| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hiroyuki Ogawa, Kosuke Kaji, Norihisa Nishimura, Hirotetsu Takagi, Koji Ishida, Hiroaki Takaya, Hideto Kawaratani, Kei Moriya, Tadashi Namisaki, Takemi Akahane, Hitoshi Yoshij. Lenvatinib prevents liver fibrosis by inhibiting hepatic stellate cell activation and sinusoidal capillarization in experimental liver fibrosis. Journal of cellular and molecular medicine. vol 25. issue 8. 2021-09-22. PMID:33609067. |
lenvatinib restrained proliferation and promoted apoptosis of lx-2 with suppressed phosphorylation of extracellular signal-regulated kinase 1/2 and akt. |
2021-09-22 |
2023-08-13 |
human |
| Shih-Chang Fu, Jhe-Wei Lin, Jui-Ming Liu, Shing-Hwa Liu, Kai-Min Fang, Chin-Chuan Su, Ren-Jun Hsu, Chin-Ching Wu, Chun-Fa Huang, Kuan-I Lee, Ya-Wen Che. Arsenic induces autophagy-dependent apoptosis via Akt inactivation and AMPK activation signaling pathways leading to neuronal cell death. Neurotoxicology. vol 85. 2021-09-22. PMID:34038756. |
arsenic induces autophagy-dependent apoptosis via akt inactivation and ampk activation signaling pathways leading to neuronal cell death. |
2021-09-22 |
2023-08-13 |
Not clear |
| Xiuzhi Zhu, Jialin Li, Huiting Ning, Zhidong Yuan, Yue Zhong, Suzhen Wu, Jin-Zhang Zen. α-Mangostin Induces Apoptosis and Inhibits Metastasis of Breast Cancer Cells via Regulating RXRα-AKT Signaling Pathway. Frontiers in pharmacology. vol 12. 2021-09-21. PMID:34539418. |
α-mangostin can trigger parp cleavage and induce apoptosis, which may be related to the induction of upregulated bax expression and downregulation of bad and cleaved caspase-3 expression in mda-mb-231 cells through blockade of akt signaling. |
2021-09-21 |
2023-08-13 |
Not clear |
| Rui-Zhen Cao, Li Min, Si Liu, Ru-Yue Tian, Hai-Yan Jiang, Juan Liu, Lin-Lin Shao, Rui Cheng, Sheng-Tao Zhu, Shui-Long Guo, Peng L. Rictor Activates Cav 1 Through the Akt Signaling Pathway to Inhibit the Apoptosis of Gastric Cancer Cells. Frontiers in oncology. vol 11. 2021-09-21. PMID:34540654. |
rictor activates cav 1 through the akt signaling pathway to inhibit the apoptosis of gastric cancer cells. |
2021-09-21 |
2023-08-13 |
Not clear |
| Zhen Cui, Jia Liu, Qiaoyu Sun, Zelai He, Chaoge Wang, Xianwen Zhang, Qianqian Ma, Duojie Li, Hao Jian. GPR120 promotes radiation resistance in esophageal cancer via regulating AKT and apoptosis pathway. Anti-cancer drugs. vol 32. issue 1. 2021-09-20. PMID:32932281. |
gpr120 promotes radiation resistance in esophageal cancer via regulating akt and apoptosis pathway. |
2021-09-20 |
2023-08-13 |
Not clear |
| Zhen Cui, Jia Liu, Qiaoyu Sun, Zelai He, Chaoge Wang, Xianwen Zhang, Qianqian Ma, Duojie Li, Hao Jian. GPR120 promotes radiation resistance in esophageal cancer via regulating AKT and apoptosis pathway. Anti-cancer drugs. vol 32. issue 1. 2021-09-20. PMID:32932281. |
the mechanisms were explored by the evaluation of the akt pathway and apoptosis protein level. |
2021-09-20 |
2023-08-13 |
Not clear |
| Zhen Cui, Jia Liu, Qiaoyu Sun, Zelai He, Chaoge Wang, Xianwen Zhang, Qianqian Ma, Duojie Li, Hao Jian. GPR120 promotes radiation resistance in esophageal cancer via regulating AKT and apoptosis pathway. Anti-cancer drugs. vol 32. issue 1. 2021-09-20. PMID:32932281. |
gpr120 regulated the biological behavior of the esophageal cancer cells via affecting akt pathway and apoptosis molecules. |
2021-09-20 |
2023-08-13 |
Not clear |
| Cihan Gur, Fatih Mehmet Kandemir, Ekrem Darendelioglu, Cuneyt Caglayan, Sefa Kucukler, Ozge Kandemir, Mustafa Ileritur. Morin protects against acrylamide-induced neurotoxicity in rats: an investigation into different signal pathways. Environmental science and pollution research international. vol 28. issue 36. 2021-09-20. PMID:33939091. |
biochemical and western blot analyses showed that acr increased malondialdehyde (mda), p38α mitogen-activated protein kinase (p38α mapk), nuclear factor kappa-b (nf-κb), tumor necrosis factor alpha (tnf-α), interleukin-1 beta (il-1β), interleukin-6 (il-6), cyclooxygenase-2 (cox-2), p53, caspase-3, bcl-2 associated x protein (bax), beclin-1, light chain 3a (lc3a), and light chain 3b (lc3b) levels and decreased those of superoxide dismutase (sod), catalase (cat), glutathione peroxidase (gpx), glutathione (gsh), b-cell lymphoma-2 (bcl-2), mammalian target of rapamycin (mtor), phosphoinositide 3-kinase (pi3k), and protein kinase b (akt) in brain tissue and therefore induced neurotoxicity by causing oxidative stress, inflammation, apoptosis, and autophagy. |
2021-09-20 |
2023-08-13 |
rat |
| Lian Liu, Ming Liu, Wei Zhao, Yuan-Ling Zhao, Yun Wan. Tetrahydropalmatine Regulates BDNF through TrkB/CAM Interaction to Alleviate the Neurotoxicity Induced by Methamphetamine. ACS chemical neuroscience. vol 12. issue 18. 2021-09-20. PMID:34448569. |
thp attenuated the ma-induced neurotoxicity by decreasing cam, increasing trkb, phosphorylating akt, up-regulating nf-κb and bdnf, and inhibiting cell apoptosis. |
2021-09-20 |
2023-08-13 |
rat |
| Kimia Kazemi, Negin Mozafari, Hajar Ashrafi, Pedram Rafiei, Amir Azad. Statins as the Controlling Agents for Non-Hodgkin's Lymphomas via Increasing the Casein Kinase 2 Interacting Protein-1: A Hypothesis. Current drug discovery technologies. vol 17. issue 5. 2021-09-17. PMID:31264550. |
knockdown of casein kinase 2 interacting protein-1 (ckip-1) in nhl promoted cell proliferation and inhibited apoptosis via enhancing phosphorylated protein kinase b (pkb or akt) expression. |
2021-09-17 |
2023-08-13 |
Not clear |
| Haiying Wu, Kan Liu, Jingli Zhan. Excess fibronectin 1 participates in pathogenesis of pre-eclampsia by promoting apoptosis and autophagy in vascular endothelial cells. Molecular human reproduction. vol 27. issue 6. 2021-09-17. PMID:33881516. |
pcdna3.1-fn1 or fn1-small interfering (si) rna was used to manipulate the expression of fn1 in human umbilical vein endothelial cells (huvecs) to assess the effects of fn1 on cell apoptosis, autophagy, and the phosphoinositide 3-kinase (pi3k)/protein kinase b (akt)/mechanistic target of rapamycin (mtor) signaling pathway. |
2021-09-17 |
2023-08-13 |
human |
| Haiying Wu, Kan Liu, Jingli Zhan. Excess fibronectin 1 participates in pathogenesis of pre-eclampsia by promoting apoptosis and autophagy in vascular endothelial cells. Molecular human reproduction. vol 27. issue 6. 2021-09-17. PMID:33881516. |
it was found that upregulation of fn1 promoted apoptosis and autophagy, in addition to significantly inhibiting the activation of akt and mtor in huvecs. |
2021-09-17 |
2023-08-13 |
human |
| Haiying Wu, Kan Liu, Jingli Zhan. Excess fibronectin 1 participates in pathogenesis of pre-eclampsia by promoting apoptosis and autophagy in vascular endothelial cells. Molecular human reproduction. vol 27. issue 6. 2021-09-17. PMID:33881516. |
by contrast, downregulation of fn1 expression inhibited cell apoptosis and autophagy, but increased akt and mtor phosphorylation in huvecs that were cultured in serum samples obtained from patients with pe. |
2021-09-17 |
2023-08-13 |
human |
| Negin Nokhandani, Mahdieh Naghavi Alhosseini, Ali Memarian, Homa Davood. Combination of 5-fluorouracil and Lipopolysaccharide Synergistically Induces Cytotoxicity and Apoptosis in MCF-7 Human Breast Cancer Cells. Iranian journal of allergy, asthma, and immunology. vol 19. issue 4. 2021-09-16. PMID:33463109. |
the effects of lps and 5-fu on cytotoxicity, apoptosis, and gene expression in nf-κb, erk, and akt signaling pathways were evaluated by mtt assay, annexin v/propidium iodide (pi) apoptosis assay, and qrt-pcr, respectively. |
2021-09-16 |
2023-08-13 |
human |
| Jungjoong Hwang, Insuk Song, Kwangho Lee, Hyoung Rae Kim, Eun-Hye Hong, Jung Soon Hwang, Sung-Hoon Ahn, Jongkook Le. KRCA-0008 suppresses ALK-positive anaplastic large-cell lymphoma growth. Investigational new drugs. vol 38. issue 5. 2021-09-14. PMID:31956933. |
additionally, it induced g0/g1 cell cycle arrest and apoptosis by blocking downstream signals including stat3, akt, and erk1/2. |
2021-09-14 |
2023-08-13 |
mouse |
| Hyo In Kim, Sol Ji Lee, Yu-Jeong Choi, Min Jeong Kim, Tai Young Kim, Seong-Gyu K. Quercetin Induces Apoptosis in Glioblastoma Cells by Suppressing Axl/IL-6/STAT3 Signaling Pathway. The American journal of Chinese medicine. vol 49. issue 3. 2021-09-14. PMID:33657989. |
further western blot assays suggested that quercetin induces apoptosis but does not affect akt or mitogen-activated protein kinases, factors related to cell proliferation. |
2021-09-14 |
2023-08-13 |
Not clear |
| Akimasa Takahashi, Abdelrahman Yousif, Linda Hong, IIana Chefet. Premature ovarian insufficiency: pathogenesis and therapeutic potential of mesenchymal stem cell. Journal of molecular medicine (Berlin, Germany). vol 99. issue 5. 2021-09-13. PMID:33641066. |
depletion of oocytes with damaged dna occurs through different cell death mechanisms, such as apoptosis, autophagy, and necroptosis, mediated by the phosphatase and tensin homolog (pten)/phosphoinositide 3-kinase (pi3k)/protein kinase b (akt)/forkhead transcription factors 3 (foxo3) pathway. |
2021-09-13 |
2023-08-13 |
mouse |
| Felipe Castro-Martinez, Aurora Candelario-Martinez, Maria R Encarnacion-Garcia, Zayda Piedra-Quintero, Raul Bonilla-Moreno, Abigail Betanzos, Rocio Perez-Orozco, Maria A Hernandez-Cueto, Jose E Muñoz-Medina, Genaro Patiño-Lopez, Michael Schnoor, Nicolas Villegas-Sepulveda, Porfirio Nav. Rictor/Mammalian Target of Rapamycin Complex 2 Signaling Protects Colonocytes from Apoptosis and Prevents Epithelial Barrier Breakdown. The American journal of pathology. vol 191. issue 9. 2021-09-13. PMID:34139193. |
mechanistically, mtorc2 activates akt, which, in turn, inhibits apoptosis by phosphorylating b-cell lymphoma 2 (bcl2) associated agonist of cell death (bad) and preventing caspase-3 activation. |
2021-09-13 |
2023-08-13 |
Not clear |
| Xiao-Bin Guo, Jia-Wen Zhai, Hui Xia, Jian-Kun Yang, Jun-Hao Zhou, Wen-Bin Guo, Cheng Yang, Ming Xia, Kang-Yi Xue, Cun-Dong Liu, Qi-Zhao Zho. Protective effect of bone marrow mesenchymal stem cell-derived exosomes against the reproductive toxicity of cyclophosphamide is associated with the p38MAPK/ERK and AKT signaling pathways. Asian journal of andrology. vol 23. issue 4. 2021-09-08. PMID:33565424. |
in addition, photophosphorylation of extracellular-regulated kinase (erk), p38 mitogen-activated protein kinase (p38mapk), and protein kinase b (akt) proteins was evaluated by western blotting as well as apoptosis in gc1-spg cells measured using flow cytometry. |
2021-09-08 |
2023-08-13 |
rat |
| Changlin Zhai, Yinggang Sun, Gang Qian, Haihua Pan, Shuoyin Xie, Zhewei Sun, Song Zhang, Huilin H. LncRNA AK087124/miR-224-5p/PTEN axis modulates endothelial cell injury in atherosclerosis through apoptosis and AKT signaling pathway. Archives of biochemistry and biophysics. vol 705. 2021-09-08. PMID:33974917. |
lncrna ak087124/mir-224-5p/pten axis modulates endothelial cell injury in atherosclerosis through apoptosis and akt signaling pathway. |
2021-09-08 |
2023-08-13 |
mouse |