| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xinxin Liu, Zhongwen Yuan, Zheng Tang, Qi Chen, Jiarun Huang, Lizhen He, Tianfeng Che. Selenium-driven enhancement of synergistic cancer chemo-/radiotherapy by targeting nanotherapeutics. Biomaterials science. vol 9. issue 13. 2021-06-30. PMID:34019044. |
the combined activity of sed@msn-fa and radiation can promote excessive production of intracellular reactive oxygen species (ros) and induce cell apoptosis by affecting p53, protein kinase b (akt), and mitogen-activated protein kinase (mapk) pathways. |
2021-06-30 |
2023-08-13 |
mouse |
| Wenbin Li, Yue Zhu, Kelin Zhang, Xianhuan Yu, Haoming Lin, Wenrui Wu, Yaorong Peng, Jian Su. PROM2 promotes gemcitabine chemoresistance via activating the Akt signaling pathway in pancreatic cancer. Experimental & molecular medicine. vol 52. issue 3. 2021-06-28. PMID:32123287. |
mechanistically, we demonstrate that prom2 could directly interacted with akt and activates the akt signaling pathway, which thus inhibiting gemcitabine-induced apoptosis. |
2021-06-28 |
2023-08-13 |
mouse |
| Hui Ma, Xiangjian Bai, Xiaolong Sun, Bohan Li, Meilin Zhu, Yiqun Dai, Qiang Huo, Hong-Mei Li, Cheng-Zhu W. Anti-cancer effects of methanol-ethyl acetate partitioned fraction from Magnolia grandiflora in human non-small cell lung cancer H1975 cells. Journal of bioenergetics and biomembranes. vol 52. issue 3. 2021-06-25. PMID:32291605. |
our study also showed that mem could induce cellular apoptosis in h1975 cells by down-regulating the protein expression levels of akt and p-akt-473, and by increasing the ratio of bax/bcl-2. |
2021-06-25 |
2023-08-13 |
mouse |
| Thomas R Holmes, Jenan Al Matouq, Matti Holmes, Natasha Sioda, Justin C Rudd, Celia Bloom, Lauren Nicola, Nicholas Y Palermo, Justin G Madson, Sándor Lovas, Laura A Hanse. Targeting 14-3-3ε activates apoptotic signaling to prevent cutaneous squamous cell carcinoma. Carcinogenesis. vol 42. issue 2. 2021-06-25. PMID:32816038. |
14-3-3ε suppressed apoptosis through activation of akt, leading to inhibition of bcl2 associated agonist of cell death and upregulation of survivin. |
2021-06-25 |
2023-08-13 |
human |
| Yang Liu, Bin Xu, Yajie Hu, Peng Liu, Shuai Lian, Hongming Lv, Yuying Yang, Hong Ji, Huanmin Yang, Juxiong Liu, Ruizhi Yao, Shize L. O-GlcNAc / Akt pathway regulates glucose metabolism and reduces apoptosis in liver of piglets with acute cold stress. Cryobiology. vol 100. 2021-06-25. PMID:33651993. |
o-glcnac / akt pathway regulates glucose metabolism and reduces apoptosis in liver of piglets with acute cold stress. |
2021-06-25 |
2023-08-13 |
Not clear |
| Peifeng Jin, Lu Ding, Lei Wang, Sheng Jiang, Jiakan Weng, Yuan Gao, Junming Fan, Li-Zhong Su. Extracellular vesicles derived from myocardial infarction plasma inhibit BMSCs apoptosis and enhance cardiac function via AKT signaling pathway. International immunopharmacology. vol 96. 2021-06-22. PMID:34020395. |
extracellular vesicles derived from myocardial infarction plasma inhibit bmscs apoptosis and enhance cardiac function via akt signaling pathway. |
2021-06-22 |
2023-08-13 |
rat |
| Peifeng Jin, Lu Ding, Lei Wang, Sheng Jiang, Jiakan Weng, Yuan Gao, Junming Fan, Li-Zhong Su. Extracellular vesicles derived from myocardial infarction plasma inhibit BMSCs apoptosis and enhance cardiac function via AKT signaling pathway. International immunopharmacology. vol 96. 2021-06-22. PMID:34020395. |
co-culturing with evs attenuated hypoxia-induced apoptosis of bmscs in evs in a dose-dependent manner, which was reversed by the pharmacological inhibition of akt signaling. |
2021-06-22 |
2023-08-13 |
rat |
| Peifeng Jin, Lu Ding, Lei Wang, Sheng Jiang, Jiakan Weng, Yuan Gao, Junming Fan, Li-Zhong Su. Extracellular vesicles derived from myocardial infarction plasma inhibit BMSCs apoptosis and enhance cardiac function via AKT signaling pathway. International immunopharmacology. vol 96. 2021-06-22. PMID:34020395. |
in conclusion, the present results suggest a potential role of plasma-derived evs in decreasing apoptosis of bmscs by activating akt signaling, promoting angiogenesis, ameliorating myocardial remodeling, and improving cardiac function in mi rats. |
2021-06-22 |
2023-08-13 |
rat |
| Changliang Huo, Li Wang, Qiuli Wang, Yanbo Yang, Bo Che. Hydroxysafflor Yellow A inhibits the viability and migration of vascular smooth muscle cells induced by serum from rats with chronic renal failure via inactivation of the PI3K/Akt signaling pathway. Experimental and therapeutic medicine. vol 22. issue 2. 2021-06-22. PMID:34149896. |
flow cytometry analysis was performed to assess apoptosis, and western blot analysis was performed to detect protein expression levels of pi3k and akt. |
2021-06-22 |
2023-08-13 |
human |
| Tania Pilli, Silvia Cantara, Carlotta Marzocchi, Furio Pacini, Bellur S Prabhakar, Maria Grazia Castagn. Vemurafenib may overcome TNF-related apoptosis-inducing ligand (TRAIL) resistance in anaplastic thyroid cancer cells. Endocrine. vol 67. issue 1. 2021-06-21. PMID:31377969. |
aim of our study was to evaluate trail-induced apoptosis in atc-derived cell lines, in vitro and in vivo, and the effect of combination with tyrosine kinase inhibitors (tkis) selective for braf (vemurafenib) or akt (mk-2206). |
2021-06-21 |
2023-08-13 |
Not clear |
| Rafael Bandeira Fabres, Nathalia Lima Montes, Yahi de Menezes Camboim, Samir Khal de Souza, Fabrício Nicola, Isadora D'Ávila Tassinari, Maria Flavia Marques Ribeiro, Carlos Alexandre Netto, Luciano Stürmer de Frag. Long-Lasting Actions of Progesterone Protect the Neonatal Brain Following Hypoxia-Ischemia. Cellular and molecular neurobiology. vol 40. issue 8. 2021-06-21. PMID:32170571. |
this is the first study suggesting prog-dependent akt activation is able to regulate negatively cleaved caspase-3 and gfap expression protecting neonatal hypoxic-ischemic brain tissue from apoptosis and reactive gliosis. |
2021-06-21 |
2023-08-13 |
rat |
| Atsuro Takeshita, Taro Yasuma, Kota Nishihama, Corina N D'Alessandro-Gabazza, Masaaki Toda, Toshiaki Totoki, Yuko Okano, Akihiro Uchida, Ryo Inoue, Liqiang Qin, Shujie Wang, Valeria Fridman D'Alessandro, Tetsu Kobayashi, Yoshiyuki Takei, Akira Mizoguchi, Yutaka Yano, Esteban C Gabazz. Thrombomodulin ameliorates transforming growth factor-β1-mediated chronic kidney disease via the G-protein coupled receptor 15/Akt signal pathway. Kidney international. vol 98. issue 5. 2021-06-21. PMID:33069430. |
treatment with recombinant thrombomodulin significantly inhibited apoptosis and mesenchymal differentiation of podocytes by interacting with the g-protein coupled receptor 15 to activate the akt signaling pathway and to upregulate the expression of anti-apoptotic proteins including survivin. |
2021-06-21 |
2023-08-13 |
mouse |
| Larissa Berloffa Belardin, Maria Beatriz Ribeiro de Andrade, Paula Intasqui, Deborah Montagnini Spaine, Ricardo Pimenta Bertolla, Mariana Pereira Antoniass. Restoration of the apoptosis pathways' proteins levels after orchiectomy in testicular tumour patients. Andrologia. vol 52. issue 11. 2021-06-21. PMID:33070399. |
comparing pre- and post-orchiectomy groups, just the apoptosis pathways' proteins presented different levels, in which bad was lower and bcl2, akt, caspase-9, p53 and caspase-8 were higher after orchiectomy. |
2021-06-21 |
2023-08-13 |
Not clear |
| Larissa Berloffa Belardin, Maria Beatriz Ribeiro de Andrade, Paula Intasqui, Deborah Montagnini Spaine, Ricardo Pimenta Bertolla, Mariana Pereira Antoniass. Restoration of the apoptosis pathways' proteins levels after orchiectomy in testicular tumour patients. Andrologia. vol 52. issue 11. 2021-06-21. PMID:33070399. |
regarding the apoptosis pathway, lower levels of jnk, bcl2, akt, caspase-9, p53 and caspase-8 and higher levels of bad were observed before orchiectomy. |
2021-06-21 |
2023-08-13 |
Not clear |
| Yaschilal Muche Belayneh, Gedefew Getnet Amare, Birhanu Geta Mehari. Updates on the molecular mechanisms of aspirin in the prevention of colorectal cancer: Review. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners. vol 27. issue 4. 2021-06-21. PMID:33427041. |
cox-independent mechanisms of anticancer effects of aspirin include down-regulation of nuclear factor kappa b activity and akt activation, modulation of bcl-2 and bax family proteins, suppression of vascular endothelial growth factor, induction of apoptosis, disruption of dna repair mechanisms, and induction of spermidine/spermine |
2021-06-21 |
2023-08-13 |
Not clear |
| Kimia Ahmadi, Shiva Roshan-Milani, Fatemeh Asgharzadeh, Masoumeh Pourjabali, Amin Abdollahzade Far. In Vitro and In Vivo Pretreatment with Selenium Mitigates Tetrahydrocannabinol-Induced Testicular Cell Apoptosis: the Role of AKT and p53 Pathways. Biological trace element research. vol 199. issue 6. 2021-06-18. PMID:32815089. |
in vitro and in vivo pretreatment with selenium mitigates tetrahydrocannabinol-induced testicular cell apoptosis: the role of akt and p53 pathways. |
2021-06-18 |
2023-08-13 |
mouse |
| Kimia Ahmadi, Shiva Roshan-Milani, Fatemeh Asgharzadeh, Masoumeh Pourjabali, Amin Abdollahzade Far. In Vitro and In Vivo Pretreatment with Selenium Mitigates Tetrahydrocannabinol-Induced Testicular Cell Apoptosis: the Role of AKT and p53 Pathways. Biological trace element research. vol 199. issue 6. 2021-06-18. PMID:32815089. |
at the end of the experiments, sertoli cells and testis tissue samples were collected for biochemical (akt, p53), cell apoptosis, and histological analyses. |
2021-06-18 |
2023-08-13 |
mouse |
| Fengge Liu, Qi Zhang, Yan Lian. MicroRNA-598 acts as an inhibitor in retinoblastoma through targeting E2F1 and regulating AKT pathway. Journal of cellular biochemistry. vol 121. issue 3. 2021-06-17. PMID:31674056. |
in addition, mir-598 was found to promote cell apoptosis and inactivate the protein kinase b (akt) pathway in rb. |
2021-06-17 |
2023-08-13 |
Not clear |
| Yuka Hotokezaka, Ikuo Katayama, Takashi Nakamur. ATM-associated signalling triggers the unfolded protein response and cell death in response to stress. Communications biology. vol 3. issue 1. 2021-06-17. PMID:32665601. |
cytoplasmic atm serves as a platform on which protein phosphatase 2a-dependent dephosphorylation of akt activates glycogen synthase kinase 3β, thereby downregulating nascent polypeptide-associated complex α subunit and γ-taxilin, triggering uprs and leading to mitochondria-dependent apoptosis. |
2021-06-17 |
2023-08-13 |
Not clear |
| Lola Buono, Simona Scalabrin, Marco De Iuliis, Adele Tanzi, Cristina Grange, Marta Tapparo, Raffaele Nuzzi, Benedetta Bussolat. Mesenchymal Stem Cell-Derived Extracellular Vesicles Protect Human Corneal Endothelial Cells from Endoplasmic Reticulum Stress-Mediated Apoptosis. International journal of molecular sciences. vol 22. issue 9. 2021-06-17. PMID:34066474. |
in parallel, they upregulated the akt pathway and limited caspase-3 activation and apoptosis. |
2021-06-17 |
2023-08-13 |
human |