| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guofu Yi, He Li, You Li, Fen Zhao, Zhiwei Ying, Menglan Liu, Jian Zhang, Xinqi Li. The protective effect of soybean protein-derived peptides on apoptosis via the activation of PI3K-AKT and inhibition on apoptosis pathway. Food science & nutrition. vol 8. issue 8. 2020-09-28. PMID:32884739. |
to further study its molecular mechanisms, western blot analysis demonstrated that sbp could activate the pi3k-akt pathway by increasing the phosphorylation of pi3k and akt and inhibiting apoptosis pathway by downregulating the expressions of pro-apoptotic proteins of bim, bax, fas, and fasl and promoting the expressions of anti-apoptotic proteins of bcl-xl and bcl-2. |
2020-09-28 |
2023-08-13 |
human |
| Xiang-Zi Zhang, Mo-Han Zhang, Xue-Sen Fang, Xiang-Shu Cui, Zheng Ji. Mechanism of AMPK-mediated apoptosis of rat gastric smooth muscle cells under high glucose condition. Bioscience reports. vol 39. issue 12. 2020-09-23. PMID:31769476. |
under high-glucose condition, activated ampk can directly or indirectly promote cells apoptosis by regulating the expression and activity of p53, akt, p70s6k, protein kinase a (pka), phospholipidol c (plc)-β3, camkii, camkiv and eukaryotic translation initiation factor 4e binding protein1 (4e-bp1) in rat gastric smooth muscle cells. |
2020-09-23 |
2023-08-13 |
rat |
| Bo Zhang, Haijun Zhang, Hao Luo, Chao Yang, Yi Yua. Sinomenine can promote the proliferation and differentiation of osteoblasts by regulating the Akt/Runx2 signaling pathway in MC3T3-E1 cells. Die Pharmazie. vol 74. issue 12. 2020-09-23. PMID:31907116. |
the proliferation and apoptosis of the cells were determined by mtt assay at 0, 24, 48 and 72 h, and flow cytometry method was used to determine the effect of sinomenine on the apoptosis of mc3t3-e1 cells at 72 h; furthermore, after 72 h, the cell culture supernatants were collected, and the levels of alkaline phosphatase and osteocalcin were examined by enzyme-linked immunosorbent assay (elisa); next, cells were collected, and the expression of type i collagen (col1a1), osteopontin (opn), protein kinase b (akt), runt-related transcription factor 2 (runx2), b-cell lymphoma 2 (bcl-2) and bcl-2-associated x protein (bax) were examined by rt-qpcr and western blot methods. |
2020-09-23 |
2023-08-13 |
mouse |
| Md Shiblur Rahaman, Mahmuda Akter, Md Mostafizur Rahman, Md Tajuddin Sikder, Toshiyuki Hosokawa, Takeshi Saito, Masaaki Kurasak. Investigating the protective actions of D-pinitol against arsenic-induced toxicity in PC12 cells and the underlying mechanism. Environmental toxicology and pharmacology. vol 74. 2020-09-22. PMID:31786496. |
protein expression of western blot analysis showed that co-exposure of d-pinitol and arsenic significantly inhibited arsenic-induced autophagy which further suppressed apoptosis through up-regulation of survival factors; mtor, p-mtor, akt, p-akt, nf-кb, nrf2, erk1, gr, bcl-x and down-regulation of death factors; p53, bax, cytochrome c, lc3, although arsenic regulated those factors negatively. |
2020-09-22 |
2023-08-13 |
human |
| Zhen-Tang Jing, Wei Liu, Shu-Xiang Wu, Yun He, Yan-Ting Lin, Wan-Nan Chen, Xin-Jian Lin, Xu Li. Correction: Hepatitis B Virus Surface Antigen Enhances the Sensitivity of Hepatocytes to Fas-Mediated Apoptosis via Suppression of AKT Phosphorylation. Journal of immunology (Baltimore, Md. : 1950). vol 205. issue 1. 2020-09-17. PMID:32482709. |
correction: hepatitis b virus surface antigen enhances the sensitivity of hepatocytes to fas-mediated apoptosis via suppression of akt phosphorylation. |
2020-09-17 |
2023-08-13 |
Not clear |
| Li-Ping Wang, Yan-Qi Liu, Jie Cui, Li W. [Study on mechanism of curcumin in treatment of acute pancreatitis based on regulation of PI3K-Akt signaling pathway by miR-198]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 15. 2020-09-17. PMID:32893562. |
the apoptosis was detected by tunel staining; the levels of serum amylase, lipase, bcl-2 and bax were detected by elisa, and the levels of pi3 k, akt and p-akt in pancreatic tissue were measured by western blot. |
2020-09-17 |
2023-08-13 |
rat |
| Pei-Pei Wang, Yong-Hui Wang, Li-Sen Wang, Tao W. [Anti-tumor effect and its related mechanisms of cinobufotalin combined with cisplatin on H22 liver cancer mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 16. 2020-09-17. PMID:32893593. |
the general condition of mice during the intervention was observed, and the inhibition rate, tumor mass, thymus index, histopathological changes of the tumors, apoptotic rate of the tumors, the expressions of phosphatidylinositol 3-kinase(pi3 k), protein kinase b(akt), apoptosis related gene(fas), fas ligand(fasl) mrna and protein phosphorylated akt(pakt) protein in the tumors of each group were compared. |
2020-09-17 |
2023-08-13 |
mouse |
| Hiroshi Moritake, Yusuke Saito, Daisuke Sawa, Naoki Sameshima, Ai Yamada, Mariko Kinoshita, Sachiyo Kamimura, Takao Konomoto, Hiroyuki Nuno. TAE226, a dual inhibitor of focal adhesion kinase and insulin-like growth factor-I receptor, is effective for Ewing sarcoma. Cancer medicine. vol 8. issue 18. 2020-09-16. PMID:31692287. |
tae226 treatment of ews cell lines induced cell cycle arrest, apoptosis, akt dephosphorylation, and inhibition of invasion. |
2020-09-16 |
2023-08-13 |
mouse |
| Xiaolong Wan, Caixia Zheng, Lei Don. Inhibition of CTRP6 prevented survival and migration in hepatocellular carcinoma through inactivating the AKT signaling pathway. Journal of cellular biochemistry. vol 120. issue 10. 2020-09-14. PMID:31111552. |
next, hep3b cells were pretreated with insulin-like growth factor-1 (igf-1) (an activator of akt), and then transfected with ctrp6 sirna, and the cell vitality, apoptosis, migration, and invasion were measured again. |
2020-09-14 |
2023-08-13 |
human |
| Xiaolong Wan, Caixia Zheng, Lei Don. Inhibition of CTRP6 prevented survival and migration in hepatocellular carcinoma through inactivating the AKT signaling pathway. Journal of cellular biochemistry. vol 120. issue 10. 2020-09-14. PMID:31111552. |
taken together, ctrp6 suppression blocked cell survival, migration, and invasion and promoted cell apoptosis through inactivating the akt signaling pathway. |
2020-09-14 |
2023-08-13 |
human |
| H-Y Liu, Y-Y Zhang, B-L Zhu, F-Z Feng, H Yan, H-Y Zhang, B Zho. miR-21 regulates the proliferation and apoptosis of ovarian cancer cells through PTEN/PI3K/AKT. European review for medical and pharmacological sciences. vol 23. issue 10. 2020-09-14. PMID:31173285. |
phosphatase and tensin homologue deleted on chromosome ten (pten) regulates cell proliferation and apoptosis by inhibiting phosphatidylinositol-3 kinase (pi3k) and protein kinase (akt) signaling. |
2020-09-14 |
2023-08-13 |
Not clear |
| Jun Song, Sai-Jun Ma, Jian-Hua Luo, Hui Liu, Li Li, Zhi-Guang Zhang, Lu-Shan Chen, Rui-Xiang Zho. Downregulation of AKT and MDM2, Melatonin Induces Apoptosis in AGS and MGC803 Cells. Anatomical record (Hoboken, N.J. : 2007). vol 302. issue 9. 2020-09-11. PMID:30809951. |
downregulation of akt and mdm2, melatonin induces apoptosis in ags and mgc803 cells. |
2020-09-11 |
2023-08-13 |
human |
| Jun Song, Sai-Jun Ma, Jian-Hua Luo, Hui Liu, Li Li, Zhi-Guang Zhang, Lu-Shan Chen, Rui-Xiang Zho. Downregulation of AKT and MDM2, Melatonin Induces Apoptosis in AGS and MGC803 Cells. Anatomical record (Hoboken, N.J. : 2007). vol 302. issue 9. 2020-09-11. PMID:30809951. |
melatonin promoted apoptosis of ags and mgc803 cells by the downregulation of akt and mdm2. |
2020-09-11 |
2023-08-13 |
human |
| Nanqu Huang, Ying Zhang, Mingji Chen, Hai Jin, Jing Nie, Yong Luo, Shaoyu Zhou, Jingshan Shi, Feng Ji. Resveratrol delays 6-hydroxydopamine-induced apoptosis by activating the PI3K/Akt signaling pathway. Experimental gerontology. vol 124. 2020-09-11. PMID:31295526. |
this study aimed to determine whether resveratrol (res) delays the progression of 6-hydroxydopamine (6-ohda)-induced apoptosis via activating the phosphoinositide 3-kinase (pi3k)/protein kinase b (akt) signaling pathway. |
2020-09-11 |
2023-08-13 |
rat |
| Isha Kapoor, Yue Li, Arishya Sharma, Huayuan Zhu, Juraj Bodo, Wei Xu, Eric D Hsi, Brian T Hill, Alexandru Almasa. Resistance to BTK inhibition by ibrutinib can be overcome by preventing FOXO3a nuclear export and PI3K/AKT activation in B-cell lymphoid malignancies. Cell death & disease. vol 10. issue 12. 2020-09-11. PMID:31801949. |
inhibition of pi3k and akt using idelalisib and mk2206, respectively increased ibrutinib-induced apoptosis in ib-r cells by downregulation of pakt |
2020-09-11 |
2023-08-13 |
Not clear |
| Ezgi Avsar Abdik, Ferda Kaleagasioglu, Hüseyin Abdik, Fikrettin Sahin, Martin R Berge. ABT-737 and erufosine combination against castration-resistant prostate cancer: a promising but cell-type specific response associated with the modulation of anti-apoptotic signaling. Anti-cancer drugs. vol 30. issue 4. 2020-09-09. PMID:30557204. |
apoptosis analysis showed that abt-737 induced increased akt expression and erpc3 induced increased mcl-1 expression in du-145 cells. |
2020-09-09 |
2023-08-13 |
Not clear |
| Yan Chen, Junzhi Li, Lei Jin, Kai Lei, Haiwang Liu, Yong Yan. Fibulin-5 contributes to colorectal cancer cell apoptosis via the ROS/MAPK and Akt signal pathways by downregulating transient receptor potential cation channel subfamily V member 1. Journal of cellular biochemistry. vol 120. issue 10. 2020-09-09. PMID:31148262. |
fibulin-5 contributes to colorectal cancer cell apoptosis via the ros/mapk and akt signal pathways by downregulating transient receptor potential cation channel subfamily v member 1. |
2020-09-09 |
2023-08-13 |
Not clear |
| Yan Chen, Junzhi Li, Lei Jin, Kai Lei, Haiwang Liu, Yong Yan. Fibulin-5 contributes to colorectal cancer cell apoptosis via the ROS/MAPK and Akt signal pathways by downregulating transient receptor potential cation channel subfamily V member 1. Journal of cellular biochemistry. vol 120. issue 10. 2020-09-09. PMID:31148262. |
moreover, nac (the scavenger of ros), sb203580 (the inhibitor of p38), pd98059 (the inhibitor of erk), and sc79 (the activator of akt) were used to uncover that fibulin-5 induced apoptosis through the ros/mitogen-activated protein kinase and akt signal pathways by downregulating trpv1. |
2020-09-09 |
2023-08-13 |
Not clear |
| Yao Ming-Yan, Zhang Jing, Guo Shu-Qin, Bai Xiao-Liang, Li Zhi-Hong, Zhou Xu. Liraglutide inhibits the apoptosis of human nucleus pulposus cells induced by high glucose through PI3K/Akt/caspase-3 signaling pathway. Bioscience reports. vol 39. issue 8. 2020-09-09. PMID:31383790. |
pretreatment of cells with the phosphoinositide 3-kinase (pi3k) inhibitor ly294002 (ly) and small interfering rnas (sirnas) glp-1r abrogated the liraglutide-induced activation of akt and the protective effects on npcs' apoptosis. |
2020-09-09 |
2023-08-13 |
human |
| Zhiliang Huang, Yu Gao, Dianchen Ho. Interleukin-22 enhances chemoresistance of lung adenocarcinoma cells to paclitaxel. Human cell. vol 33. issue 3. 2020-09-07. PMID:32452013. |
furthermore, il-22 sirna inhibited the proliferation and promoted the apoptosis of a549/ptx and h358/ptx cells, and il-22 sirna also suppressed the expression levels of akt and bcl-2 and increased the expression levels of bax and cleaved caspase 3. |
2020-09-07 |
2023-08-13 |
Not clear |