| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yonglu Li, Xinyu Feng, Yiru Zhang, Yaxuan Wang, Xin Yu, Ruoyi Jia, Ting Yu, Xiaodong Zheng, Qiang Ch. Dietary flavone from the Food & function. vol 11. issue 11. 2021-05-18. PMID:33078819. |
the intrinsic mechanism study illustrated that tvf might induce apoptosis by activating autophagy by inhibiting the akt-mtor pathway, and the main component of tvf, quercetin-3-o-rutinoside, enabled thr308 site binding to block the phosphorylation of akt, which was further evidenced by molecular docking computation. |
2021-05-18 |
2023-08-13 |
Not clear |
| Chang-Jin Lee, Min-Ji Yoon, Dong Hyun Kim, Tae Uk Kim, Youn-Jung Kan. Profilin-1; a novel regulator of DNA damage response and repair machinery in keratinocytes. Molecular biology reports. vol 48. issue 2. 2021-05-18. PMID:33590416. |
pfn1 depletion accelerated dna damage-mediated apoptosis exhibiting pten loss of function instigated by increased phosphorylated inactivation followed by high levels of akt activation. |
2021-05-18 |
2023-08-13 |
Not clear |
| Shuyan Liu, Yun Zhang, Chang Huang, Shengyun Li. miR-215-5p is an anticancer gene in multiple myeloma by targeting RUNX1 and deactivating the PI3K/AKT/mTOR pathway. Journal of cellular biochemistry. vol 121. issue 2. 2021-05-14. PMID:31498483. |
mir-215-5p inhibition inhibited apoptosis while increased the phosphorylation levels of pi3k, akt, and mtor proteins, whereas, mir-215-5p overexpression increased cell proliferation. |
2021-05-14 |
2023-08-13 |
Not clear |
| Xi-Xi Li, Yun Yu, Xiu-Yuan Lang, Cheng-Yong Jiang, Rongfeng Lan, Xiao-Yan Qi. 2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-glucoside Restores BDNF-TrkB and FGF2-Akt Signaling Axis to Attenuate Stress-induced Depression. Neuroscience. vol 430. 2021-05-14. PMID:32007553. |
besides, thsg recovered the akt signaling pathway and antagonistically restored the expression of bcl-2 and cleaved-caspase-3 to inhibit apoptosis. |
2021-05-14 |
2023-08-13 |
mouse |
| Yuanyuan Dong, Jun Zhu, Ming Zhang, Shaoyang Ge, Liang Zha. Probiotic Lactobacillus salivarius Ren prevent dimethylhydrazine-induced colorectal cancer through protein kinase B inhibition. Applied microbiology and biotechnology. vol 104. issue 17. 2021-05-14. PMID:32666185. |
these results showed that ls inhibited the colorectal carcinogenesis through suppressing akt signaling pathway, resulting in suppressing cell proliferation and inducing cell apoptosis. |
2021-05-14 |
2023-08-13 |
rat |
| Guohong Shi, Zhen Zhang, Yi Fang, Donglin Bian, Zhiqun Ba. Curcumin combined with low-intensity ultrasound suppresses the growth of glioma cells via inhibition of the AKT pathway. Neoplasma. vol 68. issue 2. 2021-05-14. PMID:33231085. |
the akt pathway activator sc79 reversed apoptosis and anti-proliferation induced by combined treatment with lius and curcumin. |
2021-05-14 |
2023-08-13 |
Not clear |
| Zhiqiang Wu, Chenchen Wang, Mingzhu Huang, Zhonghua Tao, Wangjun Yan, Yiqun D. Retracted: Naturally Occurring Sesquiterpene Lactone-Santonin, Exerts Anticancer Effects in Multi-Drug Resistant Breast Cancer Cells by Inducing Mitochondrial Mediated Apoptosis, Caspase Activation, Cell Cycle Arrest, and by Targeting Ras/Raf/MEK/ERK Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-14. PMID:33378324. |
it is now clear that the photomicrographs in figure 2 are duplicates of the same image and that figures 4 and 5 have been 'copied' from a publication "lupeol triterpene exhibits potent antitumor effects in a427 human lung carcinoma cells via mitochondrial mediated apoptosis, ros generation, loss of mitochondrial membrane potential and downregulation of m-tor/pi3ksol;akt signalling pathway" by wei he, xiang li, shuyue xia, pmid: 30003730. |
2021-05-14 |
2023-08-13 |
human |
| Hanyu Chen, Hongqing Sheng, Yushuo Zhao, Guanghui Zh. Piperine Inhibits Cell Proliferation and Induces Apoptosis of Human Gastric Cancer Cells by Downregulating Phosphatidylinositol 3-Kinase (PI3K)/Akt Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-14. PMID:33382670. |
flow cytometry and western blot were used to determine cell apoptosis and the expression level of protein (cyto c, cleaved parp, cleaved caspase-3, bax, bcl-2, bad, bcl-xl, pi3k, ppi3k, akt, and pakt), respectively. |
2021-05-14 |
2023-08-13 |
mouse |
| Eva Kiss, Gertrud Forika, Reka Mohacsi, Zsuzsanna Nemeth, Tibor Krenacs, Magdolna Dan. Methyl-Donors Can Induce Apoptosis and Attenuate Both the Akt and the Erk1/2 Mediated Proliferation Pathways in Breast and Lung Cancer Cell Lines. International journal of molecular sciences. vol 22. issue 7. 2021-05-14. PMID:33808426. |
methyl-donors can induce apoptosis and attenuate both the akt and the erk1/2 mediated proliferation pathways in breast and lung cancer cell lines. |
2021-05-14 |
2023-08-13 |
Not clear |
| Xin Yan, Hua Shen, Hongjian Jiang, Chengsheng Zhang, Dan Hu, Jun Wang, Xinqi W. Retraction Note to: External Qi of Yan Xin Qigong induces G2/M arrest and apoptosis of androgen-independent prostate cancer cells by inhibiting Akt and NF- B pathways. Molecular and cellular biochemistry. vol 476. issue 6. 2021-05-14. PMID:33895982. |
retraction note to: external qi of yan xin qigong induces g2/m arrest and apoptosis of androgen-independent prostate cancer cells by inhibiting akt and nf- b pathways. |
2021-05-14 |
2023-08-13 |
Not clear |
| Suman Dalal, Christopher R Daniels, Ying Li, Gary L Wright, Mahipal Singh, Krishna Sing. Exogenous ubiquitin attenuates hypoxia/reoxygenation-induced cardiac myocyte apoptosis via the involvement of CXCR4 and modulation of mitochondrial homeostasis. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 98. issue 4. 2021-05-13. PMID:31967865. |
two mutated ub proteins (unable to bind cxcr4) had no effect on h/r-induced apoptosis, activation of akt and gsk-3β, or oxidative stress. |
2021-05-13 |
2023-08-13 |
rat |
| Yun Liu, Baohuan Cai, Yating Chong, Hualei Zhang, Chesley-Anne Kemp, Sumin Lu, Chang-Sheng Chang, Mingqiang Ren, John K Cowell, Tianxiang H. Downregulation of PUMA underlies resistance to FGFR1 inhibitors in the stem cell leukemia/lymphoma syndrome. Cell death & disease. vol 11. issue 10. 2021-05-13. PMID:33082322. |
treatment with different tyrosine kinase inhibitors (tkis) revealed that, in both fgfr1 mutation and pten deletion-mediated resistance, sustained akt activation in resistant cells leads to compromised puma activation, resulting in suppression of tki-induced apoptosis. |
2021-05-13 |
2023-08-13 |
mouse |
| Shilai Li, Quanlin Qin, Daqing Luo, Wenhui Pan, Yuqing Wei, Yansong Xu, Jijin Zhu, Liming Shan. Hesperidin ameliorates liver ischemia/reperfusion injury via activation of the Akt pathway. Molecular medicine reports. vol 22. issue 6. 2021-05-13. PMID:33174025. |
in summary, the results of the present study suggested that hdn may protect against liver i/r injury through activating the akt pathway by ameliorating liver oxidative stress, suppressing inflammation and preventing hepatocyte apoptosis. |
2021-05-13 |
2023-08-13 |
mouse |
| Joong-Seok Woo, Gang-Sik Choo, Eun-Seon Yoo, Sung-Hyun Kim, Jae-Han Lee, So-Hee Han, Hyeong-Jin Kim, Soo-Hyun Jung, Young-Seok Park, Byeong-Soo Kim, Sang-Ki Kim, Byung-Kwon Park, Sung-Dae Cho, Jeong-Seok Nam, Chang-Sun Choi, Jeong-Hwan Che, Ji-Youn Jun. Apigenin induces apoptosis by regulating Akt and MAPK pathways in human melanoma cell A375SM. Molecular medicine reports. vol 22. issue 6. 2021-05-13. PMID:33174048. |
apigenin induces apoptosis by regulating akt and mapk pathways in human melanoma cell a375sm. |
2021-05-13 |
2023-08-13 |
human |
| Joong-Seok Woo, Gang-Sik Choo, Eun-Seon Yoo, Sung-Hyun Kim, Jae-Han Lee, So-Hee Han, Hyeong-Jin Kim, Soo-Hyun Jung, Young-Seok Park, Byeong-Soo Kim, Sang-Ki Kim, Byung-Kwon Park, Sung-Dae Cho, Jeong-Seok Nam, Chang-Sun Choi, Jeong-Hwan Che, Ji-Youn Jun. Apigenin induces apoptosis by regulating Akt and MAPK pathways in human melanoma cell A375SM. Molecular medicine reports. vol 22. issue 6. 2021-05-13. PMID:33174048. |
overall, the findings of the present study indicated that apigenin attenuated the growth of a375sm melanoma cells by inducing apoptosis via regulating the akt and mitogen‑activated protein kinase signaling pathways. |
2021-05-13 |
2023-08-13 |
human |
| Wenjing Diao, Caiying Zhu, Qisang Guo, Yuankui Cao, Yu Song, Hua Feng, Jun Li, Xiaohong Xue, Pei L. Tripartite motif‑containing 14 regulates cell proliferation and apoptosis in cervical cancer via the Akt signaling pathway. Molecular medicine reports. vol 22. issue 6. 2021-05-13. PMID:33174608. |
tripartite motif‑containing 14 regulates cell proliferation and apoptosis in cervical cancer via the akt signaling pathway. |
2021-05-13 |
2023-08-13 |
human |
| Wenjing Diao, Caiying Zhu, Qisang Guo, Yuankui Cao, Yu Song, Hua Feng, Jun Li, Xiaohong Xue, Pei L. Tripartite motif‑containing 14 regulates cell proliferation and apoptosis in cervical cancer via the Akt signaling pathway. Molecular medicine reports. vol 22. issue 6. 2021-05-13. PMID:33174608. |
trim14 also regulated cell proliferation and apoptosis of human siha, hela and caski cervical cancer cell lines through the akt signaling pathway. |
2021-05-13 |
2023-08-13 |
human |
| Wenjing Diao, Caiying Zhu, Qisang Guo, Yuankui Cao, Yu Song, Hua Feng, Jun Li, Xiaohong Xue, Pei L. Tripartite motif‑containing 14 regulates cell proliferation and apoptosis in cervical cancer via the Akt signaling pathway. Molecular medicine reports. vol 22. issue 6. 2021-05-13. PMID:33174608. |
taken together, trim14‑induced cell proliferation and apoptosis inhibition may by evoked by the activation of the akt pathway. |
2021-05-13 |
2023-08-13 |
human |
| M Mandal, S Kim, M N Younes, S A Jasser, A K El-Naggar, G B Mills, J N Myer. Retraction Note to: The Akt inhibitor KP372-1 suppresses Akt activity and cell proliferation and induces apoptosis in thyroid cancer cells. British journal of cancer. vol 124. issue 10. 2021-05-13. PMID:33603199. |
retraction note to: the akt inhibitor kp372-1 suppresses akt activity and cell proliferation and induces apoptosis in thyroid cancer cells. |
2021-05-13 |
2023-08-13 |
Not clear |
| Yingqiao Pang, Shaozhi Zhu, Haitao Pe. Pachymic acid protects against cerebral ischemia/reperfusion injury by the PI3K/Akt signaling pathway. Metabolic brain disease. vol 35. issue 4. 2021-05-11. PMID:32140824. |
pa had obviously neuroprotective effects on brain i/r injury and neuronal apoptosis, and its mechanism may be related to activation of pi3k / akt signaling pathway. |
2021-05-11 |
2023-08-13 |
rat |