| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hao Chen, Jun Chen, Long Zhao, Wenfeng Song, Zefeng Xuan, Jian Chen, Zequn Li, Guangyuan Song, Liangjie Hong, Penghong Song, Shusen Zhen. CDCA5, Transcribed by E2F1, Promotes Oncogenesis by Enhancing Cell Proliferation and Inhibiting Apoptosis via the AKT Pathway in Hepatocellular Carcinoma. Journal of Cancer. vol 10. issue 8. 2020-09-29. PMID:31205541. |
cdca5, transcribed by e2f1, promotes oncogenesis by enhancing cell proliferation and inhibiting apoptosis via the akt pathway in hepatocellular carcinoma. |
2020-09-29 |
2023-08-13 |
Not clear |
| Yu Liu, Zhenqiang Hong, Peng Chen, Jinzhao Wang, Yimin Zhou, Jianyun Huan. Baicalin inhibits growth and induces apoptosis of human osteosarcoma cells by suppressing the AKT pathway. Oncology letters. vol 18. issue 3. 2020-09-29. PMID:31452795. |
baicalin inhibits growth and induces apoptosis of human osteosarcoma cells by suppressing the akt pathway. |
2020-09-29 |
2023-08-13 |
human |
| Yu Liu, Zhenqiang Hong, Peng Chen, Jinzhao Wang, Yimin Zhou, Jianyun Huan. Baicalin inhibits growth and induces apoptosis of human osteosarcoma cells by suppressing the AKT pathway. Oncology letters. vol 18. issue 3. 2020-09-29. PMID:31452795. |
in the present study, the effect of baicalin on the proliferation and apoptosis of os cells and its underlying mechanism of akt pathway activation was explored. |
2020-09-29 |
2023-08-13 |
human |
| Mahyar Dorrigiv, Armin Zareiyan, Hossein Hosseinzade. Garlic (Allium sativum) as an antidote or a protective agent against natural or chemical toxicities: A comprehensive update review. Phytotherapy research : PTR. vol 34. issue 8. 2020-09-29. PMID:32068926. |
it has been shown that garlic and its major components can ameliorate the toxicity of different agents in brain, kidney, blood, liver, embryo, spleen, pancreas, heart, reproductive system in part through radical scavenging, antioxidant effect, reducing lipid peroxidation, anti-inflammatory, chelating agent, cytoprotective activities, increase protein synthesis in damaged tissues, suppressing apoptosis, modulation of p53, phosphoinositide 3-kinase, akt, nuclear factor (erythroid-derived 2)-like 2, antioxidant responsive element, p38 mapk, inducible nitric oxide synthase, cyclooxygenase-2, cytosolic phospholipases a2, cleaved-caspase-9, cleaved-caspase-3 bcl-2, bcl-2-associated x, peroxisome proliferator-activated receptor gamma, nf-jb, nuclear factor-kappab signaling pathways and cytochrome p450 enzymes. |
2020-09-29 |
2023-08-13 |
Not clear |
| Yi Yu, Yuyan Xiong, Diogo Ladeiras, Zhihong Yang, Xiu-Fen Min. Myosin 1b Regulates Nuclear AKT Activation by Preventing Localization of PTEN in the Nucleus. iScience. vol 19. 2020-09-28. PMID:31349190. |
taken together, we demonstrate that myo1b, by interacting with pten, prevents nuclear localization of pten contributing to nuclear akt activation and suppression of cell apoptosis. |
2020-09-28 |
2023-08-13 |
mouse |
| Han Ming Poh, Yi Shiou Chiou, Qing Yun Chong, Ru-Mei Chen, Kanchugarakoppal S Rangappa, Lan Ma, Tao Zhu, Alan Prem Kumar, Vijay Pandey, Soo-Chin Lee, Peter E Lobi. Inhibition of TFF3 Enhances Sensitivity-and Overcomes Acquired Resistance-to Doxorubicin in Estrogen Receptor-Positive Mammary Carcinoma. Cancers. vol 11. issue 10. 2020-09-28. PMID:31658702. |
the depletion of tff3 by sirna or inhibition with a small molecule tff3 inhibitor (ampc) synergistically enhanced the efficacy of doxorubicin in er+mc through the suppression of doxorubicin-induced akt activation and enhancement of doxorubicin-induced apoptosis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Nour Al Kafri, Sassan Hafiz. Tumour-Secreted Protein S (ProS1) Activates a Tyro3-Erk Signalling Axis and Protects Cancer Cells from Apoptosis. Cancers. vol 11. issue 12. 2020-09-28. PMID:31766614. |
in addition, pros1 protected cancer cells from acute apoptosis induced by staurosporine, as well as additionally, long-term serum starvation-induced apoptosis in mgh-u3 cells (tyro3 only), which reflects its additional coupling to akt signalling in these cells. |
2020-09-28 |
2023-08-13 |
human |
| Dake Hao, Chuanchao He, Bowen Ma, Lee Lankford, Lizette Reynaga, Diana L Farmer, Fuzheng Guo, Aijun Wan. Hypoxic Preconditioning Enhances Survival and Proangiogenic Capacity of Human First Trimester Chorionic Villus-Derived Mesenchymal Stem Cells for Fetal Tissue Engineering. Stem cells international. vol 2019. 2020-09-28. PMID:31781252. |
caspase-3, mts, and western blot analysis showed hp significantly reduced the apoptosis of cv-mscs under ischemic stimulus via the activation of the akt signaling pathway that was related to cell survival. |
2020-09-28 |
2023-08-13 |
human |
| Ken Kobayashi, Yusaku Tsugami, Norihiro Suzuki, Takahiro Suzuki, Takanori Nishimur. Nicotine directly affects milk production in lactating mammary epithelial cells concurrently with inactivation of STAT5 and glucocorticoid receptor in vitro. Toxicology in vitro : an international journal published in association with BIBRA. vol 63. 2020-09-28. PMID:31783125. |
nicotine treatment also induced mec apoptosis concurrently with inactivation of akt. |
2020-09-28 |
2023-08-13 |
mouse |
| Jinjing Wang, Fanghua Qi, Zhixue Wang, Zhikun Zhang, Ni Pan, Lei Huai, Shuyu Qu, Lin Zha. A review of traditional Chinese medicine for treatment of glioblastoma. Bioscience trends. vol 13. issue 6. 2020-09-28. PMID:31866614. |
we found that the same active ingredient can act on different signaling pathways, such as ginsenoside rg3 inhibited proliferation and induced apoptosis via the akt, mek signal pathway. |
2020-09-28 |
2023-08-13 |
Not clear |
| Yinming Wang, Junquan Gu, Linlin Hu, Liang Kong, Tinggang Wang, Meiqi Di, Chaosheng Li, Shuhua Gu. miR-130a alleviates neuronal apoptosis and changes in expression of Bcl-2/Bax and caspase-3 in cerebral infarction rats through PTEN/PI3K/Akt signaling pathway. Experimental and therapeutic medicine. vol 19. issue 3. 2020-09-28. PMID:32104274. |
effect of micro ribonucleic acid (mir)-130a on neuronal apoptosis in rats with cerebral infarction (ci) was studied to explore whether phosphatase and tensin homolog deleted on chromosome ten (pten)/phosphatidylinositol 3-hydroxy kinase (pi3k)/protein kinase b (akt) is involved in the regulation of neuronal apoptosis. |
2020-09-28 |
2023-08-13 |
rat |
| Hao Chen, Ji Hao, Yanzhang Wen, Yibing Lv, Lu Chen, Jingquan Yuan, Xinzhou Yan. Data of cytotoxicity, p53 and Akt downstream proteins and physiological indexes in hepatocellular carcinoma cells or HepG2-bearing nude mouse model administered by α-Humulene. Data in brief. vol 29. 2020-09-28. PMID:32181294. |
this data article contains data related to the research article entitled "α-humulene inhibits hepatocellular carcinoma (hcc) cell proliferation and induces apoptosis through the inhibition of akt signaling" (chen et al., 2019) [1]. |
2020-09-28 |
2023-08-13 |
mouse |
| Mei Li, Wen-Wei Gao, Lian Liu, Yue Gao, Ya-Feng Wang, Bo Zhao, Xiao-Xing Xion. The Akt/glycogen synthase kinase-3β pathway participates in the neuroprotective effect of interleukin-4 against cerebral ischemia/reperfusion injury. Neural regeneration research. vol 15. issue 9. 2020-09-28. PMID:32209778. |
the akt (also called protein kinase b, pkb)/glycogen synthase kinase-3β (akt/gsk-3β) signaling pathway is involved in oxidative stress, the inflammatory response, apoptosis, and autophagy. |
2020-09-28 |
2023-08-13 |
mouse |
| Jun Yao, Min Xu, Ziyao Li. Rapamycin inhibits proliferation and apoptosis of retinoblastoma cells through PI3K/AKT signaling pathway. Oncology letters. vol 19. issue 4. 2020-09-28. PMID:32218850. |
effects of rapamycin on the proliferation and apoptosis of retinoblastoma cells through the phosphatidylinositol 3-hydroxy kinase (pi3k)/protein kinase b (akt) signaling pathway were studied. |
2020-09-28 |
2023-08-13 |
Not clear |
| Xue Wu, Zheng Wang, Gaofeng Wu, Xiaofan Xu, Jian Zhang, Yan Li, Hong Zhang, Shuzhen Gu. Tetramethylpyrazine Induces Apoptosis and Inhibits Proliferation of Hypertrophic Scar-Derived Fibroblasts Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32431617. |
taken together, our investigations demonstrated that tmp could down-regulate the expression of fibrosis-related molecules, inhibit scar fibroblast proliferation and activate cell apoptosis, during which akt pathway was involved. |
2020-09-28 |
2023-08-13 |
Not clear |
| Giulia Chiabotto, Giovanni Grignani, Maja Todorovic, Valentina Martin, Maria Laura Centomo, Elisa Prola, Giorgia Giordano, Alessandra Merlini, Umberto Miglio, Enrico Berrino, Lucia Napione, Claudio Isella, Federica Capozzi, Marco Basiricò, Cristina Marsero, Ilaria Gerardi, Tiziana Venesio, Dario Sangiolo, Massimo Aglietta, Lorenzo D'Ambrosio, Ymera Pignochin. Pazopanib and Trametinib as a Synergistic Strategy against Osteosarcoma: Preclinical Activity and Molecular Insights. Cancers. vol 12. issue 6. 2020-09-28. PMID:32531992. |
pazopanib + trametinib exhibited synergistic antitumor activity by inducing apoptosis and inhibiting erk1/2 and akt. |
2020-09-28 |
2023-08-13 |
mouse |
| Junling Liu, Jianyun Liu, Mingming Bai, Hui Wan. Protective effect of puerarin against burn-induced heart injury in rats. Experimental and therapeutic medicine. vol 20. issue 1. 2020-09-28. PMID:32536996. |
in conclusion, puerarin improved cardiac function in rats following severe burn injury, which may be due to reduced myocardial injury, inhibition of cardiomyocyte apoptosis and reduced oxidative inflammatory stress; the mapk and akt signaling pathways are proposed to the underlying mechanism of these findings. |
2020-09-28 |
2023-08-13 |
rat |
| Zhe Feng, Ziyi Feng, Jie Han, Weimin Cheng, Bo Su, Jian Mo, XinJian Feng, Sitan Feng, GuoJian Chen, Peng Huang, Long Huang, Zhenwei Cu. Antinociceptive Effects of Shenling Baizhu through PI3K-Akt-mTOR Signaling Pathway in a Mouse Model of Bone Metastasis with Small-Cell Lung Cancer. Evidence-based complementary and alternative medicine : eCAM. vol 2020. 2020-09-28. PMID:32655659. |
slbz-ap relieved bmlc-induced pain and prolonged animals' survival, promoted cell apoptosis in the marrow from the tibia of bmlc mice, and inhibited mrna and protein expression of akt, mtor, p70s6, and vegf, as well as protein expression of p-akt, p-mtor, p-p70s6, and vegf upregulation in the marrow of tibia induced by bmlc, an effect which was similar to rapamycin. |
2020-09-28 |
2023-08-13 |
mouse |
| Qingfen Wang, Rui Li, Zhi Xiao, Cun Ho. Lycopene attenuates high glucose-mediated apoptosis in MPC5 podocytes by promoting autophagy via the PI3K/AKT signaling pathway. Experimental and therapeutic medicine. vol 20. issue 3. 2020-09-28. PMID:32765784. |
in addition, under hg conditions, lyc upregulated the phosphorylation levels of pi3k and akt, and reduced hg- and ly-mediated mpc5 podocyte apoptosis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Lun Gao, Junhui Liu, Pengfei Xu, Gang Deng, Baohui Liu, Fanen Yuan, Yinqiu Tan, Qian Sun, Yang Xu, Huikai Zhang, Yangzhi Qi, Shoumeng Han, Kun Yang, Rongxin Geng, Hongxiang Jiang, Qianxue Che. AKT Inhibitor SC66 Inhibits Proliferation and Induces Apoptosis in Human Glioblastoma Through Down-Regulating AKT/β-Catenin Pathway. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32848734. |
akt inhibitor sc66 inhibits proliferation and induces apoptosis in human glioblastoma through down-regulating akt/β-catenin pathway. |
2020-09-28 |
2023-08-13 |
mouse |