| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chuanbo Ha, Lihong Hu, Yuanyuan Ren, Jie Yang, Lingbiao Xi. SND1 confers chemoresistance to cisplatin-induced apoptosis by targeting GAS6-AKT in SKOV3 ovarian cancer cells. Medical oncology (Northwood, London, England). vol 39. issue 11. 2022-08-16. PMID:35972612. |
moreover, snd1 can regulate the expression of growth arrest-specific 6 (gas6) and then activate the akt signaling pathway to achieve the regulation of sensitivity to cisplatin-induced apoptosis in ovarian cancer. |
2022-08-16 |
2023-08-14 |
Not clear |
| Xiaoli Liu, Huikun Zhang, Yawen Zhao, Yongjie M. Knockdown of Girdin induced apoptosis of glioblastoma cells via the mitochondrion signaling pathway. Neuroscience. 2022-08-11. PMID:35952993. |
these findings demonstrated that knockdown of girdin may induce bad expression and reduce bcl-2 expression by inhibiting the activation of akt, leading to the release of cyt-c from mitochondria, thereby promoting glioblastoma cells apoptosis. |
2022-08-11 |
2023-08-14 |
mouse |
| Hongbo Zhang, Anthony J Domma, Felicia D Goodrum, Nathaniel J Moorman, Jeremy P Kami. The Akt Forkhead Box O Transcription Factor Axis Regulates Human Cytomegalovirus Replication. mBio. 2022-08-10. PMID:35946797. |
the protein kinase akt broadly impacts many cellular processes, including mrna translation, metabolism, apoptosis, and stress responses. |
2022-08-10 |
2023-08-14 |
human |
| Cairu Liu, Haiqin Feng, Lihong Song, Shuirui Li, Yiping Wu, Liping Yan. Synergistic effects of thalidomide and cisplatin are mediated via the PI3K/AKT and JAK1/STAT3 signaling pathways in cervical cancer. Oncology reports. vol 48. issue 4. 2022-08-03. PMID:35920185. |
relative cell viability and apoptosis, as well as the mrna and protein levels of pi3k, akt, jak1 and stat3 were evaluated. |
2022-08-03 |
2023-08-14 |
Not clear |
| Li Cong, Xiaolin Xie, Sujuan Liu, Liping Xiang, Xiaohua F. Genistein promotes M1 macrophage apoptosis and reduces inflammatory response by disrupting miR-21/TIPE2 pathway. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society. vol 30. issue 7. 2022-07-29. PMID:35903524. |
in this study, raw264.7 cells were treated with genistein, lipopolysaccharide (lps), nuclear factor-kappa b (nf-κb) inhibitor, and/or protein kinase b (akt) agonist to determine the role of genistein in apoptosis and inflammation in lps-stimulated cells. |
2022-07-29 |
2023-08-14 |
mouse |
| Yun-Ha Lee, Hyeyoon Kim, Sorim Nam, Jae-Ryang Chu, Jung-Hwan Kim, Jong-Seok Lim, Sung-Eun Kim, Mi-Kyung Sun. Protective Effects of High-Fat Diet against Murine Colitis in Association with Leptin Signaling and Gut Microbiome. Life (Basel, Switzerland). vol 12. issue 7. 2022-07-27. PMID:35888062. |
the hfd+dss mice showed significantly increased serum leptin concentrations, colonic leptin receptor expression, enhanced anti-apoptotic akt expression, and reduced pro-apoptotic mapk and bax expression compared with the nd+dss mice, suggesting the involvement of the leptin-mediated pathway in intestinal epithelial cell apoptosis. |
2022-07-27 |
2023-08-14 |
mouse |
| Kai Liu, Xiao-E Fan, Li Zhang, Ying Yang, Xiao-Ling Zho. Circ-NCX1 inhibits LPS-induced chondrocyte apoptosis by regulating the miR-133a/SIRT1 axis. The Kaohsiung journal of medical sciences. 2022-07-27. PMID:35894157. |
in addition, overexpression of circ-ncx1 inhibited chondrocyte apoptosis and promoted akt phosphorylation via the mir-133a/sirt1 axis in lps-induced chondrocytes. |
2022-07-27 |
2023-08-14 |
Not clear |
| Chunhua Bai, Jiaqi Zhao, Jielin Su, Jiaxin Chen, Xinmu Cui, Manqing Sun, Xuewu Zhan. Curcumin induces mitochondrial apoptosis in human hepatoma cells through BCLAF1-mediated modulation of PI3K/AKT/GSK-3β signaling. Life sciences. 2022-07-26. PMID:35882275. |
treatment of the human hepatoma cell lines, hepg2 and sk-hep-1, with various concentrations of curcumin revealed a time-dependent and concentration-dependent inhibition of cell proliferation, increased apoptosis, cell cycle arrest at the g0/g1 phase, reduced mitochondrial membrane potential, and reduced expression levels of pi3k, p-pi3k, akt, p-akt, gsk-3β, and p-gsk-3β. |
2022-07-26 |
2023-08-14 |
mouse |
| Shuangyue Li, Dang Wang, Mengmeng Zhang, Cong Zhang, Fengyuan Pia. Taurine Ameliorates Apoptosis via AKT Pathway in the Kidney of Diabetic Rats. Advances in experimental medicine and biology. vol 1370. 2022-07-26. PMID:35882798. |
taurine ameliorates apoptosis via akt pathway in the kidney of diabetic rats. |
2022-07-26 |
2023-08-14 |
rat |
| Shuangyue Li, Dang Wang, Mengmeng Zhang, Cong Zhang, Fengyuan Pia. Taurine Ameliorates Apoptosis via AKT Pathway in the Kidney of Diabetic Rats. Advances in experimental medicine and biology. vol 1370. 2022-07-26. PMID:35882798. |
these results indicated that taurine-ameliorated apoptosis in diabetic kidney may be through activating of the akt signaling pathway. |
2022-07-26 |
2023-08-14 |
rat |
| Hai-Long Li, Nian-Hua Deng, Xiu-Sheng He, Yue-Hua L. Small biomarkers with massive impacts: PI3K/AKT/mTOR signalling and microRNA crosstalk regulate nasopharyngeal carcinoma. Biomarker research. vol 10. issue 1. 2022-07-26. PMID:35883139. |
the phosphatidylinositol 3-kinase/protein kinase b (akt)/mammalian target of rapamycin (mtor) signalling pathway is involved in processes related to tumour initiation/progression, such as proliferation, apoptosis, metastasis, and drug resistance, and is closely related to the clinicopathological features of npc. |
2022-07-26 |
2023-08-14 |
Not clear |
| Jin Lei, Jian Zhao, Meng-Yi-Chen Long, Xue-Wei Cao, Fu-Jun Wan. In addition to its endosomal escape effect, platycodin D also synergizes with ribosomal inactivation protein to induce apoptosis in hepatoma cells through AKT and MAPK signaling pathways. Chemico-biological interactions. 2022-07-25. PMID:35872048. |
in addition to its endosomal escape effect, platycodin d also synergizes with ribosomal inactivation protein to induce apoptosis in hepatoma cells through akt and mapk signaling pathways. |
2022-07-25 |
2023-08-14 |
Not clear |
| Jin Lei, Jian Zhao, Meng-Yi-Chen Long, Xue-Wei Cao, Fu-Jun Wan. In addition to its endosomal escape effect, platycodin D also synergizes with ribosomal inactivation protein to induce apoptosis in hepatoma cells through AKT and MAPK signaling pathways. Chemico-biological interactions. 2022-07-25. PMID:35872048. |
meanwhile, we observed that cholesterol metabolism plays an important role in the activity of pd by rna-seq analysis and kegg pathway enrichment analysis, and confirm that pd, pgd and pd2 enhance the anti-tumor activity of mhbp by inducing the redistribution of free cholesterol and inhibiting the activity of cathepsin b and cathepsin d. finally, we found that pd synergized with mhbp to induce caspase-dependent apoptosis through inhibiting akt and erk1/2 signaling pathways and activating jnk and p38 mapk signaling pathways. |
2022-07-25 |
2023-08-14 |
Not clear |
| Bo Min, Yan Wang, Feng Liang, Cheng-Xiang Wang, Fan Wang, Zhi Yan. The Protective Mechanism of Afuresertib against Esophageal Cancer. Disease markers. vol 2022. 2022-07-25. PMID:35872696. |
phosphatidylinositol-3-kinase (pi3k)/protein kinase b (akt) signaling pathway is one of the signal transduction pathways most closely related to cell proliferation and apoptosis. |
2022-07-25 |
2023-08-14 |
rat |
| Lifeng Jiang, Dmitry A Goncharov, Yuanjun Shen, Derek Lin, Baojun Chang, Andressa Pena, Horace DeLisser, Elena A Goncharova, Tatiana V Kudryashov. Akt-Dependent Glycolysis-Driven Lipogenesis Supports Proliferation and Survival of Human Pulmonary Arterial Smooth Muscle Cells in Pulmonary Hypertension. Frontiers in medicine. vol 9. 2022-07-15. PMID:35836951. |
pharmacological inhibition of akt down-regulated acly and acc, significantly reduced intracellular lipid content, inhibited proliferation and induced apoptosis of human pah pavsmc. |
2022-07-15 |
2023-08-14 |
human |
| Li Bai, Kunbo Dong, Deyong Tong, Xiuna Shi, Sirong Wei, Yongguo Ca. lncRNA HIT000218960 enhances resistance to 5-fluorouracil by promoting HMGA2 and activating the AKT/mTOR/P70S6K pathway in gastric cancer cells. Experimental and therapeutic medicine. vol 24. issue 2. 2022-07-15. PMID:35837027. |
in these cells, knocking down hmga2 expression significantly increased apoptosis in addition to reducing akt, mtor and p70s6 kinase (p70s6k) phosphorylation after 5-fu treatment. |
2022-07-15 |
2023-08-14 |
Not clear |
| Chirasmita Nayak, Sanjeev Kumar Sing. Integrated Transcriptome Profiling Identifies Prognostic Hub Genes as Therapeutic Targets of Glioblastoma: Evidenced by Bioinformatics Analysis. ACS omega. vol 7. issue 26. 2022-07-11. PMID:35811900. |
go and kegg analyses of hub genes uncovered that these genes were primarily enriched in disease-associated pathways such as the inhibition of apoptosis and the dna damage repair mechanism, activation of the cell cycle, emt (epithelial-mesenchymal transition), hormone ar (androgen receptor), hormone er (estrogen receptor), pi3k/akt (phosphatidylinositol 3-kinase and akt), rtk (receptor tyrosine kinase), and tsc/mtor (tuberous sclerosis complex and mammalian target of rapamycin). |
2022-07-11 |
2023-08-14 |
Not clear |
| Lindsey Buckingham, Tianran Hao, Jillian O'Donnell, Ziyi Zhao, Xin Zhang, Yali Fan, Wenchuan Sun, Yingao Zhang, Hongyan Suo, Angeles Alvarez Secord, Chunxiao Zhou, Victoria Bae-Jum. Ipatasertib, an oral AKT inhibitor, inhibits cell proliferation and migration, and induces apoptosis in serous endometrial cancer. American journal of cancer research. vol 12. issue 6. 2022-07-11. PMID:35812065. |
ipatasertib, an oral akt inhibitor, inhibits cell proliferation and migration, and induces apoptosis in serous endometrial cancer. |
2022-07-11 |
2023-08-14 |
Not clear |
| Muzi Zhang, Yuwen Fan, Haibo Jiang, Jian Shao, Ming L. Establishment of hyperammonemia mode in yellow catfish and the mitigation of exogenous L-ornithine-L-aspartate. Developmental and comparative immunology. 2022-07-08. PMID:35803415. |
the results showed that ammonia poisoning could induce serum ammonia content elevated, liver damage (serum aminotransferase activity elevated and liver malondialdehyde accumulation), and up-regulation of cytokine (il 1, il 8 and tnfɑ), apoptosis (p53, bax, cytochrome c, caspase 3 and caspase 9) and autophagy (dynein, beclin 1, akt and pten) genes transcription, but lola could mitigate the adverse effect of ammonia poisoning. |
2022-07-08 |
2023-08-14 |
Not clear |
| Jiacui Liu, Ping Wang, Ben Huang, Qingyuan Cheng, Yiping Duan, Liangyue Chen, Tiantian Ma, Cuiwen Zhu, Dongxu Li, Wei Fan, Mingxia Y. Effective suppression of triple negative breast cancer by paclitaxel nanoparticles conjugated with transmembrane TNF-α monoclonal antibody. International journal of pharmaceutics. 2022-07-08. PMID:35803533. |
tmtnf-α mab-ptx nps exerts anti-tumor effects via promoting apoptosis and regulating mitogen-activated protein kinase (mapk), phosphatidylinositol 3-kinase (pi3k) / protein kinase b (akt)/ mammalian target of rapamycin (mtor) cascade, as well as amp-activated protein kinase (ampk) and nuclear factor kappa-b (nf-κb) pathways. |
2022-07-08 |
2023-08-14 |
mouse |