| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yutao Guan, Qianlong Wu, Miaomiao Li, Danyang Chen, Jingyao Su, Liandong Zuo, Bing Zhu, Yinghua L. Epigallocatechin-3-gallate induced HepG2 cells apoptosis through ROS-Mediated AKT /JNK and p53 signaling pathway.. Current cancer drug targets. 2022-07-06. PMID:35792125. |
epigallocatechin-3-gallate induced hepg2 cells apoptosis through ros-mediated akt /jnk and p53 signaling pathway.. hepatocarcinoma is the third leading cause of cancer-related deaths around the world. |
2022-07-06 |
2023-08-14 |
Not clear |
| Yutao Guan, Qianlong Wu, Miaomiao Li, Danyang Chen, Jingyao Su, Liandong Zuo, Bing Zhu, Yinghua L. Epigallocatechin-3-gallate induced HepG2 cells apoptosis through ROS-Mediated AKT /JNK and p53 signaling pathway.. Current cancer drug targets. 2022-07-06. PMID:35792125. |
furthermore, egcg enhanced cytotoxic effects on hepg2 cells and triggered intracellular reactive oxygen species; the signaling pathways of akt, jnk, and p53 were activated to advance cell apoptosis. |
2022-07-06 |
2023-08-14 |
Not clear |
| Lisa M Kim, Paul Y Kim, Yemarshet K Gebreyohannes, Cheuk T Leun. Sustained oncogenic signaling in the cytostatic state enables targeting of non-proliferating persistent cancer cells. Cancer research. 2022-07-06. PMID:35792658. |
under cytostatic conditions, inhibition of the proteasome selectively induced apoptosis in the population with aberrant akt activation compared to normal cells. |
2022-07-06 |
2023-08-14 |
mouse |
| Piplu Bhuiyan, G S Chuwdhury, Zhaochu Sun, Yinan Chen, Hongquan Dong, Fee Faysal Ahmed, Li Nana, Md Habibur Rahman, Yanning Qia. Network Biology Approaches to Uncover Therapeutic Targets Associated with Molecular Signaling Pathways from circRNA in Postoperative Cognitive Dysfunction Pathogenesis. Journal of molecular neuroscience : MN. 2022-07-06. PMID:35792980. |
pathway enrichment analysis indicated some key molecular pathways, including mtor signaling pathway, akt phosphorylation of cytosolic targets, mapk and nf-κb signaling pathway, pi3k/akt signaling pathway, nitric oxide signaling pathway, chaperones that modulate interferon signaling pathway, apoptosis signaling pathway, vegf signaling pathway, cellular senescence, rankl/rark signaling pathway, and age/rage pathway. |
2022-07-06 |
2023-08-14 |
Not clear |
| Lin Zhao, Yingli Yu, Li Li, Jiarui Wang, Jing Wang, Shijia Su, Jingyi Ding, Yue Zhang, Anhong Wang, Kun Zho. Isobavachalcone disrupts mitochondrial respiration and induces cytotoxicity through ROS accumulation and Akt suppression. Toxicon : official journal of the International Society on Toxinology. 2022-07-05. PMID:35780971. |
ibc initiated the accumulation of ros in cells and impaired the mitochondrial function, triggered apoptosis and suppressed the phosphorylation of akt. |
2022-07-05 |
2023-08-14 |
Not clear |
| Liwei Zhang, Yan Shi, Mingzhu Yan, Guangping Zhan. Modulatory action of withaferin-A on oxidative damage through regulation of inflammatory mediators and apoptosis via PI3K/AKT signaling pathway in high cholesterol-induced atherosclerosis in experimental rats. Journal of biochemical and molecular toxicology. 2022-06-23. PMID:35734936. |
wa reduced apoptosis via augmentation of phosphatidylinositol 3-kinase (pi3k)/protein kinase b (akt) pathway; increased b-cell lymphoma 2 and inhibited bcl-2 associated x-protein proapoptotic proteins; tnf receptor superfamily member 6, bim, caspase-3, and -9; demonstrated significant hypolipidemic and anti-inflammatory properties against hcd induced atherosclerosis in rats through regulation of inflammatory mediators and apoptosis via the pi3k/akt signaling pathway. |
2022-06-23 |
2023-08-14 |
rat |
| Gina M Castellano, Saman Zeeshan, Olga Garbuzenko, Hatim E Sabaawy, Jyoti Malhotra, Tamara Minko, Sharon R Pin. Inhibition of mTORC1/2 and DNA-PK via CC-115 Synergizes with Carboplatin and Paclitaxel in Lung Squamous Cell Carcinoma. Molecular cancer therapeutics. 2022-06-22. PMID:35732569. |
cc-115 sensitized lusc to carboplatin by inhibiting chemotherapy-induced akt activation and maintaining apoptosis, particularly in pik3ca-mutant cells lacking wild-type tp53. |
2022-06-22 |
2023-08-14 |
mouse |
| Chenyang Gu, Qiankun Zhang, Yajing Li, Rong Li, Jia Feng, Wanghao Chen, Waqas Ahmed, Ismatullah Soufiany, Shiying Huang, Jun Long, Lukui Che. The PI3K/AKT Pathway-The Potential Key Mechanisms of Traditional Chinese Medicine for Stroke. Frontiers in medicine. vol 9. 2022-06-17. PMID:35712089. |
the phosphatidylinositol 3 kinase (pi3k)/protein kinase b (akt) pathway is important for regulation of cell migration, proliferation, differentiation, and apoptosis, and plays a vital role in vascularization and oxidative stress in stroke. |
2022-06-17 |
2023-08-14 |
Not clear |
| Giulia Lottini, Matteo Baggiani, Giulia Chesi, Beatrice D'Orsi, Paola Quaranta, Michele Lai, Laura Pancrazi, Marco Onorati, Mauro Pistello, Giulia Freer, Mario Cost. Zika virus induces FOXG1 nuclear displacement and downregulation in human neural progenitors. Stem cell reports. 2022-06-17. PMID:35714598. |
growth factors, such as egf and fgf2, and thr271 residue located in foxg1 akt domain, take part in the nuclear displacement and apoptosis protection, respectively. |
2022-06-17 |
2023-08-14 |
human |
| Yizheng Zhang, Chuchu Zhang, Jiehan Li, Meimei Jiang, Shuning Guo, Ge Yang, Lingling Zhang, Feng Wang, Shiqi Yi, Jiangang Wang, Yang Fu, Yingjie Zhan. Inhibition of AKT induces p53/SIRT6/PARP1-dependent parthanatos to suppress tumor growth. Cell communication and signaling : CCS. vol 20. issue 1. 2022-06-17. PMID:35715817. |
targeting akt suppresses tumor growth through inducing apoptosis, however, during which whether other forms of cell death occurring is poorly understood. |
2022-06-17 |
2023-08-14 |
Not clear |
| Yu-Chi Chen, Chiao-Ling Hsieh, Bu-Miin Huang, Yung-Chia Che. Induction of mitochondrial-dependent apoptosis by essential oil of Toona sinensis root through Akt, mTOR and NF-κB signalling pathways in human renal cell carcinoma cells. Journal of food and drug analysis. vol 29. issue 3. 2022-06-13. PMID:35696242. |
induction of mitochondrial-dependent apoptosis by essential oil of toona sinensis root through akt, mtor and nf-κb signalling pathways in human renal cell carcinoma cells. |
2022-06-13 |
2023-08-14 |
human |
| Meiqin Liu, Shile Gao, Xingjun Xu, Lijie Zhang, Bin Xu, Donghui L. USP18 contributes to the proliferation and migration of ovarian cancer cells by regulating the AKT/mTOR signaling pathway. Acta biochimica Polonica. 2022-06-13. PMID:35696596. |
inhibition of akt attenuated the decrease in cell apoptosis induced by usp18 overexpression and increased cell viability and migration. |
2022-06-13 |
2023-08-14 |
Not clear |
| Pan Zhang, Ze-Lin Lai, Hui-Fen Chen, Min Zhang, An Wang, Tao Jia, Wen-Qin Sun, Xi-Min Zhu, Xiao-Feng Chen, Zheng Zhao, Jun Zhan. Retraction Note: Curcumin synergizes with 5-fluorouracil by impairing AMPK/ULK1-dependent autophagy, AKT activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice. Journal of experimental & clinical cancer research : CR. vol 41. issue 1. 2022-06-10. PMID:35681210. |
retraction note: curcumin synergizes with 5-fluorouracil by impairing ampk/ulk1-dependent autophagy, akt activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice. |
2022-06-10 |
2023-08-14 |
mouse |
| Hsin-Yu Ho, Ping-Ju Chen, Yi-Ching Chuang, Yu-Sheng Lo, Chia-Chieh Lin, Ming-Ju Hsieh, Mu-Kuan Che. Picrasidine I Triggers Heme Oxygenase-1-Induced Apoptosis in Nasopharyngeal Carcinoma Cells via ERK and Akt Signaling Pathways. International journal of molecular sciences. vol 23. issue 11. 2022-06-10. PMID:35682782. |
picrasidine i triggers heme oxygenase-1-induced apoptosis in nasopharyngeal carcinoma cells via erk and akt signaling pathways. |
2022-06-10 |
2023-08-14 |
Not clear |
| Nan Xing, Xianli Meng, Shaohui Wan. Isobavachalcone: A comprehensive review of its plant sources, pharmacokinetics, toxicity, pharmacological activities and related molecular mechanisms. Phytotherapy research : PTR. 2022-06-10. PMID:35684981. |
mechanically, ibc can induce the production of reactive oxygen species (ros), inhibit akt, erk, and wnt pathways, and promote apoptosis of cancer cells through mitochondrial or endoplasmic reticulum pathways. |
2022-06-10 |
2023-08-14 |
Not clear |
| Kesara Nittayaboon, Kittinun Leetanaporn, Surasak Sangkhathat, Sittirak Roytrakul, Raphatphorn Navakanitworaku. Cytotoxic effect of metformin on butyrate-resistant PMF-K014 colorectal cancer spheroid cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 151. 2022-06-09. PMID:35676792. |
the molecular mechanism revealed that amp-activated protein kinase (ampk) and akt serine/threonine kinase 1(akt) were significantly upregulated, whereas the acetyl-coa-carboxylase (acc) and mammalian target of rapamycin (mtor) were downregulated, which led to caspase activation and apoptosis. |
2022-06-09 |
2023-08-14 |
Not clear |
| Shilin Yin, Zhiwei Zhang, Hong Tang, Kai Yan. The biological clock gene PER1 affects the development of oral squamous cell carcinoma by altering the circadian rhythms of cell proliferation and apoptosis. Chronobiology international. 2022-06-09. PMID:35678317. |
after adding the akt activator sc79 to oe-per1-scc15 cells, the circadian rhythm characteristics of cell proliferation, apoptosis and p-akt and p-mtor expression were altered in opposite ways. |
2022-06-09 |
2023-08-14 |
Not clear |
| Luisa D Burgers, Yanfen Li, Stylianos Michalakis, Sarah Ciurus, Stefan Zahler, Rolf Müller, Robert Fürs. The protein biosynthesis inhibitor vioprolide A evokes anti-angiogenic and pro-survival actions by targeting NOP14 and decreasing VEGF receptor 2- and TAZ-signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 152. 2022-06-06. PMID:35665668. |
surprisingly, vioa induced pro-survival signaling in ecs by activating akt and inhibiting p53-dependent apoptosis. |
2022-06-06 |
2023-08-14 |
mouse |
| Lin Liu, Xin Zhou, Qiyu Zhang, Li Li, Yuanyuan Shang, Zhihao Wang, Ming Zhong, Yuguo Chen, Wei Zhang, Mengxiong Tan. Activin receptor-like kinase 7 silencing alleviates cardiomyocyte apoptosis, cardiac fibrosis, and dysfunction in diabetic rats. Experimental biology and medicine (Maywood, N.J.). 2022-06-06. PMID:35666032. |
histopathologic analyses of collagen content and apoptosis rate, and protein analyses of alk7, smad2/3, akt, caspase3, and bax/bcl2 were performed. |
2022-06-06 |
2023-08-14 |
human |
| Huijie Chen, Yue Zhang, Mengmeng Zou, Xue Qi, Shiwen X. Bisphenol A aggravates renal apoptosis and necroptosis in selenium-deficient chickens via oxidative stress and PI3K/AKT pathway. Journal of cellular physiology. 2022-05-26. PMID:35616291. |
we found that bpa exposure increased reactive oxygen species and malondialdehyde levels, reduced activities of catalase, gpx, and superoxide dismutase, downregulated pi3k and akt expressions, activated bcl/bax-caspase 9-caspase 3, and receptor-interacting protein kinase 1/mixed lineage kinase domain-like protein signaling pathways, resulting in apoptosis and necroptosis in the chicken kidney. |
2022-05-26 |
2023-08-13 |
chicken |