| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gene Chi Wai Man, Jianzhang Wang, Yi Song, Jack Ho Wong, Yu Zhao, Tat San Lau, Kam Tong Leung, Tak Hang Chan, Huating Wang, Joseph Kwong, Tzi Bun Ng, Chi Chiu Wan. Therapeutic potential of a novel prodrug of green tea extract in induction of apoptosis via ERK/JNK and Akt signaling pathway in human endometrial cancer. BMC cancer. vol 20. issue 1. 2021-04-22. PMID:33023525. |
therapeutic potential of a novel prodrug of green tea extract in induction of apoptosis via erk/jnk and akt signaling pathway in human endometrial cancer. |
2021-04-22 |
2023-08-13 |
human |
| Sung Chul Kwak, Yoon-Hee Cheon, Chang Hoon Lee, Hong Young Jun, Kwon-Ha Yoon, Myeung Su Lee, Ju-Young Ki. Grape Seed Proanthocyanidin Extract Prevents Bone Loss via Regulation of Osteoclast Differentiation, Apoptosis, and Proliferation. Nutrients. vol 12. issue 10. 2021-04-19. PMID:33081167. |
additionally, gspe promotes osteoclast proliferation by increasing the phosphorylation of components of the akt and mitogen-activated protein kinase signaling pathways and it also inhibits apoptosis by decreasing the activity of caspase-8, caspase-9, and caspase-3, as corroborated by a decrease in the terminal deoxynucleotidyl transferase dutp nick end labeling -positive cells. |
2021-04-19 |
2023-08-13 |
Not clear |
| Nour Al Kafri, Sassan Hafiz. Galectin-3 Stimulates Tyro3 Receptor Tyrosine Kinase and Erk Signalling, Cell Survival and Migration in Human Cancer Cells. Biomolecules. vol 10. issue 7. 2021-04-16. PMID:32664510. |
gal-3 also activated intracellular erk and akt kinases in both cell lines and furthermore protected cells from acute apoptosis induced by staurosporine but not from serum-starvation induced apoptosis. |
2021-04-16 |
2023-08-13 |
human |
| Huikai Zhang, Yang Xu, Gang Deng, Fanen Yuan, Yinqiu Tan, Lun Gao, Qian Sun, Yangzhi Qi, Kun Yang, Rongxin Geng, Hongxiang Jiang, Baohui Liu, Qianxue Che. SAA1 knockdown promotes the apoptosis of glioblastoma cells via downregulation of AKT signaling. Journal of Cancer. vol 12. issue 9. 2021-04-16. PMID:33854635. |
saa1 knockdown promotes the apoptosis of glioblastoma cells via downregulation of akt signaling. |
2021-04-16 |
2023-08-13 |
Not clear |
| Chufan Yan, Jiangyue Zhao, Yu Qin, Fangkun Zhao, Liyang Ji, Jinsong Zhan. Overexpression of ATG4a promotes autophagy and proliferation, and inhibits apoptosis in lens epithelial cells via the AMPK and Akt pathways. Molecular medicine reports. vol 22. issue 2. 2021-04-15. PMID:32626969. |
overexpression of atg4a promotes autophagy and proliferation, and inhibits apoptosis in lens epithelial cells via the ampk and akt pathways. |
2021-04-15 |
2023-08-13 |
Not clear |
| Pan Hong, Qin-Wen Liu, Yao Xie, Qi-Hua Zhang, Long Liao, Qing-Yu He, Bin Li, Wen Wen X. Echinatin suppresses esophageal cancer tumor growth and invasion through inducing AKT/mTOR-dependent autophagy and apoptosis. Cell death & disease. vol 11. issue 7. 2021-04-15. PMID:32655130. |
mechanistically, rna sequencing coupled with bioinformatics analysis and a series of functional assays revealed that echinatin induced apoptosis and autophagy through inactivation of akt/mtor signaling pathway, whereas constitutive activation of akt significantly abrogated these effects. |
2021-04-15 |
2023-08-13 |
Not clear |
| Ding Tian, Yin Xiang, Yong Tang, Zhuowang Ge, Qianhui Li, Yachen Zhan. Circ-ADAM9 targeting PTEN and ATG7 promotes autophagy and apoptosis of diabetic endothelial progenitor cells by sponging mir-20a-5p. Cell death & disease. vol 11. issue 7. 2021-04-15. PMID:32661238. |
circ-adam9 upregulated pten and atg7 in interaction with mir-20a-5p, and inhibited the phosphorylation of akt and mtor to aggravate autophagy and apoptosis of epcs under high glucose. |
2021-04-15 |
2023-08-13 |
mouse |
| Decheng Yin, Chengxiang Kong, Muhu Che. Effect of hnRNPA2/B1 on the proliferation and apoptosis of glioma U251 cells via the regulation of AKT and STAT3 pathways. Bioscience reports. vol 40. issue 7. 2021-04-14. PMID:32463472. |
effect of hnrnpa2/b1 on the proliferation and apoptosis of glioma u251 cells via the regulation of akt and stat3 pathways. |
2021-04-14 |
2023-08-13 |
human |
| G-Z Zhao, Y-Q Niu, Z-M Li, D Kou, L Zhan. MiR-200c inhibits proliferation and promotes apoptosis of Wilms tumor cells by regulating akt signaling pathway. European review for medical and pharmacological sciences. vol 24. issue 12. 2021-04-14. PMID:32633351. |
mir-200c inhibits proliferation and promotes apoptosis of wilms tumor cells by regulating akt signaling pathway. |
2021-04-14 |
2023-08-13 |
Not clear |
| Jianli Hu, William Rodemer, Guixin Zhang, Li-Qing Jin, Shuxin Li, Michael E Selze. Chondroitinase ABC Promotes Axon Regeneration and Reduces Retrograde Apoptosis Signaling in Lamprey. Frontiers in cell and developmental biology. vol 9. 2021-04-14. PMID:33842481. |
thus, cspg digestion not only enhances axon regeneration after sci, but also inhibits retrograde rs neuronal apoptosis signaling, possibly by reducing ptpσ expression and enhancing akt activation. |
2021-04-14 |
2023-08-13 |
Not clear |
| Linqiu Liu, Junjun Li, Yang H. Multifunctional epiberberine mediates multi-therapeutic effects. Fitoterapia. vol 147. 2021-04-12. PMID:33152460. |
all the available research studies indicated that epiberberine is a multi-target small molecule with a low toxicity and exerts many activities including anti-adipogenesis via akt and erk pathways, anti-dyslipidemia via inhibition on cholesterol synthesis, anti-cancer via p53/bax apoptosis pathway, anti-bacterial, improvement in diabetes and alzheimer's disease. |
2021-04-12 |
2023-08-13 |
Not clear |
| Cole Walters, Maverick Reed, Samantha Bartholomew, Ajay Bommaredd. Autophagy Induction by α-Santalol in Human Prostate Cancer Cells. Anticancer research. vol 41. issue 3. 2021-04-12. PMID:33788710. |
along with the studies from our laboratory, it is well established that α-santalol targets the phosphatidylinositol-4,5-bisphosphate 3-kinase-akt serine/ threonine kinase 1 (akt) pathway to induce apoptosis but its growth-suppressive effects have not been fully elucidated. |
2021-04-12 |
2023-08-13 |
human |
| Kyu Sic You, Yong Weon Yi, Jeonghee Cho, Yeon-Sun Seon. Dual Inhibition of AKT and MEK Pathways Potentiates the Anti-Cancer Effect of Gefitinib in Triple-Negative Breast Cancer Cells. Cancers. vol 13. issue 6. 2021-04-08. PMID:33801977. |
with drug combination screenings, we found that the triple combination of the protein kinase inhibitors (pkis) of the epidermal growth factor receptor (egfr), v-akt murine thymoma viral oncogene homolog (akt), and mapk/erk kinase (mek) is effective in inducing apoptosis in tnbc cells. |
2021-04-08 |
2023-08-13 |
rat |
| Peng Shen, Yanfeng Chen. Long noncoding RNA lncARSR confers resistance to Adriamycin and promotes osteosarcoma progression. Cell death & disease. vol 11. issue 5. 2021-04-07. PMID:32404870. |
further investigation revealed that the upregulation of lncarsr enhanced multidrug resistance-associated protein-1 (mrp1), apoptosis inhibitor survivin, and matrix metalloproteinase-2 (mmp2) through activating akt. |
2021-04-07 |
2023-08-13 |
mouse |
| Jun Jiang, Nanyang Zhou, Pian Ying, Ting Zhang, Ruojia Liang, Xuelu Jian. Emodin Promotes Apoptosis of Human Endometrial Cancer Through Regulating the MAPK and PI3K/ AKT Pathways. Open life sciences. vol 13. 2021-04-06. PMID:33817118. |
emodin promotes apoptosis of human endometrial cancer through regulating the mapk and pi3k/ akt pathways. |
2021-04-06 |
2023-08-13 |
human |
| Jun Jiang, Nanyang Zhou, Pian Ying, Ting Zhang, Ruojia Liang, Xuelu Jian. Emodin Promotes Apoptosis of Human Endometrial Cancer Through Regulating the MAPK and PI3K/ AKT Pathways. Open life sciences. vol 13. 2021-04-06. PMID:33817118. |
furthermore, the generation of reactive oxygen species (ros) was up-regulated in kle cells upon treatment with emodin, while the anti-oxidant agent n-acetyl cysteine (nac) can inhibit emodin-induced apoptosis and promote the activation of akt and bcl-2. |
2021-04-06 |
2023-08-13 |
human |
| Qinjie Weng, Mengting Zhao, Jiahuan Zheng, Lijun Yang, Zijie Xu, Zhikang Zhang, Jincheng Wang, Jiajia Wang, Bo Yang, Q Richard Lu, Meidan Ying, Qiaojun H. STAT3 dictates β-cell apoptosis by modulating PTEN in streptozocin-induced hyperglycemia. Cell death and differentiation. vol 27. issue 1. 2021-04-02. PMID:31097787. |
mechanistically, accumulating pten, induced by stat3 deficiency, directly represses phosphorylation of akt, which negatively modulates transcription factor activation, dysregulates β-cell function, positively promotes apoptotic signaling, and finally induces β-cell apoptosis. |
2021-04-02 |
2023-08-13 |
mouse |
| Xiaorui Liu, Lei Zhang, Lichun Yang, Jiuzeng Cui, Sicheng Che, Yuexia Liu, Jincheng Han, Xiaopeng An, Binyun Cao, Yuxuan Son. miR-34a/c induce caprine endometrial epithelial cell apoptosis by regulating circ-8073/CEP55 via the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR pathways. Journal of cellular physiology. vol 235. issue 12. 2021-04-02. PMID:32474960. |
mir-34a/c induced ceec apoptosis by targeting circ-8073/cep55 through the regulation of the ras/raf/mek/erk and phosphoitide 3-kinase (pi3k)/protein kinase b (akt)/mammalian target of rapamycin (mtor) pathways. |
2021-04-02 |
2023-08-13 |
Not clear |
| Yusheng Guo, Xiangsheng Cai, Hanwei Lu, Qiqi Li, Ying Zheng, Zefang Lin, Zexiong Cheng, Maoxiang Yang, Li Zhang, Lei Xiang, Xiaorong Yan. 17β-Estradiol Promotes Apoptosis of HepG2 Cells Caused by Oxidative Stress by Increasing Foxo3a Phosphorylation. Frontiers in pharmacology. vol 12. 2021-04-02. PMID:33790784. |
within a certain concentration range, 17β-estradiol induced oxidative stress and apoptosis of hepg2 cells, downregulated erα-36 expression, and increased akt and foxo3a phosphorylation. |
2021-04-02 |
2023-08-13 |
Not clear |
| Yang Zou, Rong Li, Dabin Kuang, Meiling Zuo, Wenqun Li, Wei Tong, Li Jiang, Min Zhou, Yin Chen, Wencheng Gong, Lijuan Liu, Fangfang To. Galangin Inhibits Cholangiocarcinoma Cell Growth and Metastasis through Downregulation of MicroRNA-21 Expression. BioMed research international. vol 2020. 2021-04-01. PMID:32626749. |
mechanically, galangin increases the expression of phosphatase and tensin homolog (pten), a direct target of mir-21, resulting in decreased phosphorylation of akt, a protein kinase which plays a critical role in controlling survival and apoptosis. |
2021-04-01 |
2023-08-13 |
Not clear |