| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohamed Ramadan, Yaseen A M M Elshaier, Ashraf A Aly, Mohamed Abdel-Aziz, Hazem M Fathy, Alan B Brown, Jacey R Pridgen, Kevin N Dalby, Tamer S Kaou. Development of 2'-aminospiro [pyrano[3,2-c]quinoline]-3'-carbonitrile derivatives as non-ATP competitive Src kinase inhibitors that suppress breast cancer cell migration and proliferation. Bioorganic chemistry. vol 116. 2021-11-15. PMID:34598088. |
noticeably, the cell growth suppression and apoptosis induction in the tested cell lines can be attributed to the ability of the new derivatives to suppress the erk and akt survival pathways downstream of src. |
2021-11-15 |
2023-08-13 |
Not clear |
| Parham Jabbarzadeh Kaboli, Saber Imani, Masume Jomhori, King-Hwa Lin. Chemoresistance in breast cancer: PI3K/Akt pathway inhibitors vs the current chemotherapy. American journal of cancer research. vol 11. issue 10. 2021-11-13. PMID:34765318. |
akt signalling plays a cellular defence role against chemotherapy and (1) enhances multi-drug resistance, (2) increases reactive oxygen species at breast tumor microenvironment, (3) enhances anaerobic metabolism, (4) inhibits the tricarboxylic cycle, (5) promotes pd-l1 upregulation, (6) inhibits apoptosis, (7) increases glucose uptake, and more importantly (8) recruits and interconnects the plasma membrane, nucleus, endoplasmic reticulum, and mitochondria to hijack breast cancer cells and rescue these cells from chemotherapy. |
2021-11-13 |
2023-08-13 |
Not clear |
| Jincan Chen, Yuanyuan Deng, Jie Wang, Suxiang Chen, Fa Peng, Xuerong He, Meijun Liu, Hui Luo, Jingjing Zhang, Lanmei Che. Cyclometalated Ru(II) β-carboline complexes induce cell cycle arrest and apoptosis in human HeLa cervical cancer cells via suppressing ERK and Akt signaling. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. vol 26. issue 7. 2021-11-12. PMID:34459988. |
cyclometalated ru(ii) β-carboline complexes induce cell cycle arrest and apoptosis in human hela cervical cancer cells via suppressing erk and akt signaling. |
2021-11-12 |
2023-08-13 |
human |
| Jiaxing Li, Chaoquan Hu, Hui Chao, Yu Zhang, Yong Li, Jing Hou, Limin Huan. Exosomal transfer of miR-106a-5p contributes to cisplatin resistance and tumorigenesis in nasopharyngeal carcinoma. Journal of cellular and molecular medicine. vol 25. issue 19. 2021-11-10. PMID:34469038. |
mechanistically, exosomal mir-106a-5p targets arnt2, which further activates akt phosphorylation, and thus promotes npc cell proliferation, decreases apoptosis and in turn regulates tumorigenesis. |
2021-11-10 |
2023-08-13 |
Not clear |
| Li Yu, Jie Yan. MiR-29 increases apoptosis of retinal ganglion cells in rat glaucoma model through AKT signaling pathway. Panminerva medica. vol 63. issue 1. 2021-11-09. PMID:31262145. |
mir-29 increases apoptosis of retinal ganglion cells in rat glaucoma model through akt signaling pathway. |
2021-11-09 |
2023-08-13 |
rat |
| Donia E Hafez, Eman Hafez, Islam Eddiasty, Shou-Ping Shih, Leng-Chiang Chien, Yi-Jia Hong, Hung-Yu Lin, Adam B Keeton, Gary A Piazza, Mohammad Abdel-Halim, Ashraf H Abad. Novel thiazolidine derivatives as potent selective pro-apoptotic agents. Bioorganic chemistry. vol 114. 2021-11-09. PMID:34328854. |
in addition, 2e also downregulated akt, n-cadherin, and vimentin proteins expression giving indication that 2e inhibit the pi3k/akt pathway to regulate cell cycle arrest and induce apoptosis, and can regulate the expression of epithelial-mesenchymal transition-related proteins. |
2021-11-09 |
2023-08-13 |
Not clear |
| Huifang Chen, Andong He, Haoyang Li, Honglv Chen, Huancheng Xie, Liping Luo, Yuyi Huang, Jiaqian Chen, Jieying Guan, Qiaoling He, Jianjuan Ma, Changxing Ou, Ailin Tao, Jie Ya. TSSK4 upregulation in alveolar epithelial type-II cells facilitates pulmonary fibrosis through HSP90-AKT signaling restriction and AT-II apoptosis. Cell death & disease. vol 12. issue 10. 2021-11-09. PMID:34645797. |
under this condition, kinase activity of akt is diminished to interfere its survival function, subsequently facilitating at-ii cellular apoptosis through the mitochondrial death machinery. |
2021-11-09 |
2023-08-13 |
mouse |
| Rajesh Basnet, Buddha B Basne. Overview of Protein Kinase B Enzyme: A Potential Target for Breast and Prostate Cancer. Current molecular pharmacology. vol 14. issue 4. 2021-11-08. PMID:33115397. |
protein kinase b (akt) pi3k / akt / mtor signaling pathways play a crucial role in modulating cell survival, proliferation, metastasis, metabolism, angiogenesis, and apoptosis. |
2021-11-08 |
2023-08-13 |
Not clear |
| Minke Bekker, Shameemah Abrahams, Ben Loos, Soraya Bardie. Can the interplay between autophagy and apoptosis be targeted as a novel therapy for Parkinson's disease? Neurobiology of aging. vol 100. 2021-11-08. PMID:33516928. |
moreover, besides inhibiting mammalian target of rapamycin, akt is associated with decreased bax expression, thereby acting as both an autophagy inducer and apoptosis inhibitor. |
2021-11-08 |
2023-08-13 |
Not clear |
| Xiaohao Xu, Guang Sun, Jianzeng Liu, Jingyuan Zhou, Jing Li, Zhuo Sun, Xiangzhu Li, Hong Chen, Daqing Zhao, Rui Jiang, Liwei Su. Akt activation-dependent protective effect of wild ginseng adventitious root protein against UVA-induced NIH-3T3 cell damage. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 29. issue 6. 2021-11-08. PMID:34448508. |
taken together, these results suggest that arp treatment of nih-3t3 cells effectively mitigated uva-induced cell viability decline by activating intracellular akt to reduce uva-induced dna damage, leading to reduced rates of apoptosis and cell cycle arrest after uva exposure and restoring collagen expression to normal levels. |
2021-11-08 |
2023-08-13 |
Not clear |
| Changquan Guo, Juan Dong, Yanfen Ma, Shuo Zhou, Weidong Zeng, Guang Liu, Caiqiao Zhan. LIF and bFGF enhanced chicken primordial follicle activation by Wnt/β-catenin pathway. Theriogenology. vol 176. 2021-11-04. PMID:34555602. |
the effect by lif and bfgf were shown to operate at akt and erk signaling pathways to suppress cell apoptosis and promote proliferation (p < 0.05) via the wnt/β-catenin signaling (p < 0.05). |
2021-11-04 |
2023-08-13 |
chicken |
| Changquan Guo, Juan Dong, Yanfen Ma, Shuo Zhou, Weidong Zeng, Guang Liu, Caiqiao Zhan. LIF and bFGF enhanced chicken primordial follicle activation by Wnt/β-catenin pathway. Theriogenology. vol 176. 2021-11-04. PMID:34555602. |
in conclusion, local cytokines lif and bfgf functioned to enhance the activation of chicken primordial follicles by increasing cell proliferation and decreasing apoptosis in the ovary involving akt, erk and wnt/β-catenin signaling. |
2021-11-04 |
2023-08-13 |
chicken |
| Panpan Dong, Lei Xia, Lanyawen Hu, Kai Yang, Huanhuan Wang, Ping Y. Runjing Decoction alleviated cyclophosphamide-induced oligoasthenospermia rats by inhibiting cell apoptosis via RXFP1/AKT/FOXO1 pathway. Andrologia. vol 53. issue 11. 2021-11-03. PMID:34396564. |
rjd suppressed cell apoptosis, inhibited the expression of rxfp1, foxo1, pi3k, akt and bax, and promoted the expression levels of bcl-2 in testicular tissue of oligoasthenospermia rats. |
2021-11-03 |
2023-08-13 |
rat |
| Retraction. Journal of cellular biochemistry. vol 122 Suppl 1. 2021-11-01. PMID:34288061. |
retraction: "tpx2 gene silencing inhibits cell proliferation and promotes apoptosis through negative regulation of akt signaling pathway in ovarian cancer," by yuan tian, lian-lian liu, dong-mei guo, yan wang, wen-hui zha, yang li, fu-ju wu, j cell biochem. |
2021-11-01 |
2023-08-13 |
Not clear |
| Xinxin Zhang, Xiangyu Xu, Li Lu, Xiaoning Wan, Yating Qin, Weibin Ruan, Chao Lv, Lin He, Xiaomei Gu. A new Mfn-2 related synthetic peptide promotes vascular smooth muscle cell apoptosis via regulating the mitochondrial apoptotic pathway by inhibiting Akt signaling. Journal of translational medicine. vol 19. issue 1. 2021-11-01. PMID:34538249. |
a new mfn-2 related synthetic peptide promotes vascular smooth muscle cell apoptosis via regulating the mitochondrial apoptotic pathway by inhibiting akt signaling. |
2021-11-01 |
2023-08-13 |
Not clear |
| Han-Kyul Nam, So-Ra Jeong, Min Cheol Pyo, Sang-Keun Ha, Mi-Hyun Nam, Kwang-Won Le. Methylglyoxal-Derived Advanced Glycation End Products (AGE4) Promote Cell Proliferation and Survival in Renal Cell Carcinoma Cells through the RAGE/Akt/ERK Signaling Pathways. Biological & pharmaceutical bulletin. vol 44. issue 11. 2021-11-01. PMID:34719646. |
as a result, this study demonstrated that age4-rage axis can promote the growth ability of rcc by inducing pcna, mmps, and inhibiting apoptosis in rcc via the akt and erk signaling pathways. |
2021-11-01 |
2023-08-13 |
Not clear |
| Wei Yang, Yunbin Chen, Chao Huang, Wenjian Wang, Congfu Huang, Yuanguang L. MiR-18a Inhibits PI3K/AKT Signaling Pathway to Regulate PDGF BB-Induced Airway Smooth Muscle Cell Proliferation and Phenotypic Transformation. Physiological research. vol 70. issue 6. 2021-10-30. PMID:34717064. |
cell proliferation, apoptosis and migration were detected by mtt, flow cytometry and transwell, respectively; the expression of contractile phenotype marker proteins (sm-22alpha, alpha-sm-actin, calponin) and key molecules of the phosphatidylinositol 3-kinase (pi3k)/akt pathway (pi3k, p-pi3k, akt and p-akt) in asmcs were detected by western blot. |
2021-10-30 |
2023-08-13 |
human |
| Rucun Ge, Yongtao Lv, Peipei Li, Lin Xu, Xiaoya Feng, Hongshun Q. Upregulated microRNA-126 induces apoptosis of dental pulp stem cell via mediating PTEN-regulated Akt activation. Journal of clinical laboratory analysis. vol 35. issue 2. 2021-10-29. PMID:33150661. |
upregulated microrna-126 induces apoptosis of dental pulp stem cell via mediating pten-regulated akt activation. |
2021-10-29 |
2023-08-13 |
human |
| Hui-Wen Chiu, Yi-Chou Hou, Chien-Lin Lu, Kuo-Cheng Lu, Wen-Chih Liu, Jia-Fwu Shyu, Jia-Feng Chang, Cai-Mei Zhen. Cinacalcet Improves Bone Parameters Through Regulation of Osteoclast Endoplasmic Reticulum Stress, Autophagy, and Apoptotic Pathways in Chronic Kidney Disease-Mineral and Bone Disorder. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2021-10-29. PMID:34633122. |
in vitro studies revealed that cinacalcet inhibited receptor activator of nf-κb ligand (rankl)/receptor activator of nf-κb (rank)-induced oc differentiation in a concentration-dependent manner through a close interaction between activation of caspase-related apoptosis, reversal of oc autophagy through the protein kinase b (akt)/mammalian target of rapamycin (mtor) and adenosine monophosphate-activated protein kinase (ampk) pathways, and attenuation of the oc er stress/crebh/nfatc1 signaling pathway. |
2021-10-29 |
2023-08-13 |
mouse |
| Hao Zhou, Yichong Ning, Guirong Zeng, Chang Zhou, Xiaofeng Din. Curcumin promotes cell cycle arrest and apoptosis of acute myeloid leukemia cells by inactivating AKT. Oncology reports. vol 45. issue 4. 2021-10-28. PMID:33649826. |
curcumin promotes cell cycle arrest and apoptosis of acute myeloid leukemia cells by inactivating akt. |
2021-10-28 |
2023-08-13 |
Not clear |