| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lakshmi Kanth Kotarkonda, Subhashini Bharathala, Tej Prakash Sinha, Kapil Dev Soni, Richa Aggarwal, Arul Selvi, D N Rao, Ashok Sharma, Sanjeev Bho. ALTERATION OF AKT1-GSK3Β SIGNALING PATHWAY IN TRAUMA HEMORRHAGIC SHOCK PATIENTS. Shock (Augusta, Ga.). vol 58. issue 6. 2022-12-22. PMID:36548639. |
the akt (protein kinase b) isoform, akt1, and glycogen synthase kinase 3β (akt1-gsk3β) signaling pathway controls cell survival and apoptosis. |
2022-12-22 |
2023-08-14 |
Not clear |
| Hongyu Li, Joseph C K Leung, Wai Han Yiu, Loretta Y Y Chan, Bin Li, Sarah W Y Lok, Rui Xue, Yixin Zou, Kar Neng Lai, Sydney C W Tan. Tubular β-catenin alleviates mitochondrial dysfunction and cell death in acute kidney injury. Cell death & disease. vol 13. issue 12. 2022-12-20. PMID:36539406. |
in both aki models, tubular β-catenin stabilization in tubcat animals significantly reduced bun/serum creatinine, tubular damage (ngal-positive tubules), apoptosis (tunel-positive cells) and necroptosis (phosphorylation of mlkl and rip3) through activating akt phosphorylation and p53 suppression; enhanced mitochondrial biogenesis (increased pgc-1α and nrf1) and restored mitochondrial mass (increased tim23) to re-establish mitochondrial homeostasis (increased fusion markers opa1, mfn2, and decreased fission protein drp1) through the foxo3/pgc-1α signaling cascade. |
2022-12-20 |
2023-08-14 |
mouse |
| Akbar Muhammed Shahid, In Hwa Um, Mustafa Elshani, Ying Zhang, David James Harriso. NUC-7738 regulates β-catenin signalling resulting in reduced proliferation and self-renewal of AML cells. PloS one. vol 17. issue 12. 2022-12-15. PMID:36520954. |
protein expression and immunophenotypic profiling revealed that nuc-7738 caused apoptosis in aml cell lines through reducing pi3k-p110α, phosphorylated akt (ser473) and phosphorylated gsk3β (ser9) resulting in reduced β-catenin, c-myc and cd44 expression. |
2022-12-15 |
2023-08-14 |
Not clear |
| Mathieu Chocry, Ludovic Leloup, Fabrice Parat, Mélissa Messé, Alessandra Pagano, Hervé Kovaci. Gemcitabine: An Alternative Treatment for Oxaliplatin-Resistant Colorectal Cancer. Cancers. vol 14. issue 23. 2022-12-11. PMID:36497380. |
using pamgene technology to decipher gemcitabine's effects on oxaliplatin-resistant cells, we were able to show that gemcitabine counteracts chemoresistance by strongly inhibiting the akt and src/p38 mapk pathways, leading to apoptosis induction and cell death. |
2022-12-11 |
2023-08-14 |
Not clear |
| Yifan Zhou, Feng Li. Coordination of the AMPK, Akt, mTOR, and p53 Pathways under Glucose Starvation. International journal of molecular sciences. vol 23. issue 23. 2022-12-11. PMID:36499271. |
for long-term energy stress, cell senescence is maintained by low/intermediate levels of p53 and persistent activation of mtor and akt, or cells commit apoptosis when the proteins undergo biphasic dynamics, e.g., p53 switches from intermediate levels to high levels while mtor and akt become inactivated in the later phase. |
2022-12-11 |
2023-08-14 |
Not clear |
| Minglin Liang, Cong Liu, Tao Lei, Shiyi Guo, Jie Mi. Effect of integrin α7 on cell proliferation, invasion, apoptosis and the PI3K/AKT pathway, and its association with clinicopathological features in endometrial cancer. Oncology letters. vol 25. issue 1. 2022-12-08. PMID:36478908. |
subsequently, cell proliferation, apoptosis, invasion and expression levels of pi3k, phosphorylated (p-) pi3k, akt and p-akt were determined using cell counting kit-8, tunel, transwell assays and western blotting. |
2022-12-08 |
2023-08-14 |
human |
| Turana Orujova, Abdulilah Ece, Gülşen Akalın Çiftçi, Ahmet Özdemir, Mehlika D Altınto. A new series of thiazole-hydrazone hybrids for Akt-targeted therapy of non-small cell lung cancer. Drug development research. 2022-12-05. PMID:36469421. |
furthermore, the effects of the most potent anticancer agents on apoptosis and akt inhibition were investigated. |
2022-12-05 |
2023-08-14 |
mouse |
| Caroline M Gorvin, Paul J Newey, Rajesh V Thakke. Identification of prolactin receptor variants with diverse effects on receptor signalling. Journal of molecular endocrinology. 2022-11-29. PMID:36445946. |
these altered responses included loss- and gain-of-function activities related to stat5 signalling, akt and foxo1 activity, as well as cell viability and apoptosis. |
2022-11-29 |
2023-08-14 |
Not clear |
| Shuancheng Zhang, Yucong Ma, Qianqian Zuo, Mengrui Liu, Zhifang Yu, Ying Sun, Cuimiao Song, Hongyan Sun, Guimin Hao, Bulang Gao, Huilan Du, Jingwei Che. Repeated controlled ovarian stimulation-induced ovarian and uterine damage in mice through the PI3K/AKT signaling pathway. Human cell. 2022-11-28. PMID:36441500. |
the morphology of the ovary and endometrium, ovarian apoptosis, and expressions of the vascular endothelial growth factor (vegf), leukemia inhibitory factor (lif), pi3k, akt, bax, and bcl-2 in the ovarian and uterine tissues were tested by hematoxylin-eosin (he) staining, immunohistochemistry, and western blot. |
2022-11-28 |
2023-08-14 |
mouse |
| Jingchang Ma, Yitian Liu, Chujun Duan, Shuwen Wu, Yang Xie, Lu Yang, Xuemei Li, Yuling Wang, Yuan Zhang, Ran Zhuan. CD226 knockout reduces the development of CD8+ T by impairing the TCR sensitivity of double-positive thymocytes. Immunology. 2022-11-24. PMID:36420662. |
in mechanism, cd226 knockout enhanced dpt cell apoptosis via impairing akt phosphorylation. |
2022-11-24 |
2023-08-14 |
mouse |
| Fatemeh Yarmohammadi, Zainab Ebrahimian, Gholamreza Karim. MicroRNAs target the PI3K/Akt/p53 and the Sirt1/Nrf2 signaling pathways in doxorubicin-induced cardiotoxicity. Journal of biochemical and molecular toxicology. 2022-11-23. PMID:36416353. |
studies have demonstrated that mirnas by modifying the expression of proteins such as pten, akt, and survivin can affect dox-induced cardiac apoptosis. |
2022-11-23 |
2023-08-14 |
Not clear |
| Ritesh Urade, Chon-Kit Chou, Han-Lin Chou, Bing-Hung Chen, Tsu-Nai Wang, Eing-Mei Tsai, Chun-Tzu Hung, Shyh-Jong Wu, Chien-Chih Chi. Phthalate derivative DEHP disturbs the antiproliferative effect of camptothecin in human lung cancer cells by attenuating DNA damage and activating Akt/NF-κB signaling pathway. Environmental toxicology. 2022-11-17. PMID:36394428. |
we found that dehp interferes with cpt-induced apoptosis and autophagy and increases the prosurvival pathway by reducing the dna damage marker γ-h2ax and activating the akt and nf-κb pathways. |
2022-11-17 |
2023-08-14 |
human |
| Ravel Ray, Hind Al Khashali, Ben Haddad, Jadziah Wareham, Kai-Ling Coleman, Danyah Alomari, Robert Ranzenberger, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evan. Regulation of Cisplatin Resistance in Lung Cancer Cells by Nicotine, BDNF, and a β-Adrenergic Receptor Blocker. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36361620. |
apoptosis and cell sensitivity to cisplatin increased upon co-treatment of cells with cisplatin and inhibitors against pi3k or akt. |
2022-11-11 |
2023-08-14 |
Not clear |
| Hui-Ju Yang, Bharath Kumar Velmurugan, Mu-Kuan Chen, Chia-Chieh Lin, Yu-Sheng Lo, Yi-Ching Chuang, Hsin-Yu Ho, Ming-Ju Hsieh, Jiunn-Liang K. 7-Epitaxol induces apoptosis in cisplatin-resistant head and neck squamous cell carcinoma via suppression of AKT and MAPK signalling. Journal of cellular and molecular medicine. 2022-10-29. PMID:36308422. |
7-epitaxol induces apoptosis in cisplatin-resistant head and neck squamous cell carcinoma via suppression of akt and mapk signalling. |
2022-10-29 |
2023-08-14 |
Not clear |
| Hui-Ju Yang, Bharath Kumar Velmurugan, Mu-Kuan Chen, Chia-Chieh Lin, Yu-Sheng Lo, Yi-Ching Chuang, Hsin-Yu Ho, Ming-Ju Hsieh, Jiunn-Liang K. 7-Epitaxol induces apoptosis in cisplatin-resistant head and neck squamous cell carcinoma via suppression of AKT and MAPK signalling. Journal of cellular and molecular medicine. 2022-10-29. PMID:36308422. |
at the upstream cell signalling level, 7-epitaxol reduced the phosphorylation of akt, erk1/2 and p38 to trigger apoptosis. |
2022-10-29 |
2023-08-14 |
Not clear |
| Hui-Ju Yang, Bharath Kumar Velmurugan, Mu-Kuan Chen, Chia-Chieh Lin, Yu-Sheng Lo, Yi-Ching Chuang, Hsin-Yu Ho, Ming-Ju Hsieh, Jiunn-Liang K. 7-Epitaxol induces apoptosis in cisplatin-resistant head and neck squamous cell carcinoma via suppression of AKT and MAPK signalling. Journal of cellular and molecular medicine. 2022-10-29. PMID:36308422. |
taken together, the study demonstrates the potential anticancer efficacy of 7-epitaxol in inducing apoptosis of cisplatin-resistant hnscc cells through the suppression of akt and mapk signalling pathways. |
2022-10-29 |
2023-08-14 |
Not clear |
| Xuehua Shao, Zhuhong Zhang, Xuhong Qian, Lanying Wang, Yunfei Zhang, Yanping Lu. Potential Biochemical Pesticide-Synthesis of Neofuranocoumarin and Inhibition the Proliferation of Toxins. vol 14. issue 10. 2022-10-28. PMID:36287946. |
finally, western blotting analysis detected that the phosphorylation level of akt and bad and the expression of the apoptosis inhibitor protein bcl-xl were inhibited, cleaved-parp and p53 were increased, and cytochrome c was released from the mitochondria into the cytoplasm. |
2022-10-28 |
2023-08-16 |
Not clear |
| Zhen Liu, Ye Xu, Lvqian Guo, Xinran Li, Junling Gao, Weiran Xie, Lianbo Zhao, Yuou Teng, Xuejiao Li, Peng Y. Development of 10-Hydroxycamptothecin-crizotinib conjugate based on the synergistic effect on lung cancer cells. Journal of enzyme inhibition and medicinal chemistry. vol 38. issue 1. 2022-10-28. PMID:36305251. |
the combination synergistically enhanced the cell apoptosis rate through releasing cyto-c by activation of bcl-2 family-mediated mitochondrial signalling, which was associate with inactivating of egfr related downstream signalling pathways including akt, erk, jnk, and p38 mapk. |
2022-10-28 |
2023-08-14 |
Not clear |
| Cheng-Zhu Wu, Mei-Jia Gao, Jie Chen, Xiao-Long Sun, Ke-Yi Zhang, Yi-Qun Dai, Tao Ma, Hong-Mei Li, Yu-Xin Zhan. Isobavachalcone Induces Multiple Cell Death in Human Triple-Negative Breast Cancer MDA-MB-231 Cells. Molecules (Basel, Switzerland). vol 27. issue 20. 2022-10-27. PMID:36296386. |
the initial mechanism of ibc-mediated cell death in mda-mb-231 cells involves the downregulation of akt and p-akt-473, an increase in the bax/bcl-2 ratio, and cleaved caspases-3 induced apoptosis; the upregulation of rip3, p-rip3 and mlkl induced necroptosis; as well as a simultaneous increase in lc3-ii/i ratio induced autophagy. |
2022-10-27 |
2023-08-14 |
human |
| Feng Guan, Youming Ding, Yikang He, Lu Li, Xinyu Yang, Changhua Wang, Mingbai H. Involvement of adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 in diallyl trisulfide-induced cytotoxicity in hepatocellular carcinoma cells. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 26. issue 6. 2022-10-27. PMID:36302621. |
compared with wild-type appl1, overexpression of appl1 k63r mutant dramatically increased cell apoptosis and mitigated cell survival, along with a reduction of phosphorylation of stat3, akt, and erk1/2. |
2022-10-27 |
2023-08-14 |
human |