| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qinglin Li, Yunpeng Bai, L Tiffany Lyle, Guimei Yu, Ovini Amarasinghe, Frederick Nguele Meke, Colin Carlock, Zhong-Yin Zhan. Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 34. 2020-10-22. PMID:32788364. |
prl2 deficiency elevates pten and attenuates akt signaling, leading to decreased proliferation and increased apoptosis in tumors. |
2020-10-22 |
2023-08-13 |
human |
| Han-Tsang Wu, Yi-En Liu, Kai-Wen Hsu, Yu-Fen Wang, Ya-Chi Chan, Yeh Chen, Dar-Ren Che. MLL3 Induced by Luteolin Causes Apoptosis in Tamoxifen-Resistant Breast Cancer Cells through H3K4 Monomethylation and Suppression of the PI3K/AKT/mTOR Pathway. The American journal of Chinese medicine. vol 48. issue 5. 2020-10-20. PMID:32668964. |
the combination treatment of luteolin and pi3k, akt, or mtor inhibitors synergistically increases apoptosis in tamoxifen-resistant er-positive breast cancer cells. |
2020-10-20 |
2023-08-13 |
Not clear |
| Chuan Hua He, Chun Geun Lee, Bing Ma, Suchitra Kamle, Augustine M K Choi, Jack A Elia. American journal of respiratory cell and molecular biology. vol 63. issue 3. 2020-10-16. PMID:32402213. |
the binding of the former activates mitogen-activated protein kinase, akt, and wnt/β-catenin signaling, and plays important roles in innate and adaptive immunity, cellular apoptosis, oxidative injury, allergic inflammation, tumor metastasis and wound healing, fibrosis, and repair in the lung. |
2020-10-16 |
2023-08-13 |
Not clear |
| Min Du, Gang Wen, Juan Jin, Yuanguang Chen, Jun Cao, Aman X. Mangiferin prevents the growth of gastric carcinoma by blocking the PI3K-Akt signalling pathway. Anti-cancer drugs. vol 29. issue 2. 2020-10-15. PMID:29215373. |
interestingly, the proapoptotic effect of mangiferin on sgc-7901 cells was partially blocked by the akt activator sc79, whereas ly294002 significantly increased mangiferin-induced apoptosis and growth inhibition. |
2020-10-15 |
2023-08-13 |
Not clear |
| Retraction of: Reactive Nitrogen Species Induced by Hyperglycemia Suppresses Akt Signaling and Triggers Apoptosis by Upregulating Phosphatase PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) in an LKB1-Dependent Manner. Circulation. vol 142. issue 15. 2020-10-13. PMID:32975449. |
retraction of: reactive nitrogen species induced by hyperglycemia suppresses akt signaling and triggers apoptosis by upregulating phosphatase pten (phosphatase and tensin homologue deleted on chromosome 10) in an lkb1-dependent manner. |
2020-10-13 |
2023-08-13 |
Not clear |
| Xuefeng Gu, Guoqing Wan, Yue Yang, Yihao Liu, Xintong Yang, Yanjun Zheng, Liying Jiang, Peng Zhang, Dingsheng Liu, Weiming Zhao, Gang Huang, Changlian L. SLFN5 influences proliferation and apoptosis by upregulating PTEN transcription via ZEB1 and inhibits the purine metabolic pathway in breast cancer. American journal of cancer research. vol 10. issue 9. 2020-10-13. PMID:33042620. |
knockdown and overexpression of slfn5 in brca cell lines proved that slfn5 can inhibit cell proliferation and colony formation and promote apoptosis by upregulating the transcription of a known cancer suppressor gene (the phosphatase and tensin homologue on chromosome 10, pten), resulting in molecular changes in the downstream akt pathway and in proliferation/apoptosis. |
2020-10-13 |
2023-08-13 |
mouse |
| Ekaterina Kim, Elisa Ten Hacken, Mariela Sivina, Astrid Clarke, Philip A Thompson, Nitin Jain, Alessandra Ferrajoli, Zeev Estrov, Michael J Keating, William G Wierda, Kapil N Bhalla, Jan A Burge. The BET inhibitor GS-5829 targets chronic lymphocytic leukemia cells and their supportive microenvironment. Leukemia. vol 34. issue 6. 2020-10-07. PMID:31862959. |
gs-5829 inhibited cll cell proliferation and induced leukemia cell apoptosis through deregulation of key signaling pathways, such as blk, akt, erk1/2, and myc. |
2020-10-07 |
2023-08-13 |
Not clear |
| H-B Sun, L Xu, Z-X Wang, Y Zheng, Y Zhao, Y-Y Yin, X-L Han, Z-N X. Polyoxometalate SbW9 regulates proliferation and apoptosis of NSCLC cells via PTEN-dependent AKT signaling pathway. European review for medical and pharmacological sciences. vol 23. issue 18. 2020-10-06. PMID:31599421. |
polyoxometalate sbw9 regulates proliferation and apoptosis of nsclc cells via pten-dependent akt signaling pathway. |
2020-10-06 |
2023-08-13 |
Not clear |
| Xinmin Zhao, Xianghua Wu, Huijie Wang, Hui Yu, Jialei Wan. USP53 promotes apoptosis and inhibits glycolysis in lung adenocarcinoma through FKBP51-AKT1 signaling. Molecular carcinogenesis. vol 59. issue 8. 2020-10-06. PMID:32511815. |
functional assays were carried out to examine the impact of usp53 and akt pathway on lung adenocarcinoma cell viability, apoptosis, and glycolysis in vitro, as well as tumor growth in vivo. |
2020-10-06 |
2023-08-13 |
human |
| Cheng-Yi Chang, Jian-Ri Li, Chih-Cheng Wu, Jiaan-Der Wang, Su-Lan Liao, Wen-Ying Chen, Wen-Yi Wang, Chun-Jung Che. Endoplasmic Reticulum Stress Contributes to Indomethacin-Induced Glioma Apoptosis. International journal of molecular sciences. vol 21. issue 2. 2020-10-05. PMID:31952288. |
indomethacin-induced glioma cell apoptosis was accompanied by a series of biochemical changes, including reactive oxygen species generation, endoplasmic reticulum (er) stress, apoptosis signal-regulating kinase-1 (ask1) activation, p38 hyperphosphorylation, protein phosphatase 2a (pp2a) activation, akt dephosphorylation, mcl-1 and flice-inhibiting protein (flip) downregulation, bax mitochondrial distribution, and caspases 3/caspase 8/caspase 9 activation. |
2020-10-05 |
2023-08-13 |
human |
| Yunhua Tang, Xiangyang Zhang, Fan Qi, Mingfeng Chen, Yuan Li, Longfei Liu, Wei He, Zhuo Li, Xiongbing Z. Afatinib inhibits proliferation and invasion and promotes apoptosis of the T24 bladder cancer cell line. Experimental and therapeutic medicine. vol 9. issue 5. 2020-10-01. PMID:26136904. |
mtt assay was used to estimate the proliferation of the t24 cells; flow cytometric analysis was used to estimate the effect of afatinib on t24 cell apoptosis; cell invasion ability was assessed by a transwell invasion assay; and western blot analysis was used to detect the expression of bcl-2, bax, akt, extracellular-signal-regulated kinase (erk)1/2, matrix metalloproteinase (mmp)-2 and mmp-9. |
2020-10-01 |
2023-08-13 |
human |
| Qin-Fang Deng, B O Su, Yin-Min Zhao, Liang Tang, Jie Zhang, Cai-Cun Zho. Integrin β1-mediated acquired gefitinib resistance in non-small cell lung cancer cells occurs via the phosphoinositide 3-kinase-dependent pathway. Oncology letters. vol 11. issue 1. 2020-10-01. PMID:26870244. |
cell cycle progression and apoptosis were analyzed by flow cytometry, while western blotting was used to evaluate the expression of egfr, phosphorylated (phospho)-egfr, protein kinase b (akt), phospho-akt, extracellular signal-regulated kinase (erk) and phospho-erk. |
2020-10-01 |
2023-08-13 |
Not clear |
| Kaixiong Tao, Yuping Yin, Qian Shen, Ying Chen, Ruidong Li, Weilong Chang, Jie Bai, Weizhen Liu, Liang Shi, Peng Zhan. Akt inhibitor MK-2206 enhances the effect of cisplatin in gastric cancer cells. Biomedical reports. vol 4. issue 3. 2020-10-01. PMID:26998277. |
the mtt assay demonstrated that sequential treatment of cisplatin, followed by the akt inhibitor, mk-2206, caused a synergistic effect of proliferation inhibition, and the apoptosis assay by propidium iodide/fluorescein isothiocyanate staining also showed that combination treatment induced more apoptosis compared to the monotherapy groups. |
2020-10-01 |
2023-08-13 |
human |
| Kaixiong Tao, Yuping Yin, Qian Shen, Ying Chen, Ruidong Li, Weilong Chang, Jie Bai, Weizhen Liu, Liang Shi, Peng Zhan. Akt inhibitor MK-2206 enhances the effect of cisplatin in gastric cancer cells. Biomedical reports. vol 4. issue 3. 2020-10-01. PMID:26998277. |
using western blot analysis, mk-2206 was shown to significantly suppress the phosphorylation of akt (ser473), however, the expression of total akt remained the same, and the combination treatment also increased the expression of cleaved poly adenosine diphosphate ribose polymerase, which contributed to apoptosis. |
2020-10-01 |
2023-08-13 |
human |
| Richard L Carpenter, Hui-Wen L. Regulation of Apoptosis by HER2 in Breast Cancer. Journal of carcinogenesis & mutagenesis. vol 2013. issue Suppl 7. 2020-10-01. PMID:27088047. |
her2 also suppresses p53-mediated apoptosis by upregulation of mdm2 by activation of akt. |
2020-10-01 |
2023-08-13 |
Not clear |
| Gui'e Xie, Xinpei Yu, Huichao Liang, Jingsong Chen, Xuewei Tang, Shaoqing Wu, Can Lia. Pristimerin overcomes adriamycin resistance in breast cancer cells through suppressing Akt signaling. Oncology letters. vol 11. issue 5. 2020-10-01. PMID:27123073. |
the results demonstrated that pristimerin indeed displayed potent cytocidal effect on multidrug-resistant mcf-7/adr breast cancer cells, and that these effects occurred through the suppression of akt signaling, which in turn led to the downregulation of antiapoptotic effectors and increased apoptosis. |
2020-10-01 |
2023-08-13 |
human |
| Peng Fu, Quan H. 3,4-Dihydroxyphenylethanol alleviates early brain injury by modulating oxidative stress and Akt and nuclear factor-κB pathways in a rat model of subarachnoid hemorrhage. Experimental and therapeutic medicine. vol 11. issue 5. 2020-10-01. PMID:27168841. |
these results provide evidence that dopet attenuates apoptosis in a rat sah model through modulating oxidative stress and akt and nf-κb signaling pathways. |
2020-10-01 |
2023-08-13 |
rat |
| Maria Cosenza, Monica Civallero, Stefania Fiorcari, Samantha Pozzi, Luigi Marcheselli, Alessia Bari, Paola Ferri, Stefano Sacch. The histone deacetylase inhibitor romidepsin synergizes with lenalidomide and enhances tumor cell death in T-cell lymphoma cell lines. Cancer biology & therapy. vol 17. issue 10. 2020-10-01. PMID:27657380. |
apoptosis was associated with increased hallmarks of er stress and activation of upr sensors and was mediated by dephosphorylation of the akt, mapk/erk, and stat3 pathways.the combination of romidepsin and lenalidomide shows promise as a possible treatment for t-cell lymphoma. |
2020-10-01 |
2023-08-13 |
Not clear |
| Xiao-Xiu Huang, Feng-Feng Xie, Li-Jiao Hou, Xiu-Xiu Chen, Rong-Ying Ou, Jiang-Tao Yu, Jian-Ge Qiu, Wen-Ji Zhang, Qi-Wei Jiang, Yang Yang, Di-Wei Zheng, Yao Chen, Jia-Rong Huang, Kun Wang, Meng-Ning Wei, Wen-Feng Li, Zhi Shi, Xiao-Jian Ya. Crizotinib synergizes with cisplatin in preclinical models of ovarian cancer. American journal of translational research. vol 9. issue 4. 2020-10-01. PMID:28469773. |
in this study, our data show that crizotinib can actively induce cell growth inhibition, cell cycle arrest at g2/m phase and apoptosis with the decreasing phosphorylation of the downstream signaling effectors akt and erk in human ovarian cancer cells. |
2020-10-01 |
2023-08-13 |
human |
| Ming Wang, Zhi-Jun Shu, Ying Wang, Wei Pen. Stachydrine hydrochloride inhibits proliferation and induces apoptosis of breast cancer cells via inhibition of Akt and ERK pathways. American journal of translational research. vol 9. issue 4. 2020-10-01. PMID:28469788. |
stachydrine hydrochloride inhibits proliferation and induces apoptosis of breast cancer cells via inhibition of akt and erk pathways. |
2020-10-01 |
2023-08-13 |
Not clear |