| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maheshkumar Kannan, Sridharan Jayamohan, Rajesh Kannan Moorthy, Siva Chander Chabattula, Mathan Ganeshan, Antony Joseph Velanganni Arockia. AEG-1/miR-221 Axis Cooperatively Regulates the Progression of Hepatocellular Carcinoma by Targeting PTEN/PI3K/AKT Signaling Pathway. International journal of molecular sciences. vol 20. issue 22. 2020-04-13. PMID:31698701. |
on the other hand, there were no significant expression changes of aeg-1 in mir-221 mimic and mir-221 inhibitor transfected hcc cells and inhibition of mir-221/aeg-1 axis decreased cell proliferation, invasion, migration, and angiogenesis and induced apoptosis, cell cycle arrest by upregulating p57, p53, pten, and rb and downregulating lsf, mmp9, opn, bcl-2, pi3k, akt, and lc3a in hcc cells. |
2020-04-13 |
2023-08-13 |
Not clear |
| Zhen Cheng, Weiwei Sun, Xiaohui Ni, Hua Xu, Youhua Wan. GAB2 inhibits chondrocyte apoptosis through PI3K-AKT signaling in osteoarthritis. International journal of clinical and experimental pathology. vol 13. issue 3. 2020-04-11. PMID:32269703. |
moreover, gab2 knockdown inhibited akt phosphorylation, increased bax expression, and decreased bcl2 expression, which indicated that gab2 regulates chondrocyte apoptosis through pi3k-akt signaling. |
2020-04-11 |
2023-08-13 |
Not clear |
| Yuki Ishiura, Hanako Ishimaru, Tadashi Watanabe, Masahiro Fujimur. Sulforaphane Exhibits Cytotoxic Effects against Primary Effusion Lymphoma Cells by Suppressing p38MAPK and AKT Phosphorylation. Biological & pharmaceutical bulletin. vol 42. issue 12. 2020-04-09. PMID:31787726. |
our data and previous literature indicate that sfn represses the phosphorylation of p38mapk and akt, which results in pel cell apoptosis. |
2020-04-09 |
2023-08-13 |
Not clear |
| Chuanzhen Liu, Mengmeng Tang, Xiquan Zhang, Jianhua Li, Guangqing Ca. Knockdown of miR-665 Protects Against Cardiomyocyte Ischemia/Reperfusion Injury-Induced ROS Accumulation and Apoptosis Through the Activation of Pak1/Akt Signaling in Myocardial Infarction. International heart journal. vol 61. issue 2. 2020-04-08. PMID:32132320. |
more importantly, pak1 was the target gene of mir-665, and knockdown of mir-665 depressed the accumulation of ros and cell apoptosis by targeting pak1 and promoting the phosphorylation of akt, whereas knockdown of pak1 could attenuate the protection of mir-665 inhibitor in h/r-treated h9c2 cells. |
2020-04-08 |
2023-08-13 |
rat |
| Yifan Wang, Wenying Li, Yahui Yang, Qinsong Zeng, Ka-Hing Wong, Xiaoling Li, Tianfeng Che. An integrin-targeting nanosystem as a carrier of the selenadiazole derivative to induce ROS-mediated apoptosis in bladder cancer cells, from rational design to action mechanisms. Journal of materials chemistry. B. vol 3. issue 48. 2020-04-08. PMID:32262936. |
further mechanistic studies using western blotting showed that bsec-pei-rgd triggered bladder cancer cell apoptosis by activating p38, jnk and p53 and by inactivating akt and erk. |
2020-04-08 |
2023-08-13 |
Not clear |
| Wilfred Lieberthal, Meiyi Tang, Mersema Abate, Mark Lusco, Jerrold S Levin. AMPK-mediated activation of Akt protects renal tubular cells from stress-induced apoptosis in vitro and ameliorates ischemic AKI in vivo. American journal of physiology. Renal physiology. vol 317. issue 7. 2020-04-07. PMID:30995114. |
ampk-mediated activation of akt protects renal tubular cells from stress-induced apoptosis in vitro and ameliorates ischemic aki in vivo. |
2020-04-07 |
2023-08-13 |
mouse |
| Patrycja Kurowska, Ewa Mlyczyńska, Monika Dawid, Małgorzata Opydo-Chanek, Joelle Dupont, Agnieszka Ra. In Vitro Effects of Vaspin on Porcine Granulosa Cell Proliferation, Cell Cycle Progression, and Apoptosis by Activation of GRP78 Receptor and Several Kinase Signaling Pathways Including MAP3/1, AKT, and STAT3. International journal of molecular sciences. vol 20. issue 22. 2020-04-07. PMID:31752432. |
in vitro effects of vaspin on porcine granulosa cell proliferation, cell cycle progression, and apoptosis by activation of grp78 receptor and several kinase signaling pathways including map3/1, akt, and stat3. |
2020-04-07 |
2023-08-13 |
Not clear |
| Tao Jiang, Zhao-Hui Chen, Zhe Chen, Dan Ta. SULF2 promotes tumorigenesis and inhibits apoptosis of cervical cancer cells through the ERK/AKT signaling pathway. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 53. issue 2. 2020-04-07. PMID:32049100. |
sulf2 is highly expressed in cervical cancer, and thus, downregulation of sulf2 can inhibit the erk1/2 and akt signaling pathways to suppress the proliferation, invasion, and migration of cervical cancer cells while facilitating apoptosis. |
2020-04-07 |
2023-08-13 |
mouse |
| Hai Zhang, Xiaoqing Dong, Rui Zhao, Ruijie Zhang, Chong Xu, Xiaoxue Wang, Chunxiao Liu, Xiaoyu Hu, Shile Huang, Long Che. Cadmium results in accumulation of autophagosomes-dependent apoptosis through activating Akt-impaired autophagic flux in neuronal cells. Cellular signalling. vol 55. 2020-04-06. PMID:30578829. |
of note, inhibition of akt with akt inhibitor x, or ectopic expression of dominant negative akt (dn-akt), in the presence or absence of 3-ma, significantly alleviated cd-triggered phosphorylation of akt and becn1, autophagosomes, and apoptosis. |
2020-04-06 |
2023-08-13 |
Not clear |
| Michael D Wetzel, Joseph C Wenk. Mechanisms by which hydrogen sulfide attenuates muscle function following ischemia-reperfusion injury: effects on Akt signaling, mitochondrial function, and apoptosis. Journal of translational medicine. vol 17. issue 1. 2020-04-06. PMID:30665344. |
mechanisms by which hydrogen sulfide attenuates muscle function following ischemia-reperfusion injury: effects on akt signaling, mitochondrial function, and apoptosis. |
2020-04-06 |
2023-08-13 |
Not clear |
| Michael D Wetzel, Joseph C Wenk. Mechanisms by which hydrogen sulfide attenuates muscle function following ischemia-reperfusion injury: effects on Akt signaling, mitochondrial function, and apoptosis. Journal of translational medicine. vol 17. issue 1. 2020-04-06. PMID:30665344. |
one of the emerging therapies to combat ischemic reperfusion injury complications is hydrogen sulfide, which is a gasotransmitter that diffuses across cell membranes to exert effects on various signaling pathways regulating cell survival such as akt, mitochondrial activity, and apoptosis. |
2020-04-06 |
2023-08-13 |
Not clear |
| Michael D Wetzel, Joseph C Wenk. Mechanisms by which hydrogen sulfide attenuates muscle function following ischemia-reperfusion injury: effects on Akt signaling, mitochondrial function, and apoptosis. Journal of translational medicine. vol 17. issue 1. 2020-04-06. PMID:30665344. |
this review will detail the mechanisms of hydrogen sulfide in affecting the akt signaling pathway, mitochondrial function, and apoptosis, particularly in regards to ischemic reperfusion injury in muscle tissue. |
2020-04-06 |
2023-08-13 |
Not clear |
| Chao He, Chao Liu, Lei Wang, Yangbai Sun, Yuhang Jiang, Yongqiang Ha. Histone methyltransferase NSD2 regulates apoptosis and chemosensitivity in osteosarcoma. Cell death & disease. vol 10. issue 2. 2020-04-06. PMID:30683853. |
nsd2 regulates the expression of the apoptosis regulatory proteins bcl2 and sox2 through the erk and akt pathways. |
2020-04-06 |
2023-08-13 |
Not clear |
| Tanmay Majumdar, Shagun Sharma, Manmohan Kumar, Md Arafat Hussain, Namita Chauhan, Inderjeet Kalia, Amit Kumar Sahu, Vipin Singh Rana, Ruchi Bharti, Arun Kumar Haldar, Agam P Singh, Shibnath Mazumde. Tryptophan-kynurenine pathway attenuates β-catenin-dependent pro-parasitic role of STING-TICAM2-IRF3-IDO1 signalosome in Toxoplasma gondii infection. Cell death & disease. vol 10. issue 3. 2020-04-06. PMID:30770800. |
treatment of infected cells with kynurenine or its analogue, teriflunomide suppressed kinase activity of akt, and phosphorylation of β-catenin triggering caspase-3 dependent apoptosis of infected cells to inhibit parasite growth. |
2020-04-06 |
2023-08-13 |
Not clear |
| Tongzhou Hu, Zhenghua Fei, Huafang Su, Raoying Xie, Liting Che. Polydatin inhibits proliferation and promotes apoptosis of doxorubicin-resistant osteosarcoma through LncRNA TUG1 mediated suppression of Akt signaling. Toxicology and applied pharmacology. vol 371. 2020-04-06. PMID:30974157. |
polydatin inhibits proliferation and promotes apoptosis of doxorubicin-resistant osteosarcoma through lncrna tug1 mediated suppression of akt signaling. |
2020-04-06 |
2023-08-13 |
Not clear |
| Andressa Duarte, Giórgia Gobbi Silveira, Danilo Figueiredo Soave, João Paulo Oliveira Costa, Alfredo Ribeiro Silv. The Role of the LY294002 - A Non-Selective Inhibitor of Phosphatidylinositol 3-Kinase (PI3K) Pathway- in Cell Survival and Proliferation in Cell Line SCC-25. Asian Pacific journal of cancer prevention : APJCP. vol 20. issue 11. 2020-04-06. PMID:31759362. |
in the presence or absence of pi3k pathway inhibitors, we analyzed the protein expression of pakt and akt; x-linked inhibitor of apoptosis protein; bcl-2-associated death promoter; bcl-2-like protein two inhibitor; cyclooxygenase 1; cyclooxygenase-2; and glycoprotein-associated glucose transporter 1. |
2020-04-06 |
2023-08-13 |
Not clear |
| Fangxian Liu, Liangliang Wang, Shijiang Yi, Qianghe Liu, Xiaoxiao Xu, Min S. Clinical and biological significances of heat shock protein 90 (Hsp90) in human nasopharyngeal carcinoma cells and anti-cancer effects of Hsp90 inhibitor. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 120. 2020-03-31. PMID:31634779. |
followed by treatment with hsp90 inhibitor, the npc cells exhibited inhibited cellular proliferation and growth, induced cell apoptosis, reduced proliferative proteins of erk1/2, phospho-erk1/2 (thr202+tyr204), akt, phospho-akt (ser473), bcl-2, ki-67, and elevated apaf1 expression. |
2020-03-31 |
2023-08-13 |
human |
| Lijun Yin, Xuejun Chen, Hongbo Ji, Shunli Ga. Dexmedetomidine protects against sepsis‑associated encephalopathy through Hsp90/AKT signaling. Molecular medicine reports. vol 20. issue 5. 2020-03-31. PMID:31702043. |
analysis of tunel staining indicated that dexmedetomidine improved lps‑induced neuronal apoptosis, which could be eradicated by akt short hairpin rna transfection, prazosin or yohimbine. |
2020-03-31 |
2023-08-13 |
rat |
| Yixin Yang, Dan Chen, Huan Liu, Kai Yan. Increased expression of lncRNA CASC9 promotes tumor progression by suppressing autophagy-mediated cell apoptosis via the AKT/mTOR pathway in oral squamous cell carcinoma. Cell death & disease. vol 10. issue 2. 2020-03-30. PMID:30674868. |
after the addition of the akt activator sc79 in casc9-knockdown scc15 and cal27 cells, we found that the increased autophagy and apoptosis were remarkably rescued. |
2020-03-30 |
2023-08-13 |
Not clear |
| Junjie Wang, Dongdong Fu, Soulixay Senouthai, Yanwu Yo. Critical roles of PI3K/Akt/NF‑κB survival axis in angiotensin II‑induced podocyte injury. Molecular medicine reports. vol 20. issue 6. 2020-03-30. PMID:31638199. |
cells were treated with 10‑6 mol/l of ang ii and/or ly294002 (inhibitor of akt) or 740y‑p (activator of pi3k) for 48 h to detect akt, phosphorylated (phospho)‑akt, p65 nf‑κb, and phospho‑p65 nf‑κb, nephrin, podocin and caspase‑9 expression, and podocyte apoptosis. |
2020-03-30 |
2023-08-13 |
mouse |