| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongyong Fu, Wenhui Zhang, Qingqing Yuan, Minghui Niu, Fan Zhou, Qianqian Qiu, Guoping Mao, Hong Wang, Liping Wen, Min Sun, Zheng Li, Zuping H. PAK1 Promotes the Proliferation and Inhibits Apoptosis of Human Spermatogonial Stem Cells via PDK1/KDR/ZNF367 and ERK1/2 and AKT Pathways. Molecular therapy. Nucleic acids. vol 12. 2021-01-09. PMID:30141410. |
collectively, pak1 was identified as the first molecule that controls proliferation and apoptosis of the human ssc line through pdk1/kdr/znf367 and the erk1/2 and akt pathways. |
2021-01-09 |
2023-08-13 |
human |
| Jing Song, Jixiang Bai, Shuhui Wang, Luncui Liu, Zhixuan Zha. [Effects of Quercetin on Autophagy and Phosphatidylinositol 3-kinase/Protein Kinase B/Mammalian Target of Rapamycin Signaling Pathway in Human Prostate Cancer PC-3 Cells]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 42. issue 5. 2021-01-08. PMID:33131510. |
objective to investigate the effects of quercetin on cell viability,apoptosis,autophagy,and phosphatidylinositol 3-kinase(pi3k)/protein kinase b(akt)/mammalian target of rapamycin(mtor)signaling pathway in human prostate cell carcinoma pc-3 cells.methods pc-3 cells were cultured |
2021-01-08 |
2023-08-13 |
human |
| Wenchang Lv, Shengxuan Liu, Qi Zhang, Zhen Yi, Xiaoyong Bao, Youping Feng, Yuping Re. Downregulation of Epac Reduces Fibrosis and Induces Apoptosis Through Akt Signaling in Human Keloid Fibroblasts. The Journal of surgical research. vol 257. 2021-01-07. PMID:32890866. |
downregulation of epac reduces fibrosis and induces apoptosis through akt signaling in human keloid fibroblasts. |
2021-01-07 |
2023-08-13 |
human |
| Xin-Qiang Li, Ya-Kui Liu, Jun Yi, Jia-Shou Dong, Pan-Pan Zhang, Lei Wan, Kui L. MicroRNA-143 Increases Oxidative Stress and Myocardial Cell Apoptosis in a Mouse Model of Doxorubicin-Induced Cardiac Toxicity. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-01-06. PMID:32170053. |
conclusions in a mouse model of doxorubicin-induced cardiac toxicity, mir-143 increased oxidative stress and myocardial cell apoptosis following doxorubicin treatment by inhibiting akt. |
2021-01-06 |
2023-08-13 |
mouse |
| Yun-Ju Wang, Song-Bin Chang, Chih-Yen Wang, Hui-Ting Huang, Shun-Fen Tzen. The selective lipoprotein-associated phospholipase A2 inhibitor darapladib triggers irreversible actions on glioma cell apoptosis and mitochondrial dysfunction. Toxicology and applied pharmacology. vol 402. 2021-01-06. PMID:32668280. |
in conclusion, darapladib acts as a potential anti-glioma compound via the induction of mitochondrial membrane depolarization and cell apoptosis, and the inhibition of akt signaling in glioma cells. |
2021-01-06 |
2023-08-13 |
human |
| Agustín Sánchez-Temprano, José Luis Relova, Jesús P Camiña, Yolanda Pazo. Concurrent Akt, ERK1/2 and AMPK Activation by Obestatin Inhibits Apoptotic Signaling Cascades on Nutrient-Deprived PC12 Cells. Cellular and molecular neurobiology. 2021-01-05. PMID:33400083. |
this encompasses the control of apoptosis by the interplay between akt, erk1/2 and ampk signaling pathways. |
2021-01-05 |
2023-08-13 |
Not clear |
| Ji Young Kim, Chan Hyung Kim, Eun Young Lee, Je Hoon Se. Alpha B-Crystallin Overexpression Protects Oligodendrocyte Precursor Cells Against Oxidative Stress-Induced Apoptosis Through the Akt Pathway. Journal of molecular neuroscience : MN. vol 70. issue 5. 2021-01-04. PMID:31970633. |
alpha b-crystallin overexpression protects oligodendrocyte precursor cells against oxidative stress-induced apoptosis through the akt pathway. |
2021-01-04 |
2023-08-13 |
Not clear |
| Shih-Chang Fu, Jui-Ming Liu, Kuan-I Lee, Feng-Cheng Tang, Kai-Min Fang, Ching-Yao Yang, Chin-Chuan Su, Hsin-Hung Chen, Ren-Jun Hsu, Ya-Wen Che. Cr(VI) induces ROS-mediated mitochondrial-dependent apoptosis in neuronal cells via the activation of Akt/ERK/AMPK signaling pathway. Toxicology in vitro : an international journal published in association with BIBRA. vol 65. 2021-01-04. PMID:32061800. |
collectively, these results suggest that cr(vi) exerts its cytotoxicity on neuronal cells by inducing mitochondria-dependent apoptosis through the interdependent activation of akt, erk1/2, and ampkα, which are mainly mediated by ros generation. |
2021-01-04 |
2023-08-13 |
human |
| Ankur Vaidya, Shweta Jain, Sanjeev Sahu, Pankaj Kumar Jain, Kamla Pathak, Devender Pathak, Raj Kumar, Sanjay Kumar Jai. Anticancer Agents Based on Vulnerable Components in a Signalling Pathway. Mini reviews in medicinal chemistry. vol 20. issue 10. 2020-12-31. PMID:32048968. |
the write up describes the leading molecular mechanisms for cancer therapy, including mtor, tyrosine wee1 kinase (wee1), janus kinases, pi3k/mtor signaling pathway, serine/threonine protein kinase akt, checkpoint kinase 1 (chk1), maternal embryonic leucine-zipper kinase (melk), dna methyltransferase i (dnmt1), poly (adp-ribose) polymerase (parp)-1/-2, sphingosine kinase-2 (sk2), pan-fgfr, inhibitor of apoptosis (iap), murine double minute 2 (mdm2), bcl-2 family protein and reactive oxygen species 1 (ros1). |
2020-12-31 |
2023-08-13 |
Not clear |
| Motofumi Kumazoe, Shun Hiroi, Yousuke Tanimoto, Jyunichi Miyakawa, Maasa Yamanouchi, Yumi Suemasu, Ren Yoshitomi, Motoki Murata, Yoshinori Fujimura, Takashi Takahashi, Hiroshi Tanaka, Hirofumi Tachiban. Cancer cell selective probe by mimicking EGCG. Biochemical and biophysical research communications. vol 525. issue 4. 2020-12-28. PMID:32173528. |
green tea polyphenol (-)-epigallocatechin-3-o-gallate (egcg) directly binds to cell-surface 67lr and induces apoptosis through the protein kinase b (akt)/endothelial nitric oxide synthase/nitric oxide/cyclic gmp (cgmp) axis. |
2020-12-28 |
2023-08-13 |
Not clear |
| Xunran Ni, Qian Su, Wenbo Xia, Yanli Zhang, Kejuan Jia, Zhiqiang Su, Guozhong L. Knockdown lncRNA NEAT1 regulates the activation of microglia and reduces AKT signaling and neuronal apoptosis after cerebral ischemic reperfusion. Scientific reports. vol 10. issue 1. 2020-12-28. PMID:33184298. |
knockdown lncrna neat1 regulates the activation of microglia and reduces akt signaling and neuronal apoptosis after cerebral ischemic reperfusion. |
2020-12-28 |
2023-08-13 |
Not clear |
| Huan Wang, Tingtao Chen, Linxi Wan, Jiachen Lu, Hong Wei, Ke-Yu Deng, Jing Wei, Hong-Bo Xi. Attenuated Salmonella engineered with an apoptosis-inducing factor (AIF) eukaryotic expressing system enhances its anti-tumor effect in melanoma in vitro and in vivo. Applied microbiology and biotechnology. vol 104. issue 8. 2020-12-23. PMID:32095863. |
furthermore, we observed that the colonization of the v-a-aif strain and the massive expression of aif in tumors significantly promoted apoptosis of tumor cells by upregulating the expression ratio of bcl-2-associated x protein/b cell lymphoma-2 (bax/bcl-2), suppressed the inflammatory response by downregulating toll-like receptor-4/nuclear factor kappa-b (tlr-4/nfκb) signaling pathway, seen as reduction of the expressions of phosphorylated phosphoinositide 3 kinase (pi3k) and protein kinase b (akt), and decrease of the production of interleukin-1β (il-1β) and tumor necrosis factor-α (tnf-α). |
2020-12-23 |
2023-08-13 |
mouse |
| Xiaoping Hu, Baijun Li, Luocheng Li, Bowen Li, Jinlong Luo, Bin She. Asiatic Acid Protects against Doxorubicin-Induced Cardiotoxicity in Mice. Oxidative medicine and cellular longevity. vol 2020. 2020-12-21. PMID:32509145. |
in conclusion, our results found that aa could attenuate dox-induced myocardial oxidative stress and apoptosis via activation of the akt signaling pathway. |
2020-12-21 |
2023-08-13 |
mouse |
| Zhong-Hai Shen, Xu-Qi Hu, Min-Jie Hu, Xue-Kang Pan, Hui-Gen Lu, Bao Chen, Bin Wu, Gang Che. Activation of AKT signaling via small molecule natural compound prevents against osteoblast apoptosis and osteonecrosis of the femoral head. American journal of translational research. vol 12. issue 11. 2020-12-16. PMID:33312361. |
activation of akt signaling via small molecule natural compound prevents against osteoblast apoptosis and osteonecrosis of the femoral head. |
2020-12-16 |
2023-08-13 |
Not clear |
| Wen-Jun Zhang, Ce-Gui Hu, Zheng-Ming Zhu, Hong-Liang Lu. Effect of P2X7 receptor on tumorigenesis and its pharmacological properties. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 125. 2020-12-14. PMID:32004973. |
the activation of the p2x7r can open the ion channels on the tumor cell membrane (sodium ion, calcium ion influx and potassium ion outflow), trigger rearrangement of the cytoskeleton and changes in membrane fluidity, allow small molecule substances to enter the cell, activate enzymes and kinases in related signaling pathways in cells (such as pka, pkc, erk1/2, akt, and jnk), thereby affecting the development of tumor cells, and can also indirectly affect the growth, apoptosis and migration of tumor cells through tumor microenvironment. |
2020-12-14 |
2023-08-13 |
human |
| XinHong Xue, HongRu Wang, JiangLi S. Inhibition of MiR-122 Decreases Cerebral Ischemia-reperfusion Injury by Upregulating DJ-1-Phosphatase and Tensin Homologue Deleted on Chromosome 10 (PTEN)/Phosphonosinol-3 Kinase (PI3K)/AKT. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2020-12-11. PMID:32061171. |
flow cytometry was used to detect apoptosis and western blot was used to detect the expression of dj-1, pten, akt, and p-akt. |
2020-12-11 |
2023-08-13 |
rat |
| Lavanya Ponnusamy, Gugan Kothandan, Ravi Manohara. Berberine and Emodin abrogates breast cancer growth and facilitates apoptosis through inactivation of SIK3-induced mTOR and Akt signaling pathway. Biochimica et biophysica acta. Molecular basis of disease. vol 1866. issue 11. 2020-12-08. PMID:32682817. |
berberine and emodin abrogates breast cancer growth and facilitates apoptosis through inactivation of sik3-induced mtor and akt signaling pathway. |
2020-12-08 |
2023-08-13 |
Not clear |
| Lavanya Ponnusamy, Gugan Kothandan, Ravi Manohara. Berberine and Emodin abrogates breast cancer growth and facilitates apoptosis through inactivation of SIK3-induced mTOR and Akt signaling pathway. Biochimica et biophysica acta. Molecular basis of disease. vol 1866. issue 11. 2020-12-08. PMID:32682817. |
moreover, combination treatments attenuate akt signaling, thereby inducing g0/g1 phase cell cycle arrest and apoptosis of breast cancer cells in a sik3-dependent manner. |
2020-12-08 |
2023-08-13 |
Not clear |
| Changbing Wang, Haiyang Chen, Danyang Chen, Mingqi Zhao, Zhengfang Lin, Min Guo, Tiantian Xu, Yi Chen, Liang Hua, Tao Lin, Ying Tang, Bing Zhu, Yinghua L. The Inhibition of H1N1 Influenza Virus-Induced Apoptosis by Surface Decoration of Selenium Nanoparticles with β-Thujaplicin through Reactive Oxygen Species-Mediated AKT and p53 Signaling Pathways. ACS omega. vol 5. issue 47. 2020-12-08. PMID:33283112. |
the inhibition of h1n1 influenza virus-induced apoptosis by surface decoration of selenium nanoparticles with β-thujaplicin through reactive oxygen species-mediated akt and p53 signaling pathways. |
2020-12-08 |
2023-08-13 |
mouse |
| Xue Yin, Bingyu Zhang, Lei Chen, Wei Xia, Gaoqin Liu, Xuefei Zhu, Chi Ren, Weiming Liu, Peirong L. Essential Contribution of Macrophage Tie2 Signalling in a Murine Model of Laser-Induced Choroidal Neovascularization. Scientific reports. vol 10. issue 1. 2020-12-07. PMID:32541815. |
we also observed that tems prevented apoptosis of b.end3 cells, but promoted their migration, proliferation and tube formation via vegf, extracellular signal-regulated kinase (erk) and v-akt murine thymoma viral oncogene (akt)-dependent signalling pathways. |
2020-12-07 |
2023-08-13 |
Not clear |