| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lang Zhao, Kang Fu, Xiaoxing Li, Rui Zhang, Wenjun Wang, Feng Xu, Xiaoping Ji, Yuguo Chen, Chuanbao L. Aldehyde dehydrogenase 2 protects cardiomyocytes against lipotoxicity via the AKT/glycogen synthase kinase 3 beta pathways. Biochemical and biophysical research communications. vol 525. issue 2. 2020-11-09. PMID:32089266. |
in addition, aldehyde dehydrogenase 2 overexpression inhibited the expression of bcl2 associated x, apoptosis regulator (bax) and caspase 3, while it enhanced protein kinase b (akt) and glycogen synthase kinase 3 beta (gsk-3β) phosphorylation. |
2020-11-09 |
2023-08-13 |
Not clear |
| Ya-Nan Sheng, Ying-Hua Luo, Shao-Bin Liu, Wan-Ting Xu, Yu Zhang, Tong Zhang, Hui Xue, Wen-Bo Zuo, Yan-Nan Li, Chang-Yuan Wang, Cheng-Hao Ji. Zeaxanthin Induces Apoptosis via ROS-Regulated MAPK and AKT Signaling Pathway in Human Gastric Cancer Cells. OncoTargets and therapy. vol 13. 2020-11-06. PMID:33149614. |
zeaxanthin induces apoptosis via ros-regulated mapk and akt signaling pathway in human gastric cancer cells. |
2020-11-06 |
2023-08-13 |
human |
| Lu Chen, Shuming Zhang, Yaqian Shen, Linzeng Qi, Zhaolin Zhang, Hua Tian, Zhigeng Zo. Thymus‑expressed chemokine secreted by breast cancer cells promotes metastasis and inhibits apoptosis. Oncology reports. vol 43. issue 6. 2020-11-05. PMID:32323823. |
emt markers, akt pathway molecules and apoptosis indicators were detected by reverse transcription‑quantitative pcr or wb. |
2020-11-05 |
2023-08-13 |
mouse |
| Lu Chen, Shuming Zhang, Yaqian Shen, Linzeng Qi, Zhaolin Zhang, Hua Tian, Zhigeng Zo. Thymus‑expressed chemokine secreted by breast cancer cells promotes metastasis and inhibits apoptosis. Oncology reports. vol 43. issue 6. 2020-11-05. PMID:32323823. |
furthermore, teck could increase cell migration and invasion by promoting emt and inhibit apoptosis via the akt signaling pathway. |
2020-11-05 |
2023-08-13 |
mouse |
| Zita Bognar, Anna Maria Cseh, Katalin Fekete, Csenge Antus, Rita Bognar, Antal Tapodi, Fadi H J Ramadan, Balazs Sumegi, Ferenc Gallya. Amiodarone's major metabolite, desethylamiodarone inhibits proliferation of B16-F10 melanoma cells and limits lung metastasis formation in an in vivo experimental model. PloS one. vol 15. issue 9. 2020-11-04. PMID:32977329. |
it arrested the cells in g0/g1 phase of their cycle likely via p21 in a p53-dependent fashion, and induced caspase mediated apoptosis likely via inversely regulating bcl-2 and bax levels, and reducing akt and erk1/2 activation. |
2020-11-04 |
2023-08-13 |
Not clear |
| Neeraj Chauhan, Diane M Maher, Murali M Yallapu, Bilal B Hafeez, Man M Singh, Subhash C Chauhan, Meena Jagg. A triphenylethylene nonsteroidal SERM attenuates cervical cancer growth. Scientific reports. vol 9. issue 1. 2020-11-03. PMID:31358785. |
ormeloxifene efficiently attenuated tumorigenic and metastatic properties of cervical cancer cells via arresting cell cycle at g1-s transition, inducing apoptosis, decreasing pi3k and akt phosphorylation, mitochondrial membrane potential, and modulating g1-s transition related proteins (p21, cyclin e and cdk2). |
2020-11-03 |
2023-08-13 |
mouse |
| Alina Jaglanian, Evangelia Tsian. Rosemary Extract Inhibits Proliferation, Survival, Akt, and mTOR Signaling in Triple-Negative Breast Cancer Cells. International journal of molecular sciences. vol 21. issue 3. 2020-11-03. PMID:32012648. |
furthermore, re inhibited the phosphorylation/activation of akt and mtor and enhanced the cleavage of parp, a marker of apoptosis. |
2020-11-03 |
2023-08-13 |
human |
| Lin-Hua Deng, Lan Li, You Zhai, Sarhene Michael, Chun-Yang Yang, Rui Guo, Shan-Fu Chen, Guan-Wei Fan, Ying-Qiang Zhao, Wei Li. Tianma Gouteng Decoction Exerts Cardiovascular Protection by Upregulating OPG and TRAIL in Spontaneously Hypertensive Rats. Evidence-based complementary and alternative medicine : eCAM. vol 2020. 2020-11-03. PMID:33133215. |
therefore, tgd may reverse cardiovascular remodeling in shr by upregulating the expression of opg and trail, upregulating akt, and inhibiting apoptosis, at least in part. |
2020-11-03 |
2023-08-13 |
rat |
| Aiting Yan, Cuizhu Wang, Liangfeng Zheng, Jiebo Zhou, Yan Zhan. MicroRNA-454-3p inhibits cell proliferation and invasion in esophageal cancer by targeting insulin-like growth factor 2 mRNA-binding protein 1. Oncology letters. vol 20. issue 6. 2020-11-03. PMID:33133259. |
furthermore, it was demonstrated that mir-454-3p inhibited esca cell proliferation, migration and apoptosis by targeting igf2bp1 via the erk and akt signaling pathways in a subcutaneous xenograft tumor mouse model. |
2020-11-03 |
2023-08-13 |
mouse |
| Haojun Yang, Jie Zhu, Guangyao Wang, Hanyang Liu, Yan Zhou, Jun Qia. STK35 Is Ubiquitinated by NEDD4L and Promotes Glycolysis and Inhibits Apoptosis Through Regulating the AKT Signaling Pathway, Influencing Chemoresistance of Colorectal Cancer. Frontiers in cell and developmental biology. vol 8. 2020-10-30. PMID:33117809. |
stk35 is ubiquitinated by nedd4l and promotes glycolysis and inhibits apoptosis through regulating the akt signaling pathway, influencing chemoresistance of colorectal cancer. |
2020-10-30 |
2023-08-13 |
Not clear |
| Jiang Yang, Munir M Zaman, Iliyan Vlasakov, Roopali Roy, Lan Huang, Camilia R Martin, Steven D Freedman, Charles N Serhan, Marsha A Mose. Adipocytes promote ovarian cancer chemoresistance. Scientific reports. vol 9. issue 1. 2020-10-29. PMID:31527632. |
aa acts on ovca cells directly, not through its downstream derivatives such as prostaglandins, to activate akt and inhibit cisplatin-induced apoptosis. |
2020-10-29 |
2023-08-13 |
Not clear |
| Christiana M Neophytou, Avgoustinos Mesaritis, Gregoria Gregoriou, Andreas I Constantino. d-a-Tocopheryl Polyethylene Glycol 1000 Succinate and a small-molecule Survivin suppressant synergistically induce apoptosis in SKBR3 breast cancer cells. Scientific reports. vol 9. issue 1. 2020-10-29. PMID:31591437. |
the combination of these agents reduced activation of the akt pathway, decreased survivin and bcl-2 levels, and induced caspase-dependent and independent apoptosis via the mitochondrial pathway. |
2020-10-29 |
2023-08-13 |
Not clear |
| Jie He, Henhua Dai, Qian Zhao, Jianshu Guo, Chi Che. LNCRNA Gas5 suppression protected Hl-1 cells against hypoxia injury by sponging Mir-222-3p. Experimental and molecular pathology. vol 115. 2020-10-29. PMID:32240616. |
then, the correlation of gas5 and mir-222-3p was measured which showed that mir-222-3p could resume the functions of gas5 in cell viabilities and apoptosis through protein regulation in pi3k and akt signaling pathways. |
2020-10-29 |
2023-08-13 |
human |
| Donatella Romaniello, Ilaria Marrocco, Nishanth Belugali Nataraj, Irene Ferrer, Diana Drago-Garcia, Itay Vaknin, Roni Oren, Moshit Lindzen, Soma Ghosh, Matthew Kreitman, Jeanette Clarissa Kittel, Nadege Gaborit, Gretchen Bergado Baez, Belinda Sanchez, Raya Eilam, Eli Pikarsky, Luis Paz-Ares, Yosef Yarde. Targeting HER3, a Catalytically Defective Receptor Tyrosine Kinase, Prevents Resistance of Lung Cancer to a Third-Generation EGFR Kinase Inhibitor. Cancers. vol 12. issue 9. 2020-10-28. PMID:32847130. |
we found that the underlying mechanism involves posttranslational downregulation of her3, suppression of met and axl upregulation, as well as concomitant inhibition of akt signaling and upregulation of bim, which mediates apoptosis. |
2020-10-28 |
2023-08-13 |
Not clear |
| Gul-E-Saba Chaudhry, Abdah Akim, Muhammad Naveed Zafar, M A Abdullah, Yeong Yik Sung, Tengku Sifzizul Tengku Muhamma. Induction of apoptosis and role of paclitaxel-loaded hyaluronic acid-crosslinked nanoparticles in the regulation of AKT and RhoA. Journal of advanced pharmaceutical technology & research. vol 11. issue 3. 2020-10-28. PMID:33102192. |
induction of apoptosis and role of paclitaxel-loaded hyaluronic acid-crosslinked nanoparticles in the regulation of akt and rhoa. |
2020-10-28 |
2023-08-13 |
Not clear |
| Gerda M Sanvee, Jamal Bouitbir, Stephan Krähenbüh. Insulin prevents and reverts simvastatin-induced toxicity in C2C12 skeletal muscle cells. Scientific reports. vol 9. issue 1. 2020-10-26. PMID:31092879. |
impaired activation of akt increased mrna expression of the muscle atrophy f-box (mafbx), decreased activation of the mammalian target of rapamycin complex 1 (mtorc1) and stimulated apoptosis by impairing the ser9 phosphorylation of glycogen synthase kinase 3β. |
2020-10-26 |
2023-08-13 |
Not clear |
| Gerda M Sanvee, Jamal Bouitbir, Stephan Krähenbüh. Insulin prevents and reverts simvastatin-induced toxicity in C2C12 skeletal muscle cells. Scientific reports. vol 9. issue 1. 2020-10-26. PMID:31092879. |
decreased phosphorylation of akt at both phosphorylation sites and of downstream substrates as well as apoptosis were prevented concentration-dependently by insulin. |
2020-10-26 |
2023-08-13 |
Not clear |
| Yan-Yan Luo, Sheng-Hua Wu, Hong-Yan Lu, Bing-Jie Li, Shu-Jun Li, Zhong-Yi Sun, Rui Jin, Xiao-Qing Che. Lipoxin A4 attenuates hyperoxia‑induced lung epithelial cell injury via the upregulation of heme oxygenase‑1 and inhibition of proinflammatory cytokines. Molecular medicine reports. vol 21. issue 1. 2020-10-26. PMID:31746387. |
the cell survival rates, cell viability, apoptosis rates, expression of superoxide dismutase (sod), heme oxygenase‑1 (ho‑1), il‑6 and mcp‑1, and the activations of p38 mapk, erk1/2 and akt were measured. |
2020-10-26 |
2023-08-13 |
Not clear |
| Juan Tornin, Miguel Mateu-Sanz, Aida Rodríguez, Cédric Labay, Rene Rodríguez, Cristina Cana. Pyruvate Plays a Main Role in the Antitumoral Selectivity of Cold Atmospheric Plasma in Osteosarcoma. Scientific reports. vol 9. issue 1. 2020-10-23. PMID:31337843. |
os cells show higher sensitivity to pam treatment than healthy cells, both in medium with and without pyruvate, activating apoptosis, dna damage and deregulating cellular pathways mediated by c-jun, akt, ampk or stat3. |
2020-10-23 |
2023-08-13 |
Not clear |
| Takuya Masunaga, Naoki Murao, Hiroshi Tateishi, Ryoko Koga, Takeo Ohsugi, Masami Otsuka, Mikako Fujit. Anti-cancer activity of the cell membrane-permeable phytic acid prodrug. Bioorganic chemistry. vol 92. 2020-10-22. PMID:31525525. |
cellular experiments using pro-ip6 demonstrated selective anti-cancer effects including apoptosis and inhibition of akt activation. |
2020-10-22 |
2023-08-13 |
mouse |