| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cheng Yu Wang, Xiang Dan Li, Zhi Hong Hao, Dongyuan X. Insulin-like growth factor-1 improves diabetic cardiomyopathy through antioxidative and anti-inflammatory processes along with modulation of Akt/GSK-3β signaling in rats. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 20. issue 6. 2020-09-30. PMID:27847438. |
rats with dcm displayed decreased body weight, metabolic abnormalities, elevated apoptosis (as assessed by the bcl-2/bax ratio and tunel assays), increased fibrosis, increased markers of oxidative stress (mda and sod) and inflammatory factors (tnf-α and il-1β), and decreased phosphorylation of akt and glycogen synthase kinase (gsk-3β). |
2020-09-30 |
2023-08-13 |
rat |
| Cheng Yu Wang, Xiang Dan Li, Zhi Hong Hao, Dongyuan X. Insulin-like growth factor-1 improves diabetic cardiomyopathy through antioxidative and anti-inflammatory processes along with modulation of Akt/GSK-3β signaling in rats. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 20. issue 6. 2020-09-30. PMID:27847438. |
igf-1 treatment, however, attenuated the metabolic abnormalities and myocardial apoptosis, interstitial fibrosis, oxidative stress and inflammation seen in diabetic rats, while also increasing the phosphorylation levels of akt and gsk-3β. |
2020-09-30 |
2023-08-13 |
rat |
| Pingping Fu, Qiang Wu, Jianyan Hu, Tingting Li, Fengjuan Ga. Baclofen Protects Primary Rat Retinal Ganglion Cells from Chemical Hypoxia-Induced Apoptosis Through the Akt and PERK Pathways. Frontiers in cellular neuroscience. vol 10. 2020-09-30. PMID:27867349. |
baclofen protects primary rat retinal ganglion cells from chemical hypoxia-induced apoptosis through the akt and perk pathways. |
2020-09-30 |
2023-08-13 |
rat |
| Jianjun Chen, Zhenjun Wang, Sanshui Y. AIM2 regulates viability and apoptosis in human colorectal cancer cells via the PI3K/Akt pathway. OncoTargets and therapy. vol 10. 2020-09-30. PMID:28243117. |
western blot analysis showed that aim2 promoted apoptosis in crc cells by suppressing the phosphatidylinositol 3-kinase (pi3k)/protein kinase b (akt) pathway. |
2020-09-30 |
2023-08-13 |
human |
| Yue Zhao, Qianze Dong, Enhua Wan. MicroRNA-320 inhibits invasion and induces apoptosis by targeting CRKL and inhibiting ERK and AKT signaling in gastric cancer cells. OncoTargets and therapy. vol 10. 2020-09-30. PMID:28255248. |
microrna-320 inhibits invasion and induces apoptosis by targeting crkl and inhibiting erk and akt signaling in gastric cancer cells. |
2020-09-30 |
2023-08-13 |
human |
| Zheng Liu, Feng Wang, Zhi-Wei Zhou, He-Chun Xia, Xin-Yu Wang, Yin-Xue Yang, Zhi-Xu He, Tao Sun, Shu-Feng Zho. Alisertib induces G American journal of translational research. vol 9. issue 3. 2020-09-30. PMID:28386317. |
als also bound key regulating proteins of cell cycle, apoptosis and autophagy, such as cyclin-dependent kinase 1 (cdk1/cdc2), cdk2, cyclin b1, p27 kip1, p53, cytochrome c, cleaved caspase 3, bax, bcl-2, bcl-xl, phosphatidylinositol 3-kinase (pi3k), protein kinase b (akt), mammalian target of rapamycin (mtor), 5'-adenosine monophosphate-activated protein kinase (ampk), p38 mitogen-activated protein kinase (mapk), beclin 1, phosphatase and tensin homolog (pten), and microtubule-associated protein light chain 3 (lc3). |
2020-09-30 |
2023-08-13 |
Not clear |
| Satya Sahay, Prakash Tiwari, Krishna P Gupt. Onset of the lymphocytic infiltration and hyperplasia preceding the proliferation in F1 mouse lungs from the N-ethyl-N-nitrosourea exposed mothers: Prevention during the lactation period by inositol hexaphosphate. Toxicology reports. vol 2. 2020-09-30. PMID:28962394. |
analysis of pcna, nf-κb (p50), il-6, cox-2, pstat3, stat3, caspase-3, caspase-9, parp, akt signalling and downstream cyclin d1 along with mir-155, suggested the modulation of proliferation, inflammation and apoptosis at pnd12 and 24. |
2020-09-30 |
2023-08-13 |
mouse |
| Yu-Hai Bian, Jia Xu, Wen-Yi Zhao, Zi-Zhen Zhang, Lin Tu, Hui Cao, Zhi-Gang Zhan. Targeting mTORC2 component rictor inhibits cell proliferation and promotes apoptosis in gastric cancer. American journal of translational research. vol 9. issue 9. 2020-09-30. PMID:28979705. |
furthermore, rictor knockdown attenuated cell cycle progression and enhanced apoptosis, synergistic with treatment of mtorc1 inhibitor rapamycin owing to abrogating the feedback activation of akt. |
2020-09-30 |
2023-08-13 |
Not clear |
| Kongliang Ke, Tingting Lo. MicroRNA-10a suppresses breast cancer progression via PI3K/Akt/mTOR pathway. Oncology letters. vol 14. issue 5. 2020-09-30. PMID:29113237. |
the expression of phosphorylated (p-)protein kinase b (akt), p-mammalian target of rapamycin (p-mtor), p-ribosomal protein s6 kinase β-1 (p-p70s6k), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α (pik3ca), cytochrome c (cyt c), b-cell lymphoma 2 (bcl-2), bcl-2 associated x, apoptosis regulator (bax), and cleaved caspase-3 were analyzed by western blotting. |
2020-09-30 |
2023-08-13 |
human |
| Shaohua Dai, Qirong Xu, Sheng Liu, Bentong Yu, Jichun Liu, Jian Tan. Role of autophagy and its signaling pathways in ischemia/reperfusion injury. American journal of translational research. vol 9. issue 10. 2020-09-30. PMID:29118909. |
the expression of cd31, lc3-ii, bcl-2, bax, lc3-ii, beclin 1, akt, p-akt, ampk and p-ampk, apoptosis, cell viability and migration ability were determined. |
2020-09-30 |
2023-08-13 |
Not clear |
| Shama Parween, Divya S Varghese, Mustafa T Ardah, Ashok D Prabakaran, Eric Mensah-Brown, Bright Starling Emerald, Suraiya A Ansar. Higher O-GlcNAc Levels Are Associated with Defects in Progenitor Proliferation and Premature Neuronal Differentiation during Frontiers in cellular neuroscience. vol 11. 2020-09-30. PMID:29311838. |
herein using human embryonic stem cells (hescs) as model, we show that increased levels of total o-glcnac is associated with decreased neural progenitor proliferation and premature differentiation of cortical neurons, reduced akt phosphorylation, increased apoptosis and defects in the expression of various regulators of embryonic corticogenesis. |
2020-09-30 |
2023-08-13 |
human |
| Yanxia Jiang, Hong Chang, Guoan Che. Effects of microRNA-20a on the proliferation, migration and apoptosis of multiple myeloma via the PTEN/PI3K/AKT signaling pathway. Oncology letters. vol 15. issue 6. 2020-09-30. PMID:29963125. |
cck-8 assays, transwell assays, annexin v/pi double-staining and western blotting were performed to examine the protein expressions of pten, pi3k and akt during cellullar proliferation, migration, cycling, and apoptosis. |
2020-09-30 |
2023-08-13 |
human |
| Jianghua Yu, Zhiqin Shi, Xudong Su, Yi Zhou, Bin Li, Shan Wang, Lijing Jia, Bo Zhao, Mengchu Zhu, Xiaohong Feng, Kuochang Yin, Weiping Wan. Expression of Bcl-2 and Bad in hippocampus of status epileptic rats and molecular mechanism of intervened recombinant human erythropoietin. Experimental and therapeutic medicine. vol 16. issue 2. 2020-09-30. PMID:30116338. |
apoptosis of hippocampal neurons was detected by tunel method; expression of phosphorylation protein kinase b (p-pkb/p-akt), bcl-2 and bad were detected by immunohistochemistry; the expression of bcl-2 mrna, bad mrna in hippocampal neurons of rats were detected through reverse transcription polymerase chain reaction (rt-pcr); the expression of akt, p-akt and bcl-2, bad protein in hippocampal neurons of rats were detected by western blotting. |
2020-09-30 |
2023-08-13 |
human |
| Mingshi Zhang, Jinrui Liu, Mingjun Li, Shihua Zhang, Yanmei Lu, Yanqiu Liang, Kai Zhao, Yingfu L. Insulin-like growth factor 1/insulin-like growth factor 1 receptor signaling protects against cell apoptosis through the PI3K/AKT pathway in glioblastoma cells. Experimental and therapeutic medicine. vol 16. issue 2. 2020-09-30. PMID:30116397. |
moreover, both exogenous igf1 and overexpression of igf1r promoted the phosphorylation of protein kinase b (akt), and inhibition of the phosphoinositide 3-kinase (pi3k)/akt pathway significantly attenuated the inhibitory effects of igf1/igf1r on gbm apoptosis (p<0.05). |
2020-09-30 |
2023-08-13 |
Not clear |
| Lina Zhao, Xianyu Zhang, Shusen Cu. Matrine inhibits TPC-1 human thyroid cancer cells via the miR-21/PTEN/Akt pathway. Oncology letters. vol 16. issue 3. 2020-09-30. PMID:30127885. |
flow cytometry indicated that treatment with 10 mg/ml matrine induced up to 61.8% apoptosis of the tpc-1 cells and the cell cycle was arrested at the g0/g1 phase following treatment with matrine (2, 5 and 10 mg/ml) for 48 h. quantitative polymerase chain reaction indicated that the expression of microrna (mir)-21 was downregulated and phosphatase and tensin homolog (pten) mrna levels increased up to 1.66-fold following treatment with matrine, and rac-α serine/threonine-protein kinase (akt) mrna levels were downregulated 0.34-fold following treatment with 5 mg/ml matrine, compared with the normal control group. |
2020-09-30 |
2023-08-13 |
human |
| Ziwei Fang, Jiandong Wang, Leslie H Clark, Wenchuan Sun, Yajie Yin, Weimin Kong, Stuart R Pierce, Lindsay West, Stephanie A Sullivan, Arthur-Quan Tran, Varun V Prabhu, Chunxiao Zhou, Victoria Bae-Jum. ONC201 demonstrates anti-tumorigenic and anti-metastatic activity in uterine serous carcinoma in vitro. American journal of cancer research. vol 8. issue 8. 2020-09-30. PMID:30210923. |
our results suggest that onc201 has significant anti-proliferative and anti-metastatic effects in usc cells through both induction of apoptosis and inhibition of the akt and mapk pathways. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jingyao Zhang, Yun Chen, Huiqin Luo, Linlin Sun, Mengting Xu, Jin Yu, Qigang Zhou, Guoliang Meng, Shengju Yan. Recent Update on the Pharmacological Effects and Mechanisms of Dihydromyricetin. Frontiers in pharmacology. vol 9. 2020-09-30. PMID:30410442. |
and the detailed mechanisms may be associated with several different molecules involved in cellular apoptosis, oxidative stress, and inflammation, such as amp-activated protein kinase (ampk), mitogen-activated protein kinase (mapk), protein kinase b (akt), nuclear factor-κb (nf-κb), nuclear factor e2-related factor 2 (nrf2), atp-binding cassette transporter a1 (abca1), peroxisome proliferator-activated receptor-γ (pparγ) and so on. |
2020-09-30 |
2023-08-13 |
Not clear |
| Li Wang, Wei Gu, Ying Shi, Yubao Chen, Yan Ta. Protective effects of astragaloside IV on IL-8-treated diaphragmatic muscle cells. Experimental and therapeutic medicine. vol 17. issue 1. 2020-09-30. PMID:30651831. |
il-8 treatment resulted in decreased rates of cell proliferation and increased rates of akt phosphorylation, cell apoptosis, caspase 3/9 activity, ros production and proinflammatory factor production. |
2020-09-30 |
2023-08-13 |
rat |
| Elisa Ventura, Francesca Pentimalli, Antonio Giordan. RBL2/p130: a direct AKT substrate and mediator of AKT inhibition-induced apoptosis. Oncoscience. vol 5. issue 11-12. 2020-09-30. PMID:30652113. |
rbl2/p130: a direct akt substrate and mediator of akt inhibition-induced apoptosis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Zan Liu, Licheng Ren, Xu Cui, Le Guo, Bimei Jiang, Jie Zhou, Pengfei Liang, Jizhang Zeng, Zhiyou He, Pihong Zhan. Muscular proteomic profiling of deep pressure ulcers reveals myoprotective role of JAK2 in ischemia and reperfusion injury. American journal of translational research. vol 10. issue 11. 2020-09-30. PMID:30662596. |
finally, western blot analysis determined that p-jak2, p-akt, p-mtor and p-erk1/2 levels were significantly elevated, accompanied by jak2 overexpression but without p-stat3, and inhibition of the akt and erk1/2 pathway resulted in elevated apoptosis and/or autophagy. |
2020-09-30 |
2023-08-13 |
Not clear |