| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhen-Yu Zhang, Li-Li Chen, Wei Xu, Keshavraj Sigdel, Xing-Tang Jian. Effects of silencing endothelin-1 on invasion and vascular formation in lung cancer. Oncology letters. vol 13. issue 6. 2020-10-01. PMID:28599441. |
in addition, the expression of apoptosis, growth and invasion-associated proteins, including rhoa/c, vascular endothelial growth factor, pigment epithelium-derived factor, akt, e-cadherin and cyclooxygenase-2 was evaluated by western blotting upon silencing et-1. |
2020-10-01 |
2023-08-13 |
human |
| Hailiang Xu, Yunyun Feng, Zhankui Jia, Jinjian Yang, Xueren Lu, Jun Li, Mingliang Xia, Chunru Wu, Yonggang Zhang, Jianhua Che. AXIN1 protects against testicular germ cell tumors via the PI3K/AKT/mTOR signaling pathway. Oncology letters. vol 14. issue 1. 2020-10-01. PMID:28693262. |
in addition, cell viability, apoptosis and the expression of apoptosis-associated proteins [apoptosis regulator bax (bax) and b-cell lymphoma (bcl)-2] and phosphatidylinositol 3-kinase (pi3k)/protein kinase b (akt)/mammalian target of rapamycin (mtor) signaling pathway proteins [phosphorylated (p)-mtor, mtor, p-akt, akt, p-70s ribosomal protein s6 (s6) and s6] were assessed. |
2020-10-01 |
2023-08-13 |
human |
| Huicong Yang, Yiqun Huang, Yong Zou, Xudong M. Synergistic effects of phenylhexyl isothiocyanate and LY294002 on the PI3K/Akt signaling pathway in HL-60 cells. Oncology letters. vol 14. issue 3. 2020-10-01. PMID:28927052. |
the aim of the present study was to investigate the synergistic effect of phenylhexyl isothiocyanate (phi) and ly294002 [an inhibitor of phosphoinositide 3-kinase (pi3k)] on the pi3k/protein kinase b (akt) signaling pathway, modulating histone acetylation, inhibiting cell viability and inducing apoptosis in hl-60 cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yuanwei Zang, Xiang Zhang, Lei Yan, Gangli Gu, Dawei Li, Yongzhen Zhang, Liang Fang, Shanshan Fu, Juchao Ren, Zhonghua X. Eukaryotic Translation Initiation Factor 3b is both a Promising Prognostic Biomarker and a Potential Therapeutic Target for Patients with Clear Cell Renal Cell Carcinoma. Journal of Cancer. vol 8. issue 15. 2020-10-01. PMID:28928896. |
knockdown of eif3b impaired the action of the akt pathway, thus inhibiting cell proliferation by disrupting the cell cycle and triggering apoptosis. |
2020-10-01 |
2023-08-13 |
mouse |
| S-U Woo, T Sangai, A Akcakanat, H Chen, C Wei, F Meric-Bernsta. Vertical inhibition of the PI3K/Akt/mTOR pathway is synergistic in breast cancer. Oncogenesis. vol 6. issue 10. 2020-10-01. PMID:28991258. |
we assessed the effects of mtor inhibitor rapamycin and akt inhibitor mk-2206, given as single drugs or in combination, on cell signaling, cell proliferation and apoptosis in a panel of cancer cell lines in vitro. |
2020-10-01 |
2023-08-13 |
Not clear |
| S-U Woo, T Sangai, A Akcakanat, H Chen, C Wei, F Meric-Bernsta. Vertical inhibition of the PI3K/Akt/mTOR pathway is synergistic in breast cancer. Oncogenesis. vol 6. issue 10. 2020-10-01. PMID:28991258. |
we demonstrated that mk-2206 inhibited akt phosphorylation, cell proliferation and apoptosis in a dose-dependent manner in breast cancer cell lines. |
2020-10-01 |
2023-08-13 |
Not clear |
| S-U Woo, T Sangai, A Akcakanat, H Chen, C Wei, F Meric-Bernsta. Vertical inhibition of the PI3K/Akt/mTOR pathway is synergistic in breast cancer. Oncogenesis. vol 6. issue 10. 2020-10-01. PMID:28991258. |
furthermore, the combination treatment inhibited phosphorylation of akt and s6, synergistically inhibited proliferation and induced apoptosis with a higher efficacy. |
2020-10-01 |
2023-08-13 |
Not clear |
| Maravillas Mellado-López, Richard J Griffeth, Jose Meseguer-Ripolles, Ramón Cugat, Montserrat García, Victoria Moreno-Manzan. Plasma Rich in Growth Factors Induces Cell Proliferation, Migration, Differentiation, and Cell Survival of Adipose-Derived Stem Cells. Stem cells international. vol 2017. 2020-10-01. PMID:29270200. |
indeed, akt inhibition abolished the prgf apoptosis prevention in asc exposed to 100 |
2020-10-01 |
2023-08-13 |
human |
| Ganesh V Shelke, Jayashree C Jagtap, Dae-Kyum Kim, Reecha D Shah, Gowry Das, Mruthyunjaya Shivayogi, Radha Pujari, Padma Shastr. TNF-α and IFN-γ Together Up-Regulates Par-4 Expression and Induce Apoptosis in Human Neuroblastomas. Biomedicines. vol 6. issue 1. 2020-10-01. PMID:29278364. |
the objective of this study was to examine the combined effect of interferon-gamma (ifn-γ) and tumor necrosis factor-alpha (tnf-α) on cytotoxicity and expression of prostate apoptosis response-4 (par-4) and par-4 interacting proteins b-cell lymphoma (bcl-2), nuclear factor kappa-light-chain-enhancer of activated b cells/p65 subunit (nf-κb/p65), ak mouse strain thymoma (akt) in human neuroblastoma (nb) cells. |
2020-10-01 |
2023-08-13 |
mouse |
| Ganesh V Shelke, Jayashree C Jagtap, Dae-Kyum Kim, Reecha D Shah, Gowry Das, Mruthyunjaya Shivayogi, Radha Pujari, Padma Shastr. TNF-α and IFN-γ Together Up-Regulates Par-4 Expression and Induce Apoptosis in Human Neuroblastomas. Biomedicines. vol 6. issue 1. 2020-10-01. PMID:29278364. |
the findings also demonstrated that apoptosis was associated with reduced level of pro-survival proteins-bcl-2 and akt and nf-κb/p65. |
2020-10-01 |
2023-08-13 |
mouse |
| Minglin Zhu, Xuefeng Zhou, Jinping Zha. Quercetin prevents alcohol-induced liver injury through targeting of PI3K/Akt/nuclear factor-κB and STAT3 signaling pathway. Experimental and therapeutic medicine. vol 14. issue 6. 2020-10-01. PMID:29285175. |
quercetin additionally suppressed the protein expression levels of b-cell lymphoma (bcl)-2, bcl-2 associated x apoptosis regulator, caspase-3, poly adp-ribose polymerase, and signal transducer and activator of transcription (stat) 3 phosphorylation, nuclear factor (nf)-κb and protein kinase b (akt) phosphorylation levels in alcohol-induced liver injured mice. |
2020-10-01 |
2023-08-13 |
mouse |
| Wencai Sun, Yintai Li, Suizhuan We. miR-4262 regulates chondrocyte viability, apoptosis, autophagy by targeting SIRT1 and activating PI3K/AKT/mTOR signaling pathway in rats with osteoarthritis. Experimental and therapeutic medicine. vol 15. issue 1. 2020-10-01. PMID:29434702. |
furthermore, cell viability, cell apoptosis, cell autophagy and matrix synthesis, as well as the expressions of proteins associated with the phosphoinositide 3-kinase (pi3k)/protein kinase b (akt)/mammalian target of rapamycin (mtor) signaling pathway were detected. |
2020-10-01 |
2023-08-13 |
rat |
| Jia-Tian Cao, Hui-Min Mo, Yue Wang, Kai Zhao, Tian-Tian Zhang, Chang-Qian Wang, Kai-Lin Xu, Zhi-Hua Ha. Dihydroartemisinin-induced apoptosis in human acute monocytic leukemia cells. Oncology letters. vol 15. issue 3. 2020-10-01. PMID:29435054. |
in addition, dha downregulated the levels of b-cell lymphoma (bcl)-2, protein kinase b (akt)1, akt2 and akt3 gene expression, and increased the expression of the bcl-2-associated x protein apoptosis regulator. |
2020-10-01 |
2023-08-13 |
human |
| Jia-Tian Cao, Hui-Min Mo, Yue Wang, Kai Zhao, Tian-Tian Zhang, Chang-Qian Wang, Kai-Lin Xu, Zhi-Hua Ha. Dihydroartemisinin-induced apoptosis in human acute monocytic leukemia cells. Oncology letters. vol 15. issue 3. 2020-10-01. PMID:29435054. |
therefore, dha may induce apoptosis in the amol thp-1 cell line via currently unknown underlying molecular mechanisms, including the downregulation of erk and akt, and the activation of caspase-3. |
2020-10-01 |
2023-08-13 |
human |
| Yaowei Ai, Qiaohui Zhou, Ling Li, Zhihong Pan, Mingwen Guo, Jingbo Ha. Interference of P-REX2a may inhibit proliferation and reverse the resistance of SGC7901 cells to doxorubicin. Oncology letters. vol 15. issue 3. 2020-10-01. PMID:29435055. |
when the cells were treated with 0.3 µm doxorubicin for 24 h, the rate of apoptosis in the sirna-transfected groups significantly increased and no marked changes in of pten and akt expression were observed. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jianliang Shen, Linwen Zeng, Liangming Pan, Shaofeng Yuan, Ming Wu, Xiongdong Kon. Tetramethylpyrazine regulates breast cancer cell viability, migration, invasion and apoptosis by affecting the activity of Akt and caspase-3. Oncology letters. vol 15. issue 4. 2020-10-01. PMID:29541225. |
tetramethylpyrazine regulates breast cancer cell viability, migration, invasion and apoptosis by affecting the activity of akt and caspase-3. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ji Wang, Chunying Wang, Gaofeng B. Curcumin inhibits the growth of liver cancer stem cells through the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway. Experimental and therapeutic medicine. vol 15. issue 4. 2020-10-01. PMID:29545895. |
the results of the study demonstrated that curcumin treatment inhibited the growth of lcscs, induced cell apoptosis, as well as regulated the expression of apoptosis-associated proteins and the release of cytochrome c. further experiments revealed that treatment with curcumin inhibited that the activation of the phosphatidylinositol 3-kinase (pi3k)/protein kinase b (akt)/mammalian target of rapamycin (mtor) signaling pathway. |
2020-10-01 |
2023-08-13 |
Not clear |
| Sony Maharjan, Byoung Kwon Park, Su In Lee, Yoonho Lim, Keunwook Lee, Hyung-Joo Kwo. Gomisin G Inhibits the Growth of Triple-Negative Breast Cancer Cells by Suppressing AKT Phosphorylation and Decreasing Cyclin D1. Biomolecules & therapeutics. vol 26. issue 3. 2020-10-01. PMID:29587339. |
gomisin g did not induce apoptosis but drastically inhibited akt phosphorylation and reduced the amount of retinoblastoma tumor suppressor protein (rb) and phosphorylated rb. |
2020-10-01 |
2023-08-13 |
human |
| Fu-Chi Kang, Shu-Chun Wang, Ming-Min Chang, Bo-Syong Pan, Kar-Lok Wong, Ka-Shun Cheng, Edmund Cheung So, Bu-Miin Huan. Midazolam activates caspase, MAPKs and endoplasmic reticulum stress pathways, and inhibits cell cycle and Akt pathway, to induce apoptosis in TM3 mouse Leydig progenitor cells. OncoTargets and therapy. vol 11. 2020-10-01. PMID:29588601. |
midazolam activates caspase, mapks and endoplasmic reticulum stress pathways, and inhibits cell cycle and akt pathway, to induce apoptosis in tm3 mouse leydig progenitor cells. |
2020-10-01 |
2023-08-13 |
mouse |
| Xiangwei Lv, Tongtong Xu, Qi Wu, Yao Zhou, Guidong Huang, Yongnan Xu, Guoqiang Zhon. 6-Gingerol Activates PI3K/Akt and Inhibits Apoptosis to Attenuate Myocardial Ischemia/Reperfusion Injury. Evidence-based complementary and alternative medicine : eCAM. vol 2018. 2020-10-01. PMID:29743926. |
in this study, the protective effect of 6-g on ischemia/reperfusion (i/r) damage and whether such a mechanism was related to apoptosis inhibition and activation of phosphoinositide 3-kinases (pi3k)/serine/threonine kinase (akt) signaling pathway were investigated. |
2020-10-01 |
2023-08-13 |
rat |