| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bo Qian, Zhiheng Yao, Yang Yang, Na Li, Qiao Wan. Downregulation of SDCBP inhibits cell proliferation and induces apoptosis by regulating PI3K/AKT/mTOR pathway in gastric carcinoma. Biotechnology and applied biochemistry. 2021-02-18. PMID:33432665. |
and it was further determined that pi3k inhibitor ly294002, akt inhibitor torin1, and mtor inhibitor mk-2206 suppressed the apoptosis. |
2021-02-18 |
2023-08-13 |
Not clear |
| Fatemeh Forouzanfar, Mana Shojapour, Zahra Sadat Aghili, Samira Asgharzad. Growth Factors as Tools in Photoreceptor Cell Regeneration and Vision Recovery. Current drug targets. vol 21. issue 6. 2021-02-17. PMID:31755378. |
given the results available in the related literature, the differentiation efficacy of escs toward the photoreceptor and retinal neurons and the important role of growth factors in activating signaling pathways such as akt, ras/raf1/ and erks also inhibit the ask1/jnk apoptosis pathway. |
2021-02-17 |
2023-08-13 |
Not clear |
| Jieming Ni. UNC0321 inhibits high glucose induced apoptosis in HUVEC by targeting Rab4. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 131. 2021-02-17. PMID:32877824. |
at the same time, after overexpression of rab4 in huvec cells treated with unc0321, the number of apoptosis was significantly increased, cell proliferation and migration were inhibited, and the activity of akt / mtor pathway decreased. |
2021-02-17 |
2023-08-13 |
Not clear |
| Meixi Liu, Xia Huang, Yihong Tian, Xiao Yan, Fang Wang, Junbo Chen, Qi Zhang, Qiang Zhang, Xiao Yua. Phosphorylated GSK‑3β protects stress‑induced apoptosis of myoblasts via the PI3K/Akt signaling pathway. Molecular medicine reports. vol 22. issue 1. 2021-02-16. PMID:32377749. |
cells were stained with hoechst 33258 to visualize morphological changes and apoptosis of myoblasts, and western blotting was performed to detect expression of akt, phosphorylated (p)‑akt (ser473), glycogen synthase kinase 3β (gsk‑3β) and p‑gsk‑3β (ser9). |
2021-02-16 |
2023-08-13 |
rat |
| W Rong, L Yang, C-Y Li, X-T Wu, Z-D Zhou, W-L Zhu, Y Ya. MiR-29 inhibits neuronal apoptosis in rats with cerebral infarction through regulating Akt signaling pathway. European review for medical and pharmacological sciences. vol 24. issue 2. 2021-02-12. PMID:32016990. |
mir-29 inhibits neuronal apoptosis in rats with cerebral infarction through regulating akt signaling pathway. |
2021-02-12 |
2023-08-13 |
rat |
| W Rong, L Yang, C-Y Li, X-T Wu, Z-D Zhou, W-L Zhu, Y Ya. MiR-29 inhibits neuronal apoptosis in rats with cerebral infarction through regulating Akt signaling pathway. European review for medical and pharmacological sciences. vol 24. issue 2. 2021-02-12. PMID:32016990. |
the aim of this study was to explore the influence of micro ribonucleic acid (mir)-29 on neuronal apoptosis in rats with cerebral infarction by regulating the protein kinase b (akt) signaling pathway. |
2021-02-12 |
2023-08-13 |
rat |
| Hao-Nien Chen, Kang-Hao Liang, Jun-Kai Lai, Chun-Hsin Lan, Mei-Ying Liao, Shao-Hsi Hung, Yi-Ting Chuang, Kai-Chi Chen, William Wei-Fu Tsuei, Han-Chung W. EpCAM Signaling Promotes Tumor Progression and Protein Stability of PD-L1 through the EGFR Pathway. Cancer research. vol 80. issue 22. 2021-02-12. PMID:32978170. |
treatment with the epcam neutralizing antibody, epab2-6, inhibited akt and foxo3a phosphorylation, increased foxo3a nuclear translocation, and upregulated high temperature requirement a2 (htra2) expression to promote apoptosis while decreasing pd-l1 protein levels to enhance the cytotoxic activity of cd8 |
2021-02-12 |
2023-08-13 |
Not clear |
| Yamila B Gándola, Camila Fontana, Mariana A Bojorge, Tania T Luschnat, Marcela A Moretton, Diego A Chiapetta, Sandra V Verstraeten, Lorena Gonzále. Concentration-dependent effects of sodium cholate and deoxycholate bile salts on breast cancer cells proliferation and survival. Molecular biology reports. vol 47. issue 5. 2021-02-11. PMID:32297292. |
high concentrations of bile salts induced apoptosis as well as sustained activation of p38 and akt. |
2021-02-11 |
2023-08-13 |
Not clear |
| Han C Dan, Mei Sun, Satoshi Kaneko, Richard I Feldman, Santo V Nicosia, Hong-Gang Wang, Benjamin K Tsang, Jin Q Chen. Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP). The Journal of biological chemistry. vol 291. issue 43. 2021-02-10. PMID:27825084. |
akt phosphorylation and stabilization of x-linked inhibitor of apoptosis protein (xiap). |
2021-02-10 |
2023-08-13 |
Not clear |
| Jianjun Wang, Yunchun Li, Qianfeng Ma, Jiaxin Huan. miR‑378 in combination with ultrasonic irradiation and SonoVue microbubbles transfection inhibits hepatoma cell growth. Molecular medicine reports. vol 21. issue 6. 2021-02-08. PMID:32236628. |
moreover, mir‑378 increased the rate of apoptosis and upregulated the expression of bax and p53, and suppressed the cell cycle and downregulated the expression of cyclin d1, bcl‑2, akt, β‑catenin and survivin much more effectively in the hcc cell line by applying the combined method. |
2021-02-08 |
2023-08-13 |
Not clear |
| Ayed A Dera, Prasanna Rajagopalan, Majed Al Fayi, Irfan Ahmed, Harish C Chandramoorth. Indirubin-3-monoxime and thymoquinone exhibit synergistic efficacy as therapeutic combination in in-vitro and in-vivo models of Lung cancer. Archives of pharmacal research. vol 43. issue 6. 2021-02-08. PMID:32588331. |
cell cycle, apoptosis and nfκb phosphorylation were determined by flow cytometry, while apoptotic proteins, akt and mtor were assessed by western blotting. |
2021-02-08 |
2023-08-13 |
mouse |
| Guanghua Li, Bo Li, Jingang Song, Na Wang, Zhuanglei Ga. Endomorphin-2 Analog Inhibits the Growth of DLD-1 and RKO Human Colon Cancer Cells by Inducing Cell Apoptosis. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-02-05. PMID:32336747. |
results cell proliferation of dld-1 and rko cells was inhibited by the endomorphin-2 analog in a dose-dependent manner, and a 100 µm dose reduced dld-1 and rko cell proliferation by 28% and 23%, respectively, at 72 h. endomorphin-2 analog induced cell apoptosis and the generation of ros, activated caspase-3 and caspase-9, and increased the levels of p53 and cytochrome c release, and down-regulated of akt activation in dld-1 and rko cells in a dose-dependent manner. |
2021-02-05 |
2023-08-13 |
human |
| Guanghua Li, Bo Li, Jingang Song, Na Wang, Zhuanglei Ga. Endomorphin-2 Analog Inhibits the Growth of DLD-1 and RKO Human Colon Cancer Cells by Inducing Cell Apoptosis. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-02-05. PMID:32336747. |
conclusions endomorphin-2 analog inhibited colon cancer cell proliferation, activated apoptosis, and down-regulated akt phosphorylation of human dld-1 and rko colon cancer cells in vitro in a dose-dependent manner. |
2021-02-05 |
2023-08-13 |
human |
| Xianyi Meng, Chenghong Zhang, Yu Guo, Ying Han, Chunyang Wang, Haiying Chu, Li Kong, Haiying M. TBHQ Attenuates Neurotoxicity Induced by Methamphetamine in the VTA through the Nrf2/HO-1 and PI3K/AKT Signaling Pathways. Oxidative medicine and cellular longevity. vol 2020. 2021-02-04. PMID:32351675. |
meth downregulated nrf2, ho-1, pi3k, and akt, key factors of oxidative stress, and the apoptosis signaling pathway. |
2021-02-04 |
2023-08-13 |
rat |
| Jun-Chen Ge, Yu-Xi Wang, Zhi-Biao Chen, Dong-Feng Che. Integrin alpha 7 correlates with poor clinical outcomes, and it regulates cell proliferation, apoptosis and stemness via PTK2-PI3K-Akt signaling pathway in hepatocellular carcinoma. Cellular signalling. vol 66. 2021-02-03. PMID:31698037. |
itga7 knockdown suppressed cell proliferation but promoted apoptosis, and it also downregulated cscs markers (cd44, cd133 and oct-4) as well as ptk2, pi3k and akt expressions in smmc-7721 and hep g2 cell lines. |
2021-02-03 |
2023-08-13 |
human |
| Yifan Gu, Zhewei Fei, Ronghua Zh. miR-21 modulates cisplatin resistance of gastric cancer cells by inhibiting autophagy via the PI3K/Akt/mTOR pathway. Anti-cancer drugs. vol 31. issue 4. 2021-02-02. PMID:31913198. |
gc cells became refractory to the growth inhibition and apoptosis induced by ddp treatment, activation of akt and mtor were increased in ddp-resistant gc cells. |
2021-02-02 |
2023-08-13 |
human |
| Nopparat Suthprasertporn, Nopparada Mingchinda, Kohji Fukunaga, Wipawan Thangnipo. Neuroprotection of SAK3 on scopolamine-induced cholinergic dysfunction in human neuroblastoma SH-SY5Y cells. Cytotechnology. vol 72. issue 1. 2021-02-01. PMID:31933104. |
sak3 inhibited scopolamine-induced cellular apoptosis (morphologically and by determination of pro- and anti-apoptotic factor levels), increase in ros levels, decrease in choline acetyltransferase level, phosphorylation of nf-κb, activation of akt, jnk and p38 intracellular signaling pathways, and elevation of proinflammatory cytokines il-1β and il-6, but not enhanced level of β-site amyloid precursor protein cleaving enzyme 1 (bace1). |
2021-02-01 |
2023-08-13 |
mouse |
| Jinju Wang, Hua Liu, Shuzhen Chen, Wenfeng Zhang, Yanfang Chen, Yi Yan. Moderate exercise has beneficial effects on mouse ischemic stroke by enhancing the functions of circulating endothelial progenitor cell-derived exosomes. Experimental neurology. vol 330. 2021-02-01. PMID:32325158. |
cell apoptosis, axon growth ability and gene expressions (cas-3 and akt) were measured. |
2021-02-01 |
2023-08-13 |
mouse |
| Abdelhalim Azz. Scaffold dependent role of the inositol 5'-phosphatase SHIP2, in regulation of oxidative stress induced apoptosis. Archives of biochemistry and biophysics. vol 697. 2021-02-01. PMID:33181128. |
the serine-threonine kinase akt enhances survival and suppress apoptosis. |
2021-02-01 |
2023-08-13 |
human |
| Genshen Cai, Jing Zhang, Rupeng Wan. [Down-regulation of PHLPP1 expression ameliorates high glucose-induced autophagy inhibition and apoptosis promotion of podocytes by activating PI3K/AKT/mTOR pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 37. issue 1. 2021-02-01. PMID:33441223. |
compared with ng group, the autophagy level of podocytes, the expression of pi3k and the phosphorylation level of mtor in the hg group, hg combined with si-phlpp1 group and hg combined with hcq group were significantly reduced; the apoptosis rate and c-caspase-3 protein expression level were significantly enhanced; the phosphorylation level of akt in the hg combined with si-phlpp1 group significantly increased, but it in the other two groups significantly decreased. |
2021-02-01 |
2023-08-13 |
human |