| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun Hong, Hong-Wei Ge, Jing-Quan Liu, Ren-Hua Sun, Fei-Juan Kon. Pharmacological Inhibition of PTEN Restores Remote Ischemic Postconditioning Cardioprotection in Hypercholesterolemic Mice: Potential Role of PTEN/AKT/GSK3β SIGNALS. Shock (Augusta, Ga.). vol 52. issue 5. 2020-08-12. PMID:30499878. |
following i/r, ripc significantly attenuated postischemic infarct size, hindered cardiomyocyte apoptosis, improved cardiac systolic function, decreased phosphatase and tensin homolog deleted on chromosome ten (pten) expression, and further increased akt and gsk-3β phosphorylation in non-hypercholesterolemic, but not in hypercholesterolemic mice. |
2020-08-12 |
2023-08-13 |
mouse |
| Loral Showalter, Brian J Czerniecki, Gary K Kosk. Th1 cytokines in conjunction with pharmacological Akt inhibition potentiate apoptosis of breast cancer cells Oncotarget. vol 11. issue 30. 2020-08-10. PMID:32774769. |
th1 cytokines in conjunction with pharmacological akt inhibition potentiate apoptosis of breast cancer cells targeted drug approaches have been a major focus for developing new anticancer therapies. |
2020-08-10 |
2023-08-13 |
Not clear |
| Yue Zhao, Yaqi Yu, Wenxiu Zhao, Song You, Min Feng, Chengrong Xie, Xiaoqin Chi, Yi Zhang, Xiaomin Wan. As a downstream target of the AKT pathway, NPTX1 inhibits proliferation and promotes apoptosis in hepatocellular carcinoma. Bioscience reports. vol 39. issue 6. 2020-08-03. PMID:31113871. |
as a downstream target of the akt pathway, nptx1 inhibits proliferation and promotes apoptosis in hepatocellular carcinoma. |
2020-08-03 |
2023-08-13 |
Not clear |
| Yan Xiong, Jianan Lan, Kaixin Huang, Yaruo Zhang, Lewei Zheng, Yanfeng Wang, Qifa Y. PP2Ac upregulates PI3K-Akt signaling and induces hepatocyte apoptosis in liver donor after brain death. Apoptosis : an international journal on programmed cell death. vol 24. issue 11-12. 2020-08-03. PMID:31605257. |
to further investigate the roles of pp2a and akt in regulating apoptosis of hepatocytes after bd, we cultivated human liver cell line l02 with serum deprivation and hypoxia, to simulate the ischemic and hypoxic conditions of hepatocytes in dbd. |
2020-08-03 |
2023-08-13 |
human |
| You Chen, Yongsheng Wang, Min Liu, Bingkang Zhou, Guangjie Yan. Diosmetin exhibits anti-proliferative and anti-inflammatory effects on TNF-α-stimulated human rheumatoid arthritis fibroblast-like synoviocytes through regulating the Akt and NF-κB signaling pathways. Phytotherapy research : PTR. vol 34. issue 6. 2020-07-31. PMID:31833613. |
suppression of akt or nf-κb promoted apoptosis and inhibited tnf-α-induced proliferation increase and production of il-1β, il-6, il-8, and mmp-1 in mh7a cells, and diosmetin treatment enhanced these effects. |
2020-07-31 |
2023-08-13 |
human |
| Fenghua Lv, Zhuo Wang, Yanli Huang, Aoyang Si, Yulei Che. CLEC3B protects H9c2 cardiomyocytes from apoptosis caused by hypoxia via the PI3K/Akt pathway. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 53. issue 9. 2020-07-31. PMID:32696821. |
then, cell counting kit-8 (cck-8), flow cytometry, qrt-pcr, and western blot assays were performed to investigate cell viability, apoptosis, and expression levels of clec3b, phosphatidylinositol 3-kinase (pi3k), phosphorylated pi3k (p-pi3k), protein kinase b (akt), phosphorylated akt (p-akt), and cleaved-caspase 3. |
2020-07-31 |
2023-08-13 |
rat |
| Yandong Shen, Kyle Crassini, Suneet Sandhu, Narjis Fatima, Richard I Christopherson, Stephen P Mulligan, O Giles Bes. Dual inhibition of MEK1/2 and AKT by binimetinib and MK2206 induces apoptosis of chronic lymphocytic leukemia cells under conditions that mimic the tumor microenvironment. Leukemia & lymphoma. vol 60. issue 7. 2020-07-28. PMID:30648436. |
dual inhibition of mek1/2 and akt by binimetinib and mk2206 induces apoptosis of chronic lymphocytic leukemia cells under conditions that mimic the tumor microenvironment. |
2020-07-28 |
2023-08-13 |
Not clear |
| Yandong Shen, Kyle Crassini, Suneet Sandhu, Narjis Fatima, Richard I Christopherson, Stephen P Mulligan, O Giles Bes. Dual inhibition of MEK1/2 and AKT by binimetinib and MK2206 induces apoptosis of chronic lymphocytic leukemia cells under conditions that mimic the tumor microenvironment. Leukemia & lymphoma. vol 60. issue 7. 2020-07-28. PMID:30648436. |
in the current study we demonstrate synergy between the mek1/2 inhibitor binimetinib and the akt inhibitor mk2206, which combined induce apoptosis of primary cll cells and restrict the cell cycle progression and proliferation of the osu-cll cell line. |
2020-07-28 |
2023-08-13 |
Not clear |
| Junye Chen, Yi Lu, Mengyuan Tian, Qiren Huan. Molecular mechanisms of FOXO1 in adipocyte differentiation. Journal of molecular endocrinology. vol 62. issue 3. 2020-07-24. PMID:30780132. |
forkhead box-o1 (foxo1) is a downstream target of akt and plays crucial roles in cell cycle control, apoptosis, metabolism and adipocyte differentiation. |
2020-07-24 |
2023-08-13 |
Not clear |
| Dubek Kazyken, Brian Magnuson, Cagri Bodur, Hugo A Acosta-Jaquez, Deqiang Zhang, Xin Tong, Tammy M Barnes, Gabrielle K Steinl, Nicole E Patterson, Christopher H Altheim, Naveen Sharma, Ken Inoki, Gregory D Cartee, Dave Bridges, Lei Yin, Steven M Riddle, Diane C Finga. AMPK directly activates mTORC2 to promote cell survival during acute energetic stress. Science signaling. vol 12. issue 585. 2020-07-24. PMID:31186373. |
functionally, inactivation of ampk, mtorc2, and akt increased apoptosis during acute energetic stress. |
2020-07-24 |
2023-08-13 |
Not clear |
| Wei-Feng Zheng, Shou-Yan Zhang, Hui-Fang Ma, Xue-Wei Chang, Hao Wan. C1qTNF-related protein-6 protects against doxorubicin-induced cardiac injury. Journal of cellular biochemistry. vol 120. issue 6. 2020-07-20. PMID:30719766. |
ctrp6 prevented cardiomyocytes from dox-induced apoptosis and activated the akt pathway in vitro. |
2020-07-20 |
2023-08-13 |
mouse |
| Huijun He, Daheng Wei, Hua Liu, Chen Zhu, Yue Lu, Zongwen Ke, Shuang Jiang, Jianhua Huan. Glycyrrhizin protects against sodium iodate-induced RPE and retinal injury though activation of AKT and Nrf2/HO-1 pathway. Journal of cellular and molecular medicine. vol 23. issue 5. 2020-07-20. PMID:30821111. |
the underlying mechanisms included increased phosphorylation of akt, and increased expression of nuclear factor erythroid 2-related factor2 (nrf-2) and ho-1, thereby protecting rpe from si-induced ros and apoptosis. |
2020-07-20 |
2023-08-13 |
mouse |
| Zhi-Wen Zhang, Bo Pang, Yi-Chao Chen, An-Quan Pen. TMPRSS3 regulates cell viability and apoptosis processes of HEI-OC1 cells via regulation of the circ-Slc4a2, miR-182 and Akt cascade. The journal of gene medicine. vol 21. issue 10. 2020-07-17. PMID:31408246. |
tmprss3 regulates cell viability and apoptosis processes of hei-oc1 cells via regulation of the circ-slc4a2, mir-182 and akt cascade. |
2020-07-17 |
2023-08-13 |
Not clear |
| Qian Yu, Bei Zhao, Qi He, Yuan Zhang, Xian-Bo Pen. microRNA-206 is required for osteoarthritis development through its effect on apoptosis and autophagy of articular chondrocytes via modulating the phosphoinositide 3-kinase/protein kinase B-mTOR pathway by targeting insulin-like growth factor-1. Journal of cellular biochemistry. vol 120. issue 4. 2020-07-13. PMID:30335903. |
this study aims to investigate the role of mir-206 in regulating insulin-like growth factor-1 (igf-1) in chondrocyte autophagy and apoptosis in an oa rat model via the phosphoinositide 3-kinase (p13k)/protein kinase b (akt)-mechanistic target of rapamycin (mtor) signaling pathway. |
2020-07-13 |
2023-08-13 |
rat |
| Chunting Zhang, Weiwei Liang, Hongyong Wang, Yueqing Yang, Tianhang Wang, Shuyu Wang, Xudong Wang, Ying Wang, Honglin Fen. γ-Oryzanol mitigates oxidative stress and prevents mutant SOD1-Related neurotoxicity in Drosophila and cell models of amyotrophic lateral sclerosis. Neuropharmacology. vol 160. 2020-07-08. PMID:31521619. |
moreover, orz significantly decreased neuronal apoptosis and upregulated the nuclear factor erythroid 2-related factor 2 (nrf2)/glutamate-cysteine ligase catalytic subunit (gclc) antioxidant pathway via activating akt in hsod1-g93a-expressing nsc-34 cells. |
2020-07-08 |
2023-08-13 |
drosophila_melanogaster |
| Qi Ma, Weilin Zhang, Chongzhuo Zhu, Junling Liu, Quan Che. FUNDC2 regulates platelet activation through AKT/GSK-3β/cGMP axis. Cardiovascular research. vol 115. issue 11. 2020-07-06. PMID:30576423. |
we previously found that mitochondrial protein fundc2 mediates phosphoinositide 3-kinase (pi3k)/phosphatidylinositol-3,4,5-trisphosphate (pip3)-dependent akt phosphorylation and regulates platelet apoptosis. |
2020-07-06 |
2023-08-13 |
Not clear |
| Bin Zhu, Caiping Ren, Ke Du, Hecheng Zhu, Yong Ai, Fenghua Kang, Yi Luo, Weidong Liu, Lei Wang, Yang Xu, Xingjun Jiang, Yihua Zhan. Olean-28,13b-olide 2 plays a role in cisplatin-mediated apoptosis and reverses cisplatin resistance in human lung cancer through multiple signaling pathways. Biochemical pharmacology. vol 170. 2020-07-01. PMID:31541631. |
in the present study, it was demonstrated that a novel synthesized oa family compound, olean-28,13b-olide 2 (olo-2), synergistically enhanced cisplatin (cddp)-mediated apoptosis, led to the activation of caspase-3 and the generation of reactive oxygen species (ros), induced dna damage, and inhibited the activation of the extracellular-signal-regulated kinase (erk), signal transducer and activator of transcription 3 (stat3), akt and nuclear factor-κb (nf-κb) pathways in human multidrug-resistant a549/cddp lung adenocarcinoma cells. |
2020-07-01 |
2023-08-13 |
human |
| Kaixin Li, Xiaoxia Shi, Mengxin Luo, Inam-U-Llah, Pingan Wu, Mengren Zhang, Cong Zhang, Qiujuan Li, Yachen Wang, Fengyuan Pia. Taurine protects against myelin damage of sciatic nerve in diabetic peripheral neuropathy rats by controlling apoptosis of schwann cells via NGF/Akt/GSK3β pathway. Experimental cell research. vol 383. issue 2. 2020-06-29. PMID:31415759. |
mechanistically, taurine up-regulated ngf expression and phosphorylation levels of akt and gsk3β, while, blocking activation of ngf and phosphorylation of akt and gsk3β increased apoptosis of high glucose-exposed rsc96 cells with taurine supplement. |
2020-06-29 |
2023-08-13 |
rat |
| Wei Huang, Chong Zeng, Jie Liu, Li Yuan, Weidong Liu, Lei Wang, Hecheng Zhu, Yang Xu, Yi Luo, Dan Xie, Xingjun Jiang, Caiping Re. Sodium butyrate induces autophagic apoptosis of nasopharyngeal carcinoma cells by inhibiting AKT/mTOR signaling. Biochemical and biophysical research communications. vol 514. issue 1. 2020-06-26. PMID:31023529. |
furthermore, nabu treatment inhibited the akt/mtor axis indicated by deregulated p-akt(s473) and p-mtor(s2448) and ectopic akt expression both suppressed nabu induced autophagy and apoptosis. |
2020-06-26 |
2023-08-13 |
Not clear |
| Meini Kang, Shuai Shao, Yue Zhang, Xue Liang, Kai Zhang, Guangping L. Beneficial Effects of Ticagrelor on Oxidized Low-Density Lipoprotein (ox-LDL)-Induced Apoptosis in Human Umbilical Vein Endothelial Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-06-26. PMID:31863577. |
apoptosis rates of huvecs was evaluated by flow cytometry, and the expression levels of akt, p-akt, bcl-2, bax, caspase-3, endothelial nitric oxide synthase (enos), and nitric oxide (no) concentration were assessed. |
2020-06-26 |
2023-08-13 |
human |