| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Dong, N Hu, Y Hua, X Xu, M R Kandadi, R Guo, S Jiang, S Nair, D Hu, J Re. Erratum to: "Chronic Akt activation attenuated lipopolysaccharide-induced cardiac dysfunction via Akt/GSK3β-dependent inhibition of apoptosis and ER stress" [Biochim. Biophys. Acta. 1832(6) 2013 Jun; 848-63. doi:10.1016/j.bbadis.2013.02.023. Epub 2013 Mar 6.PMID: 23474308]. Biochimica et biophysica acta. Molecular basis of disease. vol 1869. issue 1. 2022-10-25. PMID:36283242. |
erratum to: "chronic akt activation attenuated lipopolysaccharide-induced cardiac dysfunction via akt/gsk3β-dependent inhibition of apoptosis and er stress" [biochim. |
2022-10-25 |
2023-08-14 |
Not clear |
| Zhenfeng Hu, Lei Zhuo, Yanling Li, Dongpeng Duan, Jing Gu. MicroRNA‑203a‑3p suppresses endothelial cell proliferation and invasion, and promotes apoptosis in hemangioma by inactivating the VEGF‑mediated PI3K/AKT pathway. Experimental and therapeutic medicine. vol 24. issue 5. 2022-10-24. PMID:36277151. |
notably, transfection with mir-203a-3p mimics caused a reduction in cell proliferation, invasion and in the phosphorylation levels of pi3k and akt, and promoted cell apoptosis in hemecs. |
2022-10-24 |
2023-08-14 |
human |
| José Antonio Torres-Vargas, Iván Cheng-Sánchez, Beatriz Martínez-Poveda, Miguel Ángel Medina, Francisco Sarabia, Melissa García-Caballero, Ana R Quesad. Characterization of the activity and the mechanism of action of a new toluquinol derivative with improved potential as an antiangiogenic drug. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 155. 2022-10-22. PMID:36271548. |
our results point to a mechanism of action that could be related to an induction of apoptosis, as well as to an increase in the reactive oxygen species levels, a reduction of the redox capacity and the inhibition of the vegfr2, akt and erk phosphorylation in vegf-activated endothelial cells. |
2022-10-22 |
2023-08-14 |
chicken |
| Young Yun Jung, Chakrabhavi Dhananjaya Mohan, Shobith Rangappa, Jae-Young Um, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Kanchugarakoppal S Rangappa, Kwang Seok Ah. Brucein D imparts a growth inhibitory effect in multiple myeloma cells by abrogating the Akt-driven signaling pathway. IUBMB life. 2022-10-20. PMID:36262053. |
depletion of akt potentiated the apoptosis-inducing effect of bd whereas overexpression displayed resistance to bd-induced apoptosis suggesting the role of akt in chemoresistance. |
2022-10-20 |
2023-08-14 |
Not clear |
| Yu Zhao, Cuancuan Wang, Tiejun Cui, Qiaoyi Wang, Yingchun Xu, Chunbo Miao, Shaoyan Li. LncRNA FGD5-AS1 reduces cardiomyocyte apoptosis and inflammation by modulating Akt and miR-223-3p expression. American journal of translational research. vol 14. issue 9. 2022-10-17. PMID:36247255. |
lncrna fgd5-as1 reduces cardiomyocyte apoptosis and inflammation by modulating akt and mir-223-3p expression. |
2022-10-17 |
2023-08-14 |
Not clear |
| Jhe-Wei Lin, Shih-Chang Fu, Jui-Ming Liu, Shing-Hwa Liu, Kuan-I Lee, Kai-Min Fang, Ren-Jun Hsu, Chun-Fa Huang, Kun-Min Liu, Kai-Chih Chang, Chin-Chuan Su, Ya-Wen Che. Chlorpyrifos induces neuronal cell death via both oxidative stress and Akt activation downstream-regulated CHOP-triggered apoptotic pathways. Toxicology in vitro : an international journal published in association with BIBRA. 2022-10-17. PMID:36252918. |
collectively, these findings indicate that cpf exposure exerts neuronal cytotoxicity via the independent pathways of ros generation and akt activation downstream-regulated chop-triggered apoptosis, ultimately leading to neuronal cell death. |
2022-10-17 |
2023-08-14 |
Not clear |
| Natalia Cheshenko, Jeffrey B Bonanno, Hans-Heinrich Hoffmann, Rohit K Jangra, Kartik Chandran, Charles M Rice, Steven C Almo, Betsy C Herol. Cell-impermeable staurosporine analog targets extracellular kinases to inhibit HSV and SARS-CoV-2. Communications biology. vol 5. issue 1. 2022-10-16. PMID:36245045. |
we synthesized a cell-impermeable analog of staurosporine, cimss, which inhibited outer membrane hsv-induced akt phosphorylation and blocked viral entry without inducing apoptosis. |
2022-10-16 |
2023-08-14 |
Not clear |
| Zayd Ahmad, Payaningal R Somanat. AKT Isoforms in the Immune Response in Cancer. Current topics in microbiology and immunology. vol 436. 2022-10-15. PMID:36243852. |
akt is activated downstream of pi3k, and together, this signaling pathway helps regulate cellular processes including cell growth, proliferation, metabolism, survival, and apoptosis. |
2022-10-15 |
2023-08-14 |
Not clear |
| Jen-Yang Tang, Ya-Ting Chuang, Jun-Ping Shiau, Kun-Han Yang, Fang-Rong Chang, Ming-Feng Hou, Ammad Ahmad Farooqi, Hsueh-Wei Chan. Long Noncoding RNAs and Circular RNAs Regulate AKT and Its Effectors to Control Cell Functions of Cancer Cells. Cells. vol 11. issue 19. 2022-10-14. PMID:36230902. |
akt serine-threonine kinase (akt) and its effectors are essential for maintaining cell proliferation, apoptosis, autophagy, endoplasmic reticulum (er) stress, mitochondrial morphogenesis (fission/fusion), ferroptosis, necroptosis, dna damage response (damage and repair), senescence, and migration of cancer cells. |
2022-10-14 |
2023-08-14 |
Not clear |
| Maheshkumar Kannan, Sridharan Jayamohan, Rajesh Kannan Moorthy, Siva Chander Chabattula, Mathan Ganeshan, Antony Joseph Velanganni Arockia. Dysregulation of miRISC Regulatory Network Promotes Hepatocellular Carcinoma by Targeting PI3K/Akt Signaling Pathway. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232606. |
the mir-221/aeg-1 axis silencing induces apoptosis and g2/m phase arrest and inhibits cellular proliferation and angiogenesis by upregulating p57, p53, rb, and pten and downregulating lsf, lc3a, bcl-2, opn, mmp9, pi3k, and akt in hcc cells. |
2022-10-14 |
2023-08-14 |
Not clear |
| Yaling Zhang, Dejian Chen, Daojuan Wang, Lei Wang, Yajing Weng, Hongwei Wang, Xiaoke Wu, Yong Wan. Moderate Aerobic Exercise Regulates Follicular Dysfunction by Initiating Brain-Derived Neurotrophic Factor (BDNF)-Mediated Anti-Apoptotic Signaling Pathways in Polycystic Ovary Syndrome. Journal of clinical medicine. vol 11. issue 19. 2022-10-14. PMID:36233452. |
p-trkb upregulates and phosphorylates phosphatidylinositol 3-kinase (pi3k) and protein kinase b (akt) to inhibit apoptosis. |
2022-10-14 |
2023-08-14 |
rat |
| Sharmila Biswas, Baishakhi Tikader, Sandip Kar, Ganesh A Viswanatha. Modulation of signaling cross-talk between pJNK and pAKT generates optimal apoptotic response. PLoS computational biology. vol 18. issue 10. 2022-10-14. PMID:36240239. |
herein, we use an experimental data-driven mathematical modeling to quantitate the extent of synergistic signaling cross-talk between the intracellular entities phosphorylated jnk (pjnk) and phosphorylated akt (pakt) that orchestrate the phenotypic apoptosis level by modulating the activated caspase3 dynamics. |
2022-10-14 |
2023-08-14 |
Not clear |
| Yang Zhang, Tianlong Jiang, Shenghui Ni, Wenbo Liu, Peng Luo, Shimin Hao, Penghao Wang, Lei Gu. Effects of Estrogen on Proliferation and Apoptosis of Osteoblasts through Regulating GPER/AKT Pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 68. issue 6. 2022-10-13. PMID:36227667. |
this experiment was carried out to study the effects of estrogen on the proliferation and apoptosis of osteoblasts through regulating the g protein-coupled estrogen receptor (gper)/protein kinase b (akt) pathway. |
2022-10-13 |
2023-08-14 |
Not clear |
| Haixia Sun, Junling Liu, Yuxin Su, Fang Li, Mingyue Zhang, Jia Li, Meiling Son. The role and mechanism of NDST1/NULP1 regulating right ventricular hypertrophy in hypoxic pulmonary hypertension. General physiology and biophysics. vol 41. issue 5. 2022-10-12. PMID:36222339. |
an in vitro cell experiment showed that inhibition of ndst1 expression enhanced cell viability, reduced cell apoptosis, alleviated cardiomyocyte hypertrophy, decreased inflammation and increased phosphorylated akt level, however, over-expression of ndst1 had opposite effects on these aspects. |
2022-10-12 |
2023-08-14 |
rat |
| Haixia Sun, Junling Liu, Yuxin Su, Fang Li, Mingyue Zhang, Jia Li, Meiling Son. The role and mechanism of NDST1/NULP1 regulating right ventricular hypertrophy in hypoxic pulmonary hypertension. General physiology and biophysics. vol 41. issue 5. 2022-10-12. PMID:36222339. |
our study confirmed that inhibition of the ndst1/nulp1 pathway might contribute to the attenuation of hph-induced rvh, and the mechanism may be related to the reduction of inflammation, cardiomyocyte apoptosis, and akt phosphorylation. |
2022-10-12 |
2023-08-14 |
rat |
| Yupeng Chen, Lin Wu, Min Ba. MiR-485-5p Suppress the Malignant Characteristics of the Lung Adenocarcinoma via Targeting NADPH Quinone Oxidoreductase-1 to Inhibit the PI3K/Akt. Molecular biotechnology. 2022-10-11. PMID:36219369. |
the experimental outcomes indicated that mir-485-5p overexpression in luad cells reduced their malignant behaviors, suppressed pi3k and akt phosphorylation, and facilitated apoptosis. |
2022-10-11 |
2023-08-14 |
Not clear |
| Yupeng Chen, Lin Wu, Min Ba. MiR-485-5p Suppress the Malignant Characteristics of the Lung Adenocarcinoma via Targeting NADPH Quinone Oxidoreductase-1 to Inhibit the PI3K/Akt. Molecular biotechnology. 2022-10-11. PMID:36219369. |
furthermore, it was also observed that through targeting nqo1, mir-485-5p could suppress luad cell migration and proliferation, further blocking the phosphorylation of pi3k and akt and inducing apoptosis among luad cells. |
2022-10-11 |
2023-08-14 |
Not clear |
| Wendong Feng, Xiaoyan Zhao, Qiang Yao, Duqiang L. Cinobufagin inhibits proliferation and induces apoptosis of hepatocarcinoma cells by activating apoptosis, AKT, and ERK pathways. Acta biochimica Polonica. 2022-10-10. PMID:36215663. |
cinobufagin inhibits proliferation and induces apoptosis of hepatocarcinoma cells by activating apoptosis, akt, and erk pathways. |
2022-10-10 |
2023-08-14 |
human |
| Korrakod Petsri, Sunisa Thongsom, Satapat Racha, Supakarn Chamni, Saresa Jindapol, Nantawat Kaekratoke, Hongbin Zou, Pithi Chanvorachot. Novel mechanism of napabucasin, a naturally derived furanonaphthoquinone: apoptosis and autophagy induction in lung cancer cells through direct targeting on Akt/mTOR proteins. BMC complementary medicine and therapies. vol 22. issue 1. 2022-09-30. PMID:36180880. |
napabucasin (nb), a phytochemical compound, has been reported as potential anti-cancer agent, however, akt and mtor targeting mechanisms remain unclear. method: apoptosis induction was investigated by hoechst 33342/pi double staining and annexin v/pi staining with flowcytometry. |
2022-09-30 |
2023-08-14 |
Not clear |
| Xin Zheng, Xiaohong Gai, Feihu Ding, Zhongtang Lu, Kangsheng Tu, Yingmin Yao, Qingguang Li. Correction: Histone acetyltransferase PCAF Up-regulated cell apoptosis in hepatocellular carcinoma via acetylating histone H4 and inactivating AKT signaling. Molecular cancer. vol 21. issue 1. 2022-09-28. PMID:36171590. |
correction: histone acetyltransferase pcaf up-regulated cell apoptosis in hepatocellular carcinoma via acetylating histone h4 and inactivating akt signaling. |
2022-09-28 |
2023-08-14 |
Not clear |