| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zan Liu, Licheng Ren, Xu Cui, Le Guo, Bimei Jiang, Jie Zhou, Pengfei Liang, Jizhang Zeng, Zhiyou He, Pihong Zhan. Muscular proteomic profiling of deep pressure ulcers reveals myoprotective role of JAK2 in ischemia and reperfusion injury. American journal of translational research. vol 10. issue 11. 2020-09-30. PMID:30662596. |
these results demonstrated that jak2 may play an important protective role in muscular ischemia and reperfusion injury during dti development by inhibition of autophagy and apoptosis through the akt and erk1/2 pathways. |
2020-09-30 |
2023-08-13 |
Not clear |
| Meiying Ji, Zhenling Li, Zhenhua Lin, Liyan Che. Antitumor activity of the novel HDAC inhibitor CUDC-101 combined with gemcitabine in pancreatic cancer. American journal of cancer research. vol 8. issue 12. 2020-09-30. PMID:30662800. |
in addition, cudc-101 enhanced gemcitabine-induced apoptosis via inhibited pi3k/akt/mtor and erk pathway activation, as indicated by the phosphorylation status of akt, 4ebp1, s6 and erk. |
2020-09-30 |
2023-08-13 |
Not clear |
| Dan Li, Ying Ta. TIPE2 suppresses atherosclerosis by exerting a protective effect on macrophages via the inhibition of the Akt signaling pathway. Experimental and therapeutic medicine. vol 17. issue 4. 2020-09-30. PMID:30936963. |
the results demonstrated that tipe2 overexpression may promote oxldl-induced raw264.7 macrophage apoptosis by inhibiting the protein kinase b (akt) signaling pathway. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jianguo Zhang, Lei Che, Wenkai Sun, Jian Shang, Min Hao, Mengzi Tia. Correlation of OGR1 with proliferation and apoptosis of breast cancer cells. Oncology letters. vol 17. issue 5. 2020-09-30. PMID:30944627. |
the proliferation and apoptosis of breast cancer cells are influenced by the changes of ogr1 expression, which are correlated with the gene expression levels of akt and p53 to some extent, but the detailed molecular mechanism requires additional study. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yuanzhi Li, Shenquan Guo, Wenchao Liu, Tao Jin, Xifeng Li, Xuying He, Xin Zhang, Hengxian Su, Nan Zhang, Chuanzhi Dua. Silencing of SNHG12 Enhanced the Effectiveness of MSCs in Alleviating Ischemia/Reperfusion Injuries via the PI3K/AKT/mTOR Signaling Pathway. Frontiers in neuroscience. vol 13. 2020-09-30. PMID:31293373. |
however, co-culturing of bmecs with mscs markedly alleviated the reduction in bmec proliferation and the increases in bmec apoptosis and autophagy, as well as the phosphorylation of pi3k, akt, and mtor proteins in bmecs that had been induced by i/r. |
2020-09-30 |
2023-08-13 |
rat |
| Yuanzhi Li, Shenquan Guo, Wenchao Liu, Tao Jin, Xifeng Li, Xuying He, Xin Zhang, Hengxian Su, Nan Zhang, Chuanzhi Dua. Silencing of SNHG12 Enhanced the Effectiveness of MSCs in Alleviating Ischemia/Reperfusion Injuries via the PI3K/AKT/mTOR Signaling Pathway. Frontiers in neuroscience. vol 13. 2020-09-30. PMID:31293373. |
in addition, an injection mscs reduced the infarct areas and rates of cell apoptosis in maco rats, and reduced the phosphorylation of pi3k, akt, and mtor proteins. |
2020-09-30 |
2023-08-13 |
rat |
| Ying Jiang, Gangli Cai, Jun Lin, Jing Zhang, Zhilei Bo, Ying Li, Chun Wang, Yin Ton. B7-H4 is highly expressed in aggressive Epstein-Barr virus positive diffuse large B-cell lymphoma and inhibits apoptosis through upregulating Erk1/2 and Akt signalling pathways. Infectious agents and cancer. vol 14. 2020-09-30. PMID:31406503. |
b7-h4 is highly expressed in aggressive epstein-barr virus positive diffuse large b-cell lymphoma and inhibits apoptosis through upregulating erk1/2 and akt signalling pathways. |
2020-09-30 |
2023-08-13 |
Not clear |
| Mahsa Sedaghat, Siroos Choobineh, Ali Asghar Ravas. Taurine with combined aerobic and resistance exercise training alleviates myocardium apoptosis in STZ-induced diabetes rats via Akt signaling pathway. Life sciences. vol 258. 2020-09-30. PMID:32771557. |
taurine with combined aerobic and resistance exercise training alleviates myocardium apoptosis in stz-induced diabetes rats via akt signaling pathway. |
2020-09-30 |
2023-08-13 |
rat |
| Mahsa Sedaghat, Siroos Choobineh, Ali Asghar Ravas. Taurine with combined aerobic and resistance exercise training alleviates myocardium apoptosis in STZ-induced diabetes rats via Akt signaling pathway. Life sciences. vol 258. 2020-09-30. PMID:32771557. |
the aim of this study was considering the effects of taurine supplementation with combined aerobic and resistance training (care) on myocardial apoptosis and protein kinase b (akt) level changes in diabetic rat. |
2020-09-30 |
2023-08-13 |
rat |
| Qi-Fu Bo, Xiu-Mei Sun, Jin Liu, Xiao-Mei Sui, Gui-Xin L. Antitumor action of the peroxisome proliferator-activated receptor-γ agonist rosiglitazone in hepatocellular carcinoma. Oncology letters. vol 10. issue 4. 2020-09-29. PMID:26622783. |
the mechanism of rgz-induced apoptosis involves an increase in the level of activated ppar-γ (p-ppar-γ) and a decrease in p85 and akt expression. |
2020-09-29 |
2023-08-13 |
Not clear |
| Yanqiu Lu, Jiyu Lou, Xiaojun Liu, Shengfeng Wan. Oxysophocarpine reduces oxygen-glucose deprivation-induced microglial activation and injury. American journal of translational research. vol 9. issue 5. 2020-09-29. PMID:28559977. |
in addition, osc suppressed ogd/r-elicited bv-2 cell apoptosis, as indicated as follows: the restored mitochondrial membrane potential and the reduced caspase-3 activity; the decrease of bax and cleaved caspase-3 and the increase of bcl-2; the enhanced phosphorylation of akt and mtor. |
2020-09-29 |
2023-08-13 |
Not clear |
| Kai Quan, Xin Zhang, Kun Fan, Peixi Liu, Qi Yue, Bo Li, Jinfeng Wu, Baojun Liu, Yang Xu, Wei Hua, Wei Zh. Icariside II induces cell cycle arrest and apoptosis in human glioblastoma cells through suppressing Akt activation and potentiating FOXO3a activity. American journal of translational research. vol 9. issue 5. 2020-09-29. PMID:28560001. |
icariside ii induces cell cycle arrest and apoptosis in human glioblastoma cells through suppressing akt activation and potentiating foxo3a activity. |
2020-09-29 |
2023-08-13 |
human |
| Yan Meng, Weiwei Wang, Jinsong Kang, Xinxue Wang, Liankun Su. Role of the PI3K/AKT signalling pathway in apoptotic cell death in the cerebral cortex of streptozotocin-induced diabetic rats. Experimental and therapeutic medicine. vol 13. issue 5. 2020-09-29. PMID:28565857. |
taken together, these results suggested that diabetes mellitus may induce neuronal apoptosis in the cerebral cortex by downregulating akt phosphorylation. |
2020-09-29 |
2023-08-13 |
rat |
| Yitao Wan, Yuan Yuan, Yueyin Pan, Ying Zhan. Antitumor activity of high-dose pulsatile gefitinib in non-small-cell lung cancer with acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors. Experimental and therapeutic medicine. vol 13. issue 6. 2020-09-29. PMID:28587381. |
cell apoptosis and cycling were also determined by flow cytometry and the expression of phospho (p)-egfr, egfr, p-akt and akt were measured by western blot analysis. |
2020-09-29 |
2023-08-13 |
Not clear |
| Hong Yan, Xiaoxia Che, Qingtao Lv, Lili Zhang, Samina Dongol, Yilin Wang, Hengzi Sun, Jie Jian. Grifolin induces apoptosis and promotes cell cycle arrest in the A2780 human ovarian cancer cell line via inactivation of the ERK1/2 and Akt pathways. Oncology letters. vol 13. issue 6. 2020-09-29. PMID:28588729. |
grifolin induces apoptosis and promotes cell cycle arrest in the a2780 human ovarian cancer cell line via inactivation of the erk1/2 and akt pathways. |
2020-09-29 |
2023-08-13 |
human |
| He Huang, Xiao-Ji Lin, Ying Lin, Ron-Xin Yao, Mu-Qing H. Bufalin Enhances the Cytotoxity of Human Multiple Myeloma Cells H929 to AKT Inhibitor MK2206: The Role of Protein AKT Phosphorylation. Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion. vol 34. issue 2. 2020-09-29. PMID:29622868. |
this study was purposed to investigate bufalin combined with akt inhibitor mk2206 on growth inhibition and apoptosis of multiple myeloma cell line h929. |
2020-09-29 |
2023-08-13 |
human |
| Yueli Yao, Xiaoru Chang, Dong Wang, Haitao Ma, Huiling Wang, Haojun Zhang, Chengyun Li, Junling Wan. Roles of ERK1/2 and PI3K/AKT signaling pathways in mitochondria-mediated apoptosis in testes of hypothyroid rats. Toxicology research. vol 7. issue 6. 2020-09-29. PMID:30542605. |
this study aims to explore the roles of estrogen receptor (er α, β) and g protein-coupled receptor 30 (gpr30), extracellular signal regulated kinase (erk1/2) and phosphoinositide 3-kinase (pi3k)/protein kinase b (akt) signaling pathways in apoptosis in testes of hypothyroidism rats. |
2020-09-29 |
2023-08-13 |
rat |
| Yinghua Li, Min Guo, Zhengfang Lin, Mingqi Zhao, Yu Xia, Changbing Wang, Tiantian Xu, Bing Zh. Multifunctional selenium nanoparticles with Galangin-induced HepG2 cell apoptosis through p38 and AKT signalling pathway. Royal Society open science. vol 5. issue 11. 2020-09-29. PMID:30564384. |
multifunctional selenium nanoparticles with galangin-induced hepg2 cell apoptosis through p38 and akt signalling pathway. |
2020-09-29 |
2023-08-13 |
Not clear |
| Junjie Qu, Binya Liu, Bilan Li, Guiqiang Du, Yiran Li, Jingyun Wang, Laman He, Xiaoping Wa. TRIB3 suppresses proliferation and invasion and promotes apoptosis of endometrial cancer cells by regulating the AKT signaling pathway. OncoTargets and therapy. vol 12. 2020-09-29. PMID:30988628. |
trib3 suppresses proliferation and invasion and promotes apoptosis of endometrial cancer cells by regulating the akt signaling pathway. |
2020-09-29 |
2023-08-13 |
Not clear |
| Niklas Uhlenbrock, Steven Smith, Jörn Weisner, Ina Landel, Marius Lindemann, Thien Anh Le, Julia Hardick, Rajesh Gontla, Rebekka Scheinpflug, Paul Czodrowski, Petra Janning, Laura Depta, Lena Quambusch, Matthias P Müller, Bernd Engels, Daniel Rau. Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt. Chemical science. vol 10. issue 12. 2020-09-29. PMID:30996949. |
its downstream signaling influences cell proliferation, cell growth, and apoptosis, rendering akt a prominent drug target. |
2020-09-29 |
2023-08-13 |
Not clear |