| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu Huang, Liangpeng Li, Hongmei Chen, Qiao Liao, Xiaoli Yang, Dezhong Yang, Xuewei Xia, Hongyong Wang, Wei Eric Wang, Lianglong Chen, Chunyu Zen. The Protective Role of Yin-Yang 1 in Cardiac Injury and Remodeling After Myocardial Infarction. Journal of the American Heart Association. vol 10. issue 21. 2021-12-02. PMID:34713723. |
conclusions yy1 ameliorates cardiac injury and remodeling after mi by repressing cardiomyocyte apoptosis and boosting angiogenesis, which might be ascribed to the enhancement of akt phosphorylation and the subsequent vascular endothelial growth factor up-regulation. |
2021-12-02 |
2023-08-13 |
mouse |
| Juan Wang, Tongde Du, Ya Lu, Yan Lv, Yuxin Du, Jianzhong Wu, Rong Ma, Chenxin Xu, Jifeng Fen. VLX1570 regulates the proliferation and apoptosis of human lung cancer cells through modulating ER stress and the AKT pathway. Journal of cellular and molecular medicine. 2021-12-02. PMID:34854221. |
vlx1570 regulates the proliferation and apoptosis of human lung cancer cells through modulating er stress and the akt pathway. |
2021-12-02 |
2023-08-13 |
human |
| Juan Gonzalez-Valdivieso, Andres Garcia-Sampedro, Andrew R Hall, Alessandra Girotti, Francisco Javier Arias, Stephen P Pereira, Pilar Aced. Smart Nanoparticles as Advanced Anti-Akt Kinase Delivery Systems for Pancreatic Cancer Therapy. ACS applied materials & interfaces. vol 13. issue 47. 2021-12-01. PMID:34788541. |
self-assembling 73 ± 3.2 nm size nanoparticles inhibited phosphorylation and consequent activation of akt protein, blocked the nf-κb signaling pathway, and triggered caspase 3-mediated apoptosis. |
2021-12-01 |
2023-08-13 |
Not clear |
| Su-Qin Hu, Dian-Long Liu, Chun-Rui Li, Ya-Hui Xu, Ke Hu, Li-Dan Cui, Jian Gu. Wuzi-Yanzong prescription alleviates spermatogenesis disorder induced by heat stress dependent on Akt, NF-κB signaling pathway. Scientific reports. vol 11. issue 1. 2021-11-30. PMID:34552120. |
akt and nuclear factor kappa b (nf-κb) signaling pathways are involved in germ cell apoptosis and inflammation after testicular heat stress (ths). |
2021-11-30 |
2023-08-13 |
rat |
| Zhang Qing, Luo Dongliu, Gu Xuedie, Pervez Ahmed Khoso, Huang Xiaodan, Li Sh. MiR-144-3p targets STC1 to activate PI3K/AKT pathway to induce cell apoptosis and cell cycle arrest in selenium deficiency broilers. Journal of inorganic biochemistry. vol 226. 2021-11-30. PMID:34800749. |
firstly, we established the se deficient model of broilers in vivo and found that se deficiency could induce apoptosis and cell cycle arrest of bursa of fabricius cells through phosphoinositide 3-kinase (pi3k)/protein kinase b (akt) pathway. |
2021-11-30 |
2023-08-13 |
Not clear |
| Yuting Cui, Yue Xiong, Hua Li, Mengqi Zeng, Yan Wang, Yuan Li, Xuan Zou, Weiqiang Lv, Jing Gao, Ruijun Cao, Lingjie Meng, Jiangang Long, Jiankang Liu, Zhihui Fen. Chalcone-Derived Nrf2 Activator Protects Cognitive Function via Maintaining Neuronal Redox Status. Antioxidants (Basel, Switzerland). vol 10. issue 11. 2021-11-30. PMID:34829682. |
in addition, consistent benefits are also observed in an energy stress mouse model under a high-fat diet, as the administration of tak remarkably increases akt signaling-mediated antioxidative enzyme expression and prevents hippocampal neuronal apoptosis without significant effect on the mouse metabolic status. |
2021-11-30 |
2023-08-13 |
mouse |
| Sylwia K Król, Ewa Bębenek, Magdalena Dmoszyńska-Graniczka, Adrianna Sławińska-Brych, Stanisław Boryczka, Andrzej Stepula. Acetylenic Synthetic Betulin Derivatives Inhibit Akt and Erk Kinases Activity, Trigger Apoptosis and Suppress Proliferation of Neuroblastoma and Rhabdomyosarcoma Cell Lines. International journal of molecular sciences. vol 22. issue 22. 2021-11-30. PMID:34830180. |
acetylenic synthetic betulin derivatives inhibit akt and erk kinases activity, trigger apoptosis and suppress proliferation of neuroblastoma and rhabdomyosarcoma cell lines. |
2021-11-30 |
2023-08-13 |
Not clear |
| Ya Ling Bai, Mei Juan Cheng, Jing Jing Jin, Hui Ran Zhang, Lei He, Wei Zhou, Sheng Lei Zhang, Jin Sheng X. SET8，a novel regulator to ameliorate vascular calcification via activating PI3K/Akt mediated anti-apoptotic effects. Biochemistry and cell biology = Biochimie et biologie cellulaire. 2021-11-30. PMID:34846946. |
mechanistically, pi3k/akt pathway was mediated by set8 and inhibition of pi3k/akt signaling pathway by giving ly294002 or transfecting akt phosphorylation inactivated mutation plasmid increased apoptosis and calcification. |
2021-11-30 |
2023-08-13 |
Not clear |
| Ya Ling Bai, Mei Juan Cheng, Jing Jing Jin, Hui Ran Zhang, Lei He, Wei Zhou, Sheng Lei Zhang, Jin Sheng X. SET8，a novel regulator to ameliorate vascular calcification via activating PI3K/Akt mediated anti-apoptotic effects. Biochemistry and cell biology = Biochimie et biologie cellulaire. 2021-11-30. PMID:34846946. |
akt phosphorylation constitutively activated mutation could reduce apoptosis and calcification of vsmcs. |
2021-11-30 |
2023-08-13 |
Not clear |
| Zhang Hui, Qing-Qing Dong, Hua-Pan Shu, Yu-Chi Tu, Qian-Qian Liao, Li-Jun Ya. Mechanistic insights into the renoprotective role of curcumin in cisplatin-induced acute kidney injury: network pharmacology analysis and experimental validation. Bioengineered. vol 12. issue 2. 2021-11-29. PMID:34802380. |
western blotting and flow cytometry showed that cur inhibited apoptosis induced by cp by activating the akt signaling pathway in human kidney tubular epithelial cells (hk-2). |
2021-11-29 |
2023-08-13 |
human |
| Zhang Hui, Qing-Qing Dong, Hua-Pan Shu, Yu-Chi Tu, Qian-Qian Liao, Li-Jun Ya. Mechanistic insights into the renoprotective role of curcumin in cisplatin-induced acute kidney injury: network pharmacology analysis and experimental validation. Bioengineered. vol 12. issue 2. 2021-11-29. PMID:34802380. |
altogether, our findings demonstrated that cur alleviated apoptosis by activating the akt signaling pathway in cp-aki |
2021-11-29 |
2023-08-13 |
human |
| Jing-Yan Gao, Chih-Shiang Chang, Jin-Cherng Lien, Ting-Wei Chen, Jing-Lan Hu, Jing-Ru Wen. Synthetic Tryptanthrin Derivatives Induce Cell Cycle Arrest and Apoptosis via Akt and MAPKs in Human Hepatocellular Carcinoma Cells. Biomedicines. vol 9. issue 11. 2021-11-29. PMID:34829756. |
synthetic tryptanthrin derivatives induce cell cycle arrest and apoptosis via akt and mapks in human hepatocellular carcinoma cells. |
2021-11-29 |
2023-08-13 |
human |
| Jing-Yan Gao, Chih-Shiang Chang, Jin-Cherng Lien, Ting-Wei Chen, Jing-Lan Hu, Jing-Ru Wen. Synthetic Tryptanthrin Derivatives Induce Cell Cycle Arrest and Apoptosis via Akt and MAPKs in Human Hepatocellular Carcinoma Cells. Biomedicines. vol 9. issue 11. 2021-11-29. PMID:34829756. |
in addition to inducing caspase-dependent apoptosis, a1 and a6 exhibited similar regulation of the phosphorylation or expression of multiple signaling targets, including akt, nf-κb, and mitogen-activated protein kinases. |
2021-11-29 |
2023-08-13 |
human |
| Xiaolin Wang, Yuanqiang Dai, Xiaoxiu Zhang, Ke Pan, Yu Deng, Jiafeng Wang, Tao X. CXCL6 regulates cell permeability, proliferation, and apoptosis after ischemia-reperfusion injury by modulating Sirt3 expression via AKT/FOXO3a activation. Cancer biology & therapy. vol 22. issue 1. 2021-11-27. PMID:33241954. |
cxcl6 knockdown in the iri model significantly decreased hbmec permeability and promoted hbmec proliferation, concurrent with a decrease in apoptosis; it also increased sirt3 expression levels and decreased cxcl6/cxcr2 protein and phosphorylated akt ( |
2021-11-27 |
2023-08-13 |
human |
| Yongna Fan, Ping Xie, Hua Zhang, Shubin Guo, Dongfeng Gu, Mingpeng She, HuiHua L. Correction to: Proteasome-dependent inactivation of Akt is essential for 12-O-tetradecanoylphorbol 13-acetate-induced apoptosis in vascular smooth muscle cells. Apoptosis : an international journal on programmed cell death. 2021-11-27. PMID:34837563. |
correction to: proteasome-dependent inactivation of akt is essential for 12-o-tetradecanoylphorbol 13-acetate-induced apoptosis in vascular smooth muscle cells. |
2021-11-27 |
2023-08-13 |
Not clear |
| Masaaki Nakao, Ippei Shimizu, Goro Katsuumi, Yohko Yoshida, Masayoshi Suda, Yuka Hayashi, Ryutaro Ikegami, Yung Ting Hsiao, Shujiro Okuda, Tomoyoshi Soga, Tohru Minamin. Empagliflozin maintains capillarization and improves cardiac function in a murine model of left ventricular pressure overload. Scientific reports. vol 11. issue 1. 2021-11-26. PMID:34526601. |
the in vitro studies showed that catecholamine-induced endothelial apoptosis was inhibited by no, arginine, or akt activator. |
2021-11-26 |
2023-08-13 |
mouse |
| Min Guo, Ruilin Zheng, Hua-Lian Wu, Danyang Chen, Jingyao Su, Tiantian Xu, Houbo Wu, Wenzhou Xiang, Yinghua Li, Bing Zh. Inhibition of enterovirus 71 infection by polysaccharides extracted from Picochlorum sp. 122 via the AKT and ATM/ATR signaling pathways. Archives of virology. vol 166. issue 12. 2021-11-26. PMID:34536128. |
an annexin v affinity assay also indicated that ppe protects host cells from apoptosis through the akt and atm/atr signalling pathways. |
2021-11-26 |
2023-08-13 |
Not clear |
| Liang Chen, Zhenhong Ni, Junlan Huang, Ruobin Zhang, Jinfan Zhang, Bin Zhang, Liang Kuang, Xianding Sun, Dali Zhang, Nan Su, Huabing Qi, Jing Yang, Min Jin, Fengtao Luo, Hangang Chen, Siru Zhou, Xiaolan Du, Junjie Ouyang, Zuqiang Wang, Yangli Xie, Qiaoyan Tan, Lin Che. Long term usage of dexamethasone accelerating accelerates the initiation of osteoarthritis via enhancing chondrocyte apoptosis and the extracellular matrix calcification and apoptosis of chondrocytes. International journal of biological sciences. vol 17. issue 15. 2021-11-24. PMID:34803488. |
further studies showed that dex leads to calcification of extracellular matrix of chondrocytes partially through activation of akt, as well as promotes apoptosis of chondrocytes in calcified cartilage layer. |
2021-11-24 |
2023-08-13 |
mouse |
| Sahabuddin Ahmed, Mohit Kwatra, Basveshwar Gawali, Samir Ranjan Panda, V G M Naid. Potential role of TrkB agonist in neuronal survival by promoting CREB/BDNF and PI3K/Akt signaling in vitro and in vivo model of 3-nitropropionic acid (3-NP)-induced neuronal death. Apoptosis : an international journal on programmed cell death. vol 26. issue 1-2. 2021-11-22. PMID:33226552. |
akt phosphorylation additionally phosphorylates bad at serine-136 and inhibits its translocation to mitochondria thereby promoting mitochondrial biogenesis, enhanced atp production and inhibit apoptosis mediated neuronal death. |
2021-11-22 |
2023-08-13 |
mouse |
| Vaclav Seda, Eva Vojackova, Laura Ondrisova, Lenka Kostalova, Sonali Sharma, Tomas Loja, Gabriela Mladonicka Pavlasova, Daniel Zicha, Marie Kudlickova Peskova, Jan Krivanek, Kvetoslava Liskova, Leos Kren, Vladimir Benes, Katerina Musilova Litzmanova, Marek Borsky, Jan Oppelt, Jan Verner, Sarka Pospisilova, Yvona Brychtova, Anna Panovska, Zhi Tan, Shuxing Zhang, Michael Doubek, Katerina Amruz Cerna, Jiri Mayer, Marek Mra. FoxO1-GAB1 axis regulates homing capacity and tonic AKT activity in chronic lymphocytic leukemia. Blood. vol 138. issue 9. 2021-11-22. PMID:33786575. |
gab1 inhibitors induce cll cell apoptosis, impair cell migration, inhibit tonic or bcr-induced akt phosphorylation, and block compensatory akt activity during ibrutinib therapy. |
2021-11-22 |
2023-08-13 |
Not clear |