| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Changjiang Ying, Shanshan Wang, Yan Lu, Lei Chen, Yizhen Mao, Hongwei Ling, Xingbo Cheng, Xiaoyan Zho. Glucose fluctuation increased mesangial cell apoptosis related to AKT signal pathway. Archives of medical science : AMS. vol 15. issue 3. 2020-10-01. PMID:31110541. |
glucose fluctuation increased mesangial cell apoptosis related to akt signal pathway. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yeying Liu, Yuan Huang, Jie Ding, Nannan Liu, Shuang Peng, Jiangang Wang, Feng Wang, Yingjie Zhan. Targeting Akt by SC66 triggers GSK-3β mediated apoptosis in colon cancer therapy. Cancer cell international. vol 19. 2020-10-01. PMID:31168297. |
targeting akt by sc66 triggers gsk-3β mediated apoptosis in colon cancer therapy. |
2020-10-01 |
2023-08-13 |
Not clear |
| Xin Zhang, Hong-Ming Zhan. Alantolactone induces gastric cancer BGC-823 cell apoptosis by regulating reactive oxygen species generation and the AKT signaling pathway. Oncology letters. vol 17. issue 6. 2020-10-01. PMID:31186685. |
alantolactone induces gastric cancer bgc-823 cell apoptosis by regulating reactive oxygen species generation and the akt signaling pathway. |
2020-10-01 |
2023-08-13 |
human |
| Xin Zhang, Hong-Ming Zhan. Alantolactone induces gastric cancer BGC-823 cell apoptosis by regulating reactive oxygen species generation and the AKT signaling pathway. Oncology letters. vol 17. issue 6. 2020-10-01. PMID:31186685. |
in addition, alt induced apoptosis via the inhibition of rac-alpha serine/threonine-protein kinase (akt) signaling and ros generation, which was effectively inhibited by the ros scavenger, n-acetyl cysteine. |
2020-10-01 |
2023-08-13 |
human |
| Xin Zhang, Hong-Ming Zhan. Alantolactone induces gastric cancer BGC-823 cell apoptosis by regulating reactive oxygen species generation and the AKT signaling pathway. Oncology letters. vol 17. issue 6. 2020-10-01. PMID:31186685. |
therefore, the results from the present study indicated that the ros-mediated inhibition of the akt signaling pathway serves an important role in alt-induced apoptosis in bgc-823 cells. |
2020-10-01 |
2023-08-13 |
human |
| Po-Jung Pan, Yu-Chang Liu, Fei-Ting Hs. Protein Kinase B and Extracellular Signal-Regulated Kinase Inactivation is Associated with Regorafenib-Induced Inhibition of Osteosarcoma Progression In Vitro and In Vivo. Journal of clinical medicine. vol 8. issue 6. 2020-10-01. PMID:31238539. |
in these studies, we also indicated that regorafenib suppressed cell growth by prompting apoptosis of osteosarcoma cells, which is mediated through inactivation of erk and akt signaling pathways. |
2020-10-01 |
2023-08-13 |
human |
| J Chen, W Zhang, Y-Q Wu, H Chen, J-F Zha. LncRNA SNHG1 inhibits neuronal apoptosis in cerebral infarction rats through PI3K/Akt signaling pathway. European review for medical and pharmacological sciences. vol 23. issue 12. 2020-10-01. PMID:31298389. |
to investigate the effects of long non-coding ribonucleic acid (lncrna) small nucleolar rna host gene 1 (snhg1) on the neuronal apoptosis in rats with cerebral infarction through the phosphatidylinositol 3-kinase (pi3k)/protein kinase b (akt) signaling pathway. |
2020-10-01 |
2023-08-13 |
rat |
| Liuliu Yan, Lulu Lu, Fangbin Hu, Dattatrya Shetti, Kun We. Piceatannol attenuates RANKL-induced osteoclast differentiation and bone resorption by suppressing MAPK, NF-κB and AKT signalling pathways and promotes Caspase3-mediated apoptosis of mature osteoclasts. Royal Society open science. vol 6. issue 6. 2020-10-01. PMID:31312498. |
piceatannol attenuates rankl-induced osteoclast differentiation and bone resorption by suppressing mapk, nf-κb and akt signalling pathways and promotes caspase3-mediated apoptosis of mature osteoclasts. |
2020-10-01 |
2023-08-13 |
Not clear |
| Liuliu Yan, Lulu Lu, Fangbin Hu, Dattatrya Shetti, Kun We. Piceatannol attenuates RANKL-induced osteoclast differentiation and bone resorption by suppressing MAPK, NF-κB and AKT signalling pathways and promotes Caspase3-mediated apoptosis of mature osteoclasts. Royal Society open science. vol 6. issue 6. 2020-10-01. PMID:31312498. |
in conclusion, our results suggested that pic inhibited rankl-induced osteoclastogenesis and bone resorption by suppressing mapk, nf-κb and akt signalling pathways and promoted caspase3-mediated apoptosis of mature osteoclasts, which might contribute to the treatment of bone diseases characterized by excessive bone resorption. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ji-Eun Kim, Tae-Cheon Kan. PKC, AKT and ERK1/2-Mediated Modulations of PARP1, NF-κB and PEA15 Activities Distinctly Regulate Regional Specific Astroglial Responses Following Status Epilepticus. Frontiers in molecular neuroscience. vol 12. 2020-10-01. PMID:31396050. |
akt inhibition deteriorated dentate astroglial loss and led to ca1 astroglial apoptosis following se, which were ameliorated by akt activation. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yingying Zhang, Jinfeng Liu, Yan Lv, Chao Zhang, Shuai Gu. LncRNA meg3 suppresses hepatocellular carcinoma in vitro and vivo studies. American journal of translational research. vol 11. issue 7. 2020-10-01. PMID:31396320. |
furthermore, overexpression of meg3 (a) decreased proliferation, migration, and invasion of hepg2 cells; (b) enhanced apoptosis and the proportion of hepg2 cells in g1 of the cell cycle; (c) increased the expression of phosphatase and tensin homolog (pten), bcl2-associated x (bax), and p53 proteins; and (d) decreased the expression of mirna-10a-5p, akt, p-akt, bcl-2, and the matrix metalloproteinases (mmps)-2 and -9. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jin Jin, Jie Zhang, Yigui Xue, Li Luo, Siyao Wang, Haoming Tia. miRNA-15a regulates the proliferation and apoptosis of papillary thyroid carcinoma via regulating AKT pathway. OncoTargets and therapy. vol 12. 2020-10-01. PMID:31496725. |
mirna-15a regulates the proliferation and apoptosis of papillary thyroid carcinoma via regulating akt pathway. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yinci Zhang, Chunmei Xie, Amin Li, Xueke Liu, Yingru Xing, Jing Shen, Zhen Huo, Shuping Zhou, Xinkuang Liu, Yinghai Xie, Weiya Cao, Yongfang Ma, Ruyue Xu, Shiyu Cai, Xiaolong Tang, Dong M. PKI-587 enhances chemosensitivity of oxaliplatin in hepatocellular carcinoma through suppressing DNA damage repair pathway (NHEJ and HR) and PI3K/AKT/mTOR pathway. American journal of translational research. vol 11. issue 8. 2020-10-01. PMID:31497229. |
anti-tumor effects were associated with induction of mitochondrial apoptosis and inhibition of phosphorylation of mtor, akt and γ-h2ax. |
2020-10-01 |
2023-08-13 |
Not clear |
| Lei Zhang, Jianyi Gao, Tianyan Chen, Xiang Chen, Xianyan Ji, Kai Ye, Jiahong Yu, Bin Tang, Yusheng Wei, Hong Xu, Jiabo H. Microvesicles Derived from Human Embryonic Neural Stem Cells Inhibit the Apoptosis of HL-1 Cardiomyocytes by Promoting Autophagy and Regulating AKT and mTOR via Transporting HSP-70. Stem cells international. vol 2019. 2020-10-01. PMID:31772588. |
microvesicles derived from human embryonic neural stem cells inhibit the apoptosis of hl-1 cardiomyocytes by promoting autophagy and regulating akt and mtor via transporting hsp-70. |
2020-10-01 |
2023-08-13 |
human |
| Yu-Liang Li, Hao-Cheng Weng, Jui-Ling Hsu, Shu-Wha Lin, Jih-Hwa Guh, Lih-Ching Hs. The Combination of MK-2206 and WZB117 Exerts a Synergistic Cytotoxic Effect Against Breast Cancer Cells. Frontiers in pharmacology. vol 10. 2020-10-01. PMID:31780937. |
in search of anticancer agents whose effect could be enhanced by a glut1 inhibitor wzb117, we found that mk-2206, a potent allosteric akt inhibitor, when combined with wzb117, showed a synergistic effect on growth inhibition and apoptosis induction in breast cancer cells, including er(+) mcf-7 cells and triple-negative mda-mb-231 cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Xiaohong Jin, Y I Sh. Isobavachalcone induces the apoptosis of gastric cancer cells via inhibition of the Akt and Erk pathways. Experimental and therapeutic medicine. vol 11. issue 2. 2020-09-30. PMID:26893622. |
isobavachalcone induces the apoptosis of gastric cancer cells via inhibition of the akt and erk pathways. |
2020-09-30 |
2023-08-13 |
Not clear |
| Xiaohong Jin, Y I Sh. Isobavachalcone induces the apoptosis of gastric cancer cells via inhibition of the Akt and Erk pathways. Experimental and therapeutic medicine. vol 11. issue 2. 2020-09-30. PMID:26893622. |
during the ibc-induced apoptosis of mgc803 cells, transient activation of phosphorylated (p)-akt and p-erk inhibited the activation of akt and erk, upregulated bax expression, downregulated bcl-2 expression and activated caspase-3. |
2020-09-30 |
2023-08-13 |
Not clear |
| Xiaohong Jin, Y I Sh. Isobavachalcone induces the apoptosis of gastric cancer cells via inhibition of the Akt and Erk pathways. Experimental and therapeutic medicine. vol 11. issue 2. 2020-09-30. PMID:26893622. |
in addition, inhibition of the akt and erk signaling pathways may be important mechanisms underlying the ibc-induced apoptosis of gastric cancer cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Chao Yang, Xiaoxian Cui, Xiaoqin Dai, Wenting Lia. Downregulation of Foxc2 enhances apoptosis induced by 5-fluorouracil through activation of MAPK and AKT pathways in colorectal cancer. Oncology letters. vol 11. issue 2. 2020-09-30. PMID:26893778. |
downregulation of foxc2 enhances apoptosis induced by 5-fluorouracil through activation of mapk and akt pathways in colorectal cancer. |
2020-09-30 |
2023-08-13 |
human |
| Hyun Joo Jang, Eun Mi Hong, Se Woo Park, Hyun Woo Byun, Dong Hee Koh, Min Ho Choi, Sea Hyub Kae, Jin Le. Statin induces apoptosis of human colon cancer cells and downregulation of insulin-like growth factor 1 receptor via proapoptotic ERK activation. Oncology letters. vol 12. issue 1. 2020-09-30. PMID:27347133. |
it was concluded that simvastatin induces the apoptosis of human colon cancer cells and inhibits igf-1-induced erk and akt expression via the downregulation of igf-1r expression and proapoptotic erk activation. |
2020-09-30 |
2023-08-13 |
human |