| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun-Ren Chen, Xiao-Fang Xie, Xiao-Yu Cao, Gang-Min Li, Yan-Peng Yin, Cheng Pen. [Research progress on mechanism of Carthamus tinctorius in ischemic stroke therapy]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 17. 2022-09-27. PMID:36164862. |
furthermore, mediating the activation of janus kinase 2(jak2)/stat3/suppressor of cytokine signaling 3(socs3) signaling pathway and phosphoinositide 3-kinase(pi3 k)/protein kinase b(akt)/glycogen synthase kinase-3β(gsk3β) signaling pathway and regulating the release of matrix metalloproteinase(mmp) inhibitor/mmp are main ways that c. tinctorius inhibits neuronal apoptosis. |
2022-09-27 |
2023-08-14 |
Not clear |
| Md Mominur Rahman, Md Taslim Sarker, Mst Afroza Alam Tumpa, Md Yamin, Tamanna Islam, Moon Nyeo Park, Md Rezaul Islam, Abdur Rauf, Rohit Sharma, Simona Cavalu, Bonglee Ki. Exploring the recent trends in perturbing the cellular signaling pathways in cancer by natural products. Frontiers in pharmacology. vol 13. 2022-09-26. PMID:36160435. |
these natural chemicals are known to affect numerous important cellular signaling pathways, such as nf-b, mapk, wnt, notch, akt, p53, ar, er, and many others, to cause cell death signals and induce apoptosis in pre-cancerous or cancer cells without harming normal cells. |
2022-09-26 |
2023-08-14 |
human |
| Hoi Kit Matthew Leung, Emily Kwun Kwan Lo, Hani El-Nezam. Theabrownin Alleviates Colorectal Tumorigenesis in Murine AOM/DSS Model via PI3K/Akt/mTOR Pathway Suppression and Gut Microbiota Modulation. Antioxidants (Basel, Switzerland). vol 11. issue 9. 2022-09-23. PMID:36139789. |
furthermore, tb significantly reduced phosphorylation of phosphatidylinositol 3-kinase (pi3k), protein kinase b (akt), and the downstream mechanistic target of rapamycin (mtor)and cyclin d1 protein expression, which might contribute to cell proliferation suppression and apoptosis enhancement. |
2022-09-23 |
2023-08-14 |
mouse |
| Jun-Ping Shiau, Ya-Ting Chuang, Jen-Yang Tang, Kun-Han Yang, Fang-Rong Chang, Ming-Feng Hou, Ching-Yu Yen, Hsueh-Wei Chan. The Impact of Oxidative Stress and AKT Pathway on Cancer Cell Functions and Its Application to Natural Products. Antioxidants (Basel, Switzerland). vol 11. issue 9. 2022-09-23. PMID:36139919. |
this review explores the role of oxidative stress and akt pathway (akt/akt effectors) on ten cell functions, including apoptosis, autophagy, endoplasmic reticulum stress, mitochondrial morphogenesis, ferroptosis, necroptosis, dna damage response, senescence, migration, and cell-cycle progression. |
2022-09-23 |
2023-08-14 |
Not clear |
| Li-Tzu Huang, Chin-Ho Kuo, Lin Tseng, Yi-Syuan Li, Li-Hsin Cheng, Chin-Yun Cheng, Shane-Rong Sheu, Wen-Tsan Chang, Chien-Chin Chen, Hung-Chi Chen. Alpha-Mangostin Reduces Pericellular Fibronectin on Suspended Tumor Cells and Therapeutically, but Not Prophylactically, Suppresses Distant Metastasis. Life (Basel, Switzerland). vol 12. issue 9. 2022-09-23. PMID:36143411. |
immunofluorescence staining, mtt assays, flow cytometric assays, immunoblotting, and experimental metastasis mouse models were used to detect the effects of mp extracts or α-mg on perifn on stcs, tumor cell proliferation and apoptosis, the akt activity, and tumor lung metastasis. |
2022-09-23 |
2023-08-14 |
mouse |
| Julia Holzerland, Lucie Fénéant, Allison Groset. Regulation of Stress-Activated Kinases in Response to Tacaribe Virus Infection and Its Implications for Viral Replication. Viruses. vol 14. issue 9. 2022-09-23. PMID:36146824. |
importantly, the chemical inhibition of akt, p38, jnk and c-jun all dramatically reduced viral growth, even though we have shown that inhibition of apoptosis itself does not. |
2022-09-23 |
2023-08-14 |
Not clear |
| Yang Liu, Hongzhao Shi, Yajie Hu, Ruizhi Yao, Peng Liu, Yuying Yang, Shize L. RNA binding motif protein 3 (RBM3) promotes protein kinase B (AKT) activation to enhance glucose metabolism and reduce apoptosis in skeletal muscle of mice under acute cold exposure. Cell stress & chaperones. 2022-09-23. PMID:36149580. |
rna binding motif protein 3 (rbm3) promotes protein kinase b (akt) activation to enhance glucose metabolism and reduce apoptosis in skeletal muscle of mice under acute cold exposure. |
2022-09-23 |
2023-08-14 |
mouse |
| Yang Liu, Hongzhao Shi, Yajie Hu, Ruizhi Yao, Peng Liu, Yuying Yang, Shize L. RNA binding motif protein 3 (RBM3) promotes protein kinase B (AKT) activation to enhance glucose metabolism and reduce apoptosis in skeletal muscle of mice under acute cold exposure. Cell stress & chaperones. 2022-09-23. PMID:36149580. |
changes in levels of rbm3, akt, glycolysis apoptosis, and ogt were measured. |
2022-09-23 |
2023-08-14 |
mouse |
| Yang Liu, Hongzhao Shi, Yajie Hu, Ruizhi Yao, Peng Liu, Yuying Yang, Shize L. RNA binding motif protein 3 (RBM3) promotes protein kinase B (AKT) activation to enhance glucose metabolism and reduce apoptosis in skeletal muscle of mice under acute cold exposure. Cell stress & chaperones. 2022-09-23. PMID:36149580. |
the results show that acute cold exposure upregulated rbm3, ogt, and akt phosphorylation and increased energy consumption, which enhanced glycolysis and prevent apoptosis. |
2022-09-23 |
2023-08-14 |
mouse |
| Yang Liu, Hongzhao Shi, Yajie Hu, Ruizhi Yao, Peng Liu, Yuying Yang, Shize L. RNA binding motif protein 3 (RBM3) promotes protein kinase B (AKT) activation to enhance glucose metabolism and reduce apoptosis in skeletal muscle of mice under acute cold exposure. Cell stress & chaperones. 2022-09-23. PMID:36149580. |
meanwhile, inactivation of akt by wortmannin resulted in increased apoptosis and decreased glucose metabolism in skeletal muscle under acute cold exposure. |
2022-09-23 |
2023-08-14 |
mouse |
| Yang Liu, Hongzhao Shi, Yajie Hu, Ruizhi Yao, Peng Liu, Yuying Yang, Shize L. RNA binding motif protein 3 (RBM3) promotes protein kinase B (AKT) activation to enhance glucose metabolism and reduce apoptosis in skeletal muscle of mice under acute cold exposure. Cell stress & chaperones. 2022-09-23. PMID:36149580. |
compared with wild type (wt) mice, rbm3 and p65 phosphorylation were decreased in specific skeletal muscle ogt (ko) mice, whereas akt phosphorylation, glycolysis, and apoptosis were increased. |
2022-09-23 |
2023-08-14 |
mouse |
| Yang Liu, Hongzhao Shi, Yajie Hu, Ruizhi Yao, Peng Liu, Yuying Yang, Shize L. RNA binding motif protein 3 (RBM3) promotes protein kinase B (AKT) activation to enhance glucose metabolism and reduce apoptosis in skeletal muscle of mice under acute cold exposure. Cell stress & chaperones. 2022-09-23. PMID:36149580. |
taken together, o-glcnacylation of p65 upregulates rbm3 to promote akt phosphorylation, enhance glucose metabolism, and reduce apoptosis in skeletal muscle of mice under acute cold exposure. |
2022-09-23 |
2023-08-14 |
mouse |
| Xiulong Ma, Hongtao Ren, Yang Zhang, Baofeng Wang, Hongbing M. LncRNA RHPN1-AS1 inhibition induces autophagy and apoptosis in prostate cancer cells via the miR-7-5p/EGFR/PI3K/AKT/mTOR signaling pathway. Environmental toxicology. 2022-09-20. PMID:36125241. |
furthermore, overexpression of rhpn1-as1 promoted phosphorylation of phosphatidylinositol 3-kinase (pi3k), akt and mtor, inhibited lc3-i to lc3-ii conversion and reduced apoptosis in pca cells, while gsk2126458 (an inhibitor of pi3k) reversed the effect of rhpn1-as1 on pca cells. |
2022-09-20 |
2023-08-14 |
Not clear |
| Jie Zhang, Li Cen, Xiaofen Zhang, Chenxi Tang, Yishu Chen, Yuwei Zhang, Mengli Yu, Chao Lu, Meng Li, Sha Li, Bingru Lin, Tiantian Zhang, Xin Song, Chaohui Yu, Hao Wu, Zhe She. MPST deficiency promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via AKT. Redox biology. vol 56. 2022-09-20. PMID:36126419. |
mpst deficiency promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via akt. |
2022-09-20 |
2023-08-14 |
Not clear |
| Xin Ouyang, Zhimei He, Heng Fang, Huidan Zhang, Qi Yin, Linhui Hu, Fei Gao, Hao Yin, Taofang Hao, Yating Hou, Qingrui Wu, Jia Deng, Jing Xu, Yirong Wang, Chunbo Che. A protein encoded by circular ZNF609 RNA induces acute kidney injury by activating AKT/mTOR-autophagy pathway. Molecular therapy : the journal of the American Society of Gene Therapy. 2022-09-16. PMID:36110046. |
the blockade of akt and mtor signaling with pharmacological inhibitors was capable of reversing znf609-250aa induced autophagy flux impairment and cell apoptosis in hk-2 cells. |
2022-09-16 |
2023-08-14 |
Not clear |
| Junsha An, Huali Fan, Mingyu Han, Cheng Peng, Jie Xie, Fu Pen. Exploring the mechanisms of neurotoxicity caused by fuzi using network pharmacology and molecular docking. Frontiers in pharmacology. vol 13. 2022-09-16. PMID:36110545. |
it was verified that aconitine caused neurotoxicity through a variety of pathways, including mapk signaling pathway, pathways related to akt protein, destruction of cell membrane integrity, damage of mitochondrial function affecting energy metabolism and apoptosis. |
2022-09-16 |
2023-08-14 |
Not clear |
| Tanmin Lu, Yu W. Tripartite Motif Containing 26 is a Positive Predictor for Endometrial Carcinoma Patients and Regulates Cell Survival in Endometrial Carcinoma. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2022-09-15. PMID:36108622. |
trim26 could regulate akt pathway and apoptosis process to inhibit the growth of endometrial carcinoma, which can be utilized as a survival predictor. |
2022-09-15 |
2023-08-14 |
mouse |
| Junbin Wang, Xinyi Lai, Xuxing Pen. CircLIFR Inhibits Non-small Cell Lung Cancer Progression by Acting as a miR-429 Sponge to Enhance CELF2 Expression. Biochemical genetics. 2022-09-14. PMID:36104590. |
importantly, overexpression of circlifr impeded cell proliferation, migration, invasion, and inactivated protein kinase b (akt)/phosphatase and tensin homolog (pten)-signaling pathways while enhanced apoptosis and cell-cycle arrest in nsclc cells, which was overturned by upregulation of mir-429 or silencing of celf2. |
2022-09-14 |
2023-08-14 |
human |
| Niluka Goonawardane, Laura Upstone, Mark Harris, Ian M Jone. Identification of Host Factors Differentially Induced by Clinically Diverse Strains of Tick-Borne Encephalitis Virus. Journal of virology. 2022-09-13. PMID:36098513. |
hypr was associated with significant activation of irf-3, caspase-3, and caspase-8, while vs activated akt, affording protection against caspase-mediated apoptosis. |
2022-09-13 |
2023-08-14 |
human |
| Eun Hye Lee, Hyun Tae Kim, So Young Chun, Jae-Wook Chung, Seock Hwan Choi, Jun Nyung Lee, Bum Soo Kim, Eun Sang Yoo, Tae Gyun Kwon, Tae-Hwan Kim, Yun-Sok H. Role of the JNK Pathway in Bladder Cancer. OncoTargets and therapy. vol 15. 2022-09-12. PMID:36091874. |
jnk belongs to the mitogen-activated protein kinases (mapks) family; it is activated by various extracellular stimuli, such as stress, radiation, and growth factors and mediates diverse cellular functions, such as apoptosis, autophagy, proliferation, invasion, and migration by mediating akt (ak strain transforming), atg (autophagy related), mtor (mammalian target of rapamycin), and caspases 3, 8, and 9. |
2022-09-12 |
2023-08-14 |
Not clear |