Li, Cheng-Hao Ji. [Quinalizarin induces apoptosis in gastric cancer AGS cells via MAPK and Akt signaling pathway]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 37. issue 8. 2020-06-12. PMID:28801290. |
[quinalizarin induces apoptosis in gastric cancer ags cells via mapk and akt signaling pathway]. |
2020-06-12 |
2023-08-13 |
Not clear |
| Maria Boichuck, Jonathan Zorea, Moshe Elkabets, Marina Wolfson, Vadim E Fraifel. c-Met as a new marker of cellular senescence. Aging. vol 11. issue 9. 2020-06-12. PMID:31085799. |
considering the anti-apoptotic activity of akt and the involvement of stat3 in mediating the effects of proinflammatory cytokines, the findings of this study indicate that c-met could contribute through its downstream targets or partners to at least two major phenotypical features of cs - resistance to apoptosis and senescence-associated secretory phenotype. |
2020-06-12 |
2023-08-13 |
human |
| Dexiang Zhuo, Yongyang Wu, Jia Luo, Ling Deng, Xiaohua Ni. CSTP1 inhibits IL-6 expression through targeting Akt/FoxO3a signaling pathway in bladder cancer cells. Experimental cell research. vol 380. issue 1. 2020-06-08. PMID:31002815. |
previous results showed that cstp1 over-expression inhibited cell cycle progression and promoted apoptosis through dephosphorylating akt kinase at ser473 site in bladder cancer cells, but the mechanisms how cstp1 exerted tumor suppressive activity remains unclear. |
2020-06-08 |
2023-08-13 |
Not clear |
| Dejiang Pang, Chao Li, Chengcheng Yang, Yuanfeng Zou, Bin Feng, Lixia Li, Wentao Liu, Yi Geng, Qihui Luo, Zhengli Chen, Chao Huan. Polyphyllin VII Promotes Apoptosis and Autophagic Cell Death via ROS-Inhibited AKT Activity, and Sensitizes Glioma Cells to Temozolomide. Oxidative medicine and cellular longevity. vol 2019. 2020-06-05. PMID:31814867. |
polyphyllin vii promotes apoptosis and autophagic cell death via ros-inhibited akt activity, and sensitizes glioma cells to temozolomide. |
2020-06-05 |
2023-08-13 |
Not clear |
| M Chen, L-L Zhu, J-L Su, G-L Li, J Wang, Y-N Zhan. Prucalopride inhibits lung cancer cell proliferation, invasion, and migration through blocking of the PI3K/AKT/mTor signaling pathway. Human & experimental toxicology. vol 39. issue 2. 2020-06-02. PMID:31640407. |
it also induced autophagy and apoptosis and decreased the expression of the phosphorylated protein kinase b (akt) and mammalian target of rapamycin (mtor) in these cells. |
2020-06-02 |
2023-08-13 |
human |
| Guojun Yang, Yixin Yang, Hong Tang, Kai Yan. Loss of the clock gene Per1 promotes oral squamous cell carcinoma progression via the AKT/mTOR pathway. Cancer science. vol 111. issue 5. 2020-06-01. PMID:32086839. |
after addition of the akt activator sc79 to per1-oe scc15 cells, the increased autophagy and apoptosis as well as decreased proliferation were remarkably rescued. |
2020-06-01 |
2023-08-13 |
Not clear |
| Isabel Moscoso, María Cebro-Márquez, Moisés Rodríguez-Mañero, José Ramón González-Juanatey, Ricardo Lag. FNDC5/Irisin counteracts lipotoxic-induced apoptosis in hypoxic H9c2 cells. Journal of molecular endocrinology. vol 63. issue 2. 2020-05-28. PMID:31284265. |
irisin counteracts lipotoxic-induced apoptosis in hypoxic cardiomyoblasts by activating akt signaling pathway suggesting the potential therapeutic role of irisin in ischemic heart disease. |
2020-05-28 |
2023-08-13 |
Not clear |
| Yongyi Zhai, Yong Ma, Jingying Liu, Yulin Zhu, Kun Xie, Lingzhi Yu, Hao Zhan. Brain-Derived Neurotrophic Factor Alleviates Ropivacaine-Induced Neuronal Damage by Enhancing the Akt Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-05-28. PMID:31885368. |
conclusions bdnf can alleviate ropivacaine-induced neuronal injury by activating akt signaling pathway, consequently modulating the proliferation and apoptosis of neurons. |
2020-05-28 |
2023-08-13 |
human |
| Abdulrahman Alwhaibi, Arti Verma, Mir S Adil, Payaningal R Somanat. The unconventional role of Akt1 in the advanced cancers and in diabetes-promoted carcinogenesis. Pharmacological research. vol 145. 2020-05-27. PMID:31078742. |
the pro-cancerous role of akt isoforms through enhanced cell proliferation and suppression of apoptosis in cancer cells and the cells in the tumor microenvironment is considered a dogma. |
2020-05-27 |
2023-08-13 |
Not clear |
| Yao-Pang Chung, Cheng-Chieh Yen, Feng-Cheng Tang, Kuan-I Lee, Shing-Hwa Liu, Chin-Ching Wu, Shang-Shu Hsieh, Chin-Chuan Su, Chun-Ying Kuo, Ya-Wen Che. Methylmercury exposure induces ROS/Akt inactivation-triggered endoplasmic reticulum stress-regulated neuronal cell apoptosis. Toxicology. vol 425. 2020-05-26. PMID:31330229. |
collectively, these results indicate that mehg exerts its cytotoxicity in neurons by inducing ros-mediated akt inactivation up-regulated er stress, which induces apoptosis and ultimately leads to cell death. |
2020-05-26 |
2023-08-13 |
Not clear |
| Xin Chen, Yue Li, Meng Feng, Xiaoyu Hu, Hai Zhang, Ruijie Zhang, Xiaoqing Dong, Chunxiao Liu, Zhao Zhang, Shanxiang Jiang, Shile Huang, Long Che. Maduramicin induces cardiac muscle cell death by the ROS-dependent PTEN/Akt-Erk1/2 signaling pathway. Journal of cellular physiology. vol 234. issue 7. 2020-05-20. PMID:30511398. |
moreover, we found that both phosphatase and tensin homolog on chromosome 10 (pten) and protein kinase b (akt) were implicated in the regulation of erk1/2 inactivation and apoptosis in the cells and tissues exposed to mad. |
2020-05-20 |
2023-08-13 |
Not clear |
| Xiaoyu Sun, Yu Wang, Bing Xia, Zhu Li, Jialin Dai, Pingming Qiu, Ande Ma, Zhoumeng Lin, Jiang Huang, Jiawen Wang, Wei-Bing Xie, Jie Wan. Methamphetamine produces cardiac damage and apoptosis by decreasing melusin. Toxicology and applied pharmacology. vol 378. 2020-05-20. PMID:30904475. |
we conclude that meth can produce cardiac damage and apoptosis by decreasing melusin, while melusin-activated signaling by phosphorylated akt, phosphorylated gsk3β, and erk may be resistant to methamphetamine-induced myocardial apoptosis. |
2020-05-20 |
2023-08-13 |
human |
| Ali A Shati, M Dalla. Acylated Ghrelin Protects the Hearts of Rats from Doxorubicin-Induced Fas/FasL Apoptosis by Stimulating SERCA2a Mediated by Activation of PKA and Akt. Cardiovascular toxicology. vol 19. issue 6. 2020-05-18. PMID:31093930. |
acylated ghrelin protects the hearts of rats from doxorubicin-induced fas/fasl apoptosis by stimulating serca2a mediated by activation of pka and akt. |
2020-05-18 |
2023-08-13 |
rat |