| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chérifa Slim, Mohamed Amine Zaouali, Hana Nassrallah, Hiba Hadj Ammar, Hatem Majdoub, Abderrahman Bouraoui, Hassen Ben Abdenneb. Protective potential effects of fucoidan in hepatic cold ischemia-rerfusion injury in rats. International journal of biological macromolecules. vol 155. 2021-03-11. PMID:32243932. |
in addition, we noted a significant increase in the phosphorylation of ampk, akt protein kinase and gsk3-β, leading to a reduction in vdac phosphorylation, as well as a reduction in apoptosis (caspase 3), mitochondrial damage, oxidative stress and endoplasmic reticulum (er) stress markers. |
2021-03-11 |
2023-08-13 |
rat |
| Xiaoying He, Zhaomin Lin, Junya Ning, Na Li, Xiaoling Cui, Baoxiang Zhao, Fanzhen Hong, Junying Mia. Promoting TTC4 and HSP70 interaction and translocation of annexin A7 to lysosome inhibits apoptosis in vascular endothelial cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 9. 2021-03-11. PMID:33000523. |
on the one hand, increasing ttc4 and hsp70 interaction upregulated akt that inhibited apoptosis. |
2021-03-11 |
2023-08-13 |
Not clear |
| Jie-Lei Zhang, Dian-Hong Zhang, Ya-Peng Li, Lei-Ming Wu, Cui Liang, Rui Yao, Zheng Wang, Sheng-Dong Feng, Zhong-Min Wang, Yan-Zhou Zhan. Myotubularin-related protein 14 suppresses cardiac hypertrophy by inhibiting Akt. Cell death & disease. vol 11. issue 2. 2021-03-08. PMID:32080168. |
at the molecular level, prevention of ch in the absence of mtmr14 involved elevations in akt pathway components, which are key elements that regulate apoptosis and cell proliferation. |
2021-03-08 |
2023-08-13 |
mouse |
| Jie Li, Ping Yin, Xueying Chen, Xiangbo Kong, Wanzhen Zhong, Yaping Ge, Yangyang She, Xuehong Xian, Lei Qi, Zhi Lin, Justine Moe, Silian Fan. Effect of α2‑macroglobulin in the early stage of jaw osteoradionecrosis. International journal of oncology. vol 57. issue 1. 2021-03-08. PMID:32377713. |
fluorescence staining, flow cytometry and western blotting were conducted to detect the reactive oxygen species level, cell apoptosis and protein expression of superoxide dismutase 2 (sod2), heme oxygenase‑1 (ho‑1) and phosphorylated akt following irradiation. |
2021-03-08 |
2023-08-13 |
human |
| Chao Xu, Ruixia Wang, Yanfang Yang, Tongyi Xu, Yan Li, Jie Xu, Zhansheng Jian. Expression of OPN3 in lung adenocarcinoma promotes epithelial-mesenchymal transition and tumor metastasis. Thoracic cancer. vol 11. issue 2. 2021-03-05. PMID:31802643. |
opsin3 (opn3), a member of the guanine nucleotide-binding protein-coupled receptor superfamily, has been identified to affect the apoptosis of hepatoma cells by modulating the phosphorylation of akt and bcl2/bax. |
2021-03-05 |
2023-08-13 |
Not clear |
| Fu-Chi Kang, Yun-Chia Chen, Shu-Chun Wang, Edmund Cheung So, Bu-Miin Huan. Propofol induces apoptosis by activating caspases and the MAPK pathways, and inhibiting the Akt pathway in TM3 mouse Leydig stem/progenitor cells. International journal of molecular medicine. vol 46. issue 1. 2021-03-05. PMID:32319554. |
propofol induces apoptosis by activating caspases and the mapk pathways, and inhibiting the akt pathway in tm3 mouse leydig stem/progenitor cells. |
2021-03-05 |
2023-08-13 |
mouse |
| Fu-Chi Kang, Yun-Chia Chen, Shu-Chun Wang, Edmund Cheung So, Bu-Miin Huan. Propofol induces apoptosis by activating caspases and the MAPK pathways, and inhibiting the Akt pathway in TM3 mouse Leydig stem/progenitor cells. International journal of molecular medicine. vol 46. issue 1. 2021-03-05. PMID:32319554. |
additionally, propofol diminished the phosphorylation of akt to increase the apoptosis of tm3 cells. |
2021-03-05 |
2023-08-13 |
mouse |
| Fu-Chi Kang, Yun-Chia Chen, Shu-Chun Wang, Edmund Cheung So, Bu-Miin Huan. Propofol induces apoptosis by activating caspases and the MAPK pathways, and inhibiting the Akt pathway in TM3 mouse Leydig stem/progenitor cells. International journal of molecular medicine. vol 46. issue 1. 2021-03-05. PMID:32319554. |
on the whole, the findings of the present study demonstrate that propofol induces tm3 cell apoptosis by activating caspases and mapk pathways, as well as by inhibiting the akt pathway in tm3 cells. |
2021-03-05 |
2023-08-13 |
mouse |
| Shitong Xiang, Yuying Zhang, Tianyue Jiang, Ziying Ke, Yingchun Shang, Wen Ning, Zhuo Yang, Tao Zhan. Knockdown of Follistatin-like 1 disrupts synaptic transmission in hippocampus and leads to cognitive impairments. Experimental neurology. vol 333. 2021-03-05. PMID:32721453. |
it proves that fstl1 suppresses synaptic transmission by activating na/k-atpase in drg neurons and inhibits neuronal apoptosis by phosphorylation akt signaling. |
2021-03-05 |
2023-08-13 |
mouse |
| Xiong Gao, Xiaofei Li, Chi-Tang Ho, Xiaorong Lin, Yuanyuan Zhang, Bin Li, Zhongzheng Che. Cocoa tea (Camellia ptilophylla) induces mitochondria-dependent apoptosis in HCT116 cells via ROS generation and PI3K/Akt signaling pathway. Food research international (Ottawa, Ont.). vol 129. 2021-03-01. PMID:32036895. |
pretreatment with ros scavenger n-acetyl cysteine (nac) attenuated the impact of cwe on mitochondria-related apoptosis proteins, and partially recovered the inhibition of akt phosphorylation. |
2021-03-01 |
2023-08-13 |
mouse |
| Daniela Amelio, Filippo Garofal. The NOS/NO system in an example of extreme adaptation: The African lungfish. Journal of thermal biology. vol 90. 2021-03-01. PMID:32479389. |
in particular, the expression and localization patterns of nos, and its protein partners akt, hsp-90 and hif-1α, have been discussed, together with the apoptosis rate, evaluated by tunel technique. |
2021-03-01 |
2023-08-13 |
Not clear |
| Chen Wang, Xiangmin Lv, Chunbo He, John S Davis, Cheng Wang, Guohua Hu. Four and a Half LIM Domains 2 (FHL2) Contribute to the Epithelial Ovarian Cancer Carcinogenesis. International journal of molecular sciences. vol 21. issue 20. 2021-03-01. PMID:33092075. |
western blot data showed that knockdown of fhl2 downregulated akt expression level, and upregulated apoptosis related proteins such as cleaved parp, and cleaved-lamin a. |
2021-03-01 |
2023-08-13 |
Not clear |
| Libin Ma, Huadong He, Kang Jiang, Peiwu Jiang, Han He, Shengjia Feng, Kean Chen, Jia Shao, Gang Den. FAM46C inhibits cell proliferation and cell cycle progression and promotes apoptosis through PTEN/AKT signaling pathway and is associated with chemosensitivity in prostate cancer. Aging. vol 12. issue 7. 2021-02-25. PMID:32283544. |
fam46c knockdown in 22rv1 and du145 cells significantly inhibited apoptosis and promoted cell proliferation and cell cycle progression as well as activation of akt. |
2021-02-25 |
2023-08-13 |
Not clear |
| Jeremy Johnson, Zeta Chow, Dana Napier, Eun Lee, Heidi L Weiss, B Mark Evers, Piotr Rychaho. Targeting PI3K and AMPKα Signaling Alone or in Combination to Enhance Radiosensitivity of Triple Negative Breast Cancer. Cells. vol 9. issue 5. 2021-02-25. PMID:32438621. |
treatment with the akt inhibitor, mk-2206 48 h after radiotherapy decreased akt1 levels and potentiated radiation-induced apoptosis. |
2021-02-25 |
2023-08-13 |
Not clear |
| Ha Young Cho, Sang Wu Lee, Yu Hyun Jeon, Dong Hoon Lee, Go Woon Kim, Jung Yoo, So Yeon Kim, So Hee Kwo. Combination of ACY-241 and JQ1 Synergistically Suppresses Metastasis of HNSCC via Regulation of MMP-2 and MMP-9. International journal of molecular sciences. vol 21. issue 18. 2021-02-25. PMID:32961679. |
here, we report that the combination of acy-241 and jq1 shows synergistic cell growth inhibition, viability reduction, and apoptosis induction in hnscc cells through inactivation of akt and nf-κb signaling. |
2021-02-25 |
2023-08-13 |
human |
| Ayse Karatug Kaca. Indomethacin decreases insulin secretion by reducing KCa3.1 as a biomarker of pancreatic tumor and causes apoptotic cell death. Journal of biochemical and molecular toxicology. vol 34. issue 7. 2021-02-23. PMID:32128977. |
the relationship between cell death and insulin metabolism was determined with the administration of indomethacin. the cell viability by wst-1; the apoptosis and necrosis levels by elisa kits; malondialdehyde levels by spectrophotometer; and beclin, intracellular insulin, insulin secretion, kca3.1, insulin receptor (ir), glucose transporter type 2 (glut2), activating transcription factor 2 (atf2), elk1, c-jun, akt and phosphorylated atf2, elk1, c-jun, akt, intracellular betacellulin and betacellulin secretion levels by western blot analysis investigated. the ins1, ins2, ir, glut2, atf2, elk1, c-jun, akt, and betacellulin gene expression levels were determined by the real-time quantitative reverse transcription-polymerase chain reaction method. |
2021-02-23 |
2023-08-13 |
rat |
| Jyun-Bin Huang, Shih-Pin Hsu, Hsiu-Yung Pan, Shang-Der Chen, Shu-Fang Chen, Tsu-Kung Lin, Xuan-Ping Liu, Jie-Hau Li, Nai-Ching Chen, Chia-Wei Liou, Chung-Yao Hsu, Hung-Yi Chuang, Yao-Chung Chuan. Peroxisome Proliferator-Activated Receptor γ Coactivator 1α Activates Vascular Endothelial Growth Factor That Protects Against Neuronal Cell Death Following Status Epilepticus through PI3K/AKT and MEK/ERK Signaling. International journal of molecular sciences. vol 21. issue 19. 2021-02-23. PMID:33008083. |
upregulating the pgc-1α pathway will increase vegf/vegfr2 (flk-1) signaling and further activate some survival signaling that includes the mitogen activated protein kinase kinase (mek)/mitogen activated protein kinase (erk) and phosphatidylinositol 3-kinase (pi3k)/protein kinase b (akt) signaling pathways and offer neuroprotection as a consequence of apoptosis in the hippocampal neurons following status epilepticus. |
2021-02-23 |
2023-08-13 |
rat |
| Weihan Wang, Yubing Hao, Anling Zhang, Weidong Yang, Wei Wei, Guangxiu Wang, Zhifan Ji. miR-19a/b promote EMT and proliferation in glioma cells via SEPT7-AKT-NF-κB pathway. Molecular therapy oncolytics. vol 20. 2021-02-23. PMID:33614912. |
knocking down mir-19a/b in ln308 glioblastoma (gbm) cells with higher expression of mir-19a/b inhibits cell proliferation and invasion, induces apoptosis, and suppresses emt by downregulating the expression of akt, phosphorylated p-akt, nuclear factor κb (nf-κb), snail, n-cadherin, and vimentin and upregulating e-cadherin |
2021-02-23 |
2023-08-13 |
Not clear |
| Soon Young Hwang, Ngoc Hoan Nguyen, Tae Jung Kim, Youngsoo Lee, Mi Ae Kang, Jong-Soo Le. Non-Thermal Plasma Couples Oxidative Stress to TRAIL Sensitization through DR5 Upregulation. International journal of molecular sciences. vol 21. issue 15. 2021-02-19. PMID:32722598. |
dr5 (trail-r2) transcription by chop is upregulated in a pam-generated ros/rns-dependent manner, and pam itself upregulates pten expression mediated by suppression of mir-425 which is involved in akt inactivation, leading to increased apoptosis induction. |
2021-02-19 |
2023-08-13 |
Not clear |
| Junzhi Yi, Min Zhu, Feng Qiu, Yubo Zhou, Pan Shu, Ning Liu, Chenxi Wei, Shuanglin Xian. TNFAIP1 Mediates Formaldehyde-Induced Neurotoxicity by Inhibiting the Akt/CREB Pathway in N2a Cells. Neurotoxicity research. vol 38. issue 1. 2021-02-18. PMID:32335808. |
we found that exposure to 100 μm or 200 μm fa for 24 h led to decreased cell viability, increased cell apoptosis and neurite retraction, increased reactive oxygen species (ros) levels, upregulated protein expression of tnfaip1 and decreased the levels of phosphorylated akt and creb in the akt/creb pathway. |
2021-02-18 |
2023-08-13 |
mouse |