| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yang Liu, Peng Liu, Yajie Hu, Yu Cao, Jingjing Lu, Yuying Yang, Hongming Lv, Shuai Lian, Bin Xu, Shize L. Cold-Induced RNA-Binding Protein Promotes Glucose Metabolism and Reduces Apoptosis by Increasing AKT Phosphorylation in Mouse Skeletal Muscle Under Acute Cold Exposure. Frontiers in molecular biosciences. vol 8. 2021-08-17. PMID:34395524. |
cold-induced rna-binding protein promotes glucose metabolism and reduces apoptosis by increasing akt phosphorylation in mouse skeletal muscle under acute cold exposure. |
2021-08-17 |
2023-08-13 |
mouse |
| Yang Liu, Peng Liu, Yajie Hu, Yu Cao, Jingjing Lu, Yuying Yang, Hongming Lv, Shuai Lian, Bin Xu, Shize L. Cold-Induced RNA-Binding Protein Promotes Glucose Metabolism and Reduces Apoptosis by Increasing AKT Phosphorylation in Mouse Skeletal Muscle Under Acute Cold Exposure. Frontiers in molecular biosciences. vol 8. 2021-08-17. PMID:34395524. |
acute cold exposure increased energy consumption, enhanced glycolysis, increased apoptosis, and up-regulated cirp and phosphorylation of akt. |
2021-08-17 |
2023-08-13 |
mouse |
| Yang Liu, Peng Liu, Yajie Hu, Yu Cao, Jingjing Lu, Yuying Yang, Hongming Lv, Shuai Lian, Bin Xu, Shize L. Cold-Induced RNA-Binding Protein Promotes Glucose Metabolism and Reduces Apoptosis by Increasing AKT Phosphorylation in Mouse Skeletal Muscle Under Acute Cold Exposure. Frontiers in molecular biosciences. vol 8. 2021-08-17. PMID:34395524. |
in addition, cirp overexpression in c2c12 mouse myoblasts at each time point under 37°c and 32°c mild hypothermia increased akt phosphorylation, enhanced glucose metabolism, and reduced apoptosis. |
2021-08-17 |
2023-08-13 |
mouse |
| Yang Liu, Peng Liu, Yajie Hu, Yu Cao, Jingjing Lu, Yuying Yang, Hongming Lv, Shuai Lian, Bin Xu, Shize L. Cold-Induced RNA-Binding Protein Promotes Glucose Metabolism and Reduces Apoptosis by Increasing AKT Phosphorylation in Mouse Skeletal Muscle Under Acute Cold Exposure. Frontiers in molecular biosciences. vol 8. 2021-08-17. PMID:34395524. |
wortmannin inhibited the akt phosphorylation of skeletal muscle after acute cold exposure, thereby inhibiting glucose metabolism and aggravating apoptosis. |
2021-08-17 |
2023-08-13 |
mouse |
| Yang Liu, Peng Liu, Yajie Hu, Yu Cao, Jingjing Lu, Yuying Yang, Hongming Lv, Shuai Lian, Bin Xu, Shize L. Cold-Induced RNA-Binding Protein Promotes Glucose Metabolism and Reduces Apoptosis by Increasing AKT Phosphorylation in Mouse Skeletal Muscle Under Acute Cold Exposure. Frontiers in molecular biosciences. vol 8. 2021-08-17. PMID:34395524. |
taken together, acute cold exposure up-regulates cirp in mouse skeletal muscle, which regulates glucose metabolism and maintains energy balance in skeletal muscle cells through the akt signaling pathway, thus slowing down the apoptosis of skeletal muscle cells. |
2021-08-17 |
2023-08-13 |
mouse |
| Yan-Hua Fan, Huai-Wei Ding, Donghwa Kim, Jian-Yu Liu, Ji-Young Hong, Yong-Nan Xu, Daoping Wang, Xiao-Sheng Yang, Sang Kook Le. The PI3Kα inhibitor DFX24 suppresses tumor growth and metastasis in non-small cell lung cancer via ERK inhibition and EPHB6 reactivation. Pharmacological research. vol 160. 2021-08-13. PMID:32814167. |
nevertheless, ephb6 expression might also promote cancer cell growth and inhibit cell apoptosis by activating akt and erk pathway, apart from inhibition of migration and invasion. |
2021-08-13 |
2023-08-13 |
Not clear |
| Yixuan Wang, Heng Shen, Qian Sun, Linyao Zhao, Hao Liu, Liguo Ye, Yang Xu, Jiayang Cai, Yuntao Li, Lun Gao, Yinqiu Tan, Baohui Liu, Qianxue Che. The New PI3K/mTOR Inhibitor GNE-477 Inhibits the Malignant Behavior of Human Glioblastoma Cells. Frontiers in pharmacology. vol 12. 2021-08-13. PMID:34381355. |
an increase in akt activity induced by sc79 rescued the gne-477-mediated inhibition of gbm cell proliferation and apoptosis. |
2021-08-13 |
2023-08-13 |
human |
| Liming Hong, Long Yan, Zhimin Xin, Jie Hao, Wenjing Liu, Shuyu Wang, Shujie Liao, Hongmei Wang, Xiaokui Yan. Protective effects of human umbilical cord mesenchymal stem cell-derived conditioned medium on ovarian damage. Journal of molecular cell biology. vol 12. issue 5. 2021-08-12. PMID:31742349. |
furthermore, we show that the granulocyte colony-stimulating factor (g-csf)/phosphatidylinositol 3-kinase (pi3k)/protein kinase b (akt) pathway plays an important role in protecting granulosa cells from cs-induced apoptosis. |
2021-08-12 |
2023-08-13 |
mouse |
| Ling-Yu Zhang, Qian-Qian Jin, Christian Hölscher, Lin L. Glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide dual receptor agonist DA-CH5 is superior to exendin-4 in protecting neurons in the 6-hydroxydopamine rat Parkinson model. Neural regeneration research. vol 16. issue 8. 2021-08-12. PMID:33433498. |
here we showed that both exendin-4 and da-ch5 protected against 6-hydroxydopamine (6-ohda) cytotoxicity, inhibited apoptosis, improved mitogenesis and induced autophagy flux in sh-sy5y cells via activation of the insulin receptor substrate-1 (irs-1)/alpha serine/threonine-protein kinase (akt)/camp response element-binding protein (creb) pathway. |
2021-08-12 |
2023-08-13 |
rat |
| François Fabi, Pascal Adam, Sophie Parent, Laurence Tardif, Monique Cadrin, Eric Asseli. Pharmacologic inhibition of Akt in combination with chemotherapeutic agents effectively induces apoptosis in ovarian and endometrial cancer cell lines. Molecular oncology. vol 15. issue 8. 2021-08-10. PMID:33338300. |
pharmacologic inhibition of akt in combination with chemotherapeutic agents effectively induces apoptosis in ovarian and endometrial cancer cell lines. |
2021-08-10 |
2023-08-13 |
human |
| Yan Jiao, Dandan Zhao, Fuhua Gao, Xiaoyan Hu, Xinxin Hu, Mei Li, Ying Cui, Xiaoqing Wei, Ce Xie, Ying Zhao, Ying Ga. MicroRNA-520c-3p suppresses vascular endothelium dysfunction by targeting RELA and regulating the AKT and NF-κB signaling pathways. Journal of physiology and biochemistry. vol 77. issue 1. 2021-08-04. PMID:33411212. |
in summary, our study suggested that mirna-520c-3p targeting rela through akt and nf-κb signaling pathways regulated the proliferation, apoptosis, and adhesion of vascular endothelial cells. |
2021-08-04 |
2023-08-13 |
human |
| Shuxin Sun, Yang Liu, Chaobin He, Wanming Hu, Wenfeng Liu, Xin Huang, Jiali Wu, Fengxiao Xie, Chen Chen, Jun Wang, Yuan Lin, Wenbo Zhu, Guangmei Yan, Jing Cai, Shengping L. Combining NanoKnife with M1 oncolytic virus enhances anticancer activity in pancreatic cancer. Cancer letters. vol 502. 2021-08-04. PMID:33444691. |
we showed that ire triggered reactive oxygen species (ros)-dependent apoptosis in pancreatic cancer cells (pccs) mediated by phosphatidylinositol-3-kinase (pi3k)/protein kinase b (akt) pathway suppression. |
2021-08-04 |
2023-08-13 |
mouse |
| Linglei Meng, Yongting Zhang, Demao Li, Xinfang Shang, Xuejia Hao, Xin Chen, Fengxiao Ga. TIMP3 attenuates cerebral ischemia/reperfusion-induced apoptosis and oxidative stress in neurocytes by regulating the AKT pathway. Experimental and therapeutic medicine. vol 22. issue 3. 2021-08-03. PMID:34335915. |
timp3 attenuates cerebral ischemia/reperfusion-induced apoptosis and oxidative stress in neurocytes by regulating the akt pathway. |
2021-08-03 |
2023-08-13 |
mouse |
| Dimitra Aravani, Kirsty Foote, Nichola Figg, Alison Finigan, Anna Uryga, Murray Clarke, Martin Bennet. Cytokine regulation of apoptosis-induced apoptosis and apoptosis-induced cell proliferation in vascular smooth muscle cells. Apoptosis : an international journal on programmed cell death. vol 25. issue 9-10. 2021-07-30. PMID:32627119. |
apoptosis induced activation of p38mapk, jnk, and akt, but neither p38 and jnk activation nor il-6 or gm-csf induction required caspase cleavage. |
2021-07-30 |
2023-08-13 |
mouse |
| Hai Huang, Jun-Koo Yi, Su-Geun Lim, Sijun Park, Haibo Zhang, Eungyung Kim, Soyoung Jang, Mee-Hyun Lee, Kangdong Liu, Ki-Rim Kim, Eun-Kyong Kim, Youngkyun Lee, Sung-Hyun Kim, Zae-Young Ryoo, Myoung Ok Ki. Costunolide Induces Apoptosis via the Reactive Oxygen Species and Protein Kinase B Pathway in Oral Cancer Cells. International journal of molecular sciences. vol 22. issue 14. 2021-07-30. PMID:34299129. |
the results revealed that ctd suppressed the proliferation, migration and invasion of oral cancer cells effectively and induced cell cycle arrest and apoptosis; regarding the mechanism, ctd bound to akt directly by binding assay and repressed akt activities through kinase assay, which thereby downregulating the downstream of akt. |
2021-07-30 |
2023-08-13 |
mouse |
| Xia Cai, Fang Zou, Rui Xuan, Xiao-Yang La. Exosomes from mesenchymal stem cells expressing microribonucleic acid-125b inhibit the progression of diabetic nephropathy via the tumour necrosis factor receptor-associated factor 6/Akt axis. Endocrine journal. vol 68. issue 7. 2021-07-29. PMID:34024846. |
in addition, exosomally transferred mir-125b inhibited the apoptosis of hg-treated hkcs by mediating akt signalling. |
2021-07-29 |
2023-08-13 |
human |
| Zhenhua Zhou, Ningbo Xu, Nathanael Matei, Devin W McBride, Yan Ding, Hui Liang, Jiping Tang, John H Zhan. Sodium butyrate attenuated neuronal apoptosis via GPR41/Gβγ/PI3K/Akt pathway after MCAO in rats. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 41. issue 2. 2021-07-28. PMID:32151222. |
at 24 h, the effects of mcao, increased apoptosis, were ameliorated after treatment with sodium butyrate, which increased the expressions of gpr41, pi3k and phosphorylated akt. |
2021-07-28 |
2023-08-13 |
rat |
| A P O Monte, M É S Bezerra, V G Menezes, B B Gouveia, R S Barberino, T L B G Lins, V R P Barros, J M S Santos, N J Donfack, M H T Mato. Involvement of Phosphorylated Akt and FOXO3a in the Effects of Growth and Differentiation Factor-9 (GDF-9) on Inhibition of Follicular Apoptosis and Induction of Granulosa Cell Proliferation After In Vitro Culture of Sheep Ovarian Tissue. Reproductive sciences (Thousand Oaks, Calif.). vol 28. issue 8. 2021-07-28. PMID:33409876. |
involvement of phosphorylated akt and foxo3a in the effects of growth and differentiation factor-9 (gdf-9) on inhibition of follicular apoptosis and induction of granulosa cell proliferation after in vitro culture of sheep ovarian tissue. |
2021-07-28 |
2023-08-13 |
Not clear |
| Ian L P Beales, Olorunseun O Ogunwob. Leptin activates Akt in oesophageal cancer cells via multiple atorvastatin-sensitive small GTPases. Molecular and cellular biochemistry. vol 476. issue 6. 2021-07-28. PMID:33582946. |
leptin stimulated akt activity and cell proliferation and inhibited camptothecin-induced apoptosis in an akt-sensitive manner. |
2021-07-28 |
2023-08-13 |
Not clear |
| Ping Xu, Juan Xiao, Shuixia Ch. Piperlongumine attenuates oxidative stress, inflammatory, and apoptosis through modulating the GLUT-2/4 and AKT signaling pathway in streptozotocin-induced diabetic rats. Journal of biochemical and molecular toxicology. vol 35. issue 6. 2021-07-27. PMID:33724628. |
piperlongumine attenuates oxidative stress, inflammatory, and apoptosis through modulating the glut-2/4 and akt signaling pathway in streptozotocin-induced diabetic rats. |
2021-07-27 |
2023-08-13 |
rat |