| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ruyue Tian, Hailun Jiang, Linlin Shao, Yang Yu, Qingdong Guo, Bangwei Cao, Shuilong Gu. miR193b Promotes Apoptosis of Gastric Cancer Cells via Directly Mediating the Akt Pathway. BioMed research international. vol 2020. 2021-03-31. PMID:32596290. |
mir193b promotes apoptosis of gastric cancer cells via directly mediating the akt pathway. |
2021-03-31 |
2023-08-13 |
human |
| Mingkun Zhu, Sasa Miao, Wenting Zhou, Shaaban Saad Elnesr, Xinyang Dong, Xiaoting Zo. MAPK, AKT/FoxO3a and mTOR pathways are involved in cadmium regulating the cell cycle, proliferation and apoptosis of chicken follicular granulosa cells. Ecotoxicology and environmental safety. vol 214. 2021-03-31. PMID:33706141. |
low-dose cd exposure (1 μm) induced the granulosa cell proliferation, upregulated the mrna levels of rsk1 and rheb, activated foxo3a, akt, erk1/2, mtor and p70s6k1 phosphorylation, and promoted cell cycle progression from phase g1 to s. however, high-dose cd exposure (15 μm) induced reactive oxygen species (ros) generation and cell apoptosis, upregulated the mrna levels of the inflammatory factors, ask1, jnk, p38 and tak1, downregulated the expressions of rsk1 and rheb genes, and inhibited the phosphorylation of erk1/2, mtor and p70s6k1 proteins, and the cell cycle progression. |
2021-03-31 |
2023-08-13 |
chicken |
| Jae Chul Lee, Deok Yong Sim, Hyo-Jung Lee, Eunji Im, Jhin-Back Choi, Ji Eon Park, Woon Yi Park, Ji Hoon Jung, Bum Sang Shim, Sung-Hoon Ki. MicroRNA216b mediated downregulation of HSP27/STAT3/AKT signaling is critically involved in lambertianic acid induced apoptosis in human cervical cancers. Phytotherapy research : PTR. vol 35. issue 2. 2021-03-30. PMID:32822082. |
overall, our findings suggest that mirna216b mediated inhibition of hsp27/stat3/ akt signaling axis is critically involved in la-induced apoptosis in cervical cancers. |
2021-03-30 |
2023-08-13 |
human |
| b' Iva Poto\\xc4\\x8dnjak, Jelena Marini\\xc4\\x87, Lara Bati\\xc4\\x8di\\xc4\\x87, Lidija \\xc5\\xa0imi\\xc4\\x87, Dalibor Brozni\\xc4\\x87, Robert Domitrovi\\xc4\\x8. Aucubin administered by either oral or parenteral route protects against cisplatin-induced acute kidney injury in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 142. 2021-03-29. PMID:32504734.' |
mechanistically, aucubin suppressed the activation of several signaling pathways involved in inflammation and apoptosis, including nuclear factor-kappa b (nf-κb), signal transducer and activator of transcription 3 (stat3), akt, extracellular signal-regulated kinase 1/2 (erk1/2) and forkhead box o3a (foxo3a). |
2021-03-29 |
2023-08-13 |
mouse |
| Panpan Wu, Xiao Wang, Yuran Ma, Xuetao Xu, Wenfeng Liu, Zhaojun Sheng, Min Chen, Renping Zhou, Kun Zhang, Susan Goodin, Xi Zheng, Dongli L. (3E,5E)-3,5-Bis(pyridin-3-methylene)-tetrahydrothiopyran-4-one enhances the inhibitory effect of gemcitabine on pancreatic cancer cells. Bioorganic chemistry. vol 101. 2021-03-29. PMID:32599367. |
mechanistic studies showed that inhibition of cell growth and induction of apoptosis in the gem resistant panc-1 cells were associated with decreases in activation of nf-κb and akt. |
2021-03-29 |
2023-08-13 |
human |
| Hao Tang, Chaohui Duan, Zhizhou Kuang, Ruo-Pan Huan. Analyzing Signaling Pathways Using Antibody Arrays. Methods in molecular biology (Clifton, N.J.). vol 2237. 2021-03-26. PMID:33237422. |
this array-based system features a nitrocellulose membrane or glass slide solid support, spotted with antibodies targeting key proteins of major signaling pathways, including rtk, egfr, mapk, akt, apoptosis, tgfb, jak/stat, nfkb, and insulin receptor pathways. |
2021-03-26 |
2023-08-13 |
human |
| Liang Jiang, Jing Xia. 2-phenylethynesulfonamide inhibits growth of oral squamous cell carcinoma cells by blocking the function of heat shock protein 70. Bioscience reports. vol 40. issue 3. 2021-03-25. PMID:32110810. |
pes inhibited the expression of x-linked inhibitor of apoptosis protein (xiap), baculoviral iap repeat containing 2 (c-iap1), phosphorylated akt (p-akt), and phosphorylated extracellular signal-regulated kinase (p-erk). |
2021-03-25 |
2023-08-13 |
Not clear |
| Fahong Wu, Yanling Chen, Jinhai Zh. LHPP suppresses proliferation, migration, and invasion and promotes apoptosis in pancreatic cancer. Bioscience reports. vol 40. issue 3. 2021-03-25. PMID:32186702. |
moreover, lhpp-induced apoptosis was diminished by sc79 (akt activator) in paca cells. |
2021-03-25 |
2023-08-13 |
Not clear |
| Xian Liu, Yanru Zhang, PengSheng Zheng, Nan Cu. Msi1 inhibits cervical cancer cell apoptosis by downregulating BAK through AKT signaling. Journal of Cancer. vol 12. issue 8. 2021-03-25. PMID:33758618. |
msi1 inhibits cervical cancer cell apoptosis by downregulating bak through akt signaling. |
2021-03-25 |
2023-08-13 |
Not clear |
| Jiaji Gong, Fan Zhou, Simin Xie Xin Wang, Junmei Xu, Feng Xia. Caveolin-3 protects diabetic hearts from acute myocardial infarction/reperfusion injury through β2AR, cAMP/PKA, and BDNF/TrkB signaling pathways. Aging. vol 12. issue 14. 2021-03-24. PMID:32692723. |
in h9c2 cells, high-glucose (hg) stimulation further enhanced h/r injury by promoting cell apoptosis, inhibiting cell viability, and suppressing trkb and akt signaling; in contrast, the adrb2 agonist isoprenaline (iso) significantly attenuated the above-described effects of hg stimulation. |
2021-03-24 |
2023-08-13 |
Not clear |
| Wenfeng Li, Mengting Cheng, Wentao Zhang, Ruiyan He, Hongyan Yan. New Insights into the Mechanisms of Polyphenol from Plum Fruit Inducing Apoptosis in Human Lung Cancer A549 Cells Via PI3K/AKT/FOXO1 Pathway. Plant foods for human nutrition (Dordrecht, Netherlands). vol 76. issue 1. 2021-03-23. PMID:33641052. |
transcriptome analysis suggested that ppp-induced apoptosis was closely associated with regulating the phosphatidylinositol 3-kinase (pi3k)/protein kinase b (akt)/forkhead box protein o 1 (foxo1) pathway in the a549 cells. |
2021-03-23 |
2023-08-13 |
human |
| Wenfeng Li, Mengting Cheng, Wentao Zhang, Ruiyan He, Hongyan Yan. New Insights into the Mechanisms of Polyphenol from Plum Fruit Inducing Apoptosis in Human Lung Cancer A549 Cells Via PI3K/AKT/FOXO1 Pathway. Plant foods for human nutrition (Dordrecht, Netherlands). vol 76. issue 1. 2021-03-23. PMID:33641052. |
subsequently, as an activator of akt, sc79 was applied to confirm that the inhibition of akt phosphorylation play an important role in the ppp-induced apoptosis of the a549 cells. |
2021-03-23 |
2023-08-13 |
human |
| Shuyu Xiong, Mingming Ma, Yupeng Xu, Fang Wei, Qing Gu, Xiangui He, Xun X. Protective effects of peptide FK18 against neuro-excitotoxicity in SH-SY5Y cells. Experimental and therapeutic medicine. vol 21. issue 5. 2021-03-23. PMID:33747186. |
for this purpose, cell viability was determined by the mts assay, cell apoptosis was assessed by flow cytometry and the tunel assay; expression of antiapoptotic proteins bcl-2, proapoptotic protein bax and caspase-3 as well as the phosphorylation of akt and erk was estimated by western blotting. |
2021-03-23 |
2023-08-13 |
Not clear |
| Sung Min Kim, Jung-Il Kang, Hoon-Seok Yoon, Youn Kyung Choi, Ji Soo Go, Sun Kyung Oh, Meejung Ahn, Jeongtae Kim, Young Sang Koh, Jin Won Hyun, Eun-Sook Yoo, Hee-Kyoung Kan. HNG, A Humanin Analogue, Promotes Hair Growth by Inhibiting Anagen-to-Catagen Transition. International journal of molecular sciences. vol 21. issue 12. 2021-03-22. PMID:32604799. |
hng stimulated the anagen phase longer with vegf up-regulation, and it prevented apoptosis by activating erk1/2, akt, and stat3 signaling. |
2021-03-22 |
2023-08-13 |
mouse |
| Smitha V Bava, Vineshkumar T Puliyappadamba, Ayswaria Deepti, Asha Nair, Devarajan Karunagaran, Ruby John Ant. Sensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factor-κ B and the serine/threonine kinase Akt and is independent of tubulin polymerization. The Journal of biological chemistry. vol 293. issue 31. 2021-03-17. PMID:30076255. |
sensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factor-κ b and the serine/threonine kinase akt and is independent of tubulin polymerization. |
2021-03-17 |
2023-08-13 |
Not clear |
| Guiqin Hou, Ang Jia, Li Yang, Yu Zhao, Yi Hu, Wuduo Zhao, Wen Zhao, Hong-Min Liu, Zhaoming L. OP16 induces deadly autophagy and apoptosis of cells by inhibiting Akt in esophageal squamous cell carcinoma. Molecular and cellular biochemistry. vol 472. issue 1-2. 2021-03-17. PMID:32671513. |
op16 induces deadly autophagy and apoptosis of cells by inhibiting akt in esophageal squamous cell carcinoma. |
2021-03-17 |
2023-08-13 |
Not clear |
| Hongzhe Li, Xiaojian Wang, Nan Li, Jianming Qiu, Yuanyuan Zhang, Xuetao Ca. Withdrawal: hPEBP4 resists TRAIL-induced apoptosis of human prostate cancer cells by activating Akt and deactivating ERK1/2 pathways. The Journal of biological chemistry. vol 295. issue 39. 2021-03-17. PMID:32978331. |
withdrawal: hpebp4 resists trail-induced apoptosis of human prostate cancer cells by activating akt and deactivating erk1/2 pathways. |
2021-03-17 |
2023-08-13 |
human |
| Camila M Baldavira, Juliana Machado-Rugolo, Tabatha G Prieto, Daniel R Bastos, Marcelo Balancin, Alexandre M Ab'Saber, Lygia B Yaegashi, Paola C Souza, Cecilia Farhat, Teresa Y Takagaki, Maria Ap Nagai, Vera L Capelozz. The expression patterns and prognostic significance of pleckstrin homology-like domain family A (PHLDA) in lung cancer and malignant mesothelioma. Journal of thoracic disease. vol 13. issue 2. 2021-03-16. PMID:33717542. |
pleckstrin homology domain family a (phlda) genes play important roles in cancer cellular processes, including inhibiting akt activation, repressing growth factor signaling, inhibiting the negative feedback of egfr/erbb2 signaling cells, and inducing apoptosis. |
2021-03-16 |
2023-08-13 |
Not clear |
| Wei Lei, Zhenyun Hu. Jervine inhibits non-small cell lung cancer (NSCLC) progression by suppressing Hedgehog and AKT signaling via triggering autophagy-regulated apoptosis. Biochemical and biophysical research communications. vol 533. issue 3. 2021-03-15. PMID:32972750. |
jervine inhibits non-small cell lung cancer (nsclc) progression by suppressing hedgehog and akt signaling via triggering autophagy-regulated apoptosis. |
2021-03-15 |
2023-08-13 |
mouse |
| Wei Lei, Zhenyun Hu. Jervine inhibits non-small cell lung cancer (NSCLC) progression by suppressing Hedgehog and AKT signaling via triggering autophagy-regulated apoptosis. Biochemical and biophysical research communications. vol 533. issue 3. 2021-03-15. PMID:32972750. |
importantly, promoting akt activation greatly rescued the cell survival, while attenuated autophagy and apoptosis in jer-incubated nsclc cells, revealing that jer-modulated autophagic cell death was through the blockage of akt signaling. |
2021-03-15 |
2023-08-13 |
mouse |