| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cheng Huang, Hsu-Feng Lu, Yu-Hsuan Chen, Jui-Chieh Chen, Wen-Hsiang Chou, Hsiu-Chen Huan. Curcumin, demethoxycurcumin, and bisdemethoxycurcumin induced caspase-dependent and -independent apoptosis via Smad or Akt signaling pathways in HOS cells. BMC complementary medicine and therapies. vol 20. issue 1. 2020-09-04. PMID:32126993. |
curcumin, demethoxycurcumin, and bisdemethoxycurcumin induced caspase-dependent and -independent apoptosis via smad or akt signaling pathways in hos cells. |
2020-09-04 |
2023-08-13 |
Not clear |
| Rasha A Mansouri, Susan S Perciva. Cranberry extract initiates intrinsic apoptosis in HL-60 cells by increasing BAD activity through inhibition of AKT phosphorylation. BMC complementary medicine and therapies. vol 20. issue 1. 2020-09-04. PMID:32143616. |
cranberry extract initiates intrinsic apoptosis in hl-60 cells by increasing bad activity through inhibition of akt phosphorylation. |
2020-09-04 |
2023-08-13 |
Not clear |
| Yun Shi, Ya Su, Chuanli Liu, Jinglong Tao, Hao Fu, Chengzhi L. Inhibition of HES-1 might play a protective role in endothelial cells under cholesterol stimulation via PI3K/AKT signaling pathway. General physiology and biophysics. vol 39. issue 2. 2020-09-03. PMID:32329442. |
expression of hes-1, apoptosis related proteins and phosphatidylinositol 3 kinase (pi3k)/protein kinase b (akt) signaling pathway were detected using western blotting analysis. |
2020-09-03 |
2023-08-13 |
Not clear |
| Y Kakiuchi, T Yurube, K Kakutani, T Takada, M Ito, Y Takeoka, Y Kanda, S Miyazaki, R Kuroda, K Nishid. Pharmacological inhibition of mTORC1 but not mTORC2 protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism through Akt and autophagy induction. Osteoarthritis and cartilage. vol 27. issue 6. 2020-08-31. PMID:30716534. |
pharmacological inhibition of mtorc1 but not mtorc2 protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism through akt and autophagy induction. |
2020-08-31 |
2023-08-13 |
human |
| Yanrong Li, Weiyu Jiang, Qiaona Niu, Yingjie Sun, Chunchun Meng, Lei Tan, Cuiping Song, Xusheng Qiu, Ying Liao, Chan Din. eIF2α-CHOP-BCl-2/JNK and IRE1α-XBP1/JNK signaling promote apoptosis and inflammation and support the proliferation of Newcastle disease virus. Cell death & disease. vol 10. issue 12. 2020-08-31. PMID:31767828. |
further study revealed that activation of perk-eif2α induced the expression of transcription factor chop, which subsequently promoted apoptosis by downregulating bcl-2/mcl-1, promoting jnk signaling and suppressing akt signaling. |
2020-08-31 |
2023-08-13 |
human |
| Germano Aguiar Ferreira, Carolina Hassibe Thomé, Ana Maria Sper Simão, Priscila Santos Scheucher, Cleide Lúcia Araújo Silva, Fernando Chahud, Pietro Ciancaglini, Andreia Machado Leopoldino, Eduardo Magalhães Rego, Vitor Marcel Faça, Guilherme Augusto Dos Santo. The lipid raft protein NTAL participates in AKT signaling in mantle cell lymphoma. Leukemia & lymphoma. vol 60. issue 11. 2020-08-28. PMID:31060403. |
using human mantle cell lymphoma (mcl) granta-519 cell line we showed here that perifosine decreased ntal in lipid raft fractions reducing akt phosphorylation before apoptosis. |
2020-08-28 |
2023-08-13 |
mouse |
| Shu-Hong Chen, Xiao-Nan Liu, Yan Pen. MicroRNA-351 eases insulin resistance and liver gluconeogenesis via the PI3K/AKT pathway by inhibiting FLOT2 in mice of gestational diabetes mellitus. Journal of cellular and molecular medicine. vol 23. issue 9. 2020-08-28. PMID:31287224. |
additionally, mir-351 overexpression and flot2 silencing decreased the levels of flot2, phosphoenolpyruvate carboxykinase, glucose-6-phosphatase, fasting blood glucose, fasting insulin, total cholesterol, triglyceride, glyeosylated haemoglobin and homeostasis model of assessment for ir index (homa-ir), extent of pi3k and akt phosphorylation, yet increased the levels of homa for islet β-cell function, homa for insulin sensitivity index and glucose transporter 2 expression, indicating reduced cell apoptosis in pancreatic tissues and alleviated ir and liver gluconeogenesis. |
2020-08-28 |
2023-08-13 |
mouse |
| Qing Mao, Xiulin Liang, Yufu Wu, Yongxiang L. Nobiletin protects against myocardial injury and myocardial apoptosis following coronary microembolization via activating PI3K/Akt pathway in rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 392. issue 9. 2020-08-27. PMID:31073648. |
in addition, nobiletin inhibited myocardial apoptosis, which may be connected to downregulated apoptotic index, upregulated bcl-2, and cleaved caspase-3 and bax, while it increased protein levels in phosphorylated akt. |
2020-08-27 |
2023-08-13 |
rat |
| Retraction: "Down-regulation of Notch-1 and Jagged-1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of Akt, mTOR, and NF-κB signaling pathways" by Wang et al. Journal of cellular biochemistry. vol 117. issue 8. 2020-08-25. PMID:27301887. |
retraction: "down-regulation of notch-1 and jagged-1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of akt, mtor, and nf-κb signaling pathways" by wang et al. |
2020-08-25 |
2023-08-13 |
Not clear |
| Retraction: "Down-regulation of Notch-1 and Jagged-1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of Akt, mTOR, and NF-κB signaling pathways" by Wang et al. Journal of cellular biochemistry. vol 117. issue 8. 2020-08-25. PMID:27301887. |
down-regulation of notch-1 and jagged-1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of akt, mtor, and nf-κb signaling pathways. |
2020-08-25 |
2023-08-13 |
Not clear |
| Retraction: "Down-regulation of Notch-1 is associated with Akt and FoxM1 in inducing cell growth inhibition and apoptosis in prostate cancer cells" by Wang et al. Journal of cellular biochemistry. vol 117. issue 8. 2020-08-25. PMID:27301889. |
retraction: "down-regulation of notch-1 is associated with akt and foxm1 in inducing cell growth inhibition and apoptosis in prostate cancer cells" by wang et al. |
2020-08-25 |
2023-08-13 |
Not clear |
| Retraction: "Down-regulation of Notch-1 is associated with Akt and FoxM1 in inducing cell growth inhibition and apoptosis in prostate cancer cells" by Wang et al. Journal of cellular biochemistry. vol 117. issue 8. 2020-08-25. PMID:27301889. |
down-regulation of notch-1 is associated with akt and foxm1 in inducing cell growth inhibition and apoptosis in prostate cancer cells. |
2020-08-25 |
2023-08-13 |
Not clear |
| Xinyue Gu, Yang Jiang, Weinan Xue, Chengxin Song, Yangyang Wang, Yanlong Liu, Binbin Cu. SPNS2 promotes the malignancy of colorectal cancer cells via regulating Akt and ERK pathway. Clinical and experimental pharmacology & physiology. vol 46. issue 9. 2020-08-25. PMID:31206801. |
in conclusion, our results demonstrated that spns2 promoted proliferation, migration and invasion, and inhibited apoptosis by regulating s1p/s1pr1/3 axis and activating akt and erk pathway in crc cells. |
2020-08-25 |
2023-08-13 |
Not clear |
| Changli Zhang, Madeline P Smith, George K Zhou, Alon Lai, Robert C Hoy, Victoria Mroz, Olivia M Torre, Damien M Laudier, Elizabeth W Bradley, Jennifer J Westendorf, James C Iatridis, Svenja Illien-Jünge. Phlpp1 is associated with human intervertebral disc degeneration and its deficiency promotes healing after needle puncture injury in mice. Cell death & disease. vol 10. issue 10. 2020-08-20. PMID:31582730. |
the akt signaling pathway regulates cellularity and matrix production in ivds and its inactivation is known to contribute to a catabolic shift and increased cell loss via apoptosis. |
2020-08-20 |
2023-08-13 |
mouse |
| Changli Zhang, Madeline P Smith, George K Zhou, Alon Lai, Robert C Hoy, Victoria Mroz, Olivia M Torre, Damien M Laudier, Elizabeth W Bradley, Jennifer J Westendorf, James C Iatridis, Svenja Illien-Jünge. Phlpp1 is associated with human intervertebral disc degeneration and its deficiency promotes healing after needle puncture injury in mice. Cell death & disease. vol 10. issue 10. 2020-08-20. PMID:31582730. |
in mice, 3 days after ivd needle puncture injury, phlpp1 knockout (ko) promoted akt phosphorylation and cell proliferation, with less apoptosis. |
2020-08-20 |
2023-08-13 |
mouse |
| Shiyuan Chen, Hu Chen, Chaowen Yu, Ran Lu, Tao Song, Xiaogao Wang, Wenbo Tang, Yong Ga. Long noncoding RNA myocardial infarction associated transcript promotes the development of thoracic aortic by targeting microRNA-145 via the PI3K/Akt signaling pathway. Journal of cellular biochemistry. vol 120. issue 9. 2020-08-17. PMID:30989723. |
akt activation by hy-18749 improved cell viability and suppressed cell apoptosis in h-vsmcs. |
2020-08-17 |
2023-08-13 |
human |
| Z Wang, Y Li, L Fan, Q Zhao, B Tan, R Liu, F L. Silencing of TPD52 inhibits proliferation, migration, invasion but induces apoptosis of pancreatic cancer cells by deactivating Akt pathway. Neoplasma. vol 67. issue 2. 2020-08-17. PMID:31847526. |
silencing of tpd52 inhibits proliferation, migration, invasion but induces apoptosis of pancreatic cancer cells by deactivating akt pathway. |
2020-08-17 |
2023-08-13 |
mouse |
| Z Wang, Y Li, L Fan, Q Zhao, B Tan, R Liu, F L. Silencing of TPD52 inhibits proliferation, migration, invasion but induces apoptosis of pancreatic cancer cells by deactivating Akt pathway. Neoplasma. vol 67. issue 2. 2020-08-17. PMID:31847526. |
the present study revealed that silencing of tpd52 significantly suppressed the proliferation, migration and invasion, but induced apoptosis of aspc-1 and panc-1 cells in vitro by dephosphorylating akt at ser473. |
2020-08-17 |
2023-08-13 |
mouse |
| Weiwei Shi, Yanfen Tang, Ye Zhi, Zhijie Li, Shali Yu, Junkang Jiang, Jinfeng Zhu, Jinlong Li, Feng Wang, Liling Su, Xinyuan Zha. Akt inhibition-dependent downregulation of the Wnt/β-Catenin Signaling pathway contributes to antimony-induced neurotoxicity. The Science of the total environment. vol 737. 2020-08-14. PMID:32783850. |
in summary, our data provided a novel molecular mechanism of sb-associated neurotoxicity, namely that sb induces wnt/β-catenin pathway suppression through akt inhibition, thus resulted in neuronal apoptosis. |
2020-08-14 |
2023-08-13 |
mouse |
| Xuyang Wang, Jinyu Pan, Dian Liu, Mingjun Zhang, Xiaowei Li, Jingjing Tian, Ming Liu, Tao Jin, Fengshuang A. Nicorandil alleviates apoptosis in diabetic cardiomyopathy through PI3K/Akt pathway. Journal of cellular and molecular medicine. vol 23. issue 8. 2020-08-13. PMID:31131539. |
the effect of nicorandil on apoptosis was blocked by 5-hd, and it was accompanied with inhibition of the phosphorylation of pi3k, akt, enos, and mtor. |
2020-08-13 |
2023-08-13 |
rat |