| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kathleen Ponzetti, Melissa King, Anna Gates, M Sawkat Anwer, Cynthia Rl Webste. Cyclic AMP-guanine exchange factor activation inhibits JNK-dependent lipopolysaccharide-induced apoptosis in rat hepatocytes. Hepatic medicine : evidence and research. vol 2010. issue 2. 2021-10-20. PMID:21743791. |
taken together, these results suggest that lps can induce hepatocyte apoptosis directly in vitro in a jnk-dependent manner and activation of camp-gef protects against the lps-induced apoptosis most likely by reversing the effect of lps on jnk and akt. |
2021-10-20 |
2023-08-12 |
rat |
| Hong Zhang, Shi-Liang Yin, Li-Hui Wang, Li-Na Jia, Guang-Yue Su, Xiao-Qing Liu, Fan Zhou, Peter Breslin, Ran Meng, Qi-Yi Li, Jing-Yu Yang, Chun-Fu W. Seed oil of Brucea javanica induces apoptosis through the PI3K/Akt signaling pathway in acute lymphocytic leukemia Jurkat cells. Chinese journal of natural medicines. vol 19. issue 8. 2021-10-20. PMID:34419260. |
moreover, bjoe inhibited akt (protein kinase b) activation and upregulated its downstream targets p53 and foxo1 (forkhead box gene, group o-1) to initiate apoptosis. |
2021-10-20 |
2023-08-13 |
mouse |
| Soh Takagishi, Koichi Arimura, Masaharu Murata, Katsuma Iwaki, Tomohiro Okuda, Keisuke Ido, Ataru Nishimura, Sayoko Narahara, Takahito Kawano, Koji Iihar. Protein Nanoparticles Modified with PDGF-B as a Novel Therapy After Acute Cerebral Infarction. eNeuro. vol 8. issue 5. 2021-10-20. PMID:34462309. |
pdgf-b hspnp administration was associated with strong phosphorylation of akt in infarct areas and significantly increased neurotrophin (nt)-3 production as well as reduced cell apoptosis compared with hspnps alone. |
2021-10-20 |
2023-08-13 |
mouse |
| Yao Fu, Ji-Dong Zhou, Xiao-Yu Sang, Qi-Tao Zha. Gualou-Xiebai-Banxia decoction protects against type II diabetes with acute myocardial ischemia by attenuating oxidative stress and apoptosis via PI3K/Akt/eNOS signaling. Chinese journal of natural medicines. vol 19. issue 3. 2021-10-19. PMID:33781449. |
furthermore, epc apoptosis was increased in t2dm-ami rats and was associated with decreased mrna and protein levels of pi3k, akt, and enos compared to the controls. |
2021-10-19 |
2023-08-13 |
rat |
| Yao Fu, Ji-Dong Zhou, Xiao-Yu Sang, Qi-Tao Zha. Gualou-Xiebai-Banxia decoction protects against type II diabetes with acute myocardial ischemia by attenuating oxidative stress and apoptosis via PI3K/Akt/eNOS signaling. Chinese journal of natural medicines. vol 19. issue 3. 2021-10-19. PMID:33781449. |
conversely, t2dm-ami rats treated with gxb exhibited more circulating epcs and downregulated levels of cell apoptosis, combined with increased mrna and protein levels of pi3k, akt, and enos compared to those of untreated t2dm-ami rats. |
2021-10-19 |
2023-08-13 |
rat |
| Pamina Weber, Doris Baltus, Aline Jatho, Oliver Drews, Laura C Zelarayan, Thomas Wieland, Susanne Lut. RhoGEF17-An Essential Regulator of Endothelial Cell Death and Growth. Cells. vol 10. issue 4. 2021-10-19. PMID:33801779. |
the rhogef17 knockdown prevented the cells with impeded cell-cell and cell-matrix contacts from apoptosis, which was in line with a reduction in pro-caspase 3 expression and an increase in akt phosphorylation. |
2021-10-19 |
2023-08-13 |
human |
| G Wei, L Wang, X Wan, Y Ta. [ELF4 promotes proliferation and inhibits apoptosis of human insulinoma cells by activating Akt signaling]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 41. issue 9. 2021-10-19. PMID:34658346. |
[elf4 promotes proliferation and inhibits apoptosis of human insulinoma cells by activating akt signaling]. |
2021-10-19 |
2023-08-13 |
human |
| Yi Zhao, Ulf Lützen, Peter Gohlke, Ping Jiang, Thomas Herdegen, Juraj Culma. Neuroprotective and antioxidative effects of pioglitazone in brain tissue adjacent to the ischemic core are mediated by PI3K/Akt and Nrf2/ARE pathways. Journal of molecular medicine (Berlin, Germany). vol 99. issue 8. 2021-10-18. PMID:33864097. |
intracerebroventricular infusion of pioglitazone over 5 days before and 24 or 48 h after mcao alleviated neurological impairments, inhibited apoptosis 24 h, and activated the pi3k/akt pathway along with increased phosphorylation of akt (ser473) and gsk-3β (ser9) in the peri-infarct cortical areas 48 h after mcao. |
2021-10-18 |
2023-08-13 |
mouse |
| H-B Sun, L Xu, Z-X Wang, Y Zheng, Y Zhao, Y-Y Yin, X-L Han, Z-N X. Polyoxometalate SbW9 regulates proliferation and apoptosis of NSCLC cells via PTEN-dependent AKT signaling pathway. European review for medical and pharmacological sciences. vol 25. issue 7. 2021-10-15. PMID:33877676. |
polyoxometalate sbw9 regulates proliferation and apoptosis of nsclc cells via pten-dependent akt signaling pathway. |
2021-10-15 |
2023-08-13 |
Not clear |
| H-B Sun, L Xu, Z-X Wang, Y Zheng, Y Zhao, Y-Y Yin, X-L Han, Z-N X. Polyoxometalate SbW9 regulates proliferation and apoptosis of NSCLC cells via PTEN-dependent AKT signaling pathway. European review for medical and pharmacological sciences. vol 25. issue 7. 2021-10-15. PMID:33877676. |
the article "polyoxometalate sbw9 regulates proliferation and apoptosis of nsclc cells via pten-dependent akt signaling pathway, by h.-b. |
2021-10-15 |
2023-08-13 |
Not clear |
| Abdulhameed Al-Ghabkari, Aru Narendra. Targeting EZH2-mediated methylation of histone 3 inhibits proliferation of pediatric acute monocytic leukemia cells Cancer biology & therapy. vol 22. issue 4. 2021-10-15. PMID:33978549. |
screening a panel of methyltransferase inhibitors revealed that three inhibitors; gsk126, unc1999 and epz-5687 are the most potent inhibitors that suppressed ezh2 activity selectively on lysine 27 which resulted in increased apoptosis and inhibition of akt and erk protein phosphorylation in thp-1 cells. |
2021-10-15 |
2023-08-13 |
human |
| Shi-Zhou Qi, Xin-Xin Zhang, Yue Jin, Miao Wang, Li-Ping Long, Wen-Hua Jing, Kai-Ru Song, Da Wang, Hui-Yuan Ga. Phenylpropanoid-conjugated pentacyclic triterpenoids from the whole plants of Leptopus lolonum induced cell apoptosis via MAPK and Akt pathways in human hepatocellular carcinoma cells. Bioorganic chemistry. vol 111. 2021-10-14. PMID:33836342. |
phenylpropanoid-conjugated pentacyclic triterpenoids from the whole plants of leptopus lolonum induced cell apoptosis via mapk and akt pathways in human hepatocellular carcinoma cells. |
2021-10-14 |
2023-08-13 |
human |
| HuiYa Li, DanQing Hu, Guilin Chen, DeDong Zheng, ShuMei Li, YunLing Lin, HuaShan Hong, Yukun Luo, YiLang Ke, Yu Huang, LingZhen Wu, TingXiang Lan, WenYing Wang, Jun Fan. Adropin-based dual treatment enhances the therapeutic potential of mesenchymal stem cells in rat myocardial infarction. Cell death & disease. vol 12. issue 6. 2021-10-14. PMID:34006853. |
in the current study, adropin (25 ng/ml) in vitro reduced hydrogen peroxide-induced apoptosis in rat bone marrow mesenchymal stem cells (mscs) and improved mscs survival with increased phosphorylation of akt and extracellular regulated protein kinases (erk) l/2. |
2021-10-14 |
2023-08-13 |
rat |
| Zhao-Hui Dai, Zhi-Ming Jiang, Hua Tu, Li Mao, Gui-Lin Song, Zhong-Bao Yang, Fang Liu, Md Sayed Ali Sheik. miR-129 Attenuates Myocardial Ischemia Reperfusion Injury by Regulating the Expression of PTEN in Rats. BioMed research international. vol 2021. 2021-10-13. PMID:34435045. |
consistently, h/r significantly increased the apoptosis of h9c2 cells, concomitant with the downregulation of mir-129, upregulation of pten and caspase-3, and insufficient phosphorylation of akt, while mir-129 mimic obviously inhibited the expression of pten and caspase-3, increased the akt phosphorylation, and decreased the cell apoptosis. |
2021-10-13 |
2023-08-13 |
rat |
| Ahmet Yardim, Fatih Mehmet Kandemir, Selcuk Ozdemir, Sefa Kucukler, Selim Comakli, Cihan Gur, Hamit Celi. Quercetin provides protection against the peripheral nerve damage caused by vincristine in rats by suppressing caspase 3, NF-κB, ATF-6 pathways and activating Nrf2, Akt pathways. Neurotoxicology. vol 81. 2021-10-12. PMID:33038355. |
however, quercetin was determined to relieve oxidative stress, oxidative dna damage, neuronal cell damage, inflammation, er stress, and apoptosis caused by vincristine and enable akt activation. |
2021-10-12 |
2023-08-13 |
rat |
| Jiayun Liu, Shenlin Liu, Maolin Wu, Jing Deng, Xuequan Yao, Fukun Liu, Xiaoyu Wu, Guannan W. ARF3 inhibits proliferation and promotes apoptosis in gastric cancer by regulating AKT and ERK pathway. Acta biochimica Polonica. vol 68. issue 2. 2021-10-12. PMID:33847108. |
arf3 inhibits proliferation and promotes apoptosis in gastric cancer by regulating akt and erk pathway. |
2021-10-12 |
2023-08-13 |
mouse |
| Jiayun Liu, Shenlin Liu, Maolin Wu, Jing Deng, Xuequan Yao, Fukun Liu, Xiaoyu Wu, Guannan W. ARF3 inhibits proliferation and promotes apoptosis in gastric cancer by regulating AKT and ERK pathway. Acta biochimica Polonica. vol 68. issue 2. 2021-10-12. PMID:33847108. |
to sum up, arf3 may suppress proliferation, induced cycle arrest and promotes apoptosis of gc by modulating akt and erk pathway. |
2021-10-12 |
2023-08-13 |
mouse |
| M Guo, J X. [PI3K/Akt/mTOR signal pathway in endocrine disrupting chemicals-induced apoptosis and autophagy of thyroid follicular cells]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. vol 39. issue 9. 2021-10-12. PMID:34624962. |
at present, the impact of this type of substance on the thyroid has attracted much attention.this review summarized the effects of edcs on thyroid hormones, and phosphatidylinositol 3-kinase (pi3k) /protein kinase b (akt) /mammalian target of rapamycin (mtor) (pi3k/akt/mtor) signaling pathway and its role in thyroid diseases, and explore the role of pi3k/akt/mtor signaling pathway in edcs-induced apoptosis and autophagy of thyroid follicular epithelial cells.this paper could provide further understandings for thyroid diseases induced by the autophagy and apoptosis of thyroid follicular epithelial cells. |
2021-10-12 |
2023-08-13 |
human |
| Wei Han, Fan Yu, Rong Wang, Wei Guan, Feng Zh. Valproic Acid Sensitizes Glioma Cells to Luteolin Through Induction of Apoptosis and Autophagy via Akt Signaling. Cellular and molecular neurobiology. vol 41. issue 8. 2021-10-11. PMID:32719967. |
valproic acid sensitizes glioma cells to luteolin through induction of apoptosis and autophagy via akt signaling. |
2021-10-11 |
2023-08-13 |
Not clear |
| Wei Han, Fan Yu, Rong Wang, Wei Guan, Feng Zh. Valproic Acid Sensitizes Glioma Cells to Luteolin Through Induction of Apoptosis and Autophagy via Akt Signaling. Cellular and molecular neurobiology. vol 41. issue 8. 2021-10-11. PMID:32719967. |
these findings suggested that vpa enhanced the anticancer effects of luteolin by strengthening apoptosis and autophagy via akt signaling, which could be adopted as a novel therapy for glioma. |
2021-10-11 |
2023-08-13 |
Not clear |