| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zaid H Maayah, Ti Zhang, Marcus Laird Forrest, Samaa Alrushaid, Michael R Doschak, Neal M Davies, Ayman O S El-Kad. DOX-Vit D, a Novel Doxorubicin Delivery Approach, Inhibits Human Osteosarcoma Cell Proliferation by Inducing Apoptosis While Inhibiting Akt and mTOR Signaling Pathways. Pharmaceutics. vol 10. issue 3. 2020-10-01. PMID:30181466. |
dox-vit d, a novel doxorubicin delivery approach, inhibits human osteosarcoma cell proliferation by inducing apoptosis while inhibiting akt and mtor signaling pathways. |
2020-10-01 |
2023-08-13 |
human |
| Yan-Wei Wu, Chiou-Feng Lin, Yee-Shin Lin, Wu-Chou Su, Wei-Hsin Chi. Autophagy regulates vinorelbine sensitivity due to continued Keap1-mediated ROS generation in lung adenocarcinoma cells. Cell death discovery. vol 4. 2020-10-01. PMID:30245856. |
we modified as2 cells with pten overexpression, mtor knockdown, keap1 knockdown, and revealed amplified p62 and lc3 expression accompanied with decreased akt, keap1, ros, and vinorelbine-induced apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yan-Wei Wu, Chiou-Feng Lin, Yee-Shin Lin, Wu-Chou Su, Wei-Hsin Chi. Autophagy regulates vinorelbine sensitivity due to continued Keap1-mediated ROS generation in lung adenocarcinoma cells. Cell death discovery. vol 4. 2020-10-01. PMID:30245856. |
declined p62, lc3 expression were accompanied with increased akt, keap1, ros, and vinorelbine-induced apoptosis after modification of a549 cells with pten knockdown, atg5 knockdown, and keap1 overexpression. |
2020-10-01 |
2023-08-13 |
Not clear |
| ChaoYue Sun, CaiYun Li, XiaoFeng Li, Ying Zhu, ZuQing Su, XieQi Wang, QingLian He, GuangJuan Zheng, Bing Fen. Scutellarin induces apoptosis and autophagy in NSCLC cells through ERK1/2 and AKT Signaling Pathways in vitro and in vivo. Journal of Cancer. vol 9. issue 18. 2020-10-01. PMID:30271483. |
scutellarin induces apoptosis and autophagy in nsclc cells through erk1/2 and akt signaling pathways in vitro and in vivo. |
2020-10-01 |
2023-08-13 |
Not clear |
| Li Li, Min Li, Song Xu, Wenbo Bu, Mengli Zhang, Heng Gu, Xu Che. Is Ras a potential target in treatment against cutaneous squamous cell carcinoma? Journal of Cancer. vol 9. issue 18. 2020-10-01. PMID:30271499. |
in our study, salirasib treatment led to deregulation of c-raf, erk and akt signaling, blockage of mtor signaling, interruption on beclin 1-related autophagy regulation, activation of apoptosis and down-regulation of some cell cycle regulatory proteins in primary human epidermal keratinocyte (hek)s, but did not exhibit similar effects in the human cscc cell line colo-16. |
2020-10-01 |
2023-08-13 |
human |
| Ying-Yin Sun, Yu-Xin Zhao, Xiao-Feng Li, Cheng Huang, Xiao-Ming Meng, Jun L. β-Arrestin 2 Promotes Hepatocyte Apoptosis by Inhibiting Akt Pathway in Alcoholic Liver Disease. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:30283336. |
β-arrestin 2 promotes hepatocyte apoptosis by inhibiting akt pathway in alcoholic liver disease. |
2020-10-01 |
2023-08-13 |
mouse |
| Xian-Jun Wang, Wang Chen, Xiao-Ting Fu, Jin-Kui Ma, Mei-Hong Wang, Ya-Jun Hou, Da-Chen Tian, Xiao-Yan Fu, Cun-Dong Fa. Reversal of homocysteine-induced neurotoxicity in rat hippocampal neurons by astaxanthin: evidences for mitochondrial dysfunction and signaling crosstalk. Cell death discovery. vol 4. 2020-10-01. PMID:30374413. |
taken together, these results above suggested that atx has the potential to reverse hcy-induced neurotoxicity and apoptosis by inhibiting mitochondrial dysfunction, ros-mediated oxidative damage and regulation of makps and akt pathways, which validated the strategy of using atx could be a highly effective way in combating hcy-mediated neurological disorders. |
2020-10-01 |
2023-08-13 |
rat |
| Lucyna Matusewicz, Joanna Podkalicka, Aleksander F Sikorsk. Immunoliposomes with Simvastatin as a Potential Therapeutic in Treatment of Breast Cancer Cells Overexpressing HER2-An In Vitro Study. Cancers. vol 10. issue 11. 2020-10-01. PMID:30388834. |
we tested the stability and selectivity of the proposed formulation along with the toxicity, ability to induce apoptosis and the effect on signalling pathways involving akt and erk kinases. |
2020-10-01 |
2023-08-13 |
human |
| Xun Li, Xi Huang, Yuanlin Tang, Fangli Zhao, Yanmei Cao, Lian Yin, Guochun L. Assessing the Pharmacological and Therapeutic Efficacy of Traditional Chinese Medicine Liangxue Tongyu Prescription for Intracerebral Hemorrhagic Stroke in Neurological Disease Models. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:30459599. |
compound combinations including taurine and paeonol, ginsenoside rg1 and ginsenoside rb1 had as significant increase in efficiency on inhibiting the apoptosis of pc12 cells at the low concentration and up-regulating of pi3k and akt. |
2020-10-01 |
2023-08-13 |
rat |
| Hongyong Fu, Fan Zhou, Qingqing Yuan, Wenhui Zhang, Qianqian Qiu, Xing Yu, Zuping H. miRNA-31-5p Mediates the Proliferation and Apoptosis of Human Spermatogonial Stem Cells via Targeting JAZF1 and Cyclin A2. Molecular therapy. Nucleic acids. vol 14. 2020-10-01. PMID:30583099. |
we have recently demonstrated that pak1 regulates the proliferation, dna synthesis, and early apoptosis of human sscs through the pdk1/kdr/znf367 and erk1/2 and akt pathway. |
2020-10-01 |
2023-08-13 |
human |
| Xi-Gong Li, Jun-Hua Du, Yang Lu, Xiang-Jin Li. Neuroprotective effects of rapamycin on spinal cord injury in rats by increasing autophagy and Akt signaling. Neural regeneration research. vol 14. issue 4. 2020-10-01. PMID:30632514. |
rapamycin treatment has been shown to increase autophagy activity and activate akt phosphorylation, suppressing apoptosis in several models of ischemia reperfusion injury. |
2020-10-01 |
2023-08-13 |
rat |
| Matthew W Anderson, Joanna J Moss, Robert Szalai, Jon D Lan. Mathematical Modeling Highlights the Complex Role of AKT in TRAIL-Induced Apoptosis of Colorectal Carcinoma Cells. iScience. vol 12. 2020-10-01. PMID:30690394. |
mathematical modeling highlights the complex role of akt in trail-induced apoptosis of colorectal carcinoma cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Matthew W Anderson, Joanna J Moss, Robert Szalai, Jon D Lan. Mathematical Modeling Highlights the Complex Role of AKT in TRAIL-Induced Apoptosis of Colorectal Carcinoma Cells. iScience. vol 12. 2020-10-01. PMID:30690394. |
we investigated the dynamic interactions between akt and key apoptotic proteins and constructed a deterministic ordinary differential equation protein interaction model of extrinsic apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Tim Hohmann, Kerstin Feese, Thomas Greither, Chalid Ghadban, Vivian Jäger, Faramarz Dehghani, Urszula Grabie. Synthetic Cannabinoids Influence the Invasion of Glioblastoma Cell Lines in a Cell- and Receptor-Dependent Manner. Cancers. vol 11. issue 2. 2020-10-01. PMID:30709059. |
the effect of cannabinoids on micrornas (mirs), akt, and on the expression of proliferation and apoptosis markers were analyzed. |
2020-10-01 |
2023-08-13 |
human |
| Tim Hohmann, Kerstin Feese, Thomas Greither, Chalid Ghadban, Vivian Jäger, Faramarz Dehghani, Urszula Grabie. Synthetic Cannabinoids Influence the Invasion of Glioblastoma Cell Lines in a Cell- and Receptor-Dependent Manner. Cancers. vol 11. issue 2. 2020-10-01. PMID:30709059. |
micrornas and the activation of akt which are related to cell migration, apoptosis, and proliferation were evaluated and found not to be associated with changes in the invasiveness after treatment with cb ligands. |
2020-10-01 |
2023-08-13 |
human |
| Dorota Ciołczyk-Wierzbicka, Marta Zarzycka, Dorota Gil, Piotr Laidle. mTOR inhibitor Everolimus-induced apoptosis in melanoma cells. Journal of cell communication and signaling. vol 13. issue 3. 2020-10-01. PMID:30848427. |
the object of this study is a comparison of the influence of mtor inhibitor everolimus in the concentration range between 20 nm and 10 μm, used individually and in combination with selected downstream protein kinases inhibitors: ly294002 (pi3k), u0126 (erk1/2), as-703026 (mek) and mk-2206 (akt) on the expression of pro-survival proteins: p-bcl-2 (s70), p-bcl-2 (t56), bcl-2, bcl-xl, mcl-1, activity of caspase-3, proliferation and induction of apoptosis in melanoma cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Dorota Ciołczyk-Wierzbicka, Marta Zarzycka, Dorota Gil, Piotr Laidle. mTOR inhibitor Everolimus-induced apoptosis in melanoma cells. Journal of cell communication and signaling. vol 13. issue 3. 2020-10-01. PMID:30848427. |
current results clearly show that the nanomolar concentration of the mtor inhibitor everolimus in combination with the inhibitor of map kinase (as-703026) or akt kinase (mk-2206) is effective in inducing apoptosis and reducing proliferation of melanoma cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Liansheng Gao, Zhongyuan Zhang, Weilin Xu, Tao Li, Guangyu Ying, Bing Qin, Jianru Li, Jingwei Zheng, Tengfei Zhao, Feng Yan, Yongjian Zhu, Gao Che. Natrium Benzoate Alleviates Neuronal Apoptosis via the DJ-1-Related Anti-oxidative Stress Pathway Involving Akt Phosphorylation in a Rat Model of Traumatic Spinal Cord Injury. Frontiers in molecular neuroscience. vol 12. 2020-10-01. PMID:30853891. |
natrium benzoate alleviates neuronal apoptosis via the dj-1-related anti-oxidative stress pathway involving akt phosphorylation in a rat model of traumatic spinal cord injury. |
2020-10-01 |
2023-08-13 |
rat |
| Liansheng Gao, Zhongyuan Zhang, Weilin Xu, Tao Li, Guangyu Ying, Bing Qin, Jianru Li, Jingwei Zheng, Tengfei Zhao, Feng Yan, Yongjian Zhu, Gao Che. Natrium Benzoate Alleviates Neuronal Apoptosis via the DJ-1-Related Anti-oxidative Stress Pathway Involving Akt Phosphorylation in a Rat Model of Traumatic Spinal Cord Injury. Frontiers in molecular neuroscience. vol 12. 2020-10-01. PMID:30853891. |
in conclusion, nab increased dj-1, and thus reduced ros and ros-induced neuronal apoptosis by promoting akt phosphorylation in t-sci rats. |
2020-10-01 |
2023-08-13 |
rat |
| Eva Maier, Felix Attenberger, Aadhya Tiwari, Konstanze Lettau, Simone Rebholz, Birgit Fehrenbacher, Martin Schaller, Cihan Gani, Mahmoud Toulan. Dual Targeting of Y-Box Binding Protein-1 and Akt Inhibits Proliferation and Enhances the Chemosensitivity of Colorectal Cancer Cells. Cancers. vol 11. issue 4. 2020-10-01. PMID:31010234. |
dual targeting of akt and rsk sensitized hct116 cells to 5-fu by stimulating 5-fu-induced apoptosis and inhibiting repair of 5-fu-induced dna damage. |
2020-10-01 |
2023-08-13 |
Not clear |