| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeong Su Ha, Jin Yong Kang, Jeong Eun Kang, Seon Kyeong Park, Jong Min Kim, Chul-Woo Kim, Sung-Il Oh, Uk Lee, Dae-Ok Kim, Ho Jin He. Pentacyclic triterpenoid-rich fraction of the Hardy kiwi (Actinidia arguta) improves brain dysfunction in high fat diet-induced obese mice. Scientific reports. vol 10. issue 1. 2020-12-04. PMID:32238886. |
in addition, in a molecular biology study, it was observed that cfaa improves hfd-induced abnormal insulin signaling such as increase of irs phosphorylation at serine residues and reduction of akt phosphorylation caused by the increase of jnk phosphorylation and then inhibited apoptosis. |
2020-12-04 |
2023-08-13 |
mouse |
| Kaniz Fatima Binte Hossain, Md Mostafizur Rahman, Md Tajuddin Sikder, Toshiyuki Hosokawa, Takeshi Saito, Masaaki Kurasak. Selenium modulates inorganic mercury induced cytotoxicity and intrinsic apoptosis in PC12 cells. Ecotoxicology and environmental safety. vol 207. 2020-12-04. PMID:32916531. |
cytotoxic assays have been shown that ihg (5 μm) caused oxidative stress and intrinsic apoptosis via ros generation, oxidizing glutathione, damaging dna, degrading cell membrane integrity, down-regulating mtor, p-mtor, akt and erk1, and up-regulating cleaved caspase 3 and cytochrome c release in pc12 cells 48 h after incubation. |
2020-12-04 |
2023-08-13 |
human |
| Kaniz Fatima Binte Hossain, Md Mostafizur Rahman, Md Tajuddin Sikder, Toshiyuki Hosokawa, Takeshi Saito, Masaaki Kurasak. Selenium modulates inorganic mercury induced cytotoxicity and intrinsic apoptosis in PC12 cells. Ecotoxicology and environmental safety. vol 207. 2020-12-04. PMID:32916531. |
co-treatment of se (5 μm) inhibited intrinsic apoptosis and oxidative stress induced by ihg (5 μm) via inhibiting ros formation, boosting gpx contents, increasing reduced glutathione, limiting dna degradation, improving cell membrane integrity, up-regulating mtor, p-mtor, akt, erk1 and caspase 3, and down-regulating cleaved caspase 3 and cytochrome c leakage in pc12 cells. |
2020-12-04 |
2023-08-13 |
human |
| Ahmad Nasimian, Parvaneh Farzaneh, Fuyuhiko Tamanoi, S Zahra Bathai. Cytosolic and mitochondrial ROS production resulted in apoptosis induction in breast cancer cells treated with Crocin: The role of FOXO3a, PTEN and AKT signaling. Biochemical pharmacology. vol 177. 2020-12-01. PMID:32353423. |
cytosolic and mitochondrial ros production resulted in apoptosis induction in breast cancer cells treated with crocin: the role of foxo3a, pten and akt signaling. |
2020-12-01 |
2023-08-13 |
human |
| Yubiao Zhang, Weisong Cai, Guangtao Han, Siqi Zhou, Jianping Li, Mao Chen, Haohuan L. Panax notoginseng saponins prevent senescence and inhibit apoptosis by regulating the PI3K‑AKT‑mTOR pathway in osteoarthritic chondrocytes. International journal of molecular medicine. vol 45. issue 4. 2020-11-30. PMID:32124939. |
in the present study, whether pns could limit tumor necrosis factor (tnf)‑α‑induced senescence and apoptosis in chondrocytes and whether they could slow down cartilage degeneration in a surgery‑induced rat osteoarthritis (oa) model by regulating the phosphatidyl inositol 3 kinase (pi3k)‑protein kinase b (akt)‑mammalian target of rapamycin (mtor) signaling pathway was examined. |
2020-11-30 |
2023-08-13 |
rat |
| Ping He, Jing Lei, Jia-Ning Miao, Di Wu, Cheng Wan. Cordyceps sinensis attenuates HBx‑induced cell apoptosis in HK‑2 cells through suppressing the PI3K/Akt pathway. International journal of molecular medicine. vol 45. issue 4. 2020-11-30. PMID:32124952. |
the effect of c. sinensis on cell proliferation and apoptosis, the phosphatidylinositol‑3‑kinase (pi3k)/protein kinase b (akt) signaling pathway, and the enzyme activity of caspase‑3 and caspase‑9 was measured. |
2020-11-30 |
2023-08-13 |
Not clear |
| Shangguan Jian, Liang Chen, Lian Minxue, Che Hongmin, Tang Ronghua, Fan Xiaoxuan, Zhang Binbin, Guo Shiwe. Tanshinone I induces apoptosis and protective autophagy in human glioblastoma cells via a reactive oxygen species‑dependent pathway. International journal of molecular medicine. vol 45. issue 4. 2020-11-30. PMID:32124953. |
mechanistic experiments indicated that ts i activated endoplasmic reticulum (er) stress and inhibited akt signaling and apoptosis in human glioma u87 mg cells. |
2020-11-30 |
2023-08-13 |
human |
| Shangguan Jian, Liang Chen, Lian Minxue, Che Hongmin, Tang Ronghua, Fan Xiaoxuan, Zhang Binbin, Guo Shiwe. Tanshinone I induces apoptosis and protective autophagy in human glioblastoma cells via a reactive oxygen species‑dependent pathway. International journal of molecular medicine. vol 45. issue 4. 2020-11-30. PMID:32124953. |
additionally, er stress and akt signal‑mediated apoptosis and protective autophagy were found to be induced by ts i via intracellular reactive oxygen species accumulation. |
2020-11-30 |
2023-08-13 |
human |
| Jia Jia, Yanguo Yang, Tingting Yan, Tao Chen, Guangxin L. Down-regulation of RFWD3 inhibits cancer cells proliferation and migration in gastric carcinoma. General physiology and biophysics. vol 39. issue 4. 2020-11-27. PMID:32902405. |
and further study showed down-regulation of rfwd3 promotes cell apoptosis, suppresses cell migration and invasion and blocks g2/m cell cycle progression, which may be related with akt, erk/p38 and slug pathways. |
2020-11-27 |
2023-08-13 |
Not clear |
| Bingdong Jiang, Wenbo Shi, Peng Li, Yanli Wu, Yun Li, Chuanming Ba. The mechanism of and the association between interleukin-27 and chemotherapeutic drug sensitivity in lung cancer. Oncology letters. vol 21. issue 1. 2020-11-27. PMID:33240420. |
the expression of akt and apoptosis factors such as caspase-3 and bcl-2/bax also ascertained that upregulated il-27 inhibited the development of cancer and increased apoptosis in the a549 cells. |
2020-11-27 |
2023-08-13 |
Not clear |
| Ji-Min Fan, Zheng-Rong Zheng, Yi-Ming Zeng, Xiao-Yang Che. MiR-323-3p Targeting Transmembrane Protein with EGF-Like and 2 Follistatin Domain (TMEFF2) Inhibits Human Lung Cancer A549 Cell Apoptosis by Regulation of AKT and ERK Signaling Pathways. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2020-11-24. PMID:32009129. |
mir-323-3p targeting transmembrane protein with egf-like and 2 follistatin domain (tmeff2) inhibits human lung cancer a549 cell apoptosis by regulation of akt and erk signaling pathways. |
2020-11-24 |
2023-08-13 |
human |
| Wanatchaporn Arunmanee, Gea Abigail U Ecoy, Hnin Ei Ei Khine, Methawee Duangkaew, Eakachai Prompetchara, Pithi Chanvorachote, Chatchai Chaotha. Colicin N Mediates Apoptosis and Suppresses Integrin-Modulated Survival in Human Lung Cancer Cells. Molecules (Basel, Switzerland). vol 25. issue 4. 2020-11-23. PMID:32069989. |
the activation of extrinsic apoptosis evidenced with the reduction of c-flip and caspase-8, as well as the modulation of intrinsic apoptosis signaling proteins including bax and mcl-1 were observed via western blot analysis in lung cancer cells cultured with colicin n (10-15 µm) for 12 h. moreover, 5-15 µm of colicin n down-regulated the expression of activated akt (p-akt) and its upstream survival molecules, integrin β1 and αv in human lung cancer cells. |
2020-11-23 |
2023-08-13 |
human |
| Takeshi Honda, Makoto Inu. PDZRN3 protects against apoptosis in myoblasts by maintaining cyclin A2 expression. Scientific reports. vol 10. issue 1. 2020-11-20. PMID:31980707. |
depletion of pdzrn3 in mouse c2c12 myoblasts by rna interference reduced the proportion of ki-67-positive cells and the level of akt phosphorylation, implicating pdzrn3 in regulation of both cell proliferation and apoptosis. |
2020-11-20 |
2023-08-13 |
mouse |
| Yangmei Zhang, Xichang Zhou, Long Cheng, Xiang Wang, Qinglin Zhang, Youwei Zhang, Sanyuan Su. PRKAA1 Promotes Proliferation and Inhibits Apoptosis of Gastric Cancer Cells Through Activating JNK1 and Akt Pathways. Oncology research. vol 28. issue 3. 2020-11-19. PMID:31558185. |
prkaa1 promotes proliferation and inhibits apoptosis of gastric cancer cells through activating jnk1 and akt pathways. |
2020-11-19 |
2023-08-13 |
mouse |
| Yangmei Zhang, Xichang Zhou, Long Cheng, Xiang Wang, Qinglin Zhang, Youwei Zhang, Sanyuan Su. PRKAA1 Promotes Proliferation and Inhibits Apoptosis of Gastric Cancer Cells Through Activating JNK1 and Akt Pathways. Oncology research. vol 28. issue 3. 2020-11-19. PMID:31558185. |
importantly, inactivation of jnk1 or akt signaling pathway significantly inhibited prkaa1 overexpression-induced increased cell proliferation and decreased cell apoptosis in mgc-803 cells. |
2020-11-19 |
2023-08-13 |
mouse |
| Yangmei Zhang, Xichang Zhou, Long Cheng, Xiang Wang, Qinglin Zhang, Youwei Zhang, Sanyuan Su. PRKAA1 Promotes Proliferation and Inhibits Apoptosis of Gastric Cancer Cells Through Activating JNK1 and Akt Pathways. Oncology research. vol 28. issue 3. 2020-11-19. PMID:31558185. |
in conclusion, our findings suggest that prkaa1 increases proliferation and restrains apoptosis of gastric cancer cells through activating jnk1 and akt pathways. |
2020-11-19 |
2023-08-13 |
mouse |
| Lei Zhang, Zhirui Yang, Yidan Zhao, Xinyu Yang, Xintong Meng, Juan Liu, Yi Liu, Can Yan, Dan Ya. Renoprotective effects of Gushen Jiedu capsule on diabetic nephropathy in rats. Scientific reports. vol 10. issue 1. 2020-11-18. PMID:32029775. |
this study demonstrated that gsjd might play a renoprotective role by inhibiting apoptosis and regulating the mitochondrial apoptotic and akt pathways during pathological changes in dn. |
2020-11-18 |
2023-08-13 |
rat |
| Mingxing Fang, Na Liu, Xiaoguang Yao, Tieling Xu, Zhiyong Wan. Enhancement of FAK alleviates ventilator-induced alveolar epithelial cell injury. Scientific reports. vol 10. issue 1. 2020-11-17. PMID:31942012. |
the protective effect of fak promoted aec proliferation and migration and prevented cells from undergoing apoptosis, which restored the integrity of the alveoli through akt pathway. |
2020-11-17 |
2023-08-13 |
mouse |
| Xianghui Zhang, Guan'en Zho. MiR-199a-5p inhibition protects cognitive function of ischemic stroke rats by AKT signaling pathway. American journal of translational research. vol 12. issue 10. 2020-11-17. PMID:33194051. |
in conclusion, silencing mir-199a-5p can effectively improve cognitive function in ischemic stroke rats and decrease neuronal apoptosis in hippocampus by activating the akt signaling pathway. |
2020-11-17 |
2023-08-13 |
rat |
| E Sun Paik, Tae-Hyun Kim, Young Jae Cho, Jiyoon Ryu, Jung-Joo Choi, Yoo-Young Lee, Tae-Joong Kim, Chel-Hun Choi, Woo Young Kim, Jason K Sa, Jin-Ku Lee, Byoung-Gie Kim, Duk-Soo Bae, Hee Dong Han, Hyung Jun Ahn, Jeong-Won Le. Preclinical assessment of the VEGFR inhibitor axitinib as a therapeutic agent for epithelial ovarian cancer. Scientific reports. vol 10. issue 1. 2020-11-16. PMID:32184452. |
western blots were performed to assess vegfr2, erk, and akt levels, and elisa and facs to evaluate apoptosis according to axitinib treatment. |
2020-11-16 |
2023-08-13 |
Not clear |