| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuxiang Song, Kexin Wang, Juan J Loor, Qianming Jiang, Yuchen Yang, Shang Jiang, Siyuan Liu, Jiyuan He, Xiancheng Feng, Xiliang Du, Lin Lei, Wenwen Gao, Guowen Liu, Xinwei L. β-Hydroxybutyrate inhibits apoptosis in bovine neutrophils through activating ERK1/2 and AKT signaling pathways. Journal of dairy science. 2022-02-13. PMID:35151471. |
β-hydroxybutyrate inhibits apoptosis in bovine neutrophils through activating erk1/2 and akt signaling pathways. |
2022-02-13 |
2023-08-13 |
cattle |
| Yuxiang Song, Kexin Wang, Juan J Loor, Qianming Jiang, Yuchen Yang, Shang Jiang, Siyuan Liu, Jiyuan He, Xiancheng Feng, Xiliang Du, Lin Lei, Wenwen Gao, Guowen Liu, Xinwei L. β-Hydroxybutyrate inhibits apoptosis in bovine neutrophils through activating ERK1/2 and AKT signaling pathways. Journal of dairy science. 2022-02-13. PMID:35151471. |
overall, our data demonstrated that high concentrations of bhb inhibit apoptosis in bovine neutrophils by activating the erk1/2 and akt signaling pathways. |
2022-02-13 |
2023-08-13 |
cattle |
| Dingqi Sun, Jinhua Wang, Hui Zhang, Shuai Liu, Peng Wei, Haoran Wang, Zhen Xu, Qiang Fu, Keqin Zhan. Corrigendum to "MK2206 enhances cisplatin-induced cytotoxicity and apoptosis in testicular cancer through Akt signaling pathway inhibition" [Transl Oncol. 2020 Jul;13(7):100769]. Translational oncology. vol 18. 2022-02-13. PMID:35152083. |
corrigendum to "mk2206 enhances cisplatin-induced cytotoxicity and apoptosis in testicular cancer through akt signaling pathway inhibition" [transl oncol. |
2022-02-13 |
2023-08-13 |
Not clear |
| Qiu-Yuan Gong, Lin Cai, Yao Jing, Wei Wang, Dian-Xu Yang, Shi-Wen Chen, Heng-Li Tia. Urolithin A alleviates blood-brain barrier disruption and attenuates neuronal apoptosis following traumatic brain injury in mice. Neural regeneration research. vol 17. issue 9. 2022-02-10. PMID:35142690. |
we found that ua greatly reduced brain edema; increased the expression of tight junction proteins in injured cortex; increased the immunopositivity of two neuronal autophagy markers, microtubule-associated protein 1a/b light chain 3a/b (lc3) and p62; downregulated protein kinase b (akt) and mammalian target of rapamycin (mtor), two regulators of the phosphatidylinositol 3-kinase (pi3k)/akt/mtor signaling pathway; decreased the phosphorylation levels of inhibitor of nfκb (iκb) kinase alpha (ikkα) and nuclear factor kappa b (nfκb), two regulators of the neuroinflammation-related akt/ikk/nfκb signaling pathway; reduced blood-brain barrier permeability and neuronal apoptosis in injured cortex; and improved mouse neurological function. |
2022-02-10 |
2023-08-13 |
mouse |
| Dan Chen, Yi Zhang, Lian Ji, Yubin W. CREG mitigates neonatal HIE injury through survival promotion and apoptosis inhibition in hippocampal neurons via activating AKT signaling. Cell biology international. 2022-02-10. PMID:35143104. |
creg mitigates neonatal hie injury through survival promotion and apoptosis inhibition in hippocampal neurons via activating akt signaling. |
2022-02-10 |
2023-08-13 |
rat |
| Dan Chen, Yi Zhang, Lian Ji, Yubin W. CREG mitigates neonatal HIE injury through survival promotion and apoptosis inhibition in hippocampal neurons via activating AKT signaling. Cell biology international. 2022-02-10. PMID:35143104. |
besides, creg overexpression promoted survival while inhibited apoptosis in ogd/r-induced hippocampal neurons accompanied by akt signaling activation, which could be reversed by creg silence. |
2022-02-10 |
2023-08-13 |
rat |
| Dan Chen, Yi Zhang, Lian Ji, Yubin W. CREG mitigates neonatal HIE injury through survival promotion and apoptosis inhibition in hippocampal neurons via activating AKT signaling. Cell biology international. 2022-02-10. PMID:35143104. |
collectedly, we demonstrated that creg protected hippocampal neurons from hypoxic ischemia-induced injury through regulating survival and apoptosis via activating akt signaling pathway. |
2022-02-10 |
2023-08-13 |
rat |
| Alison M Schram, Igor Odintsov, Madelyn Espinosa-Cotton, Inna Khodos, Whitney J Sisso, Marissa S Mattar, Allan J W Lui, Morana Vojnic, Sara H Shameem, Thrusha Chauhan, Jean Torrisi, Jim Ford, Marie N O'Connor, Cecile A W Geuijen, Ron Cj Schackmann, Jeroen J Lammerts van Bueren, Ernesto Wasserman, Elisa de Stanchina, Eileen M O'Reilly, Marc Ladanyi, Alexander Drilon, Romel Somwa. Zenocutuzumab, a HER2xHER3 bispecific antibody, is effective therapy for tumors driven by NRG1 gene rearrangements. Cancer discovery. 2022-02-09. PMID:35135829. |
zeno inhibited her3 and akt phosphorylation, induced expression of apoptosis markers, and inhibited growth. |
2022-02-09 |
2023-08-13 |
Not clear |
| Yazhou Li, Ruiyang Han, Wei Ca. Plantamajoside modulates the proliferation, stemness, and apoptosis of lung carcinoma via restraining p38MAPK and AKT phosphorylation. Translational cancer research. vol 9. issue 6. 2022-02-04. PMID:35117750. |
plantamajoside modulates the proliferation, stemness, and apoptosis of lung carcinoma via restraining p38mapk and akt phosphorylation. |
2022-02-04 |
2023-08-13 |
Not clear |
| Xiaoxian Xie, Ruonan Shu, Chunan Yu, Zhengwei Fu, Zezhi L. Mammalian AKT, the Emerging Roles on Mitochondrial Function in Diseases. Aging and disease. vol 13. issue 1. 2022-02-03. PMID:35111368. |
interestingly, increasing studies have revealed that akt can modulate mitochondria-mediated apoptosis, redox states, dynamic balance, autophagy, and metabolism. |
2022-02-03 |
2023-08-13 |
Not clear |
| Yang Liu, Ying-Hua Luo, Shu-Mei Li, Gui-Nan Shen, Jia-Ru Wang, Yi Zhang, Yu-Chao Feng, Wan-Ting Xu, Yu Zhang, Tong Zhang, Hui Xue, Hong-Xing Wang, Yang Cui, Ying Wang, Cheng-Hao Ji. 2-(Naphthalene-2-thio)-5,8-dimethoxy-1,4-naphthoquinone induces apoptosis via ROS-mediated MAPK, AKT, and STAT3 signaling pathways in HepG2 human hepatocellular carcinoma cells. Drug and chemical toxicology. vol 45. issue 1. 2022-02-01. PMID:35100937. |
2-(naphthalene-2-thio)-5,8-dimethoxy-1,4-naphthoquinone induces apoptosis via ros-mediated mapk, akt, and stat3 signaling pathways in hepg2 human hepatocellular carcinoma cells. |
2022-02-01 |
2023-08-13 |
human |
| Yang Liu, Ying-Hua Luo, Shu-Mei Li, Gui-Nan Shen, Jia-Ru Wang, Yi Zhang, Yu-Chao Feng, Wan-Ting Xu, Yu Zhang, Tong Zhang, Hui Xue, Hong-Xing Wang, Yang Cui, Ying Wang, Cheng-Hao Ji. 2-(Naphthalene-2-thio)-5,8-dimethoxy-1,4-naphthoquinone induces apoptosis via ROS-mediated MAPK, AKT, and STAT3 signaling pathways in HepG2 human hepatocellular carcinoma cells. Drug and chemical toxicology. vol 45. issue 1. 2022-02-01. PMID:35100937. |
taken together, these findings suggest that ntdmnq induces apoptosis via ros-mediated mapk, akt and stat3 signaling pathways in hepg2 cells, and may be a potent anticancer agent. |
2022-02-01 |
2023-08-13 |
human |
| Jiao Zhang, Man-Yuan Li, Xiao Lu, Quan-Xing Liu, Dong Zhou, Gui-Xue Yang, Xiao-Qing Liu, Hong Zheng, Ji-Gang Da. CWHM-1008 Induces Apoptosis and Protective Autophagy through the Akt/mTOR Axis in LUAD Cells. Journal of oncology. vol 2021. 2022-01-31. PMID:35096055. |
potential effects of an autophagy inhibitor (ly294002) and constitutively active akt plasmid (ca-akt) on cwhm-1008-induced apoptosis were also examined. |
2022-01-31 |
2023-08-13 |
mouse |
| Susan F Steinber. N-TERTAINING A NEW SIGNALING PARADIGM FOR THE CARDIOMYOCYTE β1-ADRENERGIC RECEPTOR. Journal of cardiovascular pharmacology. 2022-01-31. PMID:35099166. |
the n-terminally truncated form of the β1ar constitutively activates the akt signaling pathway and confers protection against doxorubicin-dependent apoptosis in cardiomyocytes. |
2022-01-31 |
2023-08-13 |
Not clear |
| Jiayue Song, Fuqiang Zhang, Yu Wang, Yuxiang Wang, Jingtian Zhang, Zixuan Xiao, Xueqi Fu, Xuemin Xu, Linlin Zen. Bak interacts with AKT and is involved in TNFα/CHX-induced apoptosis. Molecular and cellular biochemistry. 2022-01-30. PMID:35094193. |
bak interacts with akt and is involved in tnfα/chx-induced apoptosis. |
2022-01-30 |
2023-08-13 |
Not clear |
| Jiayue Song, Fuqiang Zhang, Yu Wang, Yuxiang Wang, Jingtian Zhang, Zixuan Xiao, Xueqi Fu, Xuemin Xu, Linlin Zen. Bak interacts with AKT and is involved in TNFα/CHX-induced apoptosis. Molecular and cellular biochemistry. 2022-01-30. PMID:35094193. |
the addition of tnfα/chx was proposed to destroy the complex, such that the dissociated bak would exert a proapoptosis effect akt can influence the inhibition of cell apoptosis. |
2022-01-30 |
2023-08-13 |
Not clear |
| Jiayue Song, Fuqiang Zhang, Yu Wang, Yuxiang Wang, Jingtian Zhang, Zixuan Xiao, Xueqi Fu, Xuemin Xu, Linlin Zen. Bak interacts with AKT and is involved in TNFα/CHX-induced apoptosis. Molecular and cellular biochemistry. 2022-01-30. PMID:35094193. |
akt was less obvious with apoptosis but in the bak knockout cells, the anti-apoptotic effect of akt was very obvious. |
2022-01-30 |
2023-08-13 |
Not clear |
| Rong Wang, Ke-Liang Huang, Lian-Xiang Xin. TRIM35 functions as a novel tumor suppressor in breast cancer by inducing cell apoptosis through ubiquitination of PDK1. Neoplasma. 2022-01-27. PMID:35081724. |
in conclusion, trim35 functions as a tumor suppressor to suppress breast cancer proliferation by inactivating akt signaling through the increased ubiquitination of pdk1, resulting in the promotion of apoptosis. |
2022-01-27 |
2023-08-13 |
Not clear |
| Almitra Rindiarti, Yasuhiro Okamoto, Shunsuke Nakagawa, Junko Hirose, Yuichi Kodama, Takuro Nishikawa, Yoshifumi Kawan. Changes in intracellular activation-related gene expression and induction of Akt contribute to acquired resistance toward nelarabine in CCRF-CEM cell line. Leukemia & lymphoma. 2022-01-26. PMID:35080473. |
thus, changes in the expression of cellular activation-related genes, inhibition of apoptosis, and induction of akt may be involved in the development of nelarabine resistance in the ccrf-cem cell model. |
2022-01-26 |
2023-08-13 |
human |
| Huan Tian, Songyin Huang, Qing Luo, Zhuochen Lin, Huanhuan Liu, Zhixian Zhang, Wengcheng Fong, Jinghua Zhao, Fengyan Y. Akt pathway activation reduces platelet apoptosis and contributes to the increase of platelet counts in solid tumor patients. Platelets. 2022-01-24. PMID:35068286. |
akt pathway activation reduces platelet apoptosis and contributes to the increase of platelet counts in solid tumor patients. |
2022-01-24 |
2023-08-13 |
Not clear |