| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carmen Amititeloaie, Liliana Chelaru, Gabriela Luminiţa Geleţu, Anca Sava, Alexandra Jităreanu, Andreea Mihaela Tibeică, Marcel Costulean. Apoptosis of pro-B lymphocytes induced by NR4A1 activation in the presence of gingival fibroblast exosomes and TNFα, caspase 8, STAT3, and Akt pathways modulators. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 64. issue 1. 2023-05-02. PMID:37128789. |
in order to experimentally evaluate the apoptosis of pro-b type lymphocytes, induced as a result of the known activation of orphan nuclear receptor 4a1 (nr4a1), through cytosporone b (csn-b, 10 μm), in the presence or absence of exosomes derived from gingival fibroblasts, we administered as a treatment: 1 μm r-7050 [functional inhibitor of tumor necrosis factor alpha (tnfα)], 1 μm z-ietd-fmk (functional inhibitor of caspase 8), 1 μm gsk690693 (functional inhibitor of akt 1∕2∕3 pathways) and, last but not least, 1 μm scutellarin [functional inhibitor of receptor activator of nuclear factor-kappa b ligand (rankl)] and therefore of the signal transducer and activator of transcription 3 (stat3) pathway. |
2023-05-02 |
2023-08-14 |
Not clear |
| Carmen Amititeloaie, Liliana Chelaru, Gabriela Luminiţa Geleţu, Anca Sava, Alexandra Jităreanu, Andreea Mihaela Tibeică, Marcel Costulean. Apoptosis of pro-B lymphocytes induced by NR4A1 activation in the presence of gingival fibroblast exosomes and TNFα, caspase 8, STAT3, and Akt pathways modulators. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 64. issue 1. 2023-05-02. PMID:37128789. |
the inhibition of tumoral precursors development, namely the pro-b type, might be highly dependent on the inhibition of akt 1∕2∕3 pathways, the first and most important consequence being apoptosis induced by the activation of nr4a1 orphan nuclear receptors. |
2023-05-02 |
2023-08-14 |
Not clear |
| Sarah J Barnard, Josephina Haunschild, Linda Heiser, Maja T Dieterlen, Kristin Klaeske, Michael A Borger, Christian D Et. Apoptotic Cell Death in Bicuspid-Aortic-Valve-Associated Aortopathy. International journal of molecular sciences. vol 24. issue 8. 2023-04-28. PMID:37108591. |
mtor as a downstream protein of akt was significantly higher in patients with bav, whereas bcl-2 was increased in patients with tav, assuming a better protection against apoptosis. |
2023-04-28 |
2023-08-14 |
human |
| Ziling Wang, Kunhang Du, Jiying Hou, Hanxianzhi Xiao, Ling Hu, Xiongbin Chen, Lu Wang, Yaping Wan. Rg1 alleviates oxidative stress and spermatogonium apoptosis in D-gal-induced testicular toxicity by activating Akt. Redox report : communications in free radical research. vol 28. issue 1. 2023-04-27. PMID:37102430. |
rg1 alleviates oxidative stress and spermatogonium apoptosis in d-gal-induced testicular toxicity by activating akt. |
2023-04-27 |
2023-08-14 |
Not clear |
| Kang-Long Zhang, Shuang-Mei Li, Jing-Yu Hou, Ying-Hui Hong, Xu-Xiang Chen, Chang-Qing Zhou, Hao Wu, Guang-Hui Zheng, Chao-Tao Zeng, Hai-Dong Wu, Jia-Ying Fu, Tong Wan. Elabela, a Novel Peptide, Exerts Neuroprotective Effects Against Ischemic Stroke Through the APJ/miR-124-3p/CTDSP1/AKT Pathway. Cellular and molecular neurobiology. 2023-04-27. PMID:37106272. |
furthermore, adenovirus-mediated overexpression of ctdsp1 exacerbated neuronal apoptosis and axonal damage and suppressed akt phosphorylation, while treatment with ela or mir-124-3p mimics reversed these effects. |
2023-04-27 |
2023-08-14 |
mouse |
| Wei Wang, Yun Gu, Hao Ni, Qiuying Quan, Lingchuan Gu. Silencing of FAM111B inhibits tumor growth and promotes apoptosis by decreasing AKT activity in ovarian cancer. Experimental biology and medicine (Maywood, N.J.). 2023-04-25. PMID:37095701. |
silencing of fam111b inhibits tumor growth and promotes apoptosis by decreasing akt activity in ovarian cancer. |
2023-04-25 |
2023-08-14 |
Not clear |
| Dorota Ciołczyk-Wierzbica, Agnieszka Krawczyk, Marta Zarzycka, Grzegorz Zemanek, Karol Wierzbick. Three generations of mTOR kinase inhibitors in the activation of the apoptosis process in melanoma cells. Journal of cell communication and signaling. 2023-04-25. PMID:37097377. |
the subject of this research was the effect of protein kinase inhibitors involved in the akt, mek, and mtor kinase signaling pathways on the expression of pro-survival proteins, activity of caspase-3, proliferation, and induction of apoptosis in melanoma cells. |
2023-04-25 |
2023-08-14 |
human |
| Yoon-Jin Lee, Kwan-Sik Park, Su-Hak Heo, Moon-Kyun Cho, Sang-Han Le. Concurrent induction of apoptosis and necroptosis in apigenin‑treated malignant mesothelioma cells: Reversal of Warburg effect through Akt inhibition and p53 upregulation. Oncology reports. vol 49. issue 6. 2023-04-21. PMID:37083070. |
concurrent induction of apoptosis and necroptosis in apigenin‑treated malignant mesothelioma cells: reversal of warburg effect through akt inhibition and p53 upregulation. |
2023-04-21 |
2023-08-14 |
Not clear |
| Jiayi Wang, Keizo Matsushita, Jianyong Zhong, Li-Jun Ma, Hai-Chun Yang, Agnes B Fog. Low-Dose Erythropoietin Amplifies Beneficial Effects of Angiotensin II Blockade on Glomerulosclerosis. Laboratory investigation; a journal of technical methods and pathology. vol 103. issue 2. 2023-04-11. PMID:37039147. |
glomerular endothelial cells and podocytes were cultured to evaluate the effects of da on cell migration, apoptosis, and akt signaling. |
2023-04-11 |
2023-08-14 |
mouse |
| Lin Li, Weitong Qi, Yujiao Zhu, Mingming Yin, Chen Chen, Meng Wei, Zhenzhen Huang, Zhuhua Su, Jizong Jiang, Mingxue Zhang, Yihua Be. Danlou Tablet Protects Against Cardiac Remodeling and Dysfunction after Myocardial Ischemia/Reperfusion Injury through Activating AKT/FoxO3a Pathway. Journal of cardiovascular translational research. 2023-04-10. PMID:37036598. |
mechanistically, dan inhibited myocardial apoptosis through phosphorylating akt and foxo3a, thereby inhibiting downstream bim and puma expressions. |
2023-04-10 |
2023-08-14 |
human |
| Kainan Zhang, Xizhou An, Yao Zhu, Lan Huang, Xinyuan Yao, Xing Zeng, Shaoyan Liang, Jie Y. Netrin-1 inducing antiapoptotic effect of acute myeloid leukemia cells in a concentration-dependent manner through the Unc-5 netrin receptor B-focal adhesion kinase axis. Cancer biology & therapy. vol 24. issue 1. 2023-04-10. PMID:37038247. |
both fak and akt inhibitors abrogated the effects of netrin-1 on the proliferation and apoptosis of aml cells. |
2023-04-10 |
2023-08-14 |
Not clear |
| Linlin Gao, Zhenqiang Li, Wenxiao Chang, Yanyan Liu, Nan Zhan. Myeloid-derived growth factor regulates high glucose-mediated apoptosis of gingival fibroblasts and induce AKT pathway activation and nuclear factor κB pathway inhibition. Journal of dental sciences. vol 18. issue 2. 2023-04-06. PMID:37021271. |
myeloid-derived growth factor regulates high glucose-mediated apoptosis of gingival fibroblasts and induce akt pathway activation and nuclear factor κb pathway inhibition. |
2023-04-06 |
2023-08-14 |
Not clear |
| Kunhang Du, Lu Wang, Ziling Wang, Hanxianzhi Xiao, Jiying Hou, Ling Hu, Ningke Fan, Yaping Wan. Angelica Sinensis polysaccharide antagonizes 5-Fluorouracil-induced spleen injury and dysfunction by suppressing oxidative stress and apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 162. 2023-04-05. PMID:37018993. |
furthermore, asp alleviated the apoptosis of spleens in vivo and splenocytes in vitro, and reactivated pi3k / akt signalling. |
2023-04-05 |
2023-08-14 |
mouse |
| Yanchun Wang, Yilong Dong, Wenbo Zhang, Yanmei Wang, Yang Jao, Jianjun Liu, Mingzhu Zhang, Hongbing H. AMPK/mTOR/p70S6K axis prevents apoptosis of Porphyromonas gingivalis-infected gingival epithelial cells via Bad Apoptosis : an international journal on programmed cell death. 2023-04-04. PMID:37014579. |
subsequently, apoptosis was detected using flow cytometry, and expression and activity of bcl-2, bad, bax, pi3k, akt, ampk, mtor, and p70s6k proteins were analyzed using western blotting. |
2023-04-04 |
2023-08-14 |
human |
| Juan Gao, Shiqi Suo, Jingxia Li, Chunxia Wang, Ranran Deng, Yuxia Hu, Chunzheng Zhan. IGFBP‑rP1 affects the proliferation, apoptosis and macrophage polarization of endometrial cancer cells by regulating the PI3K/AKT pathway. Experimental and therapeutic medicine. vol 25. issue 4. 2023-04-03. PMID:37006880. |
overexpression of igfbp-rp1 inhibited the proliferation and induced apoptosis of ec cells, which were abolished by the overexpression of akt. |
2023-04-03 |
2023-08-14 |
Not clear |
| Shreni Agrawal, Richa Das, Amit Kumar Singh, Pradeep Kumar, Praveen Kumar Shukla, Indrani Bhattacharya, Amit Kumar Tripathi, Sunil Kumar Mishra, Kavindra Nath Tiwar. Network pharmacology-based anti-pancreatic cancer potential of kaempferol and catechin of Trema orientalis L. through computational approach. Medical oncology (Northwood, London, England). vol 40. issue 5. 2023-04-03. PMID:37010624. |
kaempferol effectively check cell migration by inhibiting erk1/2, egfr-related src, and akt pathways by scavenging ros whilst catechin inhibited tnfα-induced activation and cell cycle arrest at g1 and g2/m phases by induction of apoptosis of malignant cells. |
2023-04-03 |
2023-08-14 |
Not clear |
| Korrakod Petsri, Masashi Yokoya, Satapat Racha, Sunisa Thongsom, Chorpaka Thepthanee, Bhurichaya Innets, Zin Zin Ei, Daiki Hotta, Hongbin Zou, Pithi Chanvorachot. Novel Synthetic Derivative of Renieramycin T Right-Half Analog Induces Apoptosis and Inhibits Cancer Stem Cells via Targeting the Akt Signal in Lung Cancer Cells. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982418. |
novel synthetic derivative of renieramycin t right-half analog induces apoptosis and inhibits cancer stem cells via targeting the akt signal in lung cancer cells. |
2023-03-29 |
2023-08-14 |
Not clear |
| Meeti Punetha, Sheetal Saini, Suman Chaudhary, Renu Bala, Maninder Sharma, Pradeep Kumar, Dharmendra Kumar, P S Yada. Mitochondria-targeted antioxidant MitoQ ameliorates ROS production and improves cell viability in cryopreserved buffalo fibroblasts. Tissue & cell. vol 82. 2023-03-23. PMID:36958101. |
furthermore, expression of genes related to mitochondrial oxidative stress (nrf2, gpx, and sod), apoptosis (bak and caspase 3) and cell proliferation (akt) were also assessed. |
2023-03-23 |
2023-08-14 |
Not clear |
| Ayushi Srivastava, Dinender K Singl. PTEN-AKT pathway attenuates apoptosis and adverse remodeling in ponatinib-induced skeletal muscle toxicity following BMP-7 treatment. Physiological reports. vol 11. issue 6. 2023-03-22. PMID:36945866. |
furthermore, bmp-7 treatment significantly (p < 0.05) attenuated ponatinib-induced apoptosis, bax/bcl2 ratio, decreased pten, and increased cell survival protein akt, decreased adverse muscle remodeling, and improved muscle function. |
2023-03-22 |
2023-08-14 |
mouse |
| Tongshuai Zhang, Jinrong Wu, Xinmin Yao, Yao Zhang, Yue Wang, Yang Han, Yun Wu, Zhenyu Xu, Jing Lan, Siyu Han, Haifeng Zou, Qixu Sun, Dandan Wang, Jingyu Zhang, Guangyou Wan. The Aldose Reductase Inhibitor Epalrestat Maintains Blood-Brain Barrier Integrity by Enhancing Endothelial Cell Function during Cerebral Ischemia. Molecular neurobiology. 2023-03-20. PMID:36940077. |
in addition, bicalutamide (an akt inhibitor) and rapamycin (an mtor inhibitor) increased the epalrestat-induced reduction in apoptosis and autophagy related protein levels in bend.3 cells with ogd treatment. |
2023-03-20 |
2023-08-14 |
mouse |