| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Falko Lange, Jakob Venus, Daria Shams Esfand Abady, Katrin Porath, Anne Einsle, Tina Sellmann, Valentin Neubert, Gesine Reichart, Michael Linnebacher, Rüdiger Köhling, Timo Kirschstei. Galvanotactic Migration of Glioblastoma and Brain Metastases Cells. Life (Basel, Switzerland). vol 12. issue 4. 2022-04-23. PMID:35455071. |
to determine the effects of egf receptor antagonist afatinib and akt inhibitor capivasertib, assays of cell proliferation, apoptosis and immunoblot analyses were performed. |
2022-04-23 |
2023-08-13 |
Not clear |
| Victoria Abzianidze, Natalia Moiseeva, Diana Suponina, Sofya Zakharenkova, Nadezhda Rogovskaya, Lidia Laletina, Alvin A Holder, Denis Krivorotov, Alexander Bogachenkov, Alexander Garabadzhiu, Anton Ukolov, Vyacheslav Kosoruko. Natural Phaeosphaeride A Derivatives Overcome Drug Resistance of Tumor Cells and Modulate Signaling Pathways. Pharmaceuticals (Basel, Switzerland). vol 15. issue 4. 2022-04-23. PMID:35455394. |
milliplex map multi-pathway magnetic bead 9-plex was used, which allowed for the simultaneous detection of the following nine phosphorylated protein markers of the main intracellular signaling pathways: a universal transcription factor that controls the expression of immune-response genes, apoptosis and cell cycle nfκb (ps536); camp-dependent transcription factor (creb (ps133); mitogen-activated kinase p38 (pt180/py182); stress-activated protein kinase jnk (pt183/py185); ribosomal sk; transcription factors stat3 (ps727) and stat5a/b (py694/699); protein kinase b (akt) (ps473); and kinase regulated by extracellular signals erk1/2 (pt185/py187). |
2022-04-23 |
2023-08-13 |
human |
| Lirong Liang, Ze Fan, Danyi He, Youyi Zhao, Tian Zeng, Bing Liu, Tianyuan Ma, Junjun Kang, Hui Zhan. Sevoflurane-Induced Neurotoxicity in the Developing Hippocampus via HIPK2/AKT/mTOR Signaling. Neurotoxicity research. 2022-04-23. PMID:35460511. |
akt antagonist mk2206 partially alleviated neuronal apoptosis without affecting the expression of hipk2. |
2022-04-23 |
2023-08-13 |
mouse |
| Yuan Meng, Zhao Yang, Taoguang Huo, Hong Jian. Realgar facilitates the Nrf2-Keap1-p62 positive feedback signaling axis via MAPKs and AKT to interfere with autophagy-induced apoptosis and oxidative stress in the hippocampus. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 150. 2022-04-23. PMID:35461089. |
realgar facilitates the nrf2-keap1-p62 positive feedback signaling axis via mapks and akt to interfere with autophagy-induced apoptosis and oxidative stress in the hippocampus. |
2022-04-23 |
2023-08-13 |
rat |
| Yuan Meng, Zhao Yang, Taoguang Huo, Hong Jian. Realgar facilitates the Nrf2-Keap1-p62 positive feedback signaling axis via MAPKs and AKT to interfere with autophagy-induced apoptosis and oxidative stress in the hippocampus. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 150. 2022-04-23. PMID:35461089. |
the specific mechanism was that realgar activated mapks and akt signaling molecules to activate the nrf2-keap1-p62 positive feedback signaling axis, induced abnormal autophagy initiation and degradation, and promoted oxidative damage and apoptosis in neurons. |
2022-04-23 |
2023-08-13 |
rat |
| Ali Samy Algharib, Gamila Mohamed-Labib Shanab, Abdel-Rahman Badr Abdel-Ghaffar, Mohamed Ahmed Ismail, Rania Hassan Mohame. Bithiophene derivative induced apoptosis and suppression of Akt pathway in mouse leukemic model. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 44. issue 1. 2022-04-18. PMID:35431190. |
bithiophene derivative induced apoptosis and suppression of akt pathway in mouse leukemic model. |
2022-04-18 |
2023-08-13 |
mouse |
| Xiaoting Xi, Qianbo Chen, Jia Ma, Xuewei Wang, Yuan Xia, Xuewei Wen, Bin Cai, Yan L. Acteoside protects retinal ganglion cells from experimental glaucoma by activating the PI3K/AKT signaling pathway via caveolin 1 upregulation. Annals of translational medicine. vol 10. issue 6. 2022-04-18. PMID:35433984. |
our preliminary research found that acteoside can inhibit autophagy-induced apoptosis of rgcs via the phosphatidylinositol 3-kinase (pi3k)/protein kinase b (akt) signaling pathway. |
2022-04-18 |
2023-08-13 |
Not clear |
| Mona A Kortam, Asmaa S Alawady, Nermin Abdel Hamid Sadik, Nevine Fath. Fenofibrate mitigates testosterone induced benign prostatic hyperplasia via regulation of Akt/FOXO3a pathway and modulation of apoptosis and proliferation in rats. Archives of biochemistry and biophysics. 2022-04-17. PMID:35430215. |
fenofibrate significantly suppressed ps473 akt expression causing foxo3a nuclear inclusion, which triggered induction of apoptosis. |
2022-04-17 |
2023-08-13 |
rat |
| b' Okt\\xc3\\xa1via Tarj\\xc3\\xa1nyi, Julian Haerer, M\\xc3\\xb3nika Vecserny\\xc3\\xa9s, Gergely Berta, Alexandra Stayer-Harci, B\\xc3\\xa1lint Balogh, Korn\\xc3\\xa9lia Farkas, Ferenc Boldizs\\xc3\\xa1r, J\\xc3\\xb3zsef Szeber\\xc3\\xa9nyi, Gy\\xc3\\xb6rgy S\\xc3\\xa9t\\xc3\\xa1l\\xc3\\xb. Prolonged treatment with the proteasome inhibitor MG-132 induces apoptosis in PC12 rat pheochromocytoma cells. Scientific reports. vol 12. issue 1. 2022-04-07. PMID:35388084.' |
stress signaling via p38, jnk and c-jun was active even after 24 h of mg-132 treatment, while the survival-mediating akt phosphorylation declined and the executor of apoptosis (caspase-3) was activated by that time and apoptosis was also observable. |
2022-04-07 |
2023-08-13 |
rat |
| Sridhar Tatarao Narla, Lori Rice, David Ostrov, Steven G Swarts, Dietmar W Siemann, Daniel Scott Bushnell, Jacqueline G Holden, Joanne Lindsey Duara, Carlton Matthew Bate. FGF7 peptide (FGF7p) mimetic mitigates bladder urothelial injury from cyclophosphamide. Physiological reports. vol 10. issue 7. 2022-04-07. PMID:35388988. |
in conclusion, fgf7p appears to block bladder urothelial apoptosis via akt and its targets, similar to fgf7. |
2022-04-07 |
2023-08-13 |
mouse |
| Chongshan Dai, Meng Li, Tun Sun, Yuan Zhang, Yang Wang, Zhangqi Shen, Tony Velkov, Shusheng Tang, Jianzhong She. Colistin-induced pulmonary toxicity involves the activation of NOX4/TGF-β/mtROS pathway and the inhibition of Akt/mTOR pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-04-04. PMID:35378205. |
inhibition of autophagy or akt pathways by chloroquine (cq), 3-methyladenine (3-ma) or ly294002 promoted colistin-induced mitochondrial damage, and caspase-dependent cellular apoptosis. |
2022-04-04 |
2023-08-13 |
mouse |
| Md Imtiaz Khalil, Christopher Madere, Ishita Ghosh, Rosalyn M Adam, Arrigo De Benedett. Interaction of TLK1 and AKTIP as a Potential Regulator of AKT Activation in Castration-Resistant Prostate Cancer Progression. Pathophysiology : the official journal of the International Society for Pathophysiology. vol 28. issue 3. 2022-04-02. PMID:35366279. |
nonetheless, further investigation of the potential role of tlk1>aktip>akt in suppressing apoptosis, and conversely its reversal with j54, is warranted. |
2022-04-02 |
2023-08-13 |
Not clear |
| Xuejie Han, Xinying Guo, Jing Chang, Jie Zhang, Lu Chen, Hongxia Wang, Fenghe Du, Xiangjun Zeng, Caixia Gu. Integrinβ3 mediates the protective effects of soluble receptor for advanced glycation end-products during myocardial ischemia/reperfusion through AKT/STAT3 signaling pathway. Apoptosis : an international journal on programmed cell death. 2022-04-01. PMID:35359221. |
the results from cultured cardiomyocytes also proved that srage attenuated myocardial apoptosis and autophagy through interacting with integrinβ3 to activate akt and stat3 pathway during oxygen and glucose deprivation/reperfusion (ogd/r) treatment. |
2022-04-01 |
2023-08-13 |
mouse |
| Naomi Thielemans, Sofie Demeyer, Nicole Mentens, Olga Gielen, Sarah Provost, Jan Cool. TAL1 cooperates with PI3K/AKT pathway activation in T-cell acute lymphoblastic leukemia. Haematologica. 2022-03-31. PMID:35354248. |
we find that tal1 on its own is suppressing t-cell growth, in part by affecting apoptosis genes, while the combination with akt pathway activation reduced apoptosis and was strongly driving cell proliferation ex vivo and leukemia development in vivo. |
2022-03-31 |
2023-08-13 |
mouse |
| Hyeon Jeong Kim, Ji Won Choi, Jisun Lee, Jun Il Kim, Samir Bahadur Thapa, Jae Kyung Sohng, Yong Il Par. Aloe emodin 3-O-glucoside inhibits cell growth and migration and induces apoptosis of non-small-cell lung cancer cells via suppressing MEK/ERK and Akt signalling pathways. Life sciences. 2022-03-28. PMID:35341826. |
aloe emodin 3-o-glucoside inhibits cell growth and migration and induces apoptosis of non-small-cell lung cancer cells via suppressing mek/erk and akt signalling pathways. |
2022-03-28 |
2023-08-13 |
Not clear |
| Jorge Rodríguez-González, Arturo A Wilkins-Rodríguez, Laila Gutiérrez-Kobe. Involvement of Akt and the antiapoptotic protein Bcl-xL in the inhibition of apoptosis of dendritic cells by Leishmania mexicana. Parasite immunology. 2022-03-27. PMID:35340042. |
involvement of akt and the antiapoptotic protein bcl-xl in the inhibition of apoptosis of dendritic cells by leishmania mexicana. |
2022-03-27 |
2023-08-13 |
Not clear |
| Jorge Rodríguez-González, Arturo A Wilkins-Rodríguez, Laila Gutiérrez-Kobe. Involvement of Akt and the antiapoptotic protein Bcl-xL in the inhibition of apoptosis of dendritic cells by Leishmania mexicana. Parasite immunology. 2022-03-27. PMID:35340042. |
the intracellular parasite leishmania mexicana inhibits camptothecin (cpt)-induced apoptosis of monocyte-derived dendritic cells (modc) through the down-regulation of p38 and jnk phosphorylation, while the kinase akt is maintained active for 24 hours. |
2022-03-27 |
2023-08-13 |
Not clear |
| Jorge Rodríguez-González, Arturo A Wilkins-Rodríguez, Laila Gutiérrez-Kobe. Involvement of Akt and the antiapoptotic protein Bcl-xL in the inhibition of apoptosis of dendritic cells by Leishmania mexicana. Parasite immunology. 2022-03-27. PMID:35340042. |
in the present work we aimed to investigate the role of akt in the inhibition of apoptosis of modc by l. mexicana and in the modulation of the expression of the antiapoptotic proteins bcl-2, mcl-1, and bcl-xl. |
2022-03-27 |
2023-08-13 |
Not clear |
| Jorge Rodríguez-González, Arturo A Wilkins-Rodríguez, Laila Gutiérrez-Kobe. Involvement of Akt and the antiapoptotic protein Bcl-xL in the inhibition of apoptosis of dendritic cells by Leishmania mexicana. Parasite immunology. 2022-03-27. PMID:35340042. |
our results show that the specific inhibition of akt reverts the apoptosis protective effect exerted by l. mexicana on modc reflected by a reduction in momp, caspase 3 activation, and upregulation of bcl-xl. |
2022-03-27 |
2023-08-13 |
Not clear |
| Jorge Rodríguez-González, Arturo A Wilkins-Rodríguez, Laila Gutiérrez-Kobe. Involvement of Akt and the antiapoptotic protein Bcl-xL in the inhibition of apoptosis of dendritic cells by Leishmania mexicana. Parasite immunology. 2022-03-27. PMID:35340042. |
we demonstrated that akt is deeply involved in the inhibition of apoptosis of modc by l. mexicana. |
2022-03-27 |
2023-08-13 |
Not clear |