| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jia-Feng Wang, Yun-Peng Wang, Jian Xie, Zhen-Zhen Zhao, Sahil Gupta, Yu Guo, Song-Hui Jia, Jean Parodo, John C Marshall, Xiao-Ming Den. Upregulated PD-L1 delays human neutrophil apoptosis and promotes lung injury in an experimental mouse model of sepsis. Blood. vol 138. issue 9. 2021-11-22. PMID:34473230. |
taken together, our data suggest that increased pd-l1 expression on human neutrophils delays cellular apoptosis by triggering pi3k-dependent akt phosphorylation to drive lung injury and increase mortality during clinical and experimental sepsis. |
2021-11-22 |
2023-08-13 |
mouse |
| Ezgi Avsar Abdik, Hüseyin Abdik, Duygu Turan, Fikrettin Sahin, Martin R Berger, Ferda Kaleagasiogl. Dual Akt and Bcl-2 inhibition induces cell-type specific modulation of apoptotic and autophagic signaling in castration resistant prostate cancer cell lines. Molecular biology reports. vol 48. issue 12. 2021-11-22. PMID:34647221. |
the aim of this study was to elucidate the modulation patterns between apoptosis and autophagy following dual inhibition by akt inhibitor erufosine and bcl-2 inhibitor abt-737 in castration-resistant prostate cancer (crpc) cell lines, pc-3 (bax+) and du-145 (bax-). |
2021-11-22 |
2023-08-13 |
Not clear |
| Erika Tissino, Eliana Pivetta, Alessandra Capuano, Guido Capasso, Riccardo Bomben, Chiara Caldana, Francesca Maria Rossi, Federico Pozzo, Dania Benedetti, Renzo Boldorini, Gianluca Gaidano, Davide Rossi, Alberto Zamò, Tanja Nicole Hartmann, Roberto Doliana, Alfonso Colombatti, Valter Gattei, Paola Spessotto, Antonella Zucchett. Elastin MIcrofibriL INterfacer1 (EMILIN-1) is an alternative prosurvival VLA-4 ligand in chronic lymphocytic leukemia. Hematological oncology. 2021-11-22. PMID:34783040. |
functionally, emilin-1 gc1q domain promotes adhesion of cll cells through specific interaction with vla-4, and releases pro-survival signals for cll cells, as demonstrated by enhanced erk and akt phosphorylation and impairment of in-vitro-induced apoptosis. |
2021-11-22 |
2023-08-13 |
Not clear |
| Xiaofang Chen, Xianling Chen, Yiping Huang, Jia Lin, Yong Wu, Yuanzhong Che. TCP1 increases drug resistance in acute myeloid leukemia by suppressing autophagy via activating AKT/mTOR signaling. Cell death & disease. vol 12. issue 11. 2021-11-20. PMID:34750375. |
furthermore, tcp1 interacted with akt and mtor to activate akt/mtor signaling, which negatively regulates apoptosis and autophagy. |
2021-11-20 |
2023-08-13 |
Not clear |
| Shogo Shigeta, Goldie Y L Lui, Reid Shaw, Russell Moser, Kay E Gurley, Grace Durenberger, Rachele Rosati, Robert L Diaz, Tan A Ince, Elizabeth M Swisher, Carla Grandori, Christopher J Kem. Targeting BET Proteins BRD2 and BRD3 in Combination with PI3K-AKT Inhibition as a Therapeutic Strategy for Ovarian Clear Cell Carcinoma. Molecular cancer therapeutics. vol 20. issue 4. 2021-11-19. PMID:33509905. |
several pi3k or akt inhibitors were among the top drug combinations identified and subsequent work showed cpi0610 synergized with alpelisib or mk2206 by inducing p53-independent apoptosis. |
2021-11-19 |
2023-08-13 |
Not clear |
| Muhammad Safdar, Aixin Liang, Shahid Ali Rajput, Nasir Abbas, Muhammad Zubair, Aftab Shaukat, Aziz Ur Rehman, Huma Jamil, Yan Guo, Farman Ullah, Liguo Yan. Orexin-A Regulates Follicular Growth, Proliferation, Cell Cycle and Apoptosis in Mouse Primary Granulosa Cells via the AKT/ERK Signaling Pathway. Molecules (Basel, Switzerland). vol 26. issue 18. 2021-11-19. PMID:34577105. |
western blotting revealed that knockdown of ox1r resulted in a considerable decrease of the phosphorylation level of the akt and erk1/2 proteins, indicating that the akt/erk1/2 pathway is involved in regulating gcs proliferation and apoptosis. |
2021-11-19 |
2023-08-13 |
mouse |
| Alessio Cardinale, Serena Saladini, Leonardo Lupacchini, Irene Ruspantini, Chiara De Dominicis, Marco Papale, Francesca Silvagno, Enrico Garaci, Cristiana Mollinari, Daniela Merl. DNA repair protein DNA-PK protects PC12 cells from oxidative stress-induced apoptosis involving AKT phosphorylation. Molecular biology reports. 2021-11-19. PMID:34797489. |
dna repair protein dna-pk protects pc12 cells from oxidative stress-induced apoptosis involving akt phosphorylation. |
2021-11-19 |
2023-08-13 |
Not clear |
| Xiangjing Yu, Jie Liu, Huawei Qiu, Huiting Hao, Jinhong Zhu, Shiyun Pen. Combined inhibition of ACK1 and AKT shows potential toward targeted therapy against KRAS-mutant non-small-cell lung cancer. Bosnian journal of basic medical sciences. vol 21. issue 2. 2021-11-18. PMID:32530390. |
we showed that combined administration of ack1 and akt inhibitors at the optimal concentrations effectively suppressed nsclc cell viability and promoted apoptosis while inducing cell cycle arrest at the g2 phase. |
2021-11-18 |
2023-08-13 |
rat |
| Qingsong Li, Xi Zhan. Genistein attenuates cognitive deficits and neuroapoptosis in hippocampus induced by ketamine exposure in neonatal rats. Synapse (New York, N.Y.). vol 75. issue 1. 2021-11-18. PMID:32639628. |
finally, we found that genistein partially restored proteins associated with apoptosis, including bax, bcl-2, cleaved caspase 3, and phosphorylated gsk-3ß and akt. |
2021-11-18 |
2023-08-13 |
rat |
| Nongyao Nonpanya, Kittipong Sanookpan, Keerati Joyjamras, Duangdao Wichadakul, Boonchoo Sritularak, Chatchai Chaotham, Pithi Chanvorachot. Norcycloartocarpin targets Akt and suppresses Akt-dependent survival and epithelial-mesenchymal transition in lung cancer cells. PloS one. vol 16. issue 8. 2021-11-18. PMID:34383763. |
in searching for novel targeted therapeutic agents for lung cancer treatment, norcycloartocarpin from artocarpus gomezianus was reported in this study to promisingly interacted with akt and exerted the apoptosis induction and epithelial-to-mesenchymal transition suppression. |
2021-11-18 |
2023-08-13 |
human |
| Nongyao Nonpanya, Kittipong Sanookpan, Keerati Joyjamras, Duangdao Wichadakul, Boonchoo Sritularak, Chatchai Chaotham, Pithi Chanvorachot. Norcycloartocarpin targets Akt and suppresses Akt-dependent survival and epithelial-mesenchymal transition in lung cancer cells. PloS one. vol 16. issue 8. 2021-11-18. PMID:34383763. |
interestingly, norcycloartocarpin showed potential inhibitory role on protein kinase b (akt) the up-stream dominant molecule controlling emt and apoptosis. |
2021-11-18 |
2023-08-13 |
human |
| Rong-Jane Chen, Yi-Jhen Lyu, Yu-Ying Chen, Yen-Chien Lee, Min-Hsiung Pan, Yuan-Soon Ho, Ying-Jan Wan. Chloroquine Potentiates the Anticancer Effect of Pterostilbene on Pancreatic Cancer by Inhibiting Autophagy and Downregulating the RAGE/STAT3 Pathway. Molecules (Basel, Switzerland). vol 26. issue 21. 2021-11-18. PMID:34771150. |
the results indicated that pterostilbene combined with chloroquine significantly inhibited autophagy, decreased cell viability, and sensitized the cells to pterostilbene-induced apoptosis via downregulation of the rage/stat3 and protein kinase b (akt)/mammalian target of rapamycin (mtor) pathways in pdac cells. |
2021-11-18 |
2023-08-13 |
Not clear |
| Gulnur Kizilay, Sinasi Bayram, Onur Ersoy, Aysegul Cerkezkayabekir, Melike Sapmaz-Metin, Turan Karac. Role of JNK, TGF-β1, Akt, IL-1β and INSL-3 in proanthocyanidin protection against apoptosis in diabetic rat testis. Biotechnic & histochemistry : official publication of the Biological Stain Commission. 2021-11-18. PMID:34789048. |
role of jnk, tgf-β1, akt, il-1β and insl-3 in proanthocyanidin protection against apoptosis in diabetic rat testis. |
2021-11-18 |
2023-08-13 |
rat |
| Jianheng Wu, Xinjun Wang, Xiaowei Yuan, Qiao Shan, Zhen Wang, Yuehui Wu, Jingwei Xi. Kinesin Family Member C1 Increases Temozolomide Resistance of Glioblastoma Through Promoting DNA Damage Repair. Cell transplantation. vol 30. 2021-11-17. PMID:33588605. |
mechanistically, kifc1 silencing contributed to dna damage, cell cycle arrest, and apoptosis through regulating rad51, akt, and dna-pkcs phosphorylation. |
2021-11-17 |
2023-08-13 |
human |
| Hong Zhang, Zongwei Guo, Yafei Guo, Ziqian Wang, Yao Tang, Ting Song, Zhichao Zhan. Bim transfer between Bcl-2-like protein and Hsp70 underlines Bcl-2/Hsp70 crosstalk to regulate apoptosis. Biochemical pharmacology. vol 190. 2021-11-17. PMID:34153292. |
thus, the synergy of s1 and s1g-6 to induce a panel of cancer cell lines apoptosis by inhibiting free bim and facilitating oncogenic client akt folding and activation. |
2021-11-17 |
2023-08-13 |
Not clear |
| Terry Ting-Yu Chiou, You-Ying Chau, Jin-Bor Chen, Hsiang-Hao Hsu, Shao-Pei Hung, Wen-Chin Le. Rapamycin attenuates PLA2R activation-mediated podocyte apoptosis via the PI3K/AKT/mTOR pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 144. 2021-11-17. PMID:34700229. |
we demonstrated that podocyte apoptosis was induced by group ib secretory phospholipase a2 (spla2ib) in a concentration- and time-dependent manner via upregulation of phosphoinositide 3-kinase (pi3k), protein kinase b (akt), and mtor, and inhibited by rapamycin or ly294002. |
2021-11-17 |
2023-08-13 |
human |
| Hai-Anh Ha, Jo-Hua Chiang, Fuu-Jen Tsai, Da-Tian Bau, Yu-Ning Juan, Yu-Hsiang Lo, Mann-Jen Hour, Jai-Sing Yan. Novel quinazolinone MJ‑33 induces AKT/mTOR‑mediated autophagy‑associated apoptosis in 5FU‑resistant colorectal cancer cells. Oncology reports. vol 45. issue 2. 2021-11-15. PMID:33416156. |
the results suggested that mj‑33‑induced apoptosis was mediated by akt signaling, and subsequently modulated via the mitochondria‑dependent signaling pathway. |
2021-11-15 |
2023-08-13 |
Not clear |
| Hai Huang, Song Park, Haibo Zhang, Sijun Park, Wookbong Kwon, Enugyung Kim, Xiujuan Zhang, Soyoung Jang, Duhak Yoon, Seong-Kyoon Choi, Jun-Koo Yi, Sung-Hyun Kim, Zigang Dong, Mee-Hyun Lee, Zaeyoung Ryoo, Myoung Ok Ki. Targeting AKT with costunolide suppresses the growth of colorectal cancer cells and induces apoptosis in vitro and in vivo. Journal of experimental & clinical cancer research : CR. vol 40. issue 1. 2021-11-15. PMID:33785035. |
targeting akt with costunolide suppresses the growth of colorectal cancer cells and induces apoptosis in vitro and in vivo. |
2021-11-15 |
2023-08-13 |
Not clear |
| Liu Xiaoyu, Zhang Wei, Zhao Ming, Jia Guowe. Anti-apoptotic Effect of MiR-223-3p Suppressing PIK3C2A in Cardiomyocytes from Myocardial Infarction Rat Through Regulating PI3K/Akt Signaling Pathway. Cardiovascular toxicology. vol 21. issue 8. 2021-11-15. PMID:33999393. |
four weeks after transfection, the expression levels of mir-223-3p and pik3c2a in tissues as well as pi3k, akt, bax, and bcl-2 mrna in cells were detected by qrt-pcr and western blot, in combination with the detection of apoptosis rate by flow cytometry. |
2021-11-15 |
2023-08-13 |
rat |
| Jinxin Che, Xiaoyang Dai, Jian Gao, Haichao Sheng, Wenhu Zhan, Yang Lu, Dan Li, Zizheng Gao, Zegao Jin, Binhui Chen, Peihua Luo, Bo Yang, Yongzhou Hu, Qiaojun He, Qinjie Weng, Xiaowu Don. Discovery of Journal of medicinal chemistry. vol 64. issue 16. 2021-11-15. PMID:34375113. |
here, we demonstrate the inhibition of akt2 isozyme may be a driver for keratinocyte apoptosis, which promotes us to search for new selective akt inhibitors with an improved cutaneous safety property. |
2021-11-15 |
2023-08-13 |
Not clear |