| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Liu, Zhen-Tang Jing, Chao-Rong Xue, Shu-Xiang Wu, Wan-Nan Chen, Xin-Jian Lin, Xu Li. PI3K/AKT inhibitors aggravate death receptor-mediated hepatocyte apoptosis and liver injury. Toxicology and applied pharmacology. vol 381. 2020-05-18. PMID:31445927. |
we postulated that pi3k or akt inhibitors may exacerbate liver damage via the death factor-mediated hepatocyte apoptosis. |
2020-05-18 |
2023-08-13 |
mouse |
| Chia-Hui Huang, Yuan-Chin Lee, Jing-Ting Chiou, Yi-Jun Shi, Liang-Jun Wang, Long-Sen Chan. Arsenic trioxide-induced p38 MAPK and Akt mediated MCL1 downregulation causes apoptosis of BCR-ABL1-positive leukemia cells. Toxicology and applied pharmacology. vol 397. 2020-05-18. PMID:32305283. |
arsenic trioxide-induced p38 mapk and akt mediated mcl1 downregulation causes apoptosis of bcr-abl1-positive leukemia cells. |
2020-05-18 |
2023-08-13 |
human |
| Wei-Min Zhou, Gao-Liang Wu, Ji Huang, Jin-Gao Li, Chao Hao, Qiu-Ming He, Xiao-Dan Chen, Gong-Xian Wang, Xin-Hua T. Low expression of PDK1 inhibits renal cell carcinoma cell proliferation, migration, invasion and epithelial mesenchymal transition through inhibition of the PI3K-PDK1-Akt pathway. Cellular signalling. vol 56. 2020-05-15. PMID:30465826. |
si-pdk1 exhibited marked reductions in relation to the mrna and protein expression of pdk1, pi3k, akt as well as vimentin while elevated mrna and protein expressions of e-cadherin were detected, which ultimately suggested that cell migration, proliferation and invasion had been inhibited coupled with enhanced levels of cell apoptosis. |
2020-05-15 |
2023-08-13 |
Not clear |
| Guangya Zhang, Jiangping He, Xiaofei Ye, Jing Zhu, Xi Hu, Minyan Shen, Yuru Ma, Ziming Mao, Huaidong Song, Fengling Che. β-Thujaplicin induces autophagic cell death, apoptosis, and cell cycle arrest through ROS-mediated Akt and p38/ERK MAPK signaling in human hepatocellular carcinoma. Cell death & disease. vol 10. issue 4. 2020-05-15. PMID:30874538. |
β-thujaplicin induces autophagic cell death, apoptosis, and cell cycle arrest through ros-mediated akt and p38/erk mapk signaling in human hepatocellular carcinoma. |
2020-05-15 |
2023-08-13 |
human |
| Xiaoyi Yu, Yingzi Luo, Gangyi Chen, Hong Liu, Ni Tian, Xiaoting Zen, Qiuhong Li. Long noncoding RNA IGF2AS regulates high-glucose induced apoptosis in human retinal pigment epithelial cells. IUBMB life. vol 71. issue 10. 2020-05-15. PMID:31317640. |
akt knockdown was shown to dramatically reverse the preventive effect of igf2-as-downregulation on high-glucose-induced apoptosis in arpe-19 cells. |
2020-05-15 |
2023-08-13 |
human |
| Xiaoyi Yu, Yingzi Luo, Gangyi Chen, Hong Liu, Ni Tian, Xiaoting Zen, Qiuhong Li. Long noncoding RNA IGF2AS regulates high-glucose induced apoptosis in human retinal pigment epithelial cells. IUBMB life. vol 71. issue 10. 2020-05-15. PMID:31317640. |
we demonstrated that inhibiting igf2-as, possibly also through activation of akt signaling pathway, has a protective function in high-glucose-induced apoptosis in human retinal pigment epithelial cells in diabetic retinopathy. |
2020-05-15 |
2023-08-13 |
human |
| Di Ge, Jia Gao, Lina Han, Ying Li, Hong-Hong Liu, Wan-Cheng Yang, Fen Chang, Jing Liu, Mei Yu, Jing Zha. Novel effects of sphingosylphosphorylcholine on the apoptosis of breast cancer via autophagy/AKT/p38 and JNK signaling. Journal of cellular physiology. vol 234. issue 7. 2020-05-12. PMID:30488428. |
meanwhile, p38mapk (p38) and protein kinase b (pkb or akt) signaling pathways were also activated to inhibit apoptosis, suggesting that spc could evoke multiple signaling pathways to modulate cell apoptosis. |
2020-05-12 |
2023-08-13 |
Not clear |
| Di Ge, Jia Gao, Lina Han, Ying Li, Hong-Hong Liu, Wan-Cheng Yang, Fen Chang, Jing Liu, Mei Yu, Jing Zha. Novel effects of sphingosylphosphorylcholine on the apoptosis of breast cancer via autophagy/AKT/p38 and JNK signaling. Journal of cellular physiology. vol 234. issue 7. 2020-05-12. PMID:30488428. |
akt and p38 were in the downstream of autophagy, which is autophagy/akt/p38 signaling evoked by spc to antagonize jnk signaling and subsequent apoptosis. |
2020-05-12 |
2023-08-13 |
Not clear |
| Yuanlong Ge, Shu Wu, Zepeng Zhang, Xiaocui Li, Feng Li, Siyu Yan, Haiying Liu, Junjiu Huang, Yong Zha. Inhibition of p53 and/or AKT as a new therapeutic approach specifically targeting ALT cancers. Protein & cell. vol 10. issue 11. 2020-05-11. PMID:31115790. |
therefore, p53 and akt are the key factors that suppress spontaneous apoptosis in alt cells. |
2020-05-11 |
2023-08-13 |
mouse |
| Bowen Meng, Dongle Wu, Yangfan Cheng, Peina Huang, Yuanbo Liu, Lei Gan, Chufeng Liu, Yang Ca. Interleukin-20 differentially regulates bone mesenchymal stem cell activities in RANKL-induced osteoclastogenesis through the OPG/RANKL/RANK axis and the NF-κB, MAPK and AKT signalling pathways. Scandinavian journal of immunology. vol 91. issue 5. 2020-05-07. PMID:32090353. |
we initially found that il-20 differentially regulated preosteoclast proliferation and apoptosis; bmsc-conditioned medium (cm) significantly enhanced osteoclast formation and bone resorption, which was dose-dependently regulated by il-20; il-20 inhibited opg expression and promoted m-csf, rankl and rankl/opg expression; and il-20 differentially regulated the expression of osteoclast-specific gene and transcription factors through the opg/rankl/rank axis and the nf-kb, mapk and akt pathways. |
2020-05-07 |
2023-08-13 |
Not clear |
| Xiaoqiong Jia, Zhenping Wen, Qiuying Sun, Xiaohua Zhao, Hao Yang, Xiaoyu Shi, Tao Xi. Apatinib suppresses the Proliferation and Apoptosis of Gastric Cancer Cells via the PI3K/Akt Signaling Pathway. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. vol 24. issue 5. 2020-05-01. PMID:31786865. |
to observe the mechanism of the effects of apatinib on the proliferation and apoptosis of human gastric cancer (hgc-27) cells via the phosphatidylinositol 3-kinase (pi3k)/protein kinase b (akt) signaling pathway through in vitro cytology experiments. |
2020-05-01 |
2023-08-13 |
human |
| Qian Wang, Shengnan Jia, Yan Jiao, Libo Xu, Ding Wang, Xuyang Chen, Xindan Hu, Hang Liang, Naiyan Wen, Shengnan Zhang, Baofeng Guo, Ling Zhan. SSRP1 influences colorectal cancer cell growth and apoptosis via the AKT pathway. International journal of medical sciences. vol 16. issue 12. 2020-04-30. PMID:31839745. |
ssrp1 influences colorectal cancer cell growth and apoptosis via the akt pathway. |
2020-04-30 |
2023-08-13 |
Not clear |
| Kaidi Wang, Xuan Wang, Yiying Hou, Huihui Zhou, Kangsen Mai, Gen H. Apoptosis of cancer cells is triggered by selective crosslinking and inhibition of receptor tyrosine kinases. Communications biology. vol 2. 2020-04-23. PMID:31263775. |
the inhibition of rtks by cona led to suppression of pro-survival pathways and induction of apoptosis in multiple cancer cell lines, while overexpression of constitutively activated protein kinase b (akt) reversed the apoptotic effect. |
2020-04-23 |
2023-08-13 |
Not clear |
| M Iida, P M Harari, D L Wheeler, M Toulan. Targeting AKT/PKB to improve treatment outcomes for solid tumors. Mutation research. vol 819-820. 2020-04-22. PMID:32120136. |
likewise, akt attenuates chemotherapy-induced apoptosis. |
2020-04-22 |
2023-08-13 |
human |
| Anees Rahman, Siraj Pallichankandy, Faisal Thayyullathil, Sehamuddin Galadar. Critical role of H Free radical biology & medicine. vol 134. 2020-04-21. PMID:30735839. |
earlier, we have reported that sng induces reactive oxygen species (ros)-dependent ceramide (cer) generation and akt dephosphorylation, leading to the induction of apoptosis in human leukemic cells. |
2020-04-21 |
2023-08-13 |
human |
| Sridhar T Narla, Daniel S Bushnell, Caitlin M Schaefer, Mehdi Nouraie, Carlton M Bate. Keratinocyte Growth Factor Reduces Injury and Leads to Early Recovery from Cyclophosphamide Bladder Injury. The American journal of pathology. vol 190. issue 1. 2020-04-21. PMID:31654636. |
despite superficial cell loss, kgf suppressed intermediate and basal cell apoptosis, likely via akt signaling. |
2020-04-21 |
2023-08-13 |
mouse |
| Chanatip Ooppachai, Pornngarm Limtrakul Dejkriengkraikul, Supachai Yodkeere. Dicentrine Potentiates TNF-α-Induced Apoptosis and Suppresses Invasion of A549 Lung Adenocarcinoma Cells via Modulation of NF-κB and AP-1 Activation. Molecules (Basel, Switzerland). vol 24. issue 22. 2020-04-20. PMID:31766230. |
taken together, our results suggest that dicentrine could enhance tnf-α-induced a549 cell death by inducing apoptosis and reducing cell invasion due to, at least in part, the suppression of tak-1, mapk, akt, ap-1, and nf-κb signaling pathways. |
2020-04-20 |
2023-08-13 |
Not clear |
| Sweta Ghosh, Subir Kumar Juin, Partha Nandi, Suchandra Bhattacharyya Majumdar, Anamika Bose, Rathindranath Baral, Parames C Sil, Subrata Majumda. PKCζ mediated anti-proliferative effect of C2 ceramide on neutralization of the tumor microenvironment and melanoma regression. Cancer immunology, immunotherapy : CII. vol 69. issue 4. 2020-04-20. PMID:31996991. |
moreover, pkcζ was revealed as one of the key regulators of akt and ceramide during c2 ceramide-mediated apoptosis. |
2020-04-20 |
2023-08-13 |
Not clear |
| Yanghui Wen, Jun He, Xiaofeng Xue, Junyi Qiu, Yinkai Xu, Zuxiong Tang, Haixin Qian, Lei Qin, Xiaohua Yan. β-arrestin2 Inhibits Apoptosis and Liver Inflamation Induced by Ischemia-reperfusion in Mice via AKT and TLR4 Pathway. Archives of medical research. vol 50. issue 7. 2020-04-15. PMID:31760331. |
β-arrestin2 inhibits apoptosis and liver inflamation induced by ischemia-reperfusion in mice via akt and tlr4 pathway. |
2020-04-15 |
2023-08-13 |
mouse |
| Yong-Jie Li, Yue Wang, Yi-Ying Wan. MicroRNA-99b suppresses human cervical cancer cell activity by inhibiting the PI3K/AKT/mTOR signaling pathway. Journal of cellular physiology. vol 234. issue 6. 2020-04-13. PMID:30480801. |
next, alteration of mir-99b expression in cervical cancer was conducted to evaluate levels of pi3k, akt, mtor, p70s6k matrix metallopeptidase 2, epithelial cell adhesion molecule, and intercellular adhesion molecule 1, as well as the effect of mir-99b on cell proliferation, invasion, migration, cell cycle distribution, and apoptosis. |
2020-04-13 |
2023-08-13 |
human |