| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xi Zhang, Sutong Xu, Yong Hu, Qiulu Liu, Chenming Liu, Huazhen Chai, Yuping Luo, Lingjing Jin, Siguang L. Irisin exhibits neuroprotection by preventing mitochondrial damage in Parkinson's disease. NPJ Parkinson's disease. vol 9. issue 1. 2023-01-31. PMID:36720890. |
the results revealed that exogenous irisin conferred neuroprotection relieving apoptosis and oxidative stress, restraining mitochondrial fragmentation, and promoting mitochondrial respiration and biogenesis in pd models, and irisin exerted the aforementioned effects by activating akt signaling pathway and erk1/2 signaling pathway. |
2023-01-31 |
2023-08-14 |
Not clear |
| Oriana Y Teran, Matthew R Zanotelli, Miao-Chong Joy Lin, Richard A Cerione, Kristin F Wilso. Dock7 regulates AKT and mTOR/S6K activity required for the transformed phenotypes and survival of cancer cells. bioRxiv : the preprint server for biology. 2023-01-30. PMID:36711811. |
together, these findings indicate that dock7 protects and maintains the phosphorylation of akt to sustain a tonic mtor/s6k activity in cancer cells necessary for their resistance to anoikis and to prevent them from undergoing apoptosis during stressful conditions. |
2023-01-30 |
2023-08-14 |
Not clear |
| Rosalinda Mejía-Rodríguez, Daniel Romero-Trejo, Rosa O González, José Segovi. Combined treatments with AZD5363, AZD8542, curcumin or resveratrol induce death of human glioblastoma cells by suppressing the PI3K/AKT and SHH signaling pathways. Biochemistry and biophysics reports. vol 33. 2023-01-30. PMID:36714540. |
we found that the combined treatments with azd5363+azd8542+curcumin and azd8542+curcumin+resveratrol inhibit the pi3k/akt and shh survival pathways by decreasing the activity of akt, the reduction of the expression of smo, pp70s6k, ps6k, gli1, p21 and p27, and the activation of caspase-3 as a marker of apoptosis. |
2023-01-30 |
2023-08-14 |
human |
| Xu Yao, Jie Zhu, Lin Li, Bo Yang, Bixia Chen, Endong Bao, Xiaohui Zhan. Hsp90 protected chicken primary myocardial cells from heat-stress injury by inhibiting oxidative stress and calcium overload in mitochondria. Biochemical pharmacology. 2023-01-28. PMID:36708886. |
the mechanism involved that hsp90 could activate akt and pkm2 signals to promote bcl-2 translocation into mitochondria and its phosphorylation, thereby preventing ros production and subsequent cell apoptosis. |
2023-01-28 |
2023-08-14 |
human |
| Jingwen Wang, Ruiyang Ma, Ying Wang, Shucong Zhang, Jiale Wang, Jin Zheng, Wujun Xue, Xiaoming Din. rhMYDGF Alleviates I/R-induced Kidney Injury by Inhibiting Inflammation and Apoptosis via the Akt Pathway. Transplantation. 2023-01-26. PMID:36698245. |
rhmydgf alleviates i/r-induced kidney injury by inhibiting inflammation and apoptosis via the akt pathway. |
2023-01-26 |
2023-08-14 |
human |
| A Selen Gurkan-Alp, Arzu Z Karabay, Asli Koc, Erdem Buyukbingo. Novel indole retinoid derivative induces apoptosis and cell cycle arrest and modulates AKT and ERK signalling in HL-60 cells. Fundamental & clinical pharmacology. 2023-01-23. PMID:36690337. |
novel indole retinoid derivative induces apoptosis and cell cycle arrest and modulates akt and erk signalling in hl-60 cells. |
2023-01-23 |
2023-08-14 |
Not clear |
| Ya-Hui Chen, Jyun-Xue Wu, Shun-Fa Yang, Yi-Hsuan Hsia. Synergistic Combination of Luteolin and Asiatic Acid on Cervical Cancer In Vitro and In Vivo. Cancers. vol 15. issue 2. 2023-01-21. PMID:36672499. |
furthermore, lut combined with asa induced apoptosis and inhibited migration through downregulated pi3k/akt (pi3k, akt and p70s6k), jnk/p38 mapk and fak (integrin β1, paxillin and fak) signaling and upregulated erk signaling. |
2023-01-21 |
2023-08-14 |
Not clear |
| Wei Sun, Nai-Dan Zhang, Tong Zhang, Yan-Nan Li, Hui Xue, Jing-Long Cao, Wen-Shuang Hou, Jian Liu, Ying Wang, Cheng-Hao Ji. Cyanidin-3-O-Glucoside Induces the Apoptosis of Human Gastric Cancer MKN-45 Cells through ROS-Mediated Signaling Pathways. Molecules (Basel, Switzerland). vol 28. issue 2. 2023-01-21. PMID:36677726. |
western blot and flow cytometry results showed that c3g regulated the reduction of mitochondrial membrane potential and arrested the cell cycle in the g2/m phase through the akt signaling pathway, causing the cells to undergo apoptosis. |
2023-01-21 |
2023-08-14 |
human |
| Xiaoqian Peng, Hongsong Guo, Xiao Zhang, Zikang Yang, John Bosco Ruganzu, Zhuoyuan Yang, Xiangyuan Wu, Wei Bi, Shengfeng Ji, Weina Yan. TREM2 Inhibits Tau Hyperphosphorylation and Neuronal Apoptosis via the PI3K/Akt/GSK-3β Signaling Pathway In vivo and In vitro. Molecular neurobiology. 2023-01-20. PMID:36662361. |
in line with in vivo findings, trem2-overexpressing bv2 microglia following β-amyloid (aβ) stimulation led to a significant increase in the phosphorylation of pi3k, akt, and gsk-3β, accompanied by a decrease in tau hyperphosphorylation and apoptosis in co-cultured sh-sy5y cells. |
2023-01-20 |
2023-08-14 |
mouse |
| Zhong-Zhe Lin, Mickey C-T Hu, Chiun Hsu, Yao-Ming Wu, Yen-Shen Lu, Ja-An Annie Ho, Shiou-Hwei Yeh, Pei-Jer Chen, Ann-Lii Chen. Synergistic efficacy of telomerase-specific oncolytic adenoviral therapy and histone deacetylase inhibition in human hepatocellular carcinoma. Cancer letters. 2023-01-20. PMID:36669725. |
the correlation of akt phosphorylation with drug-induced apoptosis was validated in hcc cells with upregulated or downregulated akt signaling. |
2023-01-20 |
2023-08-14 |
human |
| Yong-Jun Zhou, Yong-Yue Pan, Li-Jun Yang, Ming-Jiang Bi. [Myrislignan Induces Apoptosis in Gastric Cancer Cell Line Through PI3K/AKT Signaling Pathway]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. vol 54. issue 1. 2023-01-17. PMID:36647656. |
to investigate the effect of myrislignan (myr) on the apoptosis of gastric cancer cell line and its relationship with phosphatidylinositol 3-kinase (pi3k)/protein kinase b (akt) signaling pathway. |
2023-01-17 |
2023-08-14 |
Not clear |
| Yueli Zhang, Xinchun Wang, Shuyun Wang, Jia Liu, Ruijia Li, Xiaoxia Li, Rui Zhan. Circ-ERBB2 knockdown sensitized colorectal cancer cells to 5-FU via miR-181a-5p/PTEN/Akt pathway. Journal of biochemical and molecular toxicology. 2023-01-14. PMID:36639866. |
in addition, phosphatase and tensin homolog (pten) was verified as mir-181a-5p's downstream target, circ-erbb2 activates the akt pathway and inhibits cell apoptosis through modulating mir-181a-5p/pten. |
2023-01-14 |
2023-08-14 |
Not clear |
| Afshin Taheriazam, Ghazaleh Gholamiyan Yousef Abad, Shima Hajimazdarany, Mohammad Hassan Imani, Setayesh Ziaolhagh, Mohammad Arad Zandieh, Seyedeh Delaram Bayanzadeh, Sepideh Mirzaei, Michael R Hamblin, Maliheh Entezari, Amir Reza Aref, Ali Zarrabi, Yavuz Nuri Ertas, Jun Ren, Romina Rajabi, Mahshid Deldar Abad Paskeh, Mehrdad Hashemi, Kiavash Hushmand. Graphene oxide nanoarchitectures in cancer biology: Nano-modulators of autophagy and apoptosis. Journal of controlled release : official journal of the Controlled Release Society. 2023-01-14. PMID:36641122. |
molecular pathways, such as atg, mapk, jnk, and akt, can be regulated by go nanomaterials, leading to effects on autophagy and apoptosis. |
2023-01-14 |
2023-08-14 |
Not clear |
| Natalia Respekta, Karolina Pich, Monika Dawid, Ewa Mlyczyńska, Patrycja Kurowska, Agnieszka Ra. The Apelinergic System: Apelin, ELABELA, and APJ Action on Cell Apoptosis: Anti-Apoptotic or Pro-Apoptotic Effect? Cells. vol 12. issue 1. 2023-01-08. PMID:36611944. |
depending on the cell/tissue, the apelinergic system modulates cell apoptosis by activating various signalling pathways, including phosphoinositide 3-kinase (pi3k), extracellular signal-regulated protein kinase (erk1/2), protein kinase b (akt), 5'amp-activated protein kinase(ampk), and protein kinase a (pka). |
2023-01-08 |
2023-08-14 |
cattle |
| Yun Wang, Qiang Fu, Yun-Jian Tao, Sheng-Nan Ying, Heng-Gao Zhong, Yue Zhu, Xiao-Han Qian, Lin Miao, Li-Hua Yan. Girdin acts as an oncogene in gastric cancer by regulating AKT/GSK3β/β-catenin signaling. Functional & integrative genomics. vol 23. issue 1. 2023-01-05. PMID:36604355. |
girdin suppressed cell apoptosis and stimulated cell migration and invasion, while akt inhibitor (mk2206) treatment reversed the effect of girdin overexpression, and gsk3β inhibitor (chir99021) treatment enhanced the effect of girdin overexpression on gc cells. |
2023-01-05 |
2023-08-14 |
Not clear |
| A Sandhya Rani, Manay Srinivas Munisekhar, S Shylaja, A Krishna, Bhavani N Sangala, E Sharath Kumar Redd. IHC expression of AKT in different grades of epithelial dysplasia: An Journal of oral and maxillofacial pathology : JOMFP. vol 26. issue 3. 2023-01-02. PMID:36588841. |
ihc expression of akt in different grades of epithelial dysplasia: an akt, also known as protein kinase b, is a serine/threonine-specific protein-kinase which plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, transcription and cell migration. |
2023-01-02 |
2023-08-14 |
human |
| Caijing Han, Bingjie Lin, Xinyu Huang, Zhaojie Mao, Xiaoting Kong, Lei Fang, Peng Xue, Anning Wang, Fengxiang Zhan. Quinoa husk peptides reduce melanin content via Akt signaling and apoptosis pathways. iScience. vol 26. issue 1. 2022-12-30. PMID:36582825. |
quinoa husk peptides reduce melanin content via akt signaling and apoptosis pathways. |
2022-12-30 |
2023-08-14 |
rat |
| Weiquan Zeng, Meizhu Wu, Ying Cheng, Liya Liu, Yuying Han, Qiurong Xie, Jiapeng Li, Lihui Wei, Yi Fang, Youqin Chen, Jun Peng, Aling She. CCT6A knockdown suppresses osteosarcoma cell growth and Akt pathway activation in vitro. PloS one. vol 17. issue 12. 2022-12-30. PMID:36584147. |
thus, cct6a knockdown inhibits cell proliferation, induces cell apoptosis, and suppresses the akt pathway. |
2022-12-30 |
2023-08-14 |
Not clear |
| De-Xi Zhou, Xiao-He Wang, Xuan Xu, Wen-Jie Chen, Jing Wei, Ting-Tao Chen, Hong We. Anti-Tumor Effects of Engineered VNP20009-Abvec-Igκ-mPD-1 Strain in Melanoma Mice via Combining the Oncolytic Therapy and Immunotherapy. Pharmaceutics. vol 14. issue 12. 2022-12-23. PMID:36559282. |
tumor cell apoptosis was promoted by down-regulating phosphoinositide 3 kinase (pi3k) and protein kinase b (akt) signaling pathways, as evidenced by an increased bcl-2-associated x protein/b cell lymphoma-2 (bax/bcl-2) expression ratio. |
2022-12-23 |
2023-08-14 |
mouse |
| Ruishuang Ma, Xin Li, Shengping Gong, Xiaoqin Ge, Ting Zhu, Xiaoxu Ge, Lijuan Weng, Qingsong Tao, Jianxin Gu. Dual Roles of Lactate in EGFR-TKI-Resistant Lung Cancer by Targeting GPR81 and MCT1. Journal of oncology. vol 2022. 2022-12-22. PMID:36545125. |
gpr81 and akt expression were significantly increased with the addition of lactate, and sigpr81 reduced akt expression resulting in a raised apoptosis rate with erlotinib treatment. |
2022-12-22 |
2023-08-14 |
Not clear |