| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Genshen Cai, Jing Zhang, Rupeng Wan. [Down-regulation of PHLPP1 expression ameliorates high glucose-induced autophagy inhibition and apoptosis promotion of podocytes by activating PI3K/AKT/mTOR pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 37. issue 1. 2021-02-01. PMID:33441223. |
compared with hg group, the apoptosis rate and c-caspase-3 protein expression in the hg combined with si-phlpp1 group were significantly reduced, while autophagy level, pi3k protein expression and phosphorylation level of mtor and akt protein were significantly elevated. |
2021-02-01 |
2023-08-13 |
human |
| Ziheng Zhang, Renyu Lin, Zhoudi Liu, Tao Yan, Yiqun Xia, Leping Zhao, Feng Lin, Xi Zhang, Chenglong Li, Yi Wan. Curcumin analog, WZ37, promotes G2/M arrest and apoptosis of HNSCC cells through Akt/mTOR inhibition. Toxicology in vitro : an international journal published in association with BIBRA. vol 65. 2021-01-29. PMID:31863822. |
moreover, co-treatment of wz37 with mk-2206 (akt inhibitor) promoted cancer cell apoptosis. |
2021-01-29 |
2023-08-13 |
Not clear |
| Zhimin Ruan, Tianshu Chu, Liyong Wu, Mingguo Zhang, Mei Zheng, Qian Zhang, Mingli Zhou, Guofu Zh. miR-155 inhibits oxidized low-density lipoprotein-induced apoptosis in different cell models by targeting the p85α/AKT pathway. Journal of physiology and biochemistry. vol 76. issue 2. 2021-01-29. PMID:32277342. |
the results demonstrated that mir-155 inhibited p85α expression and attenuated vec, vsmc, and macrophage apoptosis, at least in part by suppressing the expression of p85α-activated akt to inhibit apoptosis. |
2021-01-29 |
2023-08-13 |
mouse |
| Mingning Qiu, Jie Liu, Yongxia Su, Rong Guo, Baoyu Zhao, Jianjun Li. Diosmetin Induces Apoptosis by Downregulating AKT Phosphorylation via P53 Activation in Human Renal Carcinoma ACHN Cells. Protein and peptide letters. vol 27. issue 10. 2021-01-28. PMID:32223728. |
diosmetin induces apoptosis by downregulating akt phosphorylation via p53 activation in human renal carcinoma achn cells. |
2021-01-28 |
2023-08-13 |
human |
| Floriana Morgillo, Carminia Maria Della Corte, Morena Fasano, Fortunato Ciardiell. Mechanisms of resistance to EGFR-targeted drugs: lung cancer. ESMO open. vol 1. issue 3. 2021-01-26. PMID:27843613. |
several mechanisms of resistance have been described to egfr-tkis, such as the occurrence of secondary mutation (t790m, c797s), the activation of alternative signalling (met, hgf, axl, hh, igf-1r), the aberrance of the downstream pathways (akt mutations, loss of pten), the impairment of the egfr-tkis-mediated apoptosis pathway (bcl2-like 11/bim deletion polymorphism) and histological transformation. |
2021-01-26 |
2023-08-13 |
Not clear |
| Seung Mi Choi, Young Sik Cho, Geumi Park, Suk Kyeong Lee, Kyung-Soo Chu. Celecoxib induces apoptosis through Akt inhibition in 5-fluorouracil-resistant gastric cancer cells. Toxicological research. vol 37. issue 1. 2021-01-26. PMID:33489855. |
celecoxib induces apoptosis through akt inhibition in 5-fluorouracil-resistant gastric cancer cells. |
2021-01-26 |
2023-08-13 |
Not clear |
| Fanggui Xu, Feng Zhu, Wulin Wang, Wenjie Gao, Xin Chen, Chunzhao Y. Down-regulation of miRNA-196b expression inhibits the proliferation, migration and invasiveness of HepG2 cells while promoting their apoptosis via the PI3K/Akt signaling pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 66. issue 3. 2021-01-22. PMID:32538764. |
the hepg2 cells were also treated with pi3k/akt signaling pathway inhibitor ly294002, and its effect on cell proliferation, migration, invasion, and apoptosis, and expressions of pik3, akt, and p-akt proteins were determined. |
2021-01-22 |
2023-08-13 |
Not clear |
| Xiao-Hui Zhang, Jia-Xin Wu, Jun-Zhou Sha, Bo Yang, Jia-Rui Sun, En-Dong Ba. Heat shock protein 90 relieves heat stress damage of myocardial cells by regulating Akt and PKM2 signaling in vivo. International journal of molecular medicine. vol 45. issue 6. 2021-01-21. PMID:32236591. |
higher hsp90 levels inhibited hs‑induced myocardial damage and apoptosis, and mitochondrial dysfunction, by stimulating akt (protein kinase b) activation and pkm2 (pyruvate kinase m2) signaling, and subsequently increasing mitochondrial bcl‑2 (b‑cell lymphoma 2) levels and its phosphorylation. |
2021-01-21 |
2023-08-13 |
mouse |
| Xin Zhang, Yuyan Wang, Xiumei Liu, Anqi Zhao, Zhongheng Yang, Fanshuang Kong, Lili Sun, Yingyu Yu, Lipeng Jian. KIF2A promotes the progression via AKT signaling pathway and is upregulated by transcription factor ETV4 in human gastric cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 125. 2021-01-19. PMID:32106376. |
in summary, kif2a is upregulated by transcription factor etv4, and its knockdown can effectively inhibit the proliferation and induce the apoptosis of gc cells through the akt signaling pathway in gc cells, implying that the inhibition of kif2a expression is a potential target for gc therapy. |
2021-01-19 |
2023-08-13 |
human |
| Medhavi Ranatunga, Rajeev Rai, Simon C W Richardson, Paul Dyer, Laurence Harbige, Andrew Deacon, Lauren Pecorino, Giulia T M Gett. Leishmania aethiopica cell-to-cell spreading involves caspase-3, AkT, and NF-κB but not PKC-δ activation and involves uptake of LAMP-1-positive bodies containing parasites. The FEBS journal. vol 287. issue 9. 2021-01-18. PMID:31804757. |
collectively, these findings indicate that host cell apoptosis, demonstrated by ps exhibition, caspase-3 activation, cytochrome c release, downregulation of akt, bad phosphorylation, nf-kb activation, and independent of pkc-δ expression, is involved in l. aethiopica spreading. |
2021-01-18 |
2023-08-13 |
human |
| Wenjing Diao, Qisang Guo, Caiying Zhu, Yu Song, Hua Feng, Yuankui Cao, Ming Du, Huifen Che. USP18 promotes cell proliferation and suppressed apoptosis in cervical cancer cells via activating AKT signaling pathway. BMC cancer. vol 20. issue 1. 2021-01-15. PMID:32770981. |
usp18 promotes cell proliferation and suppressed apoptosis in cervical cancer cells via activating akt signaling pathway. |
2021-01-15 |
2023-08-13 |
human |
| Natalia Prudente de Mello, Diana Zukas Andreotti, Ana Maria Orellana, Cristoforo Scavone, Elisa Mitiko Kawamot. Inverse sex-based expression profiles of PTEN and Klotho in mice. Scientific reports. vol 10. issue 1. 2021-01-13. PMID:33214645. |
here, under physiological conditions, we show important sex differences in the underlying balancing mechanisms that lead to similar akt activity levels and autophagy and apoptosis processes in the two sexes. |
2021-01-13 |
2023-08-13 |
mouse |
| Yinmei Zhang, Junxiong Wang, Boxin Yang, Rui Qiao, Aiwei Li, Han Guo, Jie Ding, Hui Li, Hong Ye, Di Wu, Liyan Cui, Shuo Yan. Transfer of MicroRNA-216a-5p From Exosomes Secreted by Human Urine-Derived Stem Cells Reduces Renal Ischemia/Reperfusion Injury. Frontiers in cell and developmental biology. vol 8. 2021-01-11. PMID:33415108. |
uscs-exos were rich in mir-216a-5p, which targeted phosphatase and tensin homolog (pten) and regulated cell apoptosis through the akt pathway. |
2021-01-11 |
2023-08-13 |
human |
| Yinmei Zhang, Junxiong Wang, Boxin Yang, Rui Qiao, Aiwei Li, Han Guo, Jie Ding, Hui Li, Hong Ye, Di Wu, Liyan Cui, Shuo Yan. Transfer of MicroRNA-216a-5p From Exosomes Secreted by Human Urine-Derived Stem Cells Reduces Renal Ischemia/Reperfusion Injury. Frontiers in cell and developmental biology. vol 8. 2021-01-11. PMID:33415108. |
exposure of hypoxic hk-2 cells to uscs-exos pretreated with anti-mir-216a-5p can prevent the increase of mir-216-5p and akt phosphorylation levels, restore pten expression, and promote apoptosis. |
2021-01-11 |
2023-08-13 |
human |
| Ming-Ju Hsieh, Chiao-Wen Lin, Shih-Chi Su, Russel J Reiter, Andy Wei-Ge Chen, Mu-Kuan Chen, Shun-Fa Yan. Effects of miR-34b/miR-892a Upregulation and Inhibition of ABCB1/ABCB4 on Melatonin-Induced Apoptosis in VCR-Resistant Oral Cancer Cells. Molecular therapy. Nucleic acids. vol 19. 2021-01-10. PMID:31982774. |
we determined that melatonin induced the apoptosis and autophagy of vcr-resistant oral cancer cells; these actions were mediated by akt, p38, and c-jun n-terminal kinase (jnk). |
2021-01-10 |
2023-08-13 |
human |
| Yang Chen, Haiyan Ding, Min Wei, Wenhui Zha, Shuang Guan, Ning Liu, Yang Li, Yuan Tan, Yan Wang, Fuju W. MSC-Secreted Exosomal H19 Promotes Trophoblast Cell Invasion and Migration by Downregulating let-7b and Upregulating FOXO1. Molecular therapy. Nucleic acids. vol 19. 2021-01-10. PMID:32069774. |
msc-derived exosomes overexpressing h19 decreased let-7b, increased foxo1, and activated the protein kinase b (akt) signaling pathway, thus increasing invasion and migration and inhibiting apoptosis of trophoblast cells. |
2021-01-10 |
2023-08-13 |
Not clear |
| Dingqi Sun, Jinhua Wang, Hui Zhang, Shuai Liu, Peng Wei, Haoran Wang, Zhen Xu, Qiang Fu, Keqin Zhan. MK2206 Enhances Cisplatin-Induced Cytotoxicity and Apoptosis in Testicular Cancer Through Akt Signaling Pathway Inhibition. Translational oncology. vol 13. issue 7. 2021-01-10. PMID:32422572. |
mk2206 enhances cisplatin-induced cytotoxicity and apoptosis in testicular cancer through akt signaling pathway inhibition. |
2021-01-10 |
2023-08-13 |
Not clear |
| Dingqi Sun, Jinhua Wang, Hui Zhang, Shuai Liu, Peng Wei, Haoran Wang, Zhen Xu, Qiang Fu, Keqin Zhan. MK2206 Enhances Cisplatin-Induced Cytotoxicity and Apoptosis in Testicular Cancer Through Akt Signaling Pathway Inhibition. Translational oncology. vol 13. issue 7. 2021-01-10. PMID:32422572. |
in this study, we attempted to elucidate how mk2206, an allosteric akt inhibitor, enhances the cisplatin (cddp)-induced cytotoxicity and apoptosis in testicular cancer. |
2021-01-10 |
2023-08-13 |
Not clear |
| Guan-Sheng Liu, George Gardner, George Adly, Min Jiang, Wen-Feng Cai, Chi Keung Lam, Fawzi Alogaili, Nathan Robbins, Jack Rubinstein, Evangelia G Krania. A novel human S10F-Hsp20 mutation induces lethal peripartum cardiomyopathy. Journal of cellular and molecular medicine. 2021-01-09. PMID:29761889. |
subsequent studies revealed that cardiomyocyte apoptosis was elevated in mutant female hearts after the third delivery, associated with decreases in the levels of bcl-2/bax and akt phosphorylation. |
2021-01-09 |
2023-08-13 |
mouse |
| Hongyong Fu, Wenhui Zhang, Qingqing Yuan, Minghui Niu, Fan Zhou, Qianqian Qiu, Guoping Mao, Hong Wang, Liping Wen, Min Sun, Zheng Li, Zuping H. PAK1 Promotes the Proliferation and Inhibits Apoptosis of Human Spermatogonial Stem Cells via PDK1/KDR/ZNF367 and ERK1/2 and AKT Pathways. Molecular therapy. Nucleic acids. vol 12. 2021-01-09. PMID:30141410. |
pak1 promotes the proliferation and inhibits apoptosis of human spermatogonial stem cells via pdk1/kdr/znf367 and erk1/2 and akt pathways. |
2021-01-09 |
2023-08-13 |
human |